[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Prof. Dr. Matthis Synofzik\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":45},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100452922","rfc1-natural-history-study-100452922",false,"NCT05177809","RFC1 Natural History Study","RFC1-NHS","Inclusion Criteria:\n\n* RFC1: genetic diagnosis of bi-allelic pathogenic repeat expansions in RFC1\n* Unrelated healthy controls: no signs or history of neurological or psychiatric disease AND\n* Written informed consent AND\n* Participants are willing and able to comply with study procedures\n\nExclusion Criteria:\n\n* RFC1: Missing informed consent\n* Controls: evidence of neuropathy, neurodegenerative disease, or movement disorder; inability to give informed consent",true,"ALL","18 Years",{"count":20,"type":21},150,"ESTIMATED","24 Months","OBSERVATIONAL","This international, multi-center, multi-modal and prospective observational study aims to determine the phenotypic spectrum and the natural progression of the RFC1 repeat expansion disease, and to seek and validate digital, imaging, and molecular biomarkers that aid in diagnosis and serve as outcome measures in future clinical trials of this novel, but frequent ataxia with late adult-onset.",[26],"Ataxia",[28,29,30,31],"RFC1","CANVAS","Natural History Study","Biomarker","RECRUITING","2026-03-30",{"date":35,"type":36},"2026-03-31","ACTUAL",{"date":38,"type":36},"2021-12-14",{"date":40,"type":21},"2026-12",{"name":42,"class":43},"Prof. Dr. Matthis Synofzik","OTHER",10,""]