[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Purdue University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":577},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,19,0,[8,48,71,97,134,162,196,229,258,285,316,344,371,393,423,454,491,518,543],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100536881","acute-effects-of-high-intensity-interval-training-with-mindfulness-based-recovery-on-executive-function-in-children-100536881",false,"NCT06270589","Acute Effects of High-intensity Interval Training With Mindfulness-based Recovery on Executive Function in Children","Supporting High-intensity Interval Training With Mindfulness for Enhancing Childhood Executive Function","Inclusion Criteria:\n\n* Age between 10-12 years old\n* Intelligence Quotient ≥ 85\n* Capable of performing exercise based on pre-participation health screening\n* No formal diagnosis of cognitive disorders (e.g., attention deficit hyperactivity disorder) and neurological diseases (e.g., epilepsy)\n\nExclusion Criteria:\n\n* Age outside of the range of 10-12 years old\n* Intelligence Quotient \\\u003C 85\n* No capable of performing exercise based on pre-participation health screening\n* Has formal diagnosis of cognitive disorders (e.g., attention deficit hyperactivity disorder) and neurological diseases (e.g., epilepsy)",true,"ALL","10 Years","12 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this randomized cross-over trial is to learn about the effect of a single bout of 20-min mindfulness-based high-intensity interval training (MF-HIIT), MF-only, and HIIT-only in relative to sitting rest on executive function (EF) in 10-12 years old children. The main question it aims to answer are:\n\nQuestion 1: Whether a single bout of 20-min MF-HIIT has larger beneficial effect on EF performance than that following a 20-min session of MF-only and HIIT-only in relative to the sitting rest\n\nQuestion 2: Whether a single bout of 20-min MF-HIIT has a larger beneficial effect on brain functioning, as measured by the N2 and P3 components of event-related potential (ER) during EF performance than that following a 20-min session of MF-only and HIIT-only in relative to the sitting rest\n\nParticipants will visit the laboratory on 5 separate days (\\> 2-day washout between days) in which they have not previously participated in structured physical activities.\n\nParticipants will complete the testing and\u002For receive treatments below:\n\nDay 1:\n\n* Kaufman Brief Intelligence Test (KBIT) to assess intelligence quotient\n* Treadmill-based exercise test to measure cardiorespiratory fitness (maximum oxygen consumption)\n\nDays 2-5\n\n* Each day, participants will complete each of the four intervention conditions (MF-HIIT, MF-only, HIIT-only, sitting)\n* Participants' heart rate and self-reported affect and rating of physical exertion will be measured\n* Participants will complete a modified flanker task and a task-switching task to assess inhibitory control and cognitive flexibility\n* Participants will wear an EEG cap to measure the N2 and P3 components of the event-related potential during the inhibitory control and cognitive flexibility performance\n\nResearcher will compare the cognitive outcome measures following the MF-HIIT, MF-only, and HIIT-only conditions with the sitting condition to see if MF and HIIT has beneficial effects on children's EF.\n\nFurther, researcher will compare the cognitive outcome measures following the MF-HIIT compared with MF-only and HIIT-only conditions to see if combining MF with HIIT has greater beneficial effects on children's EF than MF and HIIT alone.",[28],"Healthy Volunteers",[30,31,32,33,34],"Interval Exercise","Mindfulness","Executive function","Brain function","Children","RECRUITING","2026-06-24",{"date":38,"type":39},"2026-06-29","ACTUAL",{"date":41,"type":39},"2024-06-15",{"date":43,"type":22},"2027-05-31",{"name":45,"class":46},"Purdue University","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":14,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":16,"sex":17,"minAge":54,"maxAge":19,"enrollmentInfo":55,"targetDuration":4,"studyType":23,"phases":57,"briefSummary":60,"conditions":61,"keywords":62,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":70,"locationsCount":47},"100535985","phase-1-classroom-break-cognition-and-fitness-in-elementary-school-children-100535985","NCT06258941","Classroom Break, Cognition, and Fitness in Elementary School Children","Inclusion Criteria:\n\n* Age between 8-12 years old\n* Intelligence Quotient ≥ 70\n* Capable of performing exercise based on pre-participation health screening\n* No formal diagnosis of neurological diseases (e.g., epilepsy)\n\nExclusion Criteria:\n\n* Age outside of the range of 8-12 years old\n* Intelligence Quotient \\\u003C 70\n* No capable of performing exercise based on pre-participation health screening\n* Has formal diagnosis of neurological diseases (e.g., epilepsy)","8 Years",{"count":56,"type":22},352,[58,59],"PHASE1","PHASE2","The goal of this randomized controlled trial is to learn about the effect of a 12-week school-based intervention combining mindfulness with high-intensity interval training (MF-HIIT), MF-only intervention, and HIIT-only intervention in relative to sedentary activities on executive function (EF) in 8-12 years old children. The main question it aims to answer is whether a 12-week school-based MF-HIIT intervention has larger beneficial effect on EF performance than that following a 12-week school-based MF-only and HIIT-only in relative to the sedentary activities.