[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"ProgenaBiome\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":104},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,68],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100410925","phase-1-familial-fecal-microbiota-transplant-for-the-treatment-of-subjects-with-autism-spectrum-disorders-100410925",false,"NCT04630847","Familial Fecal Microbiota Transplant for the Treatment of Subjects With Autism Spectrum Disorders","An Open-Label Phase I Clinical Trial of Vancomycin Followed by Familial Fecal Microbiota Transplant in Adult Subjects With Autism Spectrum Disorder (ASD)","Inclusion Criteria:\n\n1. Subject at least six years of age.\n2. Subject has confirmed diagnosis of ASD based on the DSM-V.\n3. Subject with ASD whose parents\u002Fcaregiver\u002Fguardian\u002FLAR can complete informed consent process.\n4. A reliable parent or caregiver who can report the side effects and communicate effectively with the research team.\n5. Comorbid gastrointestinal symptoms\n6. Stable medications during the two months prior to enrollment.\n7. Currently receiving interventions in the community or school for ASD.\n8. If female and of childbearing potential, must be willing to utilize at least one highly effective method of birth control for the duration of the study. This includes oral birth control pills, contraceptive implants, and intra-uterine devices. Diaphragms and condoms are not considered highly effective. Subjects not of reproductive potential will be exempt (e.g., post-menopausal, surgically sterilized)\n9. If male, and partner is of childbearing potential, must be willing to utilize at least one highly effective method of birth control for the duration of the study. This includes oral birth control pills, contraceptive implants, and intra-uterine devices Diaphragms and condoms are not considered highly effective. Subjects not of reproductive potential will be exempt (surgically sterilized)\n\nExclusion Criteria:\n\n1. Female subjects who are pregnant, nursing, or intend to become pregnant during the study period.\n2. Subjects whose caregivers are unable\u002Funwilling to cooperate with the protocol requirements.\n3. Subject will be excluded who are suffering with Rett syndrome and Childhood Disintegrative Disorder.\n4. Other serious co-morbid medical disorders affecting brain function and behavior, including uncontrolled seizures.\n5. Subjects unable to refrain from taking non-study antibiotics for the period of the study.\n6. Subjects diagnosed with cancer, except small localized basal cell carcinoma.\n7. Subjects known to abuse alcohol or drugs.\n8. Subjects who have undergone gastric bypass or total colectomy, or who are scheduled for these procedures.\n9. Infection with HIV.\n10. Infection with Hepatitis B or C.\n11. Allergy to benzodiazepine.\n12. Inability to stop loperamide, diphenoxylatye\u002Fatropine, or cholestyramine before the study\n13. Unable to stop opiate treatment unless on a stable dose including PRN dosing, and no dose increase planned for the duration of the study\n14. Known positive stool cultures for enteropathogens including, but not limited to Shigella, Salmonella, and Campylobacter within 30 days before enrollment. (These infection agents should be treated in advance of participation in this FMT study because they affect the good flora).\n15. Known stool studies positive for ova and\u002For parasites in 30 days prior to enrollment. (Same as above).\n16. Planned travel outside United States during study period.\n17. Hypersensitivity to vancomycin\n18. Renal insufficiency\n19. Colitis","ALL","18 Years",{"count":19,"type":20},10,"ESTIMATED","INTERVENTIONAL",[23],"PHASE1","This is an open-label clinical trial to evaluate the benefits of familial fecal microbiota transplant following a 6-week treatment with Vancomycin in adult subjects with ASD for treatment of social deficits and language delays.",[26,27],"Autism","Autism Spectrum Disorder",[29,30,31,32,33],"microbiome","dysbiosis","FMT","fecal transpant","fecal microbiota transplant","NOT_YET_RECRUITING","2025-09-18",{"date":37,"type":38},"2025-09-23","ACTUAL",{"date":40,"type":20},"2025-12",{"date":42,"type":20},"2027-07",{"name":44,"class":45},"ProgenaBiome","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":46},"100565830","phase-1-fecal-microbiotatransplant-for-the-treatment-of-parkinsons-disease-100565830","NCT06647277","Fecal MicrobiotaTransplant for the Treatment of Parkinson's Disease","An Open-Label Phase I Clinical Trial of Vancomycin Followed by Fecal Microbiota Transplant for the Treatment of Parkinson's Disease","Inclusion Criteria:\n\n* Individuals diagnosed with PD\n\nExclusion Criteria:\n\n* Non-PD individuals","85 Years",{"count":19,"type":20},[23],"FMT may significantly improve quality of life and Parkinson Disease (PD) symptom severity measurements. We hypothesize that gut microbial dysbiosis is a major contributing factor in Parkinson's disease.",[59],"Parkinson Disease","2025-06-23",{"date":62,"type":38},"2025-06-26",{"date":64,"type":20},"2026-07",{"date":66,"type":20},"2027-12",{"name":44,"class":45},{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":75,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":78,"phases":4,"briefSummary":79,"conditions":80,"keywords":91,"overallStatus":95,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":46},"100390125","a-study-to-explore-the-role-of-gut-flora-in-covid-19-infection-100390125","NCT04359836","A Study to Explore the Role of Gut Flora in COVID-19 Infection","A Non-Interventional Pilot Study to Explore the Role of Gut Flora in COVID-19 Infection","Inclusion Criteria:\n\n1. Signed informed consent, demonstrating that the patient understands the procedures required for the study and the purpose of the study\n2. Male or female of 18 years of age or older\n3. Diagnosis of COVID-19 infection by RT- PCR within 1 week of Screening\n\nExclusion Criteria:\n\n1. Refusal to sign informed consent form\n2. History of bariatric surgery, total colectomy with ileorectal anastomosis or proctocolectomy.\n3. Postoperative stoma, ostomy, or ileoanal pouch\n4. Treatment with total parenteral nutrition",true,{"count":77,"type":20},250,"OBSERVATIONAL","This study seeks to determine whether the virus which causes COVID-19, SARS-CoV-2, is shed in the stools of patients who are infected.",[81,82,83,84,85,86,87,88,89,90],"Gut Microbiome","Gastrointestinal Microbiome","COVID","COVID-19","Corona Virus Infection","Coronavirus","Coronaviridae Infections","Coronavirus 19","Coronavirus-19","COVID 19",[92,86,93,94,83,84],"Microbiome","Corona Virus","19","RECRUITING","2025-06-02",{"date":98,"type":38},"2025-06-05",{"date":100,"type":38},"2020-04-16",{"date":102,"type":20},"2027-07-31",{"name":44,"class":45},""]