[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Pennington Biomedical Research Center\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":684},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,36,0,25,[9,48,76,97,125,150,179,206,234,262,288,314,348,372,399,421,445,471,506,523,554,587,608,633,654],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100600321","continuous-glucose-monitoring-in-metabolic-surgery-100600321",false,"NCT07095972","Continuous Glucose Monitoring in Metabolic Surgery","Optimizing Glycemic Control in Metabolic Surgery With Continuous Glucose Monitoring","Inclusion criteria: (1) age 18 to 65 years; (2) body mass index (BMI) ≥35 kg\u002Fm2\n\nExclusion Criteria:\n\n(1) age \\\u003C18 or \\>65 years; (2) confirmed type 1 diabetes; (3) pregnancy or breastfeeding; (4) history of hypersensitivity to any of the components of the subcutaneous infusions; (5) without access at home to a telephone or other factor likely to interfere with ability to participate reliably in the study; (6) history of any medical, psychological or other condition, or use of any medications, including over-the-counter products, which, in the opinion of the investigators, would either interfere with the study or potentially cause harm to the volunteer; (7) patients on insulin therapy before surgery; and (8) patients receiving revisional surgery.","ALL","18 Years","65 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","We will recruit 20 severely obese participants at Metamor Institute. Participants with obesity who are eligible for MBS will be randomized to either CGM group or self-monitoring of blood glucose (SMBG) group before the surgery based on a 1:1 ratio. All participants live in Baton Rouge, Louisiana. The surgeon in Metamor will introduce our study to the patients. If the patients are interested, the evaluation process includes verifying basic personal information, assessing health status and medical history, and evaluating specific eligibility criteria relevant to the study. The study coordinator will be discussing informed consent, ensuring participants understand the study's purpose, procedures, and any associated risks or benefits. Participants are encouraged to ask questions, ensuring clarity and comfort with the study. All collected data is documented and securely stored, respecting data privacy protocols. Eligible individuals are informed about the screening visit, while those not suitable are considered for future studies.",[28],"Obesity (Disorder)",[30,31,32,33,34],"Severe Obesity","Metabolic Surgery","Continuous Glucose Monitoring","Post-Bariatric Hypoglycemia","Randomized Controlled Trial","NOT_YET_RECRUITING","2026-06-24",{"date":38,"type":39},"2026-06-25","ACTUAL",{"date":41,"type":22},"2026-07-15",{"date":43,"type":22},"2027-05-31",{"name":45,"class":46},"Pennington Biomedical Research Center","OTHER",1,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},"100633748","body-composition-outcomes-in-ms-patients-100633748","NCT07530718","Body Composition Outcomes in MS Patients","Outcome of Body Composition Assessment in Patients With Severe Obesity Undergoing Metabolic Surgery","BCOMS","Inclusion Criteria:\n\n* Being either male or female\n* Being an adult greater or equal to 18 years of age\n* BMI ≥40 kg\u002Fm2\n* Weigh less than 440 pounds\n* Being willing to comply with the study procedures\n* Being scheduled for primary metabolic surgery (either Sleeve Gastrectomy or Roux-en-Y Gastric bypass)\n\nExclusion Criteria:\n\n* Previous bariatric surgery or other complex abdominal surgery\n* Poorly controlled medical or psychiatric disorders\n* For women in child-bearing ages, being pregnant or attempting to become pregnant or currently breastfeeding\n* Having metal-containing objects in their body that may cause artifact on MRI\n* Having medical implants such as a pacemaker or metal joint replacements\n* Having a body weight greater than 440 pounds\n* Comorbid conditions that may affect body composition measurements, such as advanced liver disease or severe cardiovascular disease.\n* Cannot understand risks, benefits, and compliance required to participate.",{"count":21,"type":22},"OBSERVATIONAL","Objectives The objective of this project is to generate pilot data substantiating our hypothesis that advanced body composition measurement tools will provide more accurate and clinically relevant data on the outcomes of metabolic surgery (MS) in patients with severe obesity compared to traditional methods.\n\nTo achieve this objective, the investigators propose the following aims:\n\nAim 1: Evaluate the effectiveness of different body composition measurement tools in assessing outcomes in patients with severe obesity undergoing MS.\n\nAim 2: Assess the changes in body composition and muscle strength following MS.\n\nAim 3: Compare body compositions changes between SG and RYGB patients.",[60],"Obesity",[60,62,63,64,65],"Bariatric surgery","skeletal muscle","adipose tissue","weight loss","RECRUITING","2026-06-15",{"date":69,"type":39},"2026-06-17",{"date":71,"type":39},"2026-04-14",{"date":73,"type":22},"2027-03-31",{"name":45,"class":46},2,{"id":77,"slug":78,"hasResults":12,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":17,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":94,"leadSponsor":96,"locationsCount":47},"100615251","evaluating-the-validity-and-feasibility-of-a-smartwatch-based-eating-detection-system-to-passively-and-automatically-detect-eating-events-in-child-parent-dyads-100615251","NCT07290179","Evaluating the Validity and Feasibility of a Smartwatch-based Eating Detection System to Passively and Automatically Detect Eating Events in Child-parent Dyads","Inclusion Criteria:\n\n* Parents or caregivers (18-70 years) who have children aged 8-12 years\n* Child is willing and able to wear smartwatch during school hours (have not restrictions in the school setting)\n\nExclusion Criteria:\n\n* Any condition or circumstance that could impede study completion\n* Child does not follow a regular eating pattern\n* Child eats less than 1 meal and 1 snack in a day\n* Child is restricted or allergic to the study foods\n* Refusal or unable to use the smartwatch to collect data for the 3-day period in free - living conditions\n* Parental refusal or unable to respond Ecological Momentary Assessment prompts",true,"8 Years","12 Years",{"count":86,"type":22},35,"This study will test the validity and feasibility of an smartwatch-based system to detect eating and drinking events in both laboratory and free-living conditions.",[89],"Eating Behavior","2026-06-10",{"date":92,"type":39},"2026-06-11",{"date":90,"type":39},{"date":95,"type":22},"2026-12",{"name":45,"class":46},{"id":98,"slug":99,"hasResults":12,"nctId":100,"briefTitle":101,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":82,"sex":17,"minAge":18,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":23,"phases":107,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":47},"100539879","experimental-approach-to-test-predictions-of-body-weight-regulation-models-100539879","NCT06309576","Experimental Approach to Test Predictions of Body Weight Regulation Models","DIP","Inclusion Criteria:\n\n* Body mass index lower than 20 kg\u002Fm2 for the low body weight group, or 30 kg\u002Fm2 or greater for the obesity group\n* 18-40 years old\n* Nulliparous and regular menstrual cycle (25-35 days) during the last six months (in women)\n* Normal thyroid function, blood count, and chemistry 15 panel (normal plasma glucose will be considered at \\\u003C100 mg\u002FdL; normal serum HDL cholesterol at \\>=50 mg\u002FdL for women and \\>=40 mg\u002FdL for men; and normal serum triglycerides at \\\u003C150 mg\u002FdL).\n* Self-reported weight stability during the last six months (±3 kg)\n* Rate the liking of at least one of the flavored liquid meals (Ensure Plus, Abbot Nutrition) between 5 and 8 on a 9-point Likert scale\n* Willing to only drink up to two assigned flavors of Ensure Plus for two consecutive days\n\nExclusion Criteria:\n\n* Eating disorders as indicated by a global score ≥2.80 in the Eating Disorder Examination Questionnaire, or a previous diagnosis of an eating disorder\n* For the low body weight group, having food insecurity (with or without hunger) as assessed by the USDA\n* Recreational moderate-intensity physical activity ≥150 min\u002Fweek, recreational vigorous-intensity physical activity ≥75 min\u002Fweek, or a combination of recreational moderate-intensity and vigorous-intensity physical activity (moderate time + \\[2 × vigorous time\\]) ≥150 min\u002Fweek as assessed by the Global Physical Activity Questionnaire, or being a professional athlete\n* Cigarette or vape smoking\n* Intake of more than 14 alcoholic drinks per week\n* Use of medications that may affect energy intake and\u002For expenditure, for example, semaglutide, liraglutide, exenatide, other GLP-1 receptor agonists, phentermine-topiramate, naltrexone-bupropion, orlistat, metformin, SGLT2 inhibitors, pramlintide, levocarnitine, amphetamines, and amphetamine-like drugs\n* Human