\n\nMultiple cohorts of participants will be recruited to participate this one-semester study, including the pretest, intervention, and posttest phases.\n\nDuring the pretest phase, participants an their parents will complete the following\n\n1. Kaufman Brief Intelligence Test (KBIT) to assess intelligence quotient\n2. Fitnessgram test to assess aerobic capacity, muscle endurance, flexibility, and body mass index\n3. Child and Adolescent Mindfulness Measure (CAMM) questionnaire to assess dispositional mindfulness\n4. Computerized tasks to assess EF\n5. Parent-reported demographic and health information\n\nFollowing the pretest phase, participants will receive the 12-week classroom-based intervention, with the classroom as the intervention unit.\n\nFollowing the intervention and during the posttest phase, participants will complete the fitness, measures, EF measures, and dispositional mindfulness measure again.\n\nResearcher will compare the EFn outcome measures following the MF-HIIT, MF-only, and HIIT-only interventions with the sedentary activity intervention to see if MF and HIIT has beneficial effects on children's EF.\n\nFurther, researcher will compare the EF measures following the MF-HIIT compared with MF-only and HIIT-only interventions to see if combining MF with HIIT has greater beneficial effects on children's EF than MF and HIIT alone.",[28],[32,31,63,34,64],"Interval exercise","Fitness",{"date":66,"type":39},"2026-06-25",{"date":68,"type":39},"2025-02-14",{"date":43,"type":22},{"name":45,"class":46},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":23,"phases":82,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":4},"100633529","emergency-department-substance-use-screening-motivational-interviewing-and-active-referral-targeting-substance-use-disorder-and-overdose-prevention-100633529","NCT07527871","Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention","ED-SMART: Emergency Department-Substance Use Screening, Motivational Interviewing and Active Referral Targeting Substance Use Disorder and Overdose Prevention","ED-SMART","Inclusion Criteria:\n\n* Adult at least 18 years of age\n* Capacity and willingness to participate (including reliable phone or internet access for counseling session)\n* Lower or Moderate Risk score on one or more substance use types on National Institute on Drug Abuse (NIDA)-Modified Alcohol, Smoking, and Substance Use Involvement Test (ASSIST). Participants may also endorse alcohol use in conjunction with substance use as indicated by an Alcohol Use Disorder Identification Test-Concise (AUDIT-C) score of Moderate Risk.\n\nExclusion Criteria:\n\n* A priori participant request for participation\n* Previously enrolled in this or other study of substance use disorder prevention\n* Language other than English\n* Expected\u002Factual ED disposition of hospitalization or non-independent status\n* Prisoner at time of enrollment\n* Known to be pregnant at time of enrollment\n* Past substance use disorder or substance use treatment\n* High risk score for one or more substances on the NIDA-Modified ASSIST or problematic alcohol use alone","18 Years",{"count":81,"type":22},650,[25],"The purpose of this research study is to learn if an emergency department screening and telehealth intervention reduces substance use among individuals receiving emergency department treatment at The Ohio State University Wexner Medical Center.",[85],"Substance Use (Drugs, Alcohol)",[87],"substance use","NOT_YET_RECRUITING","2026-05-19",{"date":91,"type":39},"2026-05-22",{"date":93,"type":22},"2026-06-01",{"date":95,"type":22},"2029-09",{"name":45,"class":46},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":17,"minAge":103,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":23,"phases":107,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":133},"100599618","the-food-environment-microbial-cysteine-metabolism-and-cancer-disparities-100599618","NCT07086833","The Food Environment, Microbial Cysteine Metabolism, and Cancer Disparities","Inclusion Criteria:\n\n* Aged 45-75\n* Up to date with CRC screening colonoscopy with a high risk of CRC, defined as a history of 3 or more adenomatous polyps (APs) or an AP \\>1 cm in the past 5 years\n* Identify as Black or Non-Hispanic White\n* If female, no menstrual period for at least six months\n* Willingness to donate oral wash and stool samples\n* Willingness to complete 24-hour dietary recalls\n\nExclusion Criteria:\n\n* Antibiotic use within the last 6 months\n* Abnormal gastrointestinal transit\n* A history of organ transplantation\n* Use of illicit drugs, combustible tobacco, or dietary supplements\n* Pre- or probiotics within the last two months\n* A history of cancer treatment within the