[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Personalis Inc.\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":48},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100533774","ctdna-based-mrd-testing-for-nac-monitoring-in-tnbc-100533774",false,"NCT06230185","CtDNA Based MRD Testing for NAC Monitoring in TNBC","Breast Cancer-Minimal\u002FMolecular Residual Disease Detection and Therapy Monitoring in Patients with Early Stage TNBC-Phase I (B-STRONGER-I)","B-STRONGER-I","Inclusion Criteria:\n\n1. Have histologically documented TNBC (defined as ER expression ≤10% by IHC, PR expression≤10% by IHC and HER2 0 or 1+ by IHC or FISH ratio \\\u003C2 or HER2 gene copy number of \\\u003C6).\n2. Early-stage breast cancer (stage I-III) and scheduled to undergo NAC treatment with curative intent.\n3. Be informed of the investigational nature of the study and all pertinent aspects of the trial.\n4. Have the ability to understand and the willingness to sign a written informed consent document in accordance with institutional and federal guidelines.\n5. Be ≥ 18years of age.\n6. Patient who are scheduled to start NAC.\n7. Be willing to provide blood samples before and during treatment.\n8. Have available biopsy tissue.\n\nExclusion Criteria:\n\n1. Receiving concurrent anti-neoplastic therapy for another malignancy.\n2. Stage IV disease.\n3. Current or history of another primary cancer within 5 years of study entry, with the exception of basal or squamous cell skin cancer, or non-invasive malignancy.\n4. History of allogeneic bone marrow or organ transplant.\n5. Blood transfusion within two weeks before collection of blood for central ctDNA testing.\n6. Started systemic therapy for their breast cancer.\n7. Pregnancy","FEMALE","18 Years",{"count":20,"type":21},422,"ESTIMATED","OBSERVATIONAL","A prospective, multicenter, observational study to evaluate the correlation of Molecular Residual Disease (MRD) detection using circulating tumor DNA guided test to pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in stage I-III triple negative breast cancer (TNBC). Results from this study aim to improve MRD detection and disease outcomes for future patients.",[25,26],"TNBC - Triple-Negative Breast Cancer","Minimal Residual Disease",[28,29,30,31,32,33,34],"ctDNA","Liquid Biopsy","Breast Cancer","MRD","NAC","TNBC","NeXT Personal®","RECRUITING","2025-01-03",{"date":38,"type":39},"2025-01-07","ACTUAL",{"date":41,"type":39},"2023-11-09",{"date":43,"type":21},"2025-12-31",{"name":45,"class":46},"Personalis Inc.","INDUSTRY",14,""]