[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Petrovsky National Research Centre of Surgery\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":171},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,52,86,119,146],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100625408","prognosis-and-diagnosis-of-acute-gastrointestinal-dysfunction-in-cardiac-surgery-patients-100625408",false,"NCT07422246","Prognosis and Diagnosis of Acute Gastrointestinal Dysfunction in Cardiac Surgery Patients","PREDICT-GICS","Inclusion Criteria:\n\n* Surgery on the heart and main vessels with a high risk of developing gastrointestinal dysfunction (according to literature data and our own retrospective study);\n* Patient's consent to participate in the study\n\nExclusion Criteria:\n\n* Patient's refusal to participate in the study;\n* HIV infection in the patient;\n* Immunosuppressive therapy;\n* Oncological disease;","ALL","18 Years","95 Years",{"count":20,"type":21},100,"ESTIMATED","INTERVENTIONAL",[24],"NA","The purpose of this prospective observational clinical cohort study is to develop a scientifically based approach to the prediction and early diagnosis of intestinal dysfunction in cardiac surgery patients.\n\nThe main questions that the study should answer:\n\nWhat are the main risk factors for the development of intestinal dysfunction? What specific and non-specific biomarkers can predict the development of intestinal dysfunction? The study participants will be monitored from the moment of hospitalization until the end of their stay in a medical facility",[27,28,29,30],"Gastrointestinal Dysfunction","Cardiac Surgery Intensive Care Treatment","Cardiac Surgery","Cardiac Surgery in Adult Patient",[32,33,34,35,36,37,38],"cardiac surgery","intestinal dysfunction","gastrointestinal dysfunction","gastrointestinal complications","multiorgan dysfunction syndrome","intestinal failure","gastrointestinal failure","NOT_YET_RECRUITING","2026-02-18",{"date":42,"type":43},"2026-02-19","ACTUAL",{"date":45,"type":21},"2026-03-10",{"date":47,"type":21},"2028-09-30",{"name":49,"class":50},"Petrovsky National Research Centre of Surgery","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":22,"phases":62,"briefSummary":63,"conditions":64,"keywords":69,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":51},"100541926","antibacterial-tactics-based-on-presepsin-level-in-thoracic-aorta-surgery-patients-100541926","NCT06336213","Antibacterial Tactics Based on Presepsin Level in Thoracic Aorta Surgery Patients","Changes in Antibacterial Therapy Based on Perioperative Dynamics of Presepsin During Reconstructive Thoracic Aorta Surgery","Inclusion Criteria:\n\nThoracic aorta aneurysm\u002Fdissection\n\nExclusion Criteria:\n\nBlood sample hemolysis","75 Years",{"count":61,"type":21},50,[24],"According to the literature, presepsin was recommended not only as an effective indicator in the diagnosis of sepsis in intensive care units, but also as a reliable prognostic marker of postoperative inflammatory processes in cardiac surgery. Previous study carried out in Petrovsky NRCS related to biomarkers in cardiac surgery and presepsin in particular showed good sensitivity in infection complications prognosis.",[65,66,67,68],"Aortic Aneurysm and Dissection","Cardiac Valve Disease","Thoracic Aortic Aneurysm","Thoracic Aortic Dissection",[70,71,72,73,74,75,76,32],"biomarkers","presepsin","complications","aortic arch","aorta","aortic aneurysm","ascending aorta","RECRUITING","2026-01-28",{"date":80,"type":43},"2026-01-29",{"date":82,"type":43},"2024-01-23",{"date":84,"type":21},"2027-02-15",{"name":49,"class":50},{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":94,"targetDuration":4,"studyType":96,"phases":4,"briefSummary":97,"conditions":98,"keywords":105,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},"100577973","left-ventricular-reverse-remodeling-evaluation-after-surgical-correction-of-aortic-regurgitation-100577973","NCT06805253","Left Ventricular Reverse Remodeling Evaluation After Surgical Correction of Aortic Regurgitation","Left Ventricular Reverse Remodeling Outcomes Evaluation in Patients With Aortic Regurgitation After Surgical Treatment","ORMIX","Inclusion Criteria:\n\n* Age over 18 years\n* Planned primary elective surgery for chronic aortic regurgitation\n* Presence of functional mitral regurgitation\n* End-diastolic volume of the left ventricle \\>= 250 ml\n\nExclusion Criteria:\n\n* Infectious endocarditis\n* History of myocardial infarction\n* Indications on simultaneous myocardial revascularisation\n* Acute aortic regurgitation of any etiology\n* Previously diagnosed dilatation of the left ventricle, not associated with the development of aortic regurgitation\n* Long-term persistent or permanent form of atrial fibrillation\n* Pregnancy in the first 12 months after surgery\n* Simultaneous participation in other studies\n* Presence of implanted pacemakers\n* Refusal to sign informed consent\n* Acute coronary event diagnosed within 12 months after aortic valve surgery\n* Indications for resynchronization therapy or permanent right ventricular pacing in the first 12 months after aortic valve surgery\n* Re-do cardiac surgery for any reason within 12 months after aortic valve surgery",{"count":95,"type":21},120,"OBSERVATIONAL","Investigators assume that surgical correction approach to functional mitral regurgitation during intervention for chronic aortic regurgitation in patients with severe enlargement of the left heart chambers influences reverse