immunodeficiency virus, galactosemia, and lactose intolerance\n* Diseases that affect energy homeostasis including endocrine such as hypo\u002Fhyperthyroidism, or type 1 or 2 diabetes; cancer; chronic pulmonary diseases; cardiovascular disease; and renal disease\n* History of inflammatory bowel disease (ulcerative colitis, Crohn's), malabsorption syndromes (intestinal, pancreatic), and sprue or gluten intolerance\n* Having moderate to severe sleep apnea defined as an oxygen desaturation index \\>10 times\u002Fhour assessed by overnight oximetry to be conducted on the night following the screening visit\n* Use of oral hormonal contraceptives or less than 6 months using a hormonal intrauterine device (in women)\n* Adults who are unable to consent\n* Prisoners\n* Currently pregnant or breastfeeding (in women)","40 Years",{"count":106,"type":22},12,[25],"The regulation of human body weight and fatness is not fully understood. Although some models of regulation have been proposed (set point, dual-intervention point, others), no studies have been designed to test their predictions. In this pilot and feasibility study, the investigators will implement an experimental approach to test the predictions of models of body weight regulation in humans. Men and women with either low body weight or obesity will be exposed to a 2-day fasting followed by a 2-day ad-libitum refeeding. During the entire fasting-refeeding period, energy intake and expenditure will be accurately measured within metabolic chambers. The investigators will therefore determine the compensatory responses to fasting elicited to prevent weight loss. The results will serve to design and power future studies to better understand body weight regulation.",[60,110],"Underweight",[112,113,114,115,116],"Energy expenditure","Energy intake","Energy balance","Set point model","Dual-intervention point model","2026-05-27",{"date":119,"type":39},"2026-05-29",{"date":121,"type":39},"2025-01-17",{"date":123,"type":22},"2026-12-03",{"name":45,"class":46},{"id":126,"slug":127,"hasResults":12,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":82,"sex":17,"minAge":18,"maxAge":132,"enrollmentInfo":133,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":135,"conditions":136,"keywords":138,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":4},"100639245","evaluating-metabolic-health-in-individuals-with-extreme-obesity-100639245","NCT07613255","Evaluating Metabolic Health in Individuals With Extreme Obesity","Evaluating Energy Metabolism and Metabolic Health in Individuals With Extreme Obesity","Inclusion Criteria:\n\n* Healthy male or female\n* Between 18 - 80 years of age\n* BMI ≥60 kg\u002Fm2\n* Willing to consume pre-prepared meals\n* Willing to comply with the study procedures.\n* Willing to have biospecimens and images stored for future use.\n\nExclusion Criteria:\n\n* Diabetic individuals with complications such as:\n\n  * Diabetic eye disease requiring laser treatment\n  * Diabetic nerve disease associated with foot ulcers or amputations\n  * Diabetic vascular disease associated with gangrene or amputation\n  * Diabetic kidney disease accompanied by a creatinine greater than 2.0 mg\u002FdL\n  * Individuals with prior gastrointestinal surgery except appendectomy or cholecystectomy\n* Individuals with untreated thyroid disease\n* Individuals with untreated or poorly controlled binge eating disorder, bulimia, substance abuse or dependence, mania, and psychosis.\n* Women who are pregnant, trying to become pregnant, or currently breastfeeding.\n* Individuals with major organ system failure like cirrhosis, hepatic insufficiency, portal hypertension, severe renal insufficiency or on dialysis, severe arterial insufficiency, dementia or the inability to give an informed consent.\n* Being unwilling to comply with the study procedures.\n* Not willing to have biospecimens and\u002For images stored for future research use.","80 Years",{"count":134,"type":22},10,"This research will evaluate energy metabolism (expenditure and fat oxidation), metabolic flexibility (response to a high-fat test meal) in 10 individuals with a BMI ≥60 kgm2 using gold-standard assessments of energy metabolism, metabolic flexibility, and body composition. Males and females (18-80 y) with extreme obesity (BMI: ≥60 kg\u002Fm2) will be recruited from Baton Rouge, Louisiana. Exclusion criteria include major organ failure, uncontrolled endocrine disease, severe psychiatric illness, pregnancy, and inability to comply with study procedures. The total duration of participation for each individual is estimated at approximately 10 days. If qualified, participants (BMI≥60 kg\u002Fm2; n=10) will complete one outpatient visit and one inpatient visit with 36hr metabolic chamber testing.",[137],"BMI>40",[139,140,141,142],"metabolic flexibility","metabolism","extreme obesity","body composition","2026-05-26",{"date":119,"type":39},{"date":146,"type":22},"2026-07-01",{"date":148,"type":22},"2026-08-01",{"name":45,"class":46},{"id":151,"slug":152,"hasResults":12,"nctId":153,"briefTitle":154,"officialTitle":154,"acronym":155,"eligibilityCriteria":156,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":157,"enrollmentInfo":158,"targetDuration":4,"studyType":23,"phases":160,"briefSummary":162,"conditions":163,"keywords":168,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":173,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":47},"100604838","phase-4-glp-1r-actions-on-muscle-and-the-skeleton-100604838","NCT07154719","GLP-1R Actions on Muscle and the Skeleton","GRAMS","Inclusion Criteria:\n\n* Subjects will have a BMI between 30kg\u002Fm2\n\n  * 40kg\u002Fm2 (inclusive)\n* Be between 18 and 50 years of age (inclusive).\n* Non-Hispanic Black males and females will be enrolled at PBRC.\n* Rural males and females will be enrolled at MaineHealth.\n* Female subjects will be premenopausal.\n* Females have had their last menstrual period less than 60 days before screening.\n* Females have the absence of menopausal-associated vasomotor symptoms.\n* All subjects must be able to use Lifestyle Toolkit as prescribed for intervention arm.\n\nExclusion Criteria:\n\n\\- Males and females over the age of 50 years of age\n\n* Menopausal females.\n* Subjects on systemic corticosteroids or other agents known to increase loss of muscle and bone mass.\n* Subjects who are on medications that increase or decrease weight status.\n* Subjects having contraindications to tirzepatide in the package insert.\n* Subjects with a history of malignancy other than non-melanoma skin cancer\n* Subjects with known osteoporosis or are on osteoporosis therapies (gonadal hormones or hormone antagonists).\n* Subjects with uncontrolled thyroid or parathyroid disease that may influence the study results.\n* Subjects with a clinically significant hematologic abnormality, kidney disease, liver disease, or diabetes.\n* Females of childbearing potential who do not agree to using an effective method of contraception during the study. Medically acceptable methods include oral contraceptive medication, an intrauterine device (IUD), an implantable contraceptive (such as Implanon), or a barrier method (such as condom or diaphragm with spermicide).\n\nInjectable contraceptives such as Depo-Provera are a cause for exclusion in that they can cause bone loss.\n\nAbstinence is acceptable, as is sexual activity exclusively with same sex partners.\n\nFertility Appreciation Based Methods (natural family planning) are also acceptable forms of addressing childbearing potential in all subjects. A urine pregnancy test (UPT) will be performed on all females of childbearing potential at the screening visit, 3 and 6 months.\n\n* Unable to follow Lifestyle Toolkit as prescribed for intervention arm.\n* Patient Health Questionnaire-9 (PHQ-9) Score equal to or greater than 15 (clinical depression).\n* Adults who are unable to consent.\n* Individuals who are not yet adults (infants, children and teenagers).\n* Pregnant females.\n* Incarcerated individuals.\n* Contraindication to MRI - including but not limited to non-removable metallic or electronic implants, claustrophobia or other fear of confinement, inability to tolerate loud scanner noise, body weight greater than 500 pounds.\n* Subjects with a baseline level of 25-OH vitamin D \\\u003C15 ng\u002Fml will be excluded from the trial. The subject's physician will be notified, and the subject will be referred to their primary care physician.