[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Prof Urs Zingg\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":63},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,42],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100463907","phase-4-the-bioavailability-and-effect-on-pouch-ph-of-esomeprazole-after-gastric-bypass-100463907",false,"NCT05320796","The Bioavailability and Effect on Pouch pH of Esomeprazole After Gastric Bypass","The Bioavailability and Effect on Pouch pH of Esomeprazole as Tablets or in Solution After Laparoscopic Proximal RYGB for Morbid Obesity - an Investigator Blinded Pilot Study","Inclusion Criteria:\n\n* Proximal Roux-en-Y gastric bypass with linear stapled anastomosis 12 months prior to the study investigation\n* Routine administration of proton pump inhibitors for 6 months postoperatively\n* No intake of proton pump inhibitors at least 4 weeks prior to study investigation\n* No marginal ulcers in upper endoscopy prior to placement of wireless BRAVO™ pH monitoring capsule\n* No symptoms related to gastro-esophageal reflux or marginal ulcers (i.e. epigastric pain, retrosternal burning, regurgitation)\n* Informed consent as documented by signature\n\nExclusion Criteria:\n\n* Known intolerance or allergy for Esomeprazol\n* Contraindication for upper endoscopy\n* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant\n* Women who are pregnant or breast feeding Major hepatic dysfunction","ALL","18 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The objective of this study is to investigate the effect of Esomeprazol administered in tablets (Esomeprazol MUT Sandoz® 40mg) or in solution (Esomeprazol MUT Sandoz® 40mg in 10ml tap water) on acid production in the gastric pouch by measuring the intragastric pH and the serum concentration of esomeprazole.",[26,27,28],"Obesity","Gastric Reflux","Ulcer, Gastric","RECRUITING","2026-06-08",{"date":32,"type":33},"2026-06-09","ACTUAL",{"date":35,"type":33},"2023-11-01",{"date":37,"type":20},"2027-12-31",{"name":39,"class":40},"Prof Urs Zingg","OTHER",1,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":51,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":58,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":62,"locationsCount":41},"100449464","high-resolution-manometry-after-partial-fundoplication-for-gastro-oesophageal-reflux-100449464","NCT05132816","High Resolution Manometry After Partial Fundoplication for Gastro-oesophageal Reflux","High Resolution Manometry After Partial Fundoplication for Gastro-oesophageal Reflux: Does the Ineffective Preoperative Oesophageal Motility Change Postoperatively?","Inclusion Criteria:\n\n* Age older than 18 years\n* Ineffective esophageal motility disorder according the Chicago classification (7), defined as ≥ 7\u002F10 (70%) of swallows with weak contraction (distal contraction interval (DCI) between 100mmHg\u002Fs\u002Fcm and less than 450 mmHg\u002Fs\u002Fcm) or ≥ 5\u002F10 (50%) of swallows with failed peristalsis (DCI \\\u003C100mgHg\u002Fs\u002Fcm)Performance of partial fundoplication (180° anterior or 270° posterior) at Spital Limmattal\n* Informed Consent as documented by signature\n\nExclusion Criteria:\n\n* Age under 18 years\n* Pregnancy\n* Normal preoperative esophageal motility\n* Other specifically defined esophageal motility disorders such as Nutcracker or Jackhammer esophagus\n* Preoperative presence of a hiatal hernia with migration of \\>20% of stomach in the chest\n* Revisional surgery (after other procedures for reflux or at the hiatus)",{"count":50,"type":20},100,[52],"NA","This is a combined retro- and prospective, monocentric study. All patients who underwent or are planned for laparoscopic partial fundoplication (180° anterior or 270° posterior) between 2020-2023 are assessed for preoperative ineffective esophageal motility (IEM).\n\nThe main hypothesis is, that preoperative oesophageal motility disorders, especially hypo-contractility or failed peristalsis, are caused by gastro-oesophageal reflux. Therefore, postoperative manometry after partial wrap fundoplication (270° posterior, 180° anterior) shows a decrease in comparison to preoperative motility disorders.\n\nThe primary objective of this study is to examine the postoperative esophageal motility in patients with known preoperative motility disorders.\n\nSecondary endpoints are the presence of other oesophageal motility disorders pre- vs. postoperatively (including new onset disorders), the assessment of the Gastrointestinal Symptom Rating Scale (GSRS) pre- vs. postoperatively, and more.\n\nIf IEM is present preoperatively, patients are contacted at least 1 year after surgery and will be informed about the study and asked to participate. In case of agreement, they are invited to the study site. They undergo high-resolution manometry 18-24 months postoperatively (study intervention).",[55,56,57],"Gastroesophageal Reflux","Esophageal Motility Disorders","Upper Gastrointestinal Disorder",{"date":32,"type":33},{"date":60,"type":33},"2022-01-24",{"date":37,"type":20},{"name":39,"class":40},""]