[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Primus Pharmaceuticals\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":72},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100528162","phase-4-efficacy-of-m640-in-acute-lumbosacral-musculoskeletal-conditions-100528162",false,"NCT06157177","Efficacy of M640 in Acute Lumbosacral Musculoskeletal Conditions.","Efficacy of Modified Release Metaxalone 640 mg in Acute Lumbosacral Musculoskeletal Conditions With Spinal Stenosis and Sciatica","Inclusion Criteria:\n\n* No clinically significant conditions impacting quality or quantity of pain\n* Baseline Numeric Pain Scale ≥ 6\n* Capable of answering text or email survey reminders\n* Low back pain with or without sciatica\n\nExclusion Criteria:\n\n* Current use of other skeletal relaxants\n* Current use of other pain relievers\n* Current use of cimetidine or monoamine oxidase inhibitors",true,"ALL","18 Years","80 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","The goal of this clinical trial is to learn if a modification to metaxalone 640 mg can reduce low back and leg pain. The participants will be 18 to 80 years old, healthy with newly occurring back or leg pain. The main question aims to compare a group taking active treatment and a group taking a look-alike substance containing no active treatment. All participants will answer questions on Day 1, before treatment, and on 7-day after treatment, about:\n\n* Amount and quality of pain\n* Interference with physical activity\n* Interference with sleep",[28,29],"Sciatica Acute","Lumbar Spinal Stenosis","RECRUITING","2026-05-08",{"date":33,"type":34},"2026-05-12","ACTUAL",{"date":36,"type":34},"2023-11-15",{"date":38,"type":22},"2026-11-15",{"name":40,"class":41},"Primus Pharmaceuticals","INDUSTRY",24,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":23,"phases":52,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},"100535803","study-of-diosmin-for-the-treatment-of-digital-ulcers-in-systemic-sclerosis-100535803","NCT06256575","Study of Diosmin for the Treatment of Digital Ulcers in Systemic Sclerosis","Treatment of Digital Ulcers in Systemic Sclerosis With Diosmin: A Randomized, Double-blind, Placebo-controlled Multi-centre Pilot Study","Inclusion Criteria:\n\n* Diagnosis of systemic sclerosis (scleroderma)\n* At least one \"active\" digital ulcer\n* Medication for systemic sclerosis unchanged for 30 days\n\nExclusion Criteria:\n\n* Infection or gangrene in ulcer\n* Citrus allergy\n* Unstable heart, kidney, or liver disease\n* Active infection of any type\n* Current cancer treatment or uncured cancer\n* Pregnancy or breast feeding",{"count":51,"type":22},45,[53],"NA","This study is performed to consider the safety and healing ability of diosmin in patients with systemic sclerosis (scleroderma) and open sores on their fingers (digital ulcers). Two (2) out of three (3) participants will receive active product. The participants will have four (4) visits over eight (8) weeks. Physical exams and photos will be performed. A variety of questions will be asked describing level of pain and lifestyle changes.",[56,57],"Scleroderma, Systemic","Digital Ulcer",[59,60,61,62],"SSc","Digital Ulcers","Sclerosis","Scleroderma","2025-12-02",{"date":65,"type":34},"2025-12-04",{"date":67,"type":34},"2025-05-02",{"date":69,"type":22},"2027-08-15",{"name":40,"class":41},5,""]