remodeling of the left ventricle (LV) in the postoperative period. It is suggested that functional mitral regurgitation (MR) provides supra-physiological left ventricle volume overload and this fact plays positive role in early-stage post-operative left ventricle volume and function recovery. LV volume, systolic and diastolic function will be monitored with echocardiography (EchoCG) along with life quality in patients with different grades of functional mitral regurgitation secondary to severe chronic aortic insufficiency after surgical treatment of aortic regurgitation.",[99,100,101,102,103,104],"Aortic Valve Regurgitation","Mitral Valve Regurgitation","Left Ventricle Dilated","Left Atrium Dilated","Systolic Left Ventricular Heart Failure","Diastolic Heart Failure",[106,107,108,109],"reverse remodeling","left ventricle dilatation","mitral valve functional regurgitation recovery","left ventricle reverse remodeling","2025-06-05",{"date":112,"type":43},"2025-06-11",{"date":114,"type":43},"2024-05-09",{"date":116,"type":21},"2030-05",{"name":49,"class":50},2,{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":22,"phases":129,"briefSummary":130,"conditions":131,"keywords":136,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":51},"100552675","validation-of-hematological-indices-100552675","NCT06476171","Validation of Hematological Indices","Validation of Hematological Indices as Prognostic Markers of Inflammatory Complications and Multiple Organ Dysfunction in Cardiac Surgery Patients.","Inclusion Criteria:\n\n* age from 18 to 80 years\n* cardiac surgery\n* operation in the conditions of cardiopulmonary bypass\n* availability of voluntary informed consent of the patient to participate in the study\n\nExclusion Criteria:\n\n* refusal of the patient from the study\n* transfer of the patient to another medical institution","80 Years",{"count":128,"type":21},200,[24],"The hypothesis of the study is that hematological indices (neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and systemic index of inflammation) may be predictors of infectious complications and multiple organ dysfunction in patients after cardiac surgery.",[132,133,134,135],"Multiple Organ Dysfunction","Sepsis","Pneumonia","Wound Infection",[132,133,32,137],"hematological indices","2024-11-20",{"date":140,"type":43},"2024-11-25",{"date":142,"type":43},"2023-06-19",{"date":144,"type":21},"2025-12-30",{"name":49,"class":50},{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":152,"eligibilityCriteria":153,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":126,"enrollmentInfo":154,"targetDuration":4,"studyType":22,"phases":156,"briefSummary":157,"conditions":158,"keywords":160,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":165,"startDateStruct":166,"completionDateStruct":168,"leadSponsor":170,"locationsCount":51},"100433164","efficacy-and-safety-of-hemoperfusion-with-polymyxin-b-in-septic-shock-associated-with-severe-endotoxemia-in-cardiac-surgery-patients--vs-ss-100433164","NCT04920565","Efficacy and Safety of Hemoperfusion With Polymyxin B in Septic Shock Associated With Severe Endotoxemia in Cardiac Surgery Patients (РМХ vs SS)","Evalution of the Efficacy and Safety of Hemoperfusion Use With Polymyxin B un Patients With Severe Endotoxemia With Multiple Organ Dysfunction Syndrome After Complicated Operations With Cardiopulmonary Bypass","РМХ vs SS","Inclusion Criteria:\n\n* SOFA +2 points in comparison with the previous assessment; РСТ more than 2 ng \u002F ml; CRP more than 150 ng \u002F ml; norepinephrine infusion; intestinal paresis; positive data of blood culture; ЕАА more than 0,6\n\nExclusion Criteria:\n\n* bleeding; heparin-induced thrombocytopenia",{"count":155,"type":21},20,[24],"Sepsis is a state of multiple organ dysfunction caused by a generalized immune-inflammatory response of the body to an infectious agent, with pronounced heterogeneity and interchangeability of clinical and laboratory manifestations. Violation of autoregulation and multiple organ dysfunctions in case of not timely started and \u002F or ineffective therapy lead to the development of multiple organ failure and thanatogenesis in 40-90% of cases. At the moment, there is no standardized approach to the treatment of the entire pool of sepsis patients. Pharmacological effects on receptors for interleukins and endotoxin, antibiotic therapy and immunoprotection do not allow taking the process under complete control. The pathogenesis and clinical diversity of manifestations dictates the need for a personalized approach based on identifying a group of patients with homogeneous characteristics and the course of the process, where one or another technique would have the greatest benefit. The choice of tactics for extracorporeal therapy should be based on early support of organ function and consistent elimination of high concentrations of trigger compounds (endotoxin, other metabolic products of microorganisms and products of cytolysis of a macroorganism), as well as aimed at minimizing the loss of proteins and immune complexes.\n\nThe aim of this clinical study was to assess the efficacy and safety of the selective adsorption of endotoxin in patients with severe multiple organ dysfunction after complicated cardiac surgery.",[159],"Multiple Organ Dysfunction With Severe Endotoxemia",[161,162,163,164],"test EAA","endotoxemia","hemoperfusion with Polymyxin B","cardiac syrgery",{"date":140,"type":43},{"date":167,"type":43},"2021-11-01",{"date":169,"type":21},"2025-12",{"name":49,"class":50},""]