past 12 months\n* CRC or a genetic predisposition to CRC\n* A baseline body weight \\> 450 lbs\n* Weight gain or loss \\> 4 kg 3 months prior to study\n* Significant food allergies, food preferences or therapeutic or vegetarian diets\n* Menstrual cycle within the last 6 months\n* Antibiotics in the last 2 months\n* Cannot keep a food record for 7 consecutive days during screening after detailed instruction\n* Significant medical conditions\n* History of eating disorders\n* Alcoholism\n* Individuals under the age of 18","45 Years","75 Years",{"count":106,"type":22},40,[25],"The goal of this clinical trial is to learn if changing cysteine levels in the diet can influence how the body processes cysteine in Black and White individuals aged 45-75 with a history of non-cancerous polyps. The main questions it aims to answer are:\n\n* At the beginning of the study, do Black participants have higher levels of cortisol (a stress hormone) and compounds made from cysteine in their blood when compared to White participants?\n* Does eating less cysteine lower the body's natural cysteine activity and lead to less gut bacteria that break down cysteine?\n* Does eating less cysteine lead to less inflammation in the gut and lower levels of markers of inflammation in the blood?\n\nResearch will compare a high cysteine diet and a low cysteine diet, and each participant will eat both diets.\n\nParticipants will be in the study for 11 weeks and 2 days. Over the course of the study, participants will:\n\n* Eat a high cysteine diet for 3 weeks, and a low cysteine diet for 3 weeks\n* Eat a moderate cysteine diet for 1 week before each study diet\n* Complete surveys\n* Provide blood, stool, and saliva samples\n* Maintain food logs",[110],"Colorectal Cancer",[112,113,114,110,115,116,117,118,119,120,121,122,123,124],"Intestinal Neoplasms","Neoplasms","Colonic Diseases","Colorectal Neoplasms","Gut Microbiome","Cysteine Metabolism","Colorectal Adenomas","Intestinal Diseases","Cancer Prevention","Diet modification","Dietary Intervention","Colorectal Cancer Risk","Colorectal Cancer Prevention","2026-05-11",{"date":127,"type":39},"2026-05-14",{"date":129,"type":39},"2025-08-18",{"date":131,"type":22},"2027-12-01",{"name":45,"class":46},2,{"id":135,"slug":136,"hasResults":11,"nctId":137,"briefTitle":138,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":16,"sex":17,"minAge":79,"maxAge":103,"enrollmentInfo":140,"targetDuration":4,"studyType":23,"phases":141,"briefSummary":142,"conditions":143,"keywords":149,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":159,"leadSponsor":161,"locationsCount":47},"100636963","slowly-digestible-carbohydrates-for-glp-1-secretion-100636963","NCT07572513","Slowly Digestible Carbohydrates for GLP-1 Secretion","Inclusion Criteria:\n\n1. Healthy population\n2. BMI between 18.5 and 24.9 kg\u002Fm2\n3. Adults 18 - 45 years old\n4. Men or women\n5. Able to read\u002Fspeak English\n6. Fasting blood glucose levels ≤100 mg\u002FdL\n7. HbA1c ≤ 5.7%\n\nExclusion Criteria:\n\n1. Participants with 18 \\> Years of Age \\> 45 will be excluded.\n2. Subjects with 18.5 kg\u002Fm² \\> BMI \\> 24.9 kg\u002Fm² will be excluded.\n3. Diabetic individuals will be excluded.\n4. Individuals with history of gastrointestinal disease will be excluded from the study.\n5. Pregnant or nursing women will also be excluded.\n6. Individuals taking GLP-1 medications, or on weight-loss diets or restrictive eating patterns.\n7. Individuals suffering from dairy or gluten intolerance or allergies will be excluded.",{"count":5,"type":22},[25],"The goal of this clinical trail is to learn if the hormone, glucagon-like peptide-1 (GLP-1), is stimulated by slowly digestible carbohydrates (SDCs) in healthy adults. In the current study, researchers will observe the amount of SDC that results in clinically meaningful levels of GLP-1, shown by an increase in feelings of fullness and a decrease in hunger, and how long an elevated level of GLP-1 lasts after starch consumption. Researchers aim to address two questions: What amount of SDC maximizes GLP-1-mediated satiety, and does the impact to satiety continue in a second meal? The overall goal is to maximize ileal-digesting SDC's potential use as a food-based agent for weight loss.\n\nResearchers will compare 20, 40, and 60 g of raw corn starch compared to a maltodextrin control on total plasma GLP-1 concentrations, insulin, and blood glucose at baseline and 15, 30, 60, 90, 120, and 180 minutes post-consumption of SDC. Researchers will also measure satiety at baseline, 60, 120, 180 minutes and after a second meal.\n\nThere will be a total of 4 study visits with a least a 7-day break between visits. At each study visit, participants will:\n\n* Consume a randomized test beverage (SDC or maltodextrin)\n* Receive a blood draw at 7 timepoints over 3 hrs\n* Take a satiety questionnaire 5 times over 3 hrs\n* Consume a standardized lunch 3 hrs after the test beverage consumption",[144,145,146,147,148],"Blood Glucose","GLP-1","Satiety","Second Meal Intake","Healthy Participant Study",[145,150,151,152,146,153,154,144],"Slowly-Digestible Starch","Ileal-Digesting Starch","Dietