[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":387},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,47,76,104,130,152,180,210,237,266,289,312,344,366],{"id":9,"slug":4,"hasResults":10,"nctId":11,"briefTitle":12,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100645407",false,"NCT07681453","Blind Intubation Through the Tulip Airway Versus Direct Laryngoscopy","Comparison of Blind Endotracheal Intubation Through the Tulip Oropharyngeal Airway and Direct Laryngoscopy by Novice Operators: A Randomized Crossover Manikin Study","Inclusion Criteria:\n\n* Voluntary participation in the study\n* Anesthesia technician students with no prior airway management experience\n* Age ≥ 18 years\n* Willingness to participate in simulation-based intubation procedures\n\nExclusion Criteria:\n\n* Prior advanced airway management experience (e.g., regular intubation practice in clinical settings)\n* Refusal to participate or withdraw consent\n* Inability to complete simulation procedures for any reason",true,"ALL","18 Years",{"count":19,"type":20},60,"ESTIMATED","INTERVENTIONAL",[23],"NA","This is a randomized crossover mannequin study comparing two airway management techniques in novice operators: blind endotracheal intubation via the Tulip oropharyngeal airway versus direct laryngoscopy. The study aims to evaluate and compare the success rate and performance characteristics of both methods under simulated conditions in order to assess their effectiveness in airway management training and practice.",[26],"Airway Management",[28,29,30,31,32,33,34],"Airway management","endotracheal intubation","Tulip airway","direct laryngoscopy","simulation study","crossover trial","anesthesia education","NOT_YET_RECRUITING","2026-06-26",{"date":38,"type":39},"2026-07-02","ACTUAL",{"date":41,"type":20},"2026-07-10",{"date":43,"type":20},"2026-08-10",{"name":45,"class":46},"Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization","OTHER",{"id":48,"slug":49,"hasResults":10,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":63,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},"100644604","assessment-of-reintubation-risk-using-multiple-parameters-in-postoperative-intensive-care-unit-patients-100644604","NCT07672106","Assessment of Reintubation Risk Using Multiple Parameters in Postoperative Intensive Care Unit Patients","Inclusion Criteria:\n\nAdult patients aged 18 years and older\n\nPatients requiring postoperative intensive care follow-up after major surgery, including abdominal, vascular, orthopedic, or ear, nose, throat, head and neck surgery\n\nPatients extubated in the operating room and admitted to the intensive care unit with spontaneous breathing\n\nPatients without any clinical condition preventing the planned measurements within the first 0-2 hours after ICU admission (T0 and T1)\n\nPatients for whom written informed consent can be obtained from the patient or legally authorized representative\n\nPatients admitted to the intensive care unit within the specified study period after ethics committee approval and enrolled consecutively\n\nExclusion Criteria:\n\nPatients younger than 18 years of age\n\nPatients who leave the operating room intubated or are admitted to the intensive care unit while intubated\n\nPatients with a tracheostomy\n\nPatients with a history of diaphragmatic paralysis\n\nPatients with a significant neuromuscular disease, such as ALS, myasthenia gravis, or similar conditions\n\nPatients with conditions that significantly prevent ultrasound measurements, including marked subcutaneous emphysema, large dressings or bandages covering the measurement area, inability to access the measurement site due to drains or the surgical field, or inability to obtain technically adequate images\n\nPatients in whom the planned measurements cannot be performed due to clinical instability requiring emergency intubation immediately after ICU admission\n\nPatients from whom informed consent cannot be obtained, or patients or legally authorized representatives who refuse participation",{"count":54,"type":20},600,"OBSERVATIONAL","This prospective, non-interventional observational study will evaluate the risk of reintubation in adult postoperative patients admitted to the intensive care unit after major surgery. Reintubation after extubation is an important clinical problem because it may increase complications, prolong mechanical ventilation, and extend intensive care and hospital stay.\n\nThe study will include adult patients who are extubated in the operating room and admitted to the intensive care unit with spontaneous breathing. Within the first hours after ICU admission, bedside ultrasound measurements of diaphragm thickness, parasternal intercostal muscle thickness, and lung ultrasound score will be performed. The ROX index will also be calculated using oxygen saturation, inspired oxygen concentration, and respiratory rate. Perioperative fluid balance will be recorded from anesthesia and patient files.\n\nPatients will be followed for 48 to 72 hours after ICU admission to determine whether reintubation is required. The study aims to assess whether respiratory muscle ultrasound findings, lung ultrasound score, ROX index, and perioperative fluid balance can help predict reintubation risk in postoperative ICU patients. No additional treatment or intervention will be applied as part of the study, and all clinical decisions will be made by the responsible intensive care team according to routine clinical practice.",[58,59,60,61,62],"Postoperative Respiratory Failure","Extubation Failure","Lung Ultrasonography Score","Diaphragm Thickness","Parasternal Intercostal Muscle Thickness",[64,65,66,58],"lung ultrasonography score","Diaphragm thickness","parasternal intercostal muscle thickness","RECRUITING","2026-06-22",{"date":36,"type":39},{"date":71,"type":39},"2026-04-28",{"date":73,"type":20},"2026-10-28",{"name":45,"class":46},1,{"id":77,"slug":78,"hasResults":10,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":10,"sex":84,"minAge":17,"maxAge":85,"enrollmentInfo":86,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":88,"conditions":89,"keywords":94,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":75},"100639464","assessment-of-female-sexual-function-index-fsfi-scores-at-1-month-after-endometrial-sampling-performed-under-sedo-analgesia-or-local-anesthesia-100639464","NCT07628660","Assessment of Female Sexual Function Index (FSFI) Scores at 1 Month After Endometrial Sampling Performed Under Sedo-Analgesia or Local Anesthesia","Evaluation of One-Month Female Sexual Function Index (FSFI) Scores in Women Undergoing Endometrial Sampling Under Sedo-Analgesia Versus Local Anesthesia","FSFI-ENDO","Inclusion Criteria:\n\n* Female patients aged 18 to 60 years\n* Undergoing endometrial sampling at the Department of Obstetrics and Gynecology, Prof. Dr. Cemil Taşcıoğlu City Hospital\n* Undergoing the procedure under sedo-analgesia or local anesthesia as part of routine clinical practice\n* Attendance at the 1-month follow-up visit\n* Ability to complete the Female Sexual Function Index (FSFI) questionnaire\n\nExclusion Criteria:\n\n* Age younger than 18 years or older than 60 years\n* Presence of known chronic systemic disease\n* Incomplete clinical or follow-up data\n* Failure to attend the 1-month follow-up visit\n* Inability or unwillingness to complete the FSFI questionnaire","FEMALE","60 Years",{"count":87,"type":20},210,"Endometrial sampling is a commonly performed gynecological procedure used for the diagnosis of abnormal uterine bleeding and endometrial abnormalities. Different anesthetic techniques may be used during the procedure, including sedo-analgesia and local anesthesia.\n\nThe purpose of this prospective observational study is to evaluate whether the anesthetic technique used during endometrial sampling affects female sexual function one month after the procedure. Female sexual function will be assessed using the validated Female Sexual Function Index (FSFI) questionnaire.\n\nA total of 210 women undergoing endometrial sampling at Prof. Dr. Cemil Taşcıoğlu City Hospital will be enrolled. Participants will be assigned to groups according to the anesthetic technique used during their routine clinical care. FSFI scores obtained at the one-month follow-up visit will be compared between women who underwent the procedure under sedo-analgesia and those who received local anesthesia.\n\nSecondary analyses will include comparison of FSFI scores according to symptom status and histopathological diagnosis.\n\nThe findings of this study may contribute to a better understanding of the impact of anesthetic techniques on postoperative sexual health and quality of life in women undergoing gynecological procedures.",[90,91,92,93],"Female Sexual Dysfunction","Endometrial Sampling","Female Sexual Function Index (FSFI)","Abnormal Uterine Bleeding, Unspecified",[95],"Endometrial Sampling,Female Sexual Function Index,Sedo-Analgesia,Local Anesthesia,Abnormal Uterine Bleeding,Sexual Health","2026-06-01",{"date":98,"type":39},"2026-06-05",{"date":100,"type":39},"2026-04-15",{"date":102,"type":20},"2027-05-15",{"name":45,"class":46},{"id":105,"slug":106,"hasResults":10,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":110,"eligibilityCriteria":111,"healthyVolunteers":15,"sex":84,"minAge":17,"maxAge":112,"enrollmentInfo":113,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":115,"conditions":116,"keywords":119,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":129},"100639760","protective-effect-of-lactation-against-gestational-diabetes-mellitus-in-subsequent-pregnancies-a-prospective-observational-cohort-study-100639760","NCT07624968","Protective Effect of Lactation Against Gestational Diabetes Mellitus in Subsequent Pregnancies: A Prospective Observational Cohort Study","Protective Effect of Lactation Against Gestational Diabetes Mellitus in Subsequent Pregnancy: A Prospective Observational Cohort Study","LACGDM","Inclusion Criteria:\n\n* Pregnant individuals aged 18 to 50 years.\n* Singleton pregnancy.\n* Conception during the lactation period.\n* Follow-up at Prof. Dr. Cemil Taşcıoğlu City Hospital or Esenyurt Necmi Kadıoğlu State Hospital.\n* Availability of glycemic parameters including fasting plasma glucose, HbA1c, glycosuria, and 75-g oral glucose tolerance test (OGTT) results.\n* Availability of routine ultrasonographic measurements including fetal abdominal circumference percentile (AC), estimated fetal weight percentile (EFW), and amniotic fluid index (AFI).\n\nExclusion Criteria:\n\n* Age below 18 years.\n* Age above 50 years.\n* Multiple pregnancy.\n* Known chronic systemic disease or pre-existing diabetes mellitus.\n* Missing clinical, laboratory, or ultrasonographic data.","50 Years",{"count":114,"type":20},140,"Gestational diabetes mellitus (GDM) is a common metabolic disorder of pregnancy associated with increased maternal and fetal morbidity. Lactation has been suggested to improve maternal glucose metabolism, enhance insulin sensitivity, and reduce the risk of future glucose intolerance. However, evidence regarding the protective effect of lactation on the development of GDM in subsequent pregnancies remains limited.\n\nThis prospective observational cohort study aims to evaluate the association between lactation and the risk of gestational diabetes mellitus and related pregnancy complications in women who conceive during the lactation period. Routine glycemic markers including fasting plasma glucose, HbA1c, glycosuria, and 75-g oral glucose tolerance test (OGTT) results will be recorded. Ultrasonographic findings including fetal abdominal circumference percentile, estimated fetal weight percentile, and amniotic fluid index will also be assessed. The study will investigate whether lactation is associated with a reduced risk of GDM, fetal macrosomia, and polyhydramnios in subsequent pregnancies.",[117,118],"Gestational Diabetes Mellitus (GDM)","Lactating Mother",[120],"Gestational Diabetes Mellitus,Lactation,Breastfeeding,Glucose Metabolism,Maternal Health","2026-05-29",{"date":123,"type":39},"2026-06-03",{"date":125,"type":39},"2026-01-15",{"date":127,"type":20},"2027-12-31",{"name":45,"class":46},2,{"id":131,"slug":132,"hasResults":10,"nctId":133,"briefTitle":134,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":136,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":138,"conditions":139,"keywords":141,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":75},"100640135","comparison-of-different-scales-for-the-prediction-of-difficult-airway-100640135","NCT07606079","Comparison of Different Scales for The Prediction of Difficult Airway","Inclusion Criteria:\n\n* Patients aged 18 years and older who agreed to participate in the study\n\nExclusion Criteria:\n\n* Patients who refused to participate in the study\n* Patients with limited neck mobility\n* Patients whose mouth opening is smaller than the width of their own three fingers",{"count":137,"type":20},850,"Although many tests exist for predicting a difficult airway, the search for a test with substantially higher specificity and sensitivity is still ongoing. The aim of this study is to evaluate the specificity and sensitivity of modified thyromental distance and modified sternomental distance measurements, scaled according to the patient's own three-finger breadth, in predicting difficult laryngoscopy and difficult tracheal intubation.",[140],"Modified Thyromental Distance",[142,143],"Difficult airway","Modified thyromental distance","2026-05-20",{"date":146,"type":39},"2026-05-26",{"date":148,"type":39},"2026-01-01",{"date":150,"type":20},"2026-06-30",{"name":45,"class":46},{"id":153,"slug":154,"hasResults":10,"nctId":155,"briefTitle":156,"officialTitle":157,"acronym":4,"eligibilityCriteria":158,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":159,"enrollmentInfo":160,"targetDuration":4,"studyType":21,"phases":161,"briefSummary":162,"conditions":163,"keywords":168,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":75},"100617991","effects-of-periodic-recruitment-maneuvers-on-atelectasis-and-respiratory-mechanics-during-elective-spine-surgery-assessed-by-lung-ultrasonography-100617991","NCT07325812","Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics During Elective Spine Surgery Assessed by Lung Ultrasonography","Evaluation of the Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics in Elective Spine Surgery Using Lung Ultrasonography","Inclusion Criteria:\n\n* Adults aged 18 to 65 years\n* Scheduled for elective lumbar spine surgery under general anesthesia\n* Surgery planned to be performed in the prone position\n* Expected surgical duration of at least 2 hours\n* American Society of Anesthesiologists (ASA) physical status I-II\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* Body mass index (BMI) greater than 30 kg\u002Fm²\n* History of thoracic surgery\n* Known or suspected chronic pulmonary disease (e.g., chronic obstructive pulmonary disease, restrictive lung disease)\n* Clinically significant cardiac disease\n* Pregnancy or breastfeeding\n* Known airway anomalies\n\nIntraoperative surgical duration shorter than 2 hours\n\nRefusal or inability to provide informed consent","65 Years",{"count":19,"type":20},[23],"During general anesthesia, particularly in patients undergoing spine surgery in the prone (face-down) position, increased intrathoracic and abdominal pressure may reduce lung compliance and promote the development of atelectasis (partial lung collapse). Atelectasis can impair intraoperative oxygenation and may increase the risk of postoperative pulmonary complications. Alveolar recruitment maneuvers (ARM) are routinely used in anesthesia practice to reopen collapsed lung regions; however, it remains unclear whether periodic application of ARM throughout surgery provides additional benefit compared with standard single-time application.\n\nThis prospective, randomized controlled clinical study aims to evaluate whether periodic alveolar recruitment maneuvers applied during elective spine surgery in the prone position reduce intraoperative atelectasis and improve respiratory mechanics compared with the standard approach of performing ARM only after positioning and before extubation. Adult patients undergoing elective spine surgery under general anesthesia will be randomly assigned to either a periodic ARM group or a standard ARM group.\n\nLung aeration will be assessed using lung ultrasound, a non-invasive and radiation-free bedside imaging method. The primary outcome is the incidence of intraoperative atelectasis assessed before extubation. Secondary outcomes include lung ultrasound aeration scores, respiratory mechanics parameters (such as airway pressures and compliance), oxygenation indices, and the occurrence of transient intraoperative respiratory or hemodynamic events.\n\nThe findings of this study may help optimize intraoperative ventilation strategies in prone spine surgery and contribute to improved perioperative respiratory safety.",[164,165,166,167],"Atelectasis","Mechanical Ventilation","General Anesthesia","Prone Position",[164,169,170,167,171],"Alveolar Recruitment Maneuver","Lung Ultrasound","Respiratory Mechanics","2026-04-02",{"date":174,"type":39},"2026-04-08",{"date":176,"type":20},"2026-04",{"date":178,"type":20},"2026-07",{"name":45,"class":46},{"id":181,"slug":182,"hasResults":10,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":187,"targetDuration":4,"studyType":21,"phases":189,"briefSummary":191,"conditions":192,"keywords":195,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":202,"lastUpdatePostDateStruct":203,"startDateStruct":205,"completionDateStruct":207,"leadSponsor":209,"locationsCount":129},"100631408","phase-2-yittrium-90y-90-fibroblast-activation-protein-inhibitor-fapi-therapy-in-patients-with-non-small-cell-lung-cancer-phase-ii-100631408","NCT07500285","Yittrium-90(Y-90) Fibroblast Activation Protein Inhibitor (FAPI) Therapy in Patients With Non-Small Cell Lung Cancer (Phase II)","A Novel Therapeutic Target in Non-Small Cell Lung Cancer: Evaluation of the Efficacy of Yttrium-90 (Y-90) Fibroblast Activation Protein Inhibitor (FAPI) - A Phase II Study","Inclusion Criteria:\n\n* Age ≥18 years\n* Histologically confirmed diagnosis of non-small cell lung cancer (NSCLC)\n* Metastatic disease\n* Prior staging with F-18 FDG PET\u002FCT\n* Ga-68 FAPI PET\u002FCT demonstrating increased tracer uptake in tumor lesions (SUVmax ≥10 in more than 50% of metastatic lesions)\n* Disease progression or resistance after all standard approved therapies as determined by a multidisciplinary tumor board\n* Eastern Cooperative Oncology Group (ECOG) performance status 0-2\n* Adequate organ function:\n* Serum creatinine ≤150 μmol\u002FL\n* Hemoglobin ≥8.0 g\u002FdL\n* White blood cell count ≥2.0 × 10⁹\u002FL\n* Platelet count ≥50 × 10⁹\u002FL\n* Total bilirubin ≤3 × upper limit of normal\n* Serum albumin ≥2.0 g\u002FdL\n* Ability to understand and willingness to sign written informed consent\n\nExclusion Criteria:\n\n* Age \\\u003C18 years\n* Diagnosis of small cell lung cancer\n* History of another active malignancy\n* Pregnancy or breastfeeding\n* Severe uncontrolled medical illness that would interfere with study participation\n* Refusal or inability to provide written informed consent",{"count":188,"type":20},10,[190],"PHASE2","Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide and accounts for approximately 80% of all lung cancer cases. Despite advances in chemotherapy, radiotherapy, and immunotherapy, the prognosis of patients with advanced-stage metastatic NSCLC remains poor, with limited therapeutic options after the development of treatment resistance.\n\nFibroblast Activation Protein (FAP) is highly expressed in cancer-associated fibroblasts in a wide range of solid tumors and represents a promising target for tumor-specific theranostic approaches. Gallium-68-labeled FAPI (Ga-68 FAPI) PET\u002FCT has recently demonstrated high sensitivity in imaging primary lung tumors and metastatic lesions.