\n* Any significant EKG abnormalities that are considered a risk for utilizing weight management therapies.","50 Years",{"count":159,"type":22},50,[161],"PHASE4","The GRAMS study objectives are to assess the musculoskeletal changes that occur after weight loss using GLP-1 based therapy. A lifestyle intervention with diet and exercise is included to assess any mitigating effects are provided, versus a control group with regular exercise and diet.",[164,60,165,166,167],"Musculoskeletal Abnormalities","Sarcopenic Obesity","Osteoporosis","Drug Effect",[169,170,171,172],"GLP-1 agonists","Obesity treatments","Muscleskeletal loss","Tirzepatide",{"date":119,"type":39},{"date":175,"type":39},"2025-10-09",{"date":177,"type":22},"2027-05-01",{"name":45,"class":46},{"id":180,"slug":181,"hasResults":12,"nctId":182,"briefTitle":183,"officialTitle":183,"acronym":4,"eligibilityCriteria":184,"healthyVolunteers":12,"sex":17,"minAge":157,"maxAge":4,"enrollmentInfo":185,"targetDuration":4,"studyType":23,"phases":187,"briefSummary":188,"conditions":189,"keywords":193,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":47},"100640788","lifestyle-intervention-to-improve-muscle-function-in-older-adults-100640788","NCT07597980","Lifestyle Intervention to Improve Muscle Function in Older Adults","Inclusion Criteria:\n\n1. Age \\> 50 years.\n2. Body mass index (BMI) ≥ 30 kg\u002Fm2.\n3. Homeostatic model assessment of insulin resistance ≥ 3.\n4. Mini-Mental State Examination (MMSE) \\> 25.\n5. Geriatric Depression Scale-15 (GDS-15) \\\u003C 9.\n6. Sedentary (less than 90 minutes\u002Fweek of moderate to vigorous activity).\n7. Ability to provide written informed consent.\n\nExclusion Criteria:\n\n1. Diagnosis of cancer (received within five years) or diabetes (type 1 and 2), or significant musculoskeletal, or cardiovascular, or hepatic, or renal, disease or dysfunction.\n2. Clinically significant gastrointestinal malabsorption syndromes such as chronic diarrhea, celiac disease, or clinically significant abnormal laboratory markers.\n3. Fluctuation in body weight \\> 3 kg in the preceding two months\n4. Condition that impedes testing of the study hypothesis or makes it unsafe to exercise or consume the study foods.",{"count":186,"type":22},80,[25],"The goal of this randomized controlled two-arm trial is to determine the effect of a diet and exercise intervention for 12 weeks on body composition, muscle function, and energy balance in 80 adults aged 50 years and over with obesity and insulin resistance. The main questions the trial aims to answer are: Will 12 weeks of a structured nutrition plan + exercise reduce fat mass, improve muscle function, and increase energy deficit compared to the usual diet + exercise. The hypothesis is that 12 weeks of a structured nutrition plan + exercise will reduce fat mass, improve muscle function, and produce greater energy deficit than the usual diet + exercise. Participants will be provided with all meals for 12 weeks and will exercise at the Center under supervision three times each week. Pre and post-intervention, body composition, physical function, and energy deficit will be measured.",[190,191,192],"Body Composition","Physical Function","Energy Balance",[194,195,196,197],"Fat mass","muscle mass","physical function","energy deficit","2026-05-19",{"date":200,"type":39},"2026-05-22",{"date":202,"type":22},"2026-06",{"date":204,"type":22},"2030-12",{"name":45,"class":46},{"id":207,"slug":208,"hasResults":12,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":212,"eligibilityCriteria":213,"healthyVolunteers":82,"sex":17,"minAge":214,"maxAge":157,"enrollmentInfo":215,"targetDuration":4,"studyType":23,"phases":216,"briefSummary":217,"conditions":218,"keywords":223,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":230,"completionDateStruct":231,"leadSponsor":233,"locationsCount":47},"100638562","eating-almonds-before-a-meal-to-control-blood-sugar-100638562","NCT07603739","Eating Almonds Before a Meal to Control Blood Sugar","Interindividual Variability in the Effect of Premeal Almond Supplementation on Glycemic Control - a Double Crossover Study","NUTS","Inclusion Criteria:\n\n* Adults aged 25-50 years\n* Females over 40 years must have had a cycle in the last 6 months\n* Body mass index (BMI) at least 18.5 and at most 55.0 kg\u002Fm2\n* Impaired blood glucose by at least one of the following criteria:\n* Fasting blood glucose at least 100 mg\u002FdL (5.6 mmol\u002FL) and less than 125 mg\u002FdL (6.9 mmol\u002FL)\n* HbA1c at least 5.7% and less than 6.5%\n* Willing and able to comply with study foods\n* Willing and able to ingest acetaminophen as part of study procedures\n* Able to read, speak, and understand English\n\nExclusion Criteria:\n\n* Weight change ≥5% in past 6 months, actively trying to lose weight, or unwilling to remain weight stable throughout the study based on self-report\n* Recent history within past 12 months of medical provider-diagnosed cardiovascular, renal, or liver disease that required treatment\n* Current or past diagnosis of cancer (except skin cancer) in the last 5 years\n* Current or past diagnosis of type 1 or type 2 diabetes\n* Recent history within past 12 months of medical provider-diagnosed gastrointestinal or neurological disorders if not managed\u002Fstable for at least 3 months (with or without treatment)\n* Recent history within past 12 months of medical provider-diagnosed psychiatric disorders including eating disorders or severe depression if not managed\u002Fstable for at least 3 months (with or without treatment)\n* Food allergies or other reasons preventing consumption of study foods\n* Any glucose-lowering medication except biguanides (e.g., Metformin) if stable for at least 3 months or incretins (i.e., GLP-1RA-based) if stable for at least 3 months\n* Current smoking or vaping or history of smoking or vaping in the past 6 months\n* Binge and\u002For heavy drinking (i.e., \\>3 drinks on any given occasion and\u002For \\>7 drinks\u002Fweek)\n* Currently pregnant or planning to become pregnant or breastfeed in the next 3 months by self-report","25 Years",{"count":7,"type":22},[25],"The goal of this study is to learn whether eating a small serving of almonds before meals can improve blood sugar control in adults who have early signs of problems with blood sugar regulation. The main questions it aims to answer are:\n\n1. Does eating almonds before a meal reduce the rise in blood sugar after eating?\n2. Do some people consistently benefit more than others from eating almonds before meals?",[219,220,221,222],"Glucose Control","Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)","Precision Medicine","Nutrition",[222,221,224,219,225,226,227],"Precision Nutrition","Impaired Glucose Tolerance","Insulin Resistance","Prediabetes","2026-05-16",{"date":200,"type":39},{"date":202,"type":22},{"date":232,"type":22},"2028-07",{"name":45,"class":46},{"id":235,"slug":236,"hasResults":12,"nctId":237,"briefTitle":238,"officialTitle":239,"acronym":4,"eligibilityCriteria":240,"healthyVolunteers":82,"sex":17,"minAge":18,"maxAge":157,"enrollmentInfo":241,"targetDuration":4,"studyType":23,"phases":243,"briefSummary":244,"conditions":245,"keywords":247,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":254,"lastUpdatePostDateStruct":255,"startDateStruct":257,"completionDateStruct":259,"leadSponsor":261,"locationsCount":75},"100603692","dietary-iron-requirements-100603692","NCT07139821","Dietary Iron Requirements","Dietary Iron Requirements in US Adults","Inclusion Criteria:\n\n* Males and premenopausal females age 18-50 y\n* Previously participated in an iron stable isotope study or willing to consume an oral stable iron isotope and undergo a one-year equilibration period\n* Willing to refrain from iron-containing supplements for the duration of the study\n* Willing to refrain from tobacco smoking for the duration of the study\n* Have not donated blood 3 months prior to the start of the study and willing to refrain from donating blood for the duration of the study\n* Willing to have blood stored for future use\n* Able and willing to comply with study requirements and consent to participate\n\nExclusion Criteria:\n\n* Females: pregnant or lactating or plans to become pregnant during the study period\n* Inability to provide informed consent and engage in informed consent procedures\n* Plans to relocate outside the study area",{"count":242,"type":22},300,[25],"Dietary Reference Intakes (DRIs) for iron are based on a relatively small number of studies in European populations. This research study will determine iron needs in a representative sample of adults living in the US using the iron isotope dilution technique. Following administration and equilibration of a stable iron isotope, participants will be followed for a 12 week study period. Blood will be collected every 4 weeks and the isotopic composition will be determined. Results will help update dietary iron guidelines making sure they better match the specific needs of the US population.",[246],"Iron Absorption",[248,249,250,251,252,253],"Iron absorption","Iron losses","Iron requirements","Iron deficiency","Iron deficiency anemia","Iron isotopes","2026-04-23",{"date":256,"type":39},"2026-04-29",{"date":258,"type":39},"2026-02-06",{"date":260,"type":22},"2029-05-31",{"name":45,"class":46},{"id":263,"slug":264,"hasResults":12,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":268,"eligibilityCriteria":269,"healthyVolunteers":12,"sex":17,"minAge":270,"maxAge":19,"enrollmentInfo":271,"targetDuration":4,"studyType":23,"phases":273,"briefSummary":274,"conditions":275,"keywords":276,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":281,"startDateStruct":283,"completionDateStruct":285,"leadSponsor":287,"locationsCount":47},"100634683","iron-absorption-in-the-low-oxygen-exposure-and-weight-status-lows-study-100634683","NCT07542873","Iron Absorption in The Low Oxygen Exposure and Weight Status (LOWS) Study","Effects of Energy Restriction and Intermittent Hypoxia on Iron Absorption in Obesity","LOWS-IRON","Inclusion Criteria:\n\n* Obese (BMI between 30-39.9 kg\u002Fm2)\n* Born at altitudes below 2,100 meters (\\~7,000 feet)\n* Currently residing in Baton Rouge, Louisiana or surrounding area\n* Not taking any medication(s) that interfere with oxygen delivery\u002Ftransport for 4 weeks prior to and throughout the entire study (e.g., includes sedatives, sleeping aids, tranquilizers and\u002For any medication that depresses ventilation, diuretics, alpha and beta blockers).\n* Willing to refrain from smoking, vaping, chewing tobacco, and dietary supplement use throughout the entire study.\n* Willing to have a hypoxic tent set-up in their home and spend 8 consecutive hours per night in the tent for 8 weeks\n\nExclusion Criteria:\n\n* Living in areas that are more than 1,200 m (\\~4,000 feet), or have traveled to areas that are more than 1,200 m for five days or more within the last 2 months\n* Cardiovascular abnormalities, gastrointestinal disorders, or any condition that interferes with oxygen delivery\u002Ftransport (e.g., kidney disease, cardiovascular disease, etc.)\n* Oxygen saturation \\\u003C 95% while awake or oxygen saturation dips below 88% for a total of ≥ 10 min overnight in normoxic conditions\n* Evidence of apnea or other sleeping disorders\n* Evidence of prior high-altitude pulmonary edema (HAPE) or high-altitude cerebral edema (HACE) diagnosis\n* Diagnosis or family history of sickle cell anemia\u002Ftrait\n* Hematocrit \\\u003C42% for males, \\\u003C36% for females\n* Hemoglobin \\\u003C13 g\u002FdL for males, \\\u003C12 g\u002FdL for females\n* Blood donation within 8 weeks of beginning the study\n* Present condition of alcoholism, anabolic steroids, or other substance abuse issues\n* Women who are pregnant, lactating, planning to become pregnant, or who have had an irregular menstrual cycle in the past 6 mo.\n* Weight gain or loss \\> 10% of body weight during the past 6 months\n* Adults unable to consent","22 Years",{"count":272,"type":22},30,[25],"Declines in iron status are common in those with obesity and may be due to obesity-related chronic inflammation; however, the effects of reducing inflammation following diet-induced weight loss on iron metabolism are poorly understood. Low environmental oxygen exposure increases dietary iron absorption and availability to supply iron for erythropoiesis but has not yet been tested in the context of weight loss. This study is designed to investigate diet-induced weight loss (inflammation reduction) and overnight low oxygen exposure (erythropoiesis stimulating agent) as strategies to improve dietary iron absorption in obesity.",[28],[277,278,279,113,112,248,280],"Body weight","Normobaric hypoxia","Negative energy balance","Iron metabolism",{"date":282,"type":39},"2026-04-21",{"date":284,"type":39},"2025-04-21",{"date":286,"type":22},"2026-06-30",{"name":45,"class":46},{"id":289,"slug":290,"hasResults":12,"nctId":291,"briefTitle":292,"officialTitle":293,"acronym":4,"eligibilityCriteria":294,"healthyVolunteers":82,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":295,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":297,"conditions":298,"keywords":300,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":309,"completionDateStruct":311,"leadSponsor":313,"locationsCount":4},"100634606","weight-loss-goals-and-satisfaction-survey-100634606","NCT07541872","Weight Loss Goals and Satisfaction Survey","An Evaluation of 3D Visualization Tools and Their Effect on Weight Loss Goals and Satisfaction","Inclusion Criteria:\n\n* Adults over 18 years of age\n* BMI ≥ 24.5 kg\u002Fm2\n* currently seeking weight loss\n* Willingness to provide informed consent\n* Willingness to answer all questions related to enrollment criteria and provide the necessary information to render a personalized avatar, including sex, age, race\u002Fethnicity, weight, and height.\n\nExclusion Criteria:\n\n• History of body shape-altering procedures (i.e., breast augmentation, bariatric surgery, amputation)",{"count":296,"type":22},250,"The goal of this observational survey pilot study is to learn how 3D visualization tools (i.e., personalized avatars) influence weight loss goals, satisfaction, confidence, and commitment compared to numerical weight outcomes in weight loss-seeking adults.\n\nThe main questions it aims to answer are:\n\n1. What are contemporary weight loss goals (defined as dream, happy, acceptable, and disappointing weight loss outcomes), and how do they compare to goals reported in prior studies?\n2. Does presenting weight loss outcomes using personalized 3D avatars result in different levels of satisfaction compared to presenting equivalent outcomes numerically as body weight?\n3. Do predictive 3D avatars affect participants' confidence and commitment to achieving weight loss differentially than numerical weight loss goals?\n\nResearchers will compare visual (3D avatar-based) weight loss outcomes to numerical (pounds lost) weight loss outcomes to see if visual presentation lowers satisfaction with potential weight loss and alters confidence and commitment.\n\nParticipants will:\n\n* Complete a one-time online survey\n* Provide demographic and self-reported anthropometric information to generate personalized 3D avatars\n* Report weight loss goals and rate satisfaction with potential weight loss outcomes shown numerically and as 3D avatars.\n* Complete questionnaires assessing psychological and behavioral weight-related factors.",[299],"Overweight and Obesity",[65,301,302,303,304,305,306],"health behavior","motivation","three-dimensional imaging","digital health","treatment expectations","health communication","2026-04-13",{"date":282,"type":39},{"date":310,"type":22},"2026-08",{"date":312,"type":22},"2026-09",{"name":45,"class":46},{"id":315,"slug":316,"hasResults":12,"nctId":317,"briefTitle":318,"officialTitle":318,"acronym":319,"eligibilityCriteria":320,"healthyVolunteers":82,"sex":17,"minAge":18,"maxAge":321,"enrollmentInfo":322,"targetDuration":4,"studyType":23,"phases":324,"briefSummary":325,"conditions":326,"keywords":328,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":347,"locationsCount":47},"100407291","testing-the-adipose-expandability-hypothesis-in-vivo-during-overfeeding-100407291","NCT04583514","Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding","EAT 2","Inclusion Criteria:\n\n* Men and pre-menopausal women\n* 18-42 years of age\n* BMI 23-35 kg\u002Fm2 (± 0.5 will be accepted)\n* Are willing to drink deuterium-labeled water (2H2O) for 8 weeks\n* Are willing to be randomized to either a CTL or 30% OF group\n* For women, if not using pharmaceutical (hormonal) contraception (i.e. birth control pills, vaginal ring, injections, or implant), must agree to use either a double barrier method as a form of birth control to prevent pregnancy (i.e. male condom with spermicide, with or without cervical cap or diaphragm); use implants or intrauterine contraceptive devices; have a tubal ligation (surgically sterile); practice abstinence; or be in an established relationship with a vasectomized or same sex partner during the entire duration of the study\n* Must be willing to adhere to all study procedures, including attendance at all study visits\n* If enrolled, agree to maintain the same level of physical activity throughout the duration of the study\n* Must be willing to have blood stored for future research\n\nExclusion Criteria:\n\n* Unstable weight in the last 3 months (± \\~5% weight change)\n* Diagnosis of Type 1 or 2 diabetes or a fasting blood glucose \\> 110 mg\u002FdL\n* Average screening blood pressure \\> 140\u002F90 mmHg\n* Diagnosis of major organ disease (e.g. heart, kidney, lung, thyroid, liver disease) or abnormal liver enzymes that are, in the opinion of the MI, clinically significant and represent a problem for study inclusion.\n* Self-reported positive test for human immunodeficiency virus, hepatitis B or hepatitis C\n* Any current or previous eating disorders\n* Chronic use of systemic glucocorticoids (steroids), systemic adrenergic-stimulating agents, beta-blockers, antipsychotic medications, thiazolidinediones and other medications that may cause clinically significant weight gain or loss)\n* Chronic use of prescription weight loss medications or over the counter weight loss medications which, in the opinion of the MI, will impact the study\n* Chronic use of anti-depressant medications for less than 3 months\n* Chronic smokers or users of tobacco products who cannot abstain for the duration of the inpatient visits\n* Previous bariatric or other surgeries for obesity\n* Had cancer in the last 5 years (some skin cancers acceptable)\n* Pregnancy, breastfeeding, or planned pregnancy for the upcoming 6 months\n* Partial or full hysterectomy\n* PCOS\n* Diagnosed psychotic conditions.","42 Years",{"count":323,"type":22},58,[25],"Adipose, or fat, tissue is a plastic organ that retains the ability to expand and store excess calories during positive energy balance in humans. The capacity of subcutaneous (subQ) adipose tissue to expand and remodel is an important determinant of obesity-related health complications, and impaired expansion of subQ fat tissue is thought to contribute to the risk of diseases such as the Metabolic Syndrome (MetS) and type 2 diabetes mellitus (T2D). The objectives of the study are to evaluate the changes and mechanisms of (subQ) adipose tissue expandability that occur as a result of short-term weight gain and to investigate the effects on cardio-metabolic health outcomes. Findings from this study will provide new insight into the dynamics of adipose expansion and remodeling during changes in energy balance and how this may impact future fat tissue function and metabolic health.",[299,327],"Metabolic Syndrome",[329,330,331,332,333,334,335,336,337,338,339],"Overweight","Adipose tissue","Subcutaneous abdominal","Subcutaneous femoral","Adipocyte","Adipose turnover","Adipose kinetics","Adipogenesis","Ectopic fat","Insulin sensitivity","Deuterium","2026-04-02",{"date":342,"type":39},"2026-04-08",{"date":344,"type":39},"2020-09-15",{"date":346,"type":22},"2026-12-31",{"name":45,"class":46},{"id":349,"slug":350,"hasResults":12,"nctId":351,"briefTitle":352,"officialTitle":353,"acronym":354,"eligibilityCriteria":355,"healthyVolunteers":82,"sex":17,"minAge":356,"maxAge":357,"enrollmentInfo":358,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":360,"conditions":361,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":364,"lastUpdatePostDateStruct":365,"startDateStruct":367,"completionDateStruct":369,"leadSponsor":371,"locationsCount":47},"100261507","measurement-of-energy-metabolism-in-infants-100261507","NCT02683473","Measurement of Energy Metabolism in Infants","Measurement of Energy Metabolism in Infants: BabyEE Pilot","BabyEE Pilot","Inclusion Criteria:\n\n* Healthy, full-term infant\n* Aged 1 month (28 days) to 3 months (12 weeks, 6 days) at the first visit\n* Exclusively fed breast milk and\u002For infant formula\n* Willing to accept doubly-labeled water\n\nExclusion Criteria:\n\n* Unable to complete 3 clinic visits within about 14 days at Pennington Biomedical Research Center\n* Born preterm (\\\u003C 37 weeks gestation)\n* Congenital abnormality or disability\n* Gastric reflux\n* Acute illness within 7 days of the study (fever, diarrhea)\n* Use of medications to treat a chronic condition (does not include use of vitamin supplements or PRN medication for flatulence or reflux such as Pepcid)","1 Month","3 Months",{"count":359,"type":22},70,"The purpose of this study is to measure energy expenditure during the first 3 months of life in infants.",[362,363],"Infant Development","Infant Overnutrition","2026-03-16",{"date":366,"type":39},"2026-03-18",{"date":368,"type":39},"2016-03-16",{"date":370,"type":22},"2027-06-30",{"name":45,"class":46},{"id":373,"slug":374,"hasResults":12,"nctId":375,"briefTitle":376,"officialTitle":376,"acronym":377,"eligibilityCriteria":378,"healthyVolunteers":82,"sex":17,"minAge":18,"maxAge":379,"enrollmentInfo":380,"targetDuration":4,"studyType":23,"phases":382,"briefSummary":383,"conditions":384,"keywords":386,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":392,"startDateStruct":394,"completionDateStruct":396,"leadSponsor":398,"locationsCount":47},"100521484","cardiovascular-risk-and-circadian-misalignment-in-short-sleepers---role-of-extended-eating-period-100521484","NCT06070194","Cardiovascular Risk and Circadian Misalignment in Short Sleepers - Role of Extended Eating Period","CRISP","Inclusion Criteria:\n\n* Age: 18-45 years\n* BMI: 25-35 kg\u002Fm2\n* Habitual sleep duration: ≤6.5 h\u002Fnight\n* Habitual eating period: \\>14h\u002Fday\n* Absence of chronic health conditions including hypertension (defined as systolic clinical BP of \\>140 or diastolic BP of \\>90 mmHg or use of BP lowering drugs), dyslipidemia (defined as LDL \\>190mg\u002FdL or Triglycerides \\>400 mg\u002FdL or use of lipid lowering medications), diabetes (defined as fasting glucose \\>126 mg\u002FdL and \u002For HbA1C \\>6.5%, or use of glucose lowering medication), and cardiovascular disease. However, individuals with prehypertension, and\u002For prediabetes will be allowed to participate.\n* Individuals with seasonal allergies will also be included.\n* Women of child-bearing age will be allowed to participate if they agree to use acceptable birth control during the study period.\n* Must be able to provide written informed consent.\n* Ability to follow the prescribed eating duration and maintain habitual diet, sleep and physical activity.\n* Use of certain mediations will be allowed including birth control, second generation antihistamines, antacids, acne-related ointments etc.\n\nExclusion Criteria:\n\n* Irregular sleep habits \u002F night shift \u002F rotating shift work in past 1 month.\n* Frequent travel related jet lag.\n* Pregnant\u002F breast-feeding\u002F history of irregular menstrual cycles.\n* Sleep disorders such as insomnia (defined as Insomnia Severity Index score ≥15), and sleep apnea (overnight oximetry defined oxygen desaturation index of \\>10 events\u002Fh of sleep).\n* Presence of excessive daytime sleepiness (defined as Epworth Sleepiness Scale score \\>10).\n* Recent changes in body weight (≥5%) within 3 months.\n* Uncontrolled depression and \u002For anxiety, history of psychosis or bipolar disorder.\n* Uncontrolled depression and\u002For depression is defined as PHQ-9 score of ≥15 or a positive response for suicidal thoughts (Q9 of the PHQ-9 - any response other than not at all).\n* Any medication or condition that, in the opinion of the medical investigator, could interfere with the study outcomes or put the subject at risk by participating in the study.\n* Blood or plasma donation during the past 2 months.","45 Years",{"count":381,"type":22},100,[25],"Short sleep duration confers high cardiovascular and metabolic risk, but lifestyle factors and molecular mechanisms that contribute to increased blood pressure and poor glucose control during short sleep are not completely understood. Habitual short sleepers are constantly eating, the proposed studies will evaluate if this behavior contributes to heightened cardiovascular and metabolic risk. The study will evaluate if restricted eating duration (8 hours\u002Fday) could improve cardiovascular and metabolic health in habitual short sleepers.",[385],"Sleep Deprivation",[387,388,389,390,391],"eating duration","short sleep duration","time-restricted eating","blood pressure","insulin resistance",{"date":393,"type":39},"2026-02-10",{"date":395,"type":39},"2023-12-05",{"date":397,"type":22},"2028-06-30",{"name":45,"class":46},{"id":400,"slug":401,"hasResults":12,"nctId":402,"briefTitle":403,"officialTitle":404,"acronym":405,"eligibilityCriteria":406,"healthyVolunteers":82,"sex":17,"minAge":18,"maxAge":407,"enrollmentInfo":408,"targetDuration":4,"studyType":23,"phases":409,"briefSummary":410,"conditions":411,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":413,"lastUpdatePostDateStruct":414,"startDateStruct":416,"completionDateStruct":418,"leadSponsor":420,"locationsCount":47},"100524931","breath-analysis--malnutrition-100524931","NCT06115148","Breath Analysis & Malnutrition","Breath Ammonia as a Malnutrition Screening Tool","BAM-S","Inclusion Criteria:\n\n1. Age: 18-95 years\n2. Malnutrition group (Cross-sectional study only); not involved in intervention: Diagnosed with malnutrition (verified in medical history)\n\nExclusion Criteria:\n\n1. Chronic kidney, liver or pulmonary disease\n2. Anabolic steroid use other than testosterone (e.g., oxandrolone)\n3. Patients judged unsuitable for enrollment by the study medical investigator\n4. Pregnant women or women who are nursing\n5. Unable or unwilling to consume study beverages or fast for 24 hours each arm","95 Years",{"count":106,"type":22},[25],"The purpose of this research study is to understand how breath is related to nutritional status. The procedures involved in this study include blood and breath sampling, questionnaires about health history, medications, nutritional status and diet, and a physical examination. Breath markers will be compared between individuals with and without malnutrition and be compared to indicators of malnutrition. Some individuals will undergo an interventional study involving 2 days of consuming study beverages and fasting along with providing additional breath samples to see if the breath changes in response to short-term changes in nutritional status.",[412],"Malnutrition","2026-01-16",{"date":415,"type":39},"2026-01-21",{"date":417,"type":39},"2023-08-17",{"date":419,"type":22},"2026-12-30",{"name":45,"class":46},{"id":422,"slug":423,"hasResults":12,"nctId":424,"briefTitle":425,"officialTitle":425,"acronym":426,"eligibilityCriteria":427,"healthyVolunteers":82,"sex":17,"minAge":428,"maxAge":429,"enrollmentInfo":430,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":432,"conditions":433,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":437,"lastUpdatePostDateStruct":438,"startDateStruct":440,"completionDateStruct":442,"leadSponsor":444,"locationsCount":47},"100616449","cancan-body-composition-study-100616449","NCT07305753","CanCan Body Composition Study","Cancan","Inclusion Criteria:\n\n* Being either male or female\n* Being an adult \\>20 - \\\u003C40 or \\>70 years of age.\n* Having a body weight of less than 440 pounds\n* Being willing to comply with the study procedures\n* Not having a chronic illness (e.g., diabetes, cancer, etc.)\n* Must be willing to have biospecimens and imaging stored for research use\n\nExclusion Criteria:\n\n* Being pregnant, attempting to become pregnant, or breastfeeding\n* Having medical implants such as a pacemaker or metal joint replacements\n* Having had a mastectomy, breast reduction, or breast implants\n* Having hair that cannot fit in a swim cap\n* Having a body weight greater than 440 pounds\n* Taking medications that alter the body's fluid compartments (ex: diuretics)\n* Not willing to have biospecimens and imaging stored for future research use.","20 Years","90 Years",{"count":431,"type":22},40,"The aim of this study is to develop a dataset with reference body composition measurements using criterion methods. This dataset will be used to develop new protocols to study patients with cancer. Obtaining measurements of sodium bromide (NaBr), deuterium dilution (D2O), and D3-Creatine in a stratified sample of adults will determine the accuracy (and precision) of the available devices for ECW, TBW, and skeletal muscle mass measurements.",[434,435,436],"Healthy Participants","Young Healthy Adults","Elderly (People Aged 65 or More)","2025-12-12",{"date":439,"type":39},"2025-12-26",{"date":441,"type":39},"2025-10-15",{"date":443,"type":22},"2026-05-30",{"name":45,"class":46},{"id":446,"slug":447,"hasResults":12,"nctId":448,"briefTitle":449,"officialTitle":450,"acronym":451,"eligibilityCriteria":452,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":453,"targetDuration":4,"studyType":23,"phases":455,"briefSummary":456,"conditions":457,"keywords":461,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":463,"lastUpdatePostDateStruct":464,"startDateStruct":466,"completionDateStruct":468,"leadSponsor":470,"locationsCount":47},"100613341","effect-of-physiologic-insulin-administration-on-insulin-sensitivity-and-cognition-100613341","NCT07265323","Effect of Physiologic Insulin Administration on Insulin Sensitivity and Cognition","Effect of Physiologic Insulin Intervention on Insulin Sensitivity and Cognition","MIND-IT","Inclusion Criteria:\n\n* Mini Mental State Examination (MMSE) score \\\u003C 25\n\nExclusion Criteria:\n\n* On daily medication for the specific treatment of anxiety including benzodiazepines.\n* An infant, child, or teenager\n* A pregnant woman\n* A prisoner\n* Having any condition that impedes testing of the study hypothesis or are otherwise deemed to be unsuitable (determined by the investigative team).",{"count":454,"type":22},8,[25],"The goal of this clinical trial is to determine if a weekly delivery of insulin at short intervals lasting up to 2 hours can improve insulin sensitivity and cognition in adults with Alzheimer's Disease. It will also provide information about the safety and feasibility of this intervention.\n\nThe main questions it aims to answer are:\n\nDoes the intervention improve insulin sensitivity (how the body uses glucose)?\n\nDoes the intervention improve cognition, measured by the Montreal Cognitive Assessment (MoCA) and the Revised Memory and Behavior Problems Checklist (RMBPC)?\n\nWhat changes occur in brain glucose uptake (FDG-PET)?\n\nParticipants will:\n\nReceive the intervention once a week for 6 months, with each session lasting up to 2 hours\n\nComplete cognitive assessments. Adverse events will be assessed throughout the study.",[458,459,460],"Alzheimer s Disease","Alzheimer Blood Biomarkers","Insulin Sensitivity",[462,460],"Alzheimer's disease","2025-12-02",{"date":465,"type":39},"2025-12-04",{"date":467,"type":22},"2025-12",{"date":469,"type":22},"2027-05",{"name":45,"class":46},{"id":472,"slug":473,"hasResults":12,"nctId":474,"briefTitle":475,"officialTitle":476,"acronym":477,"eligibilityCriteria":478,"healthyVolunteers":82,"sex":479,"minAge":104,"maxAge":480,"enrollmentInfo":481,"targetDuration":4,"studyType":23,"phases":482,"briefSummary":483,"conditions":484,"keywords":489,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":499,"lastUpdatePostDateStruct":500,"startDateStruct":502,"completionDateStruct":504,"leadSponsor":505,"locationsCount":47},"100591106","impact-of-lean-pork-on-endothelial-function-in-perimenopause-100591106","NCT06976112","Impact of Lean Pork on Endothelial Function in Perimenopause","Effects of Lean Pork Intake on Endothelial Function and Vasomotor Symptoms in Perimenopausal Women","LEAP","Inclusion Criteria:\n\n* Are female\n* Are between 40 and 55 years of age\n* Have a BMI (a number calculated from participant height and weight) between 28 and45 kg\u002Fm2\n* Are experiencing irregular menstrual cycles but have not gone longer than 12 consecutive months without a period\n* Are experiencing severe vasomotor (menopause) symptoms\n* Are doing less than 3 hours per week of structured exercise\n* Have systolic blood pressure between 120 and 140 mmHg and\u002For diastolic blood pressure between 80 and 90 mmHg\n* Have \"sugary\" hemoglobin called hemoglobin A1c less than or equal to 6.5%\n* Are willing and able to refrain from using oral mouth wash for the duration of the study because the alcohol in mouth wash inhibits nitrate synthesis\n* Are willing and able to comply with both the study diets\n* Are willing to collect blood for future research\n* Can read, speak, and understand English\n\nExclusion Criteria:\n\n* Hysterectomy (partial or full) or oophorectomy\n* Using hormone replacement therapy use and\u002For hormonal contraception use 6 months prior to study start\n* Has systolic blood pressure ≥140 mmHg and\u002For diastolic blood pressure ≥ 90 mmHg)\n* Triglycerides ≥350 mg\u002FdL, low-density lipoprotein cholesterol (LDL-C) ≥190 mg\u002FdL, and\u002For taking a lipid-lowering medication -Diagnosed cardiovascular disease, diabetes (type 1 or 2), or endocrine- related disease (e.g. thyroid, PCOS), unstable gastrointestinal disease, kidney, liver, and\u002For pancreatic disease\n* Diagnosed cancer (except skin cancer) in the last 5 years\n* Taking \\>1 blood pressure medication and\u002For taking 1 blood pressure medication for \\\u003C3 months\n* Taking phosphodiesterase-5 inhibitors, anti-coagulants, corticosteroids, metformin, or insulin.\n* Weight change ≥6.6 pounds in the past 3 months, actively trying to lose weight, or unwilling to remain weight stable throughout the study\n* Current smoking or vaping, Binge and\u002For heavy drinker\n* Food allergies or other reasons preventing consumption of study foods with both study diets","FEMALE","55 Years",{"count":272,"type":22},[25],"The goal of this study is to examine the impact of a diet high in fresh lean pork, compared to a plant-based diet, on cardiovascular function and vasomotor symptoms in perimenopausal women with overweight and obesity. The main questions it aims to answer are:\n\n1. How does a diet high in pork, compared to a plant-based diet, affects blood lipids, endothelial function, and blood pressure?\n2. How does a diet high in pork, compared to a plant-based diet, affects blood nitrate, cardiometabolic biomarkers, inflammatory biomarkers, and vasomotor symptoms?\n\nResearchers will compare the diet high in pork to a plant-based diet to see if pork helps improve cardiovascular and mesopause symptoms.\n\nParticipants will:\n\n* Consume both of the diets, each for 4 weeks, with a washout period between 2 and 6 weeks in between the diets trials\n* Visit the clinic 5 times with weekly meal pick ups during the diet trials\n* Undergo testing procedures including: weight and body composition, blood pressure and pulse, endothelial function using ultrasound of upper arm, microvascular blood flow, blood draws, physical activity measurements, and questionnaires.",[485,486,487,488],"Cardiovascular Outcome","Overweight and Obese Women","Perimenopausal Women","Vasomotor Symptoms (VMS)",[490,491,492,493,494,495,496,497,498],"Perimenopause","Perimenopausal","Vasomotor Symptoms","VMS","Menopause","Cardiovascular Health","Blood pressure","Pork","Vegetarian","2025-11-26",{"date":501,"type":39},"2025-11-28",{"date":503,"type":39},"2025-08-01",{"date":469,"type":22},{"name":45,"class":46},{"id":507,"slug":508,"hasResults":12,"nctId":509,"briefTitle":510,"officialTitle":510,"acronym":4,"eligibilityCriteria":511,"healthyVolunteers":82,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":512,"targetDuration":4,"studyType":23,"phases":513,"briefSummary":514,"conditions":515,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":499,"lastUpdatePostDateStruct":517,"startDateStruct":518,"completionDateStruct":520,"leadSponsor":522,"locationsCount":47},"100532381","aim-high-readiness--meeting-the-standards-in-military-pre-recruits-100532381","NCT06212063","Aim High: Readiness & Meeting the Standards in Military Pre-Recruits","Inclusion Criteria:\n\n* Must be either staff, cadre, or cadets in the YCP program.