[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Prolaio\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":72},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,51],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":22,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100625305","study-of-the-progression-of-chronic-cardiovascular-conditions-100625305",false,"NCT07420907","Study of the Progression of Chronic Cardiovascular Conditions","A Non-interventional Observational Study of the Sustained Use of Prolaio Digital Health Devices to Monitor the Natural History of Chronic Cardiovascular Conditions in Ambulatory Patients","OCORO","Inclusion Criteria:\n\n* 18 years of age and older\n* Ability to understand study assessments and give informed consent to data collection\n* Ability to comply with the study protocol\n* Ability to understand and respond to instructions in English\n* Has diagnosis of qualifying Cardiovascular Disease(s) (CVD) including but not limited to: HF, AS, HCM, HTN, DCM, etc.\n* Resides in the United States\n\nExclusion Criteria:\n\n* Allergy to adhesive used in biosensor patch\n* Life threatening disease process outside of area under study, such as actively treated cancer or pre\u002Fpost-transplant such as hepatic failure; end-stage renal disease.\n* Severe CVD defined by hospital admission for cardiac diagnosis within 30 days of enrollment or documentation of NYHA functional class IV\n* Self-reported weight of 400 pounds or greater","ALL","18 Years",{"count":20,"type":21},5000,"ESTIMATED","5 Years","OBSERVATIONAL","This study will collect physiologic data in patients with cardiovascular conditions and observe the natural history of those conditions for research purposes.",[26,27,28,29,30,31,32,33,34,35,36,37],"Cardiovascular Disease (CVD)","Heart Failure","Aortic Stenosis","Aortic Stenosis Disease","Hypertension","Hypertension (HTN)","Hypertrophic Cardiomyopathy Patients","Hypertrophic Cardiomyopathy Without Obstruction","Hypertrophic Cardiomyopathy, Obstructive","Dilated Cardiomyopathy (DCM)","Dilated Cardiomyopathy","Dilated Cardiomyopathy, Familial","RECRUITING","2026-02-16",{"date":41,"type":42},"2026-02-19","ACTUAL",{"date":44,"type":42},"2025-10-30",{"date":46,"type":21},"2030-10",{"name":48,"class":49},"Prolaio","INDUSTRY",1,{"id":52,"slug":53,"hasResults":11,"nctId":54,"briefTitle":55,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},"100491392","observational-non-interventional-study-supporting-validation-of-vo2max-estimation-methods-using-results-in-patients-receiving-standard-of-care-cardiopulmonary-exercise-tests-cpet-100491392","NCT05678530","Observational, Non-Interventional Study Supporting Validation of VO2Max Estimation Methods Using Results in Patients Receiving Standard of Care Cardiopulmonary Exercise Tests (CPET)","Inclusion Criteria:\n\n1. Willing and able to comply with protocol procedures and available for the duration of the study.\n2. Willing to sign and date informed consent document for study participation.\n3. Participant is undergoing the Cardiopulmonary Exercise Test (CPET) as Standard of Care\n\nExclusion Criteria:\n\n1. Participant is pregnant, lactating or ≤30 days post-partum.\n2. Participant has limited or no intrinsic sinus node function (i.e. chronic atrial pacing).\n\n   • If participant has an indwelling cardiac device and programming cannot be sufficiently ascertained to assure sinus node competence and lack of atrial pacing, the patient should be excluded.\n3. Barostim (™) or similar noncardiac electrical pulse generating device in situ.\n4. Complex congenital heart disease (even repaired or palliated) with the following exception:\n\n   • Biventricular physiology without severe valvar dysfunction (e.g. free pulmonary insufficiency) at the discretion of the investigator.\n5. Any history of allergy to adhesive\n6. Any cognitive or physical limitations that, in the opinion of the investigator, limits the participant's ability to fully follow study procedures and\u002For reach a respiratory exchange ratio of 1.0.",true,{"count":59,"type":21},1000,"In this study, the hypothesis being explored is that VO2Max and other CPET parameters can be accurately estimated from biosignals (namely, motion from accelerometers and cardiopulmonary variables from EKG) collected during activities of daily living using wearable biosensors worn by study participants. This study will aim to collect development and validation data for a machine learning algorithm and to evaluate the performance of the algorithm. A total of 1000 participants will be enrolled including: (Normal) 100 participants, self-reported healthy male and female participants aged 18 to 80 and (Standard of Care) 900 participants.",[62],"Cardiopulmonary","2025-12-22",{"date":65,"type":42},"2025-12-30",{"date":67,"type":42},"2019-06-06",{"date":69,"type":21},"2027-03-31",{"name":48,"class":49},16,""]