\n\nThis Phase II study aims to evaluate the safety, feasibility, dosimetry, and therapeutic efficacy of Yttrium-90-labeled FAPI (Y-90 FAPI) radionuclide therapy in patients with chemotherapy-resistant metastatic NSCLC showing significant FAP expression on Ga-68 FAPI PET\u002FCT imaging.",[193,194],"Non-Small Cell Lung Cancer","Metastatic Lung Carcinoma",[196,197,198,199,200,201],"non-small cell lung cancer","Fibroblast Activation Protein","Yttrium-90 FAPI","Targeted Radionuclide Therapy","Phase II Clinical Trial","90Y-FAPI Radioligand Therapy","2026-03-28",{"date":204,"type":39},"2026-03-31",{"date":206,"type":20},"2026-04-10",{"date":208,"type":20},"2027-11-15",{"name":45,"class":46},{"id":211,"slug":212,"hasResults":10,"nctId":213,"briefTitle":214,"officialTitle":215,"acronym":4,"eligibilityCriteria":216,"healthyVolunteers":15,"sex":84,"minAge":17,"maxAge":217,"enrollmentInfo":218,"targetDuration":4,"studyType":21,"phases":220,"briefSummary":221,"conditions":222,"keywords":225,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":75},"100631148","the-effect-of-the-valsalva-maneuver-in-endometrial-biopsy-a-randomized-controlled-trial-100631148","NCT07496905","The Effect of the Valsalva Maneuver in Endometrial Biopsy: A Randomized Controlled Trial","The Effect of the Valsalva Maneuver on Pain and Procedure Success in Endometrial Biopsy: A Randomized Controlled Trial","Inclusion Criteria:\n\n-Endometrial sampling indication in reproductive age group of patients over 18 years of age, who can communicate in Turkish.\n\nExclusion Criteria:\n\n* Patients under 18 years of age - postmenopausal\n* Pregnancy\n* Patients with known stenotic cervical os\n* Patients with a history of acute cervicitis;\n* Patients with intense anxiety;\n* Need for simultaneous endocervical curettage;\n* Need for general or local anesthesia\n* Having used analgesic medication before the procedure;\n* History of a known malignancy, uterine anomaly, or leiomyoma affecting the cervical canal or uterine cavity, or uterine prolapse;\n* Patients with known chronic plevic pain","55 Years",{"count":219,"type":20},120,[23],"Endometrial sampling with a pipelle is a common procedure used to collect a small sample from the lining of the uterus. During the procedure, the cervix is sometimes held with a surgical instrument called a tenaculum, which may cause pain and anxiety for some women.\n\nThe Valsalva maneuver is a simple technique in which a person takes a deep breath and pushes as if trying to exhale forcefully. This increases pressure inside the abdomen and may help keep the uterus and cervix more stable during the procedure.\n\nThis study aims to compare pipelle sampling performed with the Valsalva maneuver to the standard method using a tenaculum. The study will evaluate whether the Valsalva maneuver can reduce pain and anxiety while maintaining procedure success and improving patient satisfaction.",[223,224],"Pain in Endometrial Biopsy","Abnormal Uterine Bleeding",[226,227,228],"endometrial biopsy","valsalva maneuver","Pain","2026-03-23",{"date":231,"type":39},"2026-03-27",{"date":233,"type":39},"2025-01-01",{"date":235,"type":20},"2026-12-01",{"name":45,"class":46},{"id":238,"slug":239,"hasResults":10,"nctId":240,"briefTitle":241,"officialTitle":242,"acronym":243,"eligibilityCriteria":244,"healthyVolunteers":10,"sex":84,"minAge":245,"maxAge":112,"enrollmentInfo":246,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":248,"conditions":249,"keywords":252,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":261,"completionDateStruct":263,"leadSponsor":265,"locationsCount":75},"100630601","urinary-incontinence-and-pelvic-floor-muscle-activity-in-multiple-sclerosis-100630601","NCT07489794","URINARY INCONTINENCE AND PELVIC FLOOR MUSCLE ACTIVITY IN MULTIPLE SCLEROSIS","FACTORS ASSOCIATED WITH URINARY INCONTINENCE AND EVALUATION OF PELVIC FLOOR MUSCLE ACTIVITY IN PATIENTS WITH MULTIPLE SCLEROSIS: CROSS-SECTIONAL STUDY","MS-UI-PFM","Inclusion Criteria:\n\nDiagnosis of multiple sclerosis (MS) according to the 2017 revised McDonald criteria.\n\nFemale patients aged 30-50 years (age range with higher prevalence of urinary incontinence in MS).\n\nExperiencing urinary incontinence (UI) symptoms according to the International Continence Society (ICS) definition.\n\nEDSS (Expanded Disability Status Scale) score below 6.5.\n\nPatients with no communication difficulties. -\n\nExclusion Criteria:\n\nMS patients who do not provide consent to participate in the study.\n\nMS patients who have had a medication change within the last 6 months.\n\nPregnant MS patients.\n\nHistory of vaginal or cesarean delivery within the last 6 months.\n\nPelvic organ prolapse.\n\nUrinary tract infection\n\n\\-","30 Years",{"count":247,"type":20},47,"This study aims to investigate the relationship between urinary incontinence severity and surface electromyography (EMG) findings in women with multiple sclerosis. It will also examine the association of urinary incontinence with disability, quality of life, physical activity, and fatigue.",[250,251],"Multiple Sclerosis","Urinary Incontinence (UI)",[253,254,255,256,257],"multiple sclerosis","urinary incontinence","Electromyography","Fatigue","Physical Activity","2026-03-18",{"date":260,"type":39},"2026-03-24",{"date":262,"type":39},"2026-03-09",{"date":264,"type":20},"2026-10-30",{"name":45,"class":46},{"id":267,"slug":268,"hasResults":10,"nctId":269,"briefTitle":270,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":272,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":274,"conditions":275,"keywords":279,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":281,"lastUpdatePostDateStruct":282,"startDateStruct":284,"completionDateStruct":286,"leadSponsor":288,"locationsCount":75},"100622950","efficacy-of-transcutaneous-pulsed-radiofrequency-in-postherpetic-neuralgia-100622950","NCT07390279","Efficacy of Transcutaneous Pulsed Radiofrequency in Postherpetic Neuralgia","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Diagnosis of postherpetic neuralgia (PHN)\n* No invasive or noninvasive treatment related to PHN (e.g., capsaicin, lidocaine patches) within the past 3 months\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Patients with a cardiac pacemaker\n* Known allergy to transcutaneous electrode pads\n* Active skin infection at the pad application site\n* Presence of a metallic implant in the treatment area\n* Circulatory disorders or skin lesions at the treatment site\n* Inability to maintain appropriate positioning\n* Inability to communicate effectively\n* Presence of psychosis or progressive neurological deficits\n* Pregnancy",{"count":273,"type":20},35,"Postherpetic neuralgia (PHN) is a chronic pain syndrome that may be resistant to treatment and can lead to physical and social disability as well as psychological disturbances, persisting for years in some patients. Varicella zoster virus remains latent in the sensory neurons of individuals who have previously had chickenpox. Reactivation of the latent virus results in herpes zoster. Herpes zoster typically begins with dermatomal pain, followed within a few days by the development of characteristic dermatomal skin rashes. These cutaneous lesions usually resolve within 2-4 weeks; however, pain may persist even after the rash has healed.\n\nThere is variability in the literature regarding the definition of PHN. The development of PHN is associated with increased central neuronal sensitization, reduced inhibitory neuronal function, inflammation and nerve injury in the peripheral nervous system, and abnormal neural transmission following nerve damage. PHN is the most common complication of herpes zoster and occurs in approximately 9-19% of affected patients. Its incidence increases with age, occurring in about 2% of patients under 50 years of age, approximately 20% of those over 50 years, and nearly 35% of patients over 80 years of age.\n\nVarious treatment options are available for the management of PHN-related pain, including pharmacological and interventional approaches. Systemic agents include tricyclic antidepressants, calcium channel alpha-2-delta ligands, serotonin-norepinephrine reuptake inhibitors, and opioids, while topical treatments include lidocaine and capsaicin. Interventional treatment options for PHN include epidural and intrathecal injections, sympathetic nerve blocks, erector spinae plane block, subcutaneous injections, and spinal cord stimulation.",[276,277,278],"Postherpetic Neuralgia","Chronic Pain","Neuropathy",[280],"postherpetic neuralgia","2026-01-28",{"date":283,"type":39},"2026-02-05",{"date":285,"type":20},"2026-02-01",{"date":287,"type":20},"2026-08-03",{"name":45,"class":46},{"id":290,"slug":291,"hasResults":10,"nctId":292,"briefTitle":293,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":15,"sex":84,"minAge":17,"maxAge":112,"enrollmentInfo":296,"targetDuration":298,"studyType":55,"phases":4,"briefSummary":299,"conditions":300,"keywords":302,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":309,"leadSponsor":311,"locationsCount":4},"100620461","serum-progesterone-and-threatened-abortion-during-lactation-100620461","NCT07357922","Serum Progesterone and Threatened Abortion During Lactation","Association Between Maternal Serum Progesterone Levels and Threatened Abortion in Lactating Pregnant Women","Inclusion Criteria:\n\n* Female participants aged 18 to 50 years.\n* Pregnant women who conceived during the lactation period.\n* Singleton pregnancy.\n* First-trimester pregnancy.\n* Availability of first-trimester serum progesterone measurement obtained as part of routine antenatal care.\n* Ongoing follow-up at the participating hospitals.\n\nExclusion Criteria:\n\n* Age under 18 years or over 50 years.\n* Multiple pregnancies.\n* Known chronic medical diseases.\n* Use of progesterone supplementation before serum progesterone measurement.\n* Missing or incomplete clinical or laboratory data.",{"count":297,"type":20},150,"4 Months","This study aims to evaluate the effect of first-trimester maternal serum progesterone levels on threatened abortion in women who conceive during the lactation period. Serum progesterone concentrations will be measured in lactating pregnant women during the first trimester, and their association with the etiology of threatened abortion will be analyzed.\n\nThreatened abortion is defined as vaginal bleeding occurring in the first trimester of pregnancy and represents a risk for early pregnancy loss. Previous studies have shown that serum progesterone levels may be lower in cases of threatened abortion compared to healthy pregnancies and play an essential role in predicting miscarriage risk. Serum progesterone is therefore considered a useful biomarker for assessing pregnancy viability and prognosis.