\n\nExclusion Criteria:\n\n* Not staff, cadre, or cadets in the YCP program.",{"count":381,"type":22},[25],"The primary objective of the proposed study is to complete a comprehensive needs assessment of the Louisiana National Guard (LANG) Youth Challenge Program (YCP) in the YCP leadership and junior cadet population related to nutrition, fitness, sleep, and mental health and resilience. Results of this needs assessment will further inform the development of the intervention skills training program.\n\nThe secondary objective of this work is to provide a scalable, integrated physical and mental optimization training program that would be integrated into relevant systems and maintained over time as a core tool for young individuals readying themselves to join the Army. The program would include an environmental intervention approach as well as nutrition, physical activity, sleep, and stress reduction\u002Fpositive coping guidance.",[516],"Health Behavior",{"date":465,"type":39},{"date":519,"type":39},"2024-09-17",{"date":521,"type":22},"2027-01-15",{"name":45,"class":46},{"id":524,"slug":525,"hasResults":12,"nctId":526,"briefTitle":527,"officialTitle":528,"acronym":529,"eligibilityCriteria":530,"healthyVolunteers":82,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":531,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":533,"conditions":534,"keywords":539,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":545,"lastUpdatePostDateStruct":546,"startDateStruct":548,"completionDateStruct":550,"leadSponsor":552,"locationsCount":553},"100545316","military-health-and-nutrition-examination-study-100545316","NCT06380322","Military Health and Nutrition Examination Study","Stand Ready: Military Health and Nutrition Examination Study","MHANES","Inclusion Criteria:\n\n* U.S. Army Soldiers ≥ 18 years old\n* Willing to have biological samples stored for future use\n* Willing to have data linked to the Soldier Performance, Health, and Readiness (SPHERE) database\n\nExclusion Criteria:\n\n* Soldiers under the age of 18 years\n* Soldiers with an inability to understand verbal or written instructions or testing materials in English\n* Soldiers relocating or getting out of the Army in the next 30 days\n* Pregnant females\n* Soldiers currently in Basic Training (BCT) and\u002For One-Station Unit Training (OSUT)",{"count":532,"type":22},650,"The Military Health and Nutrition Examination Study (MHANES) is a Department of Defense funded study conducted by Pennington Biomedical Research Center and the US Army Research Institute of Environmental Medicine. This cross-sectional study will assess, in a large, diverse sample of Army Service Members (n=600), food and supplement intake, cardiovascular health, body composition, biomarkers of nutritional status, measures of health status, injury prevalence, mental wellbeing, gut microbiome composition, and physical performance outcomes. The proposed study is modeled after the National Health and Nutrition Examination Survey (NHANES) and customized for the Army population.",[535,536,537,538],"Hypertension","Type 2 Diabetes","Dyslipidemias","Cardiovascular Diseases",[540,541,190,542,543,544],"Diet Quality","Healthy Eating Index","Dietary Supplements","Gut Microbiome","Army Combat Fitness Test","2025-11-10",{"date":547,"type":39},"2025-11-12",{"date":549,"type":39},"2024-08-24",{"date":551,"type":22},"2026-12-01",{"name":45,"class":46},3,{"id":555,"slug":556,"hasResults":12,"nctId":557,"briefTitle":558,"officialTitle":559,"acronym":560,"eligibilityCriteria":561,"healthyVolunteers":82,"sex":17,"minAge":562,"maxAge":563,"enrollmentInfo":564,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":565,"conditions":566,"keywords":573,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":580,"lastUpdatePostDateStruct":581,"startDateStruct":583,"completionDateStruct":585,"leadSponsor":586,"locationsCount":47},"100600324","studying-phenotypic-risks-for-obesity-and-underlying-traits-in-young-infants-100600324","NCT07096011","Studying Phenotypic Risks for Obesity and Underlying Traits in Young Infants","Studying Phenotypic Risks for Obesity and Underlying Traits in Young Infants: A Pilot Study","SPROUT","Inclusion Criteria:\n\n* Aged 2 weeks to less than 17 weeks at screening\n* Being fed human milk as a primary source of food\n* Be willing to consume one meal of infant formula\n* Be willing to complete a DXA measurement\n\nExclusion Criteria:\n\n* Unable to complete the screening visit and two clinic visits within 14 days\n* Born with health conditions that would render procedures unsafe\n* Born earlier than 35 days and 0 weeks gestation\n* Eating supplemental foods\n* Physician diagnosed feeding difficulties that may require a special type of nipple for bottle feeding","2 Weeks","16 Weeks",{"count":431,"type":22},"The purpose of this research study is to understand how infants metabolize different meals and to develop clinical tools which identify infants as having two different phenotypes. The phenotypes are the 1) metabolic \"thriftiness\" and 2) the metabolic flexibility.",[567,568,569,570,571,572],"Infant Body Composition and Metabolism","Metabolism","Energy Expenditure","Infant Formula","Human Milk, Breast Milk","Metabolic Flexibility",[574,140,575,576,577,578,579,139],"infant","energy expenditure","infant formula","breast milk","human milk","thrifty phenotype","2025-08-21",{"date":582,"type":39},"2025-08-22",{"date":584,"type":39},"2025-07-28",{"date":469,"type":22},{"name":45,"class":46},{"id":588,"slug":589,"hasResults":12,"nctId":590,"briefTitle":591,"officialTitle":592,"acronym":593,"eligibilityCriteria":594,"healthyVolunteers":82,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":595,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":597,"conditions":598,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":580,"lastUpdatePostDateStruct":601,"startDateStruct":603,"completionDateStruct":605,"leadSponsor":607,"locationsCount":47},"100129879","pennington-center-longitudinal-study-pcls-100129879","NCT00959270","Pennington Center Longitudinal Study (PCLS)","Pennington Center Longitudinal (PCLS)","PCLS","Inclusion Criteria:\n\n* 18 years or older\n* volunteer to Participate\n\nExclusion Criteria:\n\n* younger than 18 years\n* Pregnant",{"count":596,"type":22},30000,"The purpose of this study is to develop a cohort of volunteers that can be studied and followed up into the future for changes in health behaviors and development of health problems.",[599,600],"Health Behaviors","Development of Health Problems",{"date":602,"type":39},"2025-08-28",{"date":604,"type":4},"2009-05",{"date":606,"type":22},"2050-02",{"name":45,"class":46},{"id":609,"slug":610,"hasResults":12,"nctId":611,"briefTitle":612,"officialTitle":613,"acronym":614,"eligibilityCriteria":615,"healthyVolunteers":82,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":616,"targetDuration":4,"studyType":23,"phases":618,"briefSummary":619,"conditions":620,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":584,"lastUpdatePostDateStruct":626,"startDateStruct":628,"completionDateStruct":630,"leadSponsor":632,"locationsCount":47},"100512893","assessing-the-value-of-avocados-on-glycemic-control-in-type-2-diabetes-100512893","NCT05958368","Assessing the Value of Avocados on Glycemic Control in Type 2 Diabetes","The Effects of Hass Avocados on Glycemic Control in Persons With Type 2 Diabetes: A Randomized Controlled Crossover Trial","AVOCADO-T2D","Inclusion Criteria:\n\n* Participant reported diagnosis of Type 2 diabetes\n* HbA1c between 5.7%-11% (inclusive) and \u002F or fasting blood glucose of ≥ 100 mg\u002FdL\n* BMI 27-50 kg\u002Fm2 (inclusive)\n* Age range - 18 - 65 years (inclusive)\n* On stable regimen of all medications (including diabetes) for at least 3 months (brief regimens of medications such as antibiotics, steroids, etc. are permitted)\n* Willing to follow all requirements of study protocol including blood draws\n* Under the care of a physician who will be responsible for managing the subject's diabetes\n* Willing to give release to provide their treating MD with information about the trial\n\nExclusion Criteria:\n\n* Not willing or unable to consume study foods including avocados\n* Participation in a weight control program within the past 3 months or weight loss of ≥ 5 kg in the previous 3 months\n* Taking prescription or OTC weight loss medications within last 4 weeks\n* History of a surgical procedure for weight loss in last 5 years (e.g. gastroplasty, gastric by-pass, gastrectomy or partial gastrectomy, adjustable banding, gastric sleeve)\n* History of major surgery within three months of enrollment\n* Type 1 diabetes, insulin dependent type 2 diabetes, thiazolidinediones (including rosiglitazone and pioglitazone)\n* Renal insufficiency consisting of potassium over 5.5 (mmol\u002FL) on a non-hemolyzed specimen, or a creatinine over 2.5 mg\u002FdL\n* Bilirubin over 3 (mg\u002FdL) or an albumin less than 3 (g\u002FdL)\n* ALT \\> 3 (IU\u002FL) times the upper limit of normal (normal range is 7-56)\n* Evidence of more than 1 severe hypoglycemic event (episode requiring emergency medical services) in the past 12 months, unless the participant's treating physician provides written clearance for participation.