[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Professor Ernest Hung-Yu Ng\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":94},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,48,69],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100517894","microfluidic-chip-vs-density-gradient-centrifugation-on-the-euploidy-rate-of-pre-implantation-genetic-testing-100517894",false,"NCT06023472","Microfluidic Chip vs Density Gradient Centrifugation on the Euploidy Rate of Pre-implantation Genetic Testing","A Randomized Comparison of Microfluidic Chip vs Density Gradient Centrifugation on the Euploidy Rate of Pre-implantation Genetic Testing","Inclusion Criteria:\n\n* Women aged \\\u003C43 years at the time of ovarian stimulation for IVF\n* Women undergoing PGT for monogenic diseases, structural rearrangement of chromosomes or aneuploidy\n* Sperm concentration of the raw semen with at least 0.15 million motile sperm per ml or 100 motile sperm per 50 low power field (200x) of observation\n\nExclusion Criteria:\n\n* Use of frozen semen for insemination\n* Use of donor oocytes and spermatozoa\n* Submucosal fibroid or hydrosalpinx shown on pelvic scanning and not surgically treated;\n* Women who had been recruited into this study before and\n* Women joining other randomized trials","ALL","43 Years",{"count":19,"type":20},318,"ESTIMATED","INTERVENTIONAL",[23],"NA","Infertile women attending for PGT at the Centre of Assisted Reproduction and Embryology, Queen Mary Hospital and Kwong Wah Hospital will be recruited during ovarian stimulation for IVF. Subsequently, they will be randomly assigned on the day of oocyte retrieval by a laboratory staff into one of the following two groups in a 1:1 ratio : (1) the microfluidic chip group and (2) the density gradient centrifugation group for sperm preparation and subsequent use in fertilization. Other IVF procedures will be the same as the standard practice of the Centre. Both women and clinicians will be blinded from the group allocation i.e. a double blind study.",[26,27,28,29],"Infertility","Genetic Disease","Chromosomal Rearrangement","Aneuploidy",[31,32,33,34],"microfluidic chip","density gradient centrifugation","euploidy rate","pre-implantation genetic testing","RECRUITING","2024-12-03",{"date":38,"type":39},"2024-12-06","ACTUAL",{"date":41,"type":39},"2024-11-01",{"date":43,"type":20},"2028-11-30",{"name":45,"class":46},"Professor Ernest Hung-Yu Ng","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":17,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":60,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":64,"startDateStruct":65,"completionDateStruct":66,"leadSponsor":68,"locationsCount":47},"100516499","microfluidic-chip-method-versus-density-gradient-centrifugation-method-in-ivf-100516499","NCT06005311","Microfluidic Chip Method Versus Density-gradient Centrifugation Method in IVF","A Randomized Double-blind Controlled Study of the Cumulative Live Birth Rate of IVF Following Sperm Preparation by Microfluidic Chip Method Versus Density-gradient Centrifugation Method","Inclusion Criteria:\n\n* Infertile women aged \\\u003C43 years at the time of ovarian stimulation for IVF\n\nExclusion Criteria:\n\n* Women undergoing preimplantation genetic testing monogenic diseases, structural rearrangement of chromosomes or aneuploidy;\n* Male factor requiring surgical sperm retrieval such as microscopic epididymal sperm aspiration and testicular sperm extraction;\n* Use of donor oocytes and spermatozoa;\n* Submucosal fibroid or hydrosalpinx shown on pelvic scanning and not surgically treated;\n* Women who had been recruited into this study before and\n* Women joining other randomized trials",{"count":56,"type":20},1136,[23],"Infertile patients attending IVF treatment at the Centre of Assisted Reproduction and Embryology, Queen Mary Hospital and Kwong Wah Hospital will be recruited during ovarian stimulation for IVF. Subsequently, they will be randomly assigned on the day of oocyte retrieval by a laboratory staff into one of the following two groups: (1) the microfluidic chip group and (2) the density gradient group for sperm preparation and subsequent use in fertilization. Other IVF procedures will be the same as our usual practice. Both patients and clinicians were blinded from the group allocation i.e. a double blind study. The primary outcome is the cumulative live birth rate defined as the number of pregnancies leading to live birth within 6 months of randomisation.",[26],[31,61,62,63],"density-gradient centrifugation","in-vitro fertilisation","sperm preparation",{"date":38,"type":39},{"date":41,"type":39},{"date":67,"type":20},"2029-11-30",{"name":45,"class":46},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":4,"maxAge":4,"enrollmentInfo":78,"targetDuration":4,"studyType":21,"phases":80,"briefSummary":81,"conditions":82,"keywords":83,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":47},"100514472","microfluidic-chip-method-versus-density-gradient-centrifugation-method-on-semen-parameters-100514472","NCT05978947","Microfluidic Chip Method Versus Density Gradient Centrifugation Method on Semen Parameters","Effect of Sperm Preparation by a Microfluidic Chip Method Versus a Density Gradient Centrifugation Method on Semen Parameters","Inclusion Criteria:\n\n* Sperm concentration of the raw semen with at least 5 million motile sperm per ml with a total volume of not less than 1.5ml.\n\nExclusion Criteria:\n\n* Sperm concentration of the raw semen of less than 5 million motile sperm per ml\n* Men unable to provide an ejaculated semen sample",true,"MALE",{"count":79,"type":20},80,[23],"Infertility affects many couples, with male infertility being a common cause. In vitro fertilization (IVF) is an effective treatment, but its success rates are not high. Semen quality can affect IVF outcomes, and the current method used to process semen can damage the sperm and DNA. Scientists are now testing a new method called microfluidic chip technology, which reduces DNA damage and increases sperm movement. This study will compare the effectiveness of the chip method and the current method on semen quality in men attending a fertility clinic. The study will randomly assign semen collected to one of the two methods and assess the semen quality using different tests, as well as the difference in using two different microfluidic chip platform . The primary outcome will be DNA fragmentation, and other outcomes include sperm count and motility. Semen samples would be collected from study subjects for analysis and that both the samples and results would not be used in patients' treatment.",[26],[84,85,86],"Semen parameters","Microfluidic chip","Density Gradient Centrifugation",{"date":88,"type":39},"2024-12-05",{"date":90,"type":39},"2023-07-01",{"date":92,"type":20},"2025-03-31",{"name":45,"class":46},""]