\n\nDuring lactation, progesterone levels may vary depending on breastfeeding duration and maternal hormonal status, and generally remain low, similar to follicular-phase levels in non-pregnant women. However, normal reference values during lactation are not well established. This study aims to contribute new data to the limited literature on the relationship between lactation, serum progesterone levels, and threatened abortion, and to provide insights that may help improve early pregnancy loss prevention strategies.",[301],"Threatened Abortion",[303,301,304],"Serum Progesterone Levels","Lactation During Pregnancy","2026-01-23",{"date":307,"type":39},"2026-01-26",{"date":148,"type":20},{"date":310,"type":20},"2028-01-01",{"name":45,"class":46},{"id":313,"slug":314,"hasResults":10,"nctId":315,"briefTitle":316,"officialTitle":317,"acronym":4,"eligibilityCriteria":318,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":319,"enrollmentInfo":320,"targetDuration":4,"studyType":21,"phases":322,"briefSummary":323,"conditions":324,"keywords":330,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":339,"completionDateStruct":341,"leadSponsor":343,"locationsCount":4},"100594554","effect-of-laughter-therapy-on-breast-cancer-patients-100594554","NCT07020962","Effect of Laughter Therapy on Breast Cancer Patients","The Effect of Laughter Therapy on Distress, Depression and Psychological Well-being in Breast Cancer Patients Before Surgical Intervention: A Randomised Controlled Trial","Inclusion Criteria:\n\n* Voluntary acceptance to participate in the study,\n* Being diagnosed with breast cancer and being in the patient group in which surgical operation is planned,\n* Not having participated in laughter yoga practice before,\n* Being literate,\n* Not having a psychiatric disease (diagnosis)\n* Not having a communication and understanding disability related to vision, hearing\n* Being in the age group of 18 and over\n\nExclusion Criteria:\n\n* Not wanting to participate in the study,\n* Being in the patient group with a condition recommended not to do laughter yoga (having undergone surgery in the abdominal region in the last three months, uncontrolled hypertension, glaucoma, hernia, epilepsy),\n* Not having participated in any of the laughter yoga sessions,\n* Having physical restriction\u002Frespiratory problems and not being able to perform yoga movements.","100 Years",{"count":321,"type":20},56,[23],"The aim of this study is to examine the effect of laughter therapy applied to breast cancer patients before surgical intervention on distress, depression and psychological well-being of patients.\n\nThis research will be carried out as an experimental research with a randomised control group.\n\nThe population of the study will consist of breast cancer patients diagnosed with breast cancer in a city hospital and scheduled for surgery in the breast-endocrine surgery clinic. The research will be carried out with patients who meet the inclusion criteria and agree to participate in the study. The sample size for the study was calculated using the G\\* Power 3.1.9.7 programme (Faul et al., 2007). In the calculation, since there was no similar study for two-way mixed design analysis of variance, the required sample size was calculated as 48, 24 in each group, based on the medium effect size (effect size f=0.25), 5% margin of error (alpha=0.05), inter-measurement correlation value 0.5 and 80% power (1-β=0.80). Considering the data losses, the number was increased by 20% and a total of 56 patients in the intervention and control groups constituted the sample of the study.\n\nHypothesis(es):\n\nH1: The effect of laughter therapy applied to breast cancer patients on distress over time is different in the experimental and control groups.\n\nH2: The effect of laughter therapy applied to breast cancer patients on depression over time is different in the experimental and control groups.\n\nH3: The effect of laughter therapy applied to breast cancer patients on psychological well-being according to time is different in experimental and control groups.\n\nIn obtaining the research data; Personal Information Form, Distress Thermometer, Psychological well-being scale prepared by the researchers in line with the literature will be used.\n\nThe research data will be collected face-to-face through data collection forms from breast cancer patients diagnosed with breast cancer and scheduled for surgery in the breast-endocrine surgery clinic. Individuals who agree to participate in the study and meet the inclusion criteria will be assigned to the experimental and control groups by providing randomisation. Which caregivers will be in the intervention group and which will be in the control group will be determined according to the randomisation table determined by https:\u002F\u002Fwww.randomizer.org\u002F over the internet. Group 1: Intervention Group, Group 2: Control Group. Data collection tools will be applied to the individuals in the experimental and control groups as a pre-test. Individuals in the experimental group will receive laughter therapy three days a week for 30-45 minutes (6 sessions). Individuals in the control group will receive only standard nursing care. Data collection tools will be applied to the individuals in both groups for post-test, 1 and 3-month follow-up tests immediately after all laughter sessions with the experimental group are completed.",[325,326,327,328,329],"Laughter Therapy","Psychological