\n* Those on higher doses of diuretics (furosemide 40mg or higher or comparable)\n* Unstable heart disease (an ongoing workup or treatment for a cardiac symptom such as unstable angina, coronary ischemia)\n* Presence of implanted cardiac defibrillator\n* Blood pressure ≥180\u002F100 mm Hg. If a potential participant has a BP above the inclusion criteria it is acceptable to re-test this potential participant within one week of the original test.\n* Thyroid disease for which the participant is untreated or has had treatment changed within the last 6 months. History of thyroid disease or current thyroid disease treated with a stable medication regimen for at least 6 months is acceptable\n* Uncontrolled gastrointestinal disorders including chronic malabsorptive conditions, peptic ulcer disease, Crohn's disease, chronic diarrhea, or active gallbladder disease\n* Current cancer or cancer treatment, or a history of cancer or cancer treatment within the last 3 years. Persons with successfully resected non-melanoma carcinoma of the skin may be enrolled.\n* Dementia, psychiatric illness, or substance abuse that may interfere with adherence (e.g., illness that is currently unstable or resistant to first-line therapy; substance abuse in the past year)\n* Women who are pregnant, lactating, trying to become pregnant or unwilling to use an effective means of birth control\n* Currently consuming \\>14 alcoholic drinks (1 drink = 12 fl oz beer, 4 fl oz wine or 1.5 fl oz liquor) per week and unwilling to stop intake during study participation\n* Participation in another clinical trial within 30 days prior to enrollment\n* Any other condition or factor which in the opinion of the study physician or investigator makes it inadvisable for the candidate to participate in the trial",{"count":617,"type":22},48,[25],"The objective of this study is to assess the effects of Hass Avocados on glycemic control. The investigators hypothesize that Hass Avocado consumption will reduce fasting blood sugar compared to an isocaloric amount of other fruit during controlled feeding.",[621,622,623,624,625,299],"Diabetes Mellitus, Type 2","Insulin","Fructosamine","C-Reactive Protein","Glucose",{"date":627,"type":39},"2025-07-31",{"date":629,"type":39},"2023-10-10",{"date":631,"type":22},"2026-12-15",{"name":45,"class":46},{"id":634,"slug":635,"hasResults":12,"nctId":636,"briefTitle":637,"officialTitle":638,"acronym":639,"eligibilityCriteria":640,"healthyVolunteers":82,"sex":17,"minAge":18,"maxAge":104,"enrollmentInfo":641,"targetDuration":4,"studyType":23,"phases":642,"briefSummary":643,"conditions":644,"keywords":4,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":647,"lastUpdatePostDateStruct":648,"startDateStruct":650,"completionDateStruct":652,"leadSponsor":653,"locationsCount":47},"100378443","evaluating-glial-acetate-metabolism-as-a-biomarker-of-hypoglycemic-counterregulation-100378443","NCT04207619","Evaluating Glial Acetate Metabolism as a Biomarker of Hypoglycemic Counterregulation","Evaluating Glial Acetate Metabolism as a Biomarker of Hypoglycemic Counterregulation Using 13C Magnetic Resonance Spectroscopy.","E-VAL","Inclusion Criteria:\n\n* Healthy male or female\n* Ages 18-40 years\n* BMI between 20 kg\u002Fm2 and 30 kg\u002Fm2 (±0.5 kg\u002Fm2 will be accepted)\n* Medically cleared for participation in the study\n\nExclusion Criteria:\n\n* Contraindication to MRI\n* Consume \\>10 alcoholic drinks\u002Fweek\n* History of chronic smoking or have quit less than 10 years ago\n* History of clinically diagnosed diabetes or a fasting blood glucose \\>126 mg\u002FdL\n* Average screening blood pressure \\>140\u002F90 mmHg\n* History of cardiovascular disease\n* Pregnant, planning to become pregnant, or breastfeeding\n* Use of medications affecting glucose metabolism, e.g., benzodiazepines, thiazide diuretics, cortisone, and prednisone.\n* Use of beta-adrenergic antagonists.\n* Based on the investigative team's clinical judgement, a subject may not be appropriate for participation in the study.",{"count":134,"type":22},[25],"Hypoglycemic complications are a major impediment to the maintenance of healthy glucose levels in persons with diabetes. The investigators recently completed a clinical pilot and feasibility study (GLIMPSE, NCT02690168), which identified a novel biomarker, glial acetate metabolism, that appears to predict the susceptibility to hypoglycemia. By providing an assay to predict hypoglycemic events and therefore diabetic complications, the development of this biomarker could significantly improve the treatment of persons with diabetes.\n\nThe goal of this study is to determine the efficacy of our biomarker for predicting susceptibility to insulin-induced hypoglycemia. In order to accomplish this goal the investigatiors will pair our 13C magnetic resonance spectroscopy procedure to assess glial acetate metabolism, developed in the GLIMPSE study, with a hyperinsulinemic-hypoglycemic clamp procedure, developed in the HYPOCLAMP study (NCT03839511). The two procedures will be separated by a three day interval. The investigators will then correlate the participants' rates of glial acetate metabolism with their neuroendocrine responses to the hypoglycemic clamp. This proof of concept study will test the hypothesis that glial acetate metabolism is inversely proportional to the neuroendocrine response to hypoglycemia, that is, as glial acetate metabolism increases the neuroendocrine response will decrease.",[645,646],"Diabetes","Hypoglycemia","2025-07-21",{"date":649,"type":39},"2025-07-24",{"date":651,"type":39},"2020-02-19",{"date":312,"type":22},{"name":45,"class":46},{"id":655,"slug":656,"hasResults":12,"nctId":657,"briefTitle":658,"officialTitle":659,"acronym":660,"eligibilityCriteria":661,"healthyVolunteers":82,"sex":662,"minAge":428,"maxAge":663,"enrollmentInfo":664,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":665,"conditions":666,"keywords":670,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":677,"lastUpdatePostDateStruct":678,"startDateStruct":680,"completionDateStruct":682,"leadSponsor":683,"locationsCount":47},"100535522","diet-induced-changes-in-genetic-material-100535522","NCT06252922","Diet-Induced Changes in GEnetic Material","A Pilot Study to Examine Metabolic Flexibility as a Mechanism for Diet- Induced Epigenetic Alterations in Male Gametes","DIG 'EM","Inclusion Criteria:\n\n* Male based on biological sex\n* Age 20-35 years\n* BMI between 18.5 and 24.9 kg\u002Fm2\n* White\u002FCaucasian\n* Willing to consume pre-prepared meals\n* Willing to wear an accelerometer and continuous glucose monitor (CGM)\n* Willing to track diet intake\n* Willing to stay 24 hours, including overnight in a research clinic\n* Willing to provide blood and sperm samples\n* Willing to consent to whole-genome sequencing of DNA\n\nExclusion Criteria:\n\n* Unstable weight in the last 3 months (±5% weight loss or gain)\n* Shift work or working in a factory setting\n* Habitual smoking or use of tobacco products, including vaping, within the past 6 months.\n* History of clinically diagnosed diabetes\n* Hypertension (\\>140\u002F90 mmHg measured at screening)\n* Has undergone bariatric surgery\n* History of cardiovascular disease, neurological disease, or other chronic diseases, including cancer\n* History of human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS)\n* Adherence to special or restrained diets (e.g., low-CHO, low-fat, or vegetarian\u002Fvegan diets) or food allergies associated with study foods.\n* Currently engaging in \\>150 minutes moderate-intensity or \\>75 minutes of vigorous-intensity physical activity each week\n* Drinking more than 14 servings of beer or alcohol per week\n* Depressive (Score ≥10), anxiety (Score ≥8), and stress (Score≥15) symptomology (Score ≥16) from the 42-item Depression, Anxiety, Stress Scales (DASS)","MALE","35 Years",{"count":134,"type":22},"This is a pilot study in 10 men to test the hypothesis that perturbations in substrate flux and the circulating metabolic and pro-inflammatory milieus during a high-fat diet paradigm will modulate DNA methylation of genes in sperm associated with obesity and cardiometabolic dysfunction.",[667,668,669],"Diet, Healthy","Body Weight","Metabolic Disturbance",[671,672,673,572,674,675,676],"Healthy Weight","High-Fat Diet","Sperm DNA Methylation","DNA Damage","Substrate Flux","Preconception","2025-05-27",{"date":679,"type":39},"2025-05-31",{"date":681,"type":39},"2023-11-11",{"date":419,"type":22},{"name":45,"class":46},""]