Well-being","Breast Cancer","Distress","Depression",[331,332,333,334,335],"breast cancer","psychological well-being","depression","distress","laughter therapy","2025-06-12",{"date":338,"type":39},"2025-06-13",{"date":340,"type":20},"2025-06-25",{"date":342,"type":20},"2025-10-30",{"name":45,"class":46},{"id":345,"slug":346,"hasResults":10,"nctId":347,"briefTitle":348,"officialTitle":349,"acronym":4,"eligibilityCriteria":350,"healthyVolunteers":10,"sex":16,"minAge":351,"maxAge":352,"enrollmentInfo":353,"targetDuration":354,"studyType":55,"phases":4,"briefSummary":355,"conditions":356,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":359,"startDateStruct":361,"completionDateStruct":363,"leadSponsor":365,"locationsCount":4},"100593469","comparison-of-analgesic-efficacy-of-fascia-transversalis-plan-block-and-caudal-epidural-block-in-pediatric-patients-undergoing-orchiopexy-100593469","NCT07006844","Comparison of Analgesic Efficacy of Fascia Transversalis Plan Block and Caudal Epidural Block in Pediatric Patients Undergoing Orchiopexy","Comparison of Analgesic Efficacy of Fascia Transversalis Plan Block and Caudal Epidural Block in Pediatric Patients Undergoing Orchiopexy. Our Study, it Was Planned to Compare the Postoperative Analgesic Efficacy of Routinely Applied Fascia Transversalis Plan Block and Caudal Epidural Block for Analgesia After General Anesthesia in Pediatric Patients Undergoing Orchiopexy (Unilateral) According to the Surgery and Suitability of the Patient and the Competence of the Anesthesiologist","Inclusion Criteria:\n\nASA I-II, patients who will undergo unilateral orchiopexy under general anesthesia patients between the ages of 1-7 years, who have no contraindications for block application, and whose participation in the study is accepted by their legal guardian will be included in the study.\n\nExclusion Criteria:\n\nLack of consent by the patient's legal guardian, contraindications for block (bleeding diathesis, regional infection, neuromuscular disease), patients over 7 years of age","1 Year","7 Years",{"count":19,"type":20},"1 Day","Orchiopexy is a surgery with a high frequency in the pediatric population. The use of regional anesthesia techniques has become widespread and its importance has increased in order to provide more effective and prolonged perioperative analgesia, as well as to prevent the side effects of opioids such as respiratory depression and to reduce systemic analgesic consumption. In this study, it was planned to compare the postoperative analgesic efficacy of routinely applied fascia transversalis plan block and caudal epidural block for analgesia after general anesthesia in pediatric patients undergoing orchiopexy (unilateral) according to the surgery and suitability of the patient and the competence of the anesthesiologist.\n\nASA I-II, patients who will undergo unilateral orchiopexy under general anesthesia, patients between the ages of 1-7 years, who have no contraindications for block application, and whose participation in the study is accepted by their legal guardian will be included in the study. After induction of general anesthesia and ensuring airway safety with a laryngeal mask, one of the regional anesthesia methods (fascia transversalis plan block or caudal epidural block) deemed appropriate for the patient is applied by the specialist of the room before the surgical incision. Postoperative analgesic needs of the patients and FLACC score will be evaluated at 30 minutes, 1, 2, 4, 6, 12 and 24 hours postoperatively.",[357],"Orchiopexy","2025-06-04",{"date":360,"type":39},"2025-06-05",{"date":362,"type":20},"2025-06-07",{"date":364,"type":20},"2026-01-07",{"name":45,"class":46},{"id":367,"slug":368,"hasResults":10,"nctId":369,"briefTitle":370,"officialTitle":371,"acronym":4,"eligibilityCriteria":372,"healthyVolunteers":10,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":373,"targetDuration":4,"studyType":55,"phases":4,"briefSummary":375,"conditions":376,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":379,"lastUpdatePostDateStruct":380,"startDateStruct":382,"completionDateStruct":384,"leadSponsor":386,"locationsCount":75},"100547097","the-impact-of-laparotomy-and-analgesia-methods-on-diaphragm-100547097","NCT06403540","The Impact of Laparotomy and Analgesia Methods on Diaphragm","The Impact of Laparotomy and Analgesia Methods on Postoperative Diaphragm Muscle Contraction in Major Abdominal Surgeries.","Inclusion Criteria:\n\n* over 18 years,\n* major abdominal surgery cases\n\nExclusion Criteria:\n\n* body mass index (BMI) \\>35 kg\u002Fm2\n* illiteracy,\n* communication issues,\n* neuromuscular disorders,\n* Advanced chronic respiratory disease,\n* Previous abdominal or thoracic surgery",{"count":374,"type":20},90,"Major abdominal surgeries are traditionally performed via laparotomy. Analgesia is routinely administered during the postoperative period. The goal is to investigate the effects of laparotomy and analgesia methods on diaphragm function.",[377,378],"Colorectal Neoplasms","Gastrectomy","2025-04-29",{"date":381,"type":39},"2025-04-30",{"date":383,"type":39},"2025-01-30",{"date":385,"type":20},"2025-08-01",{"name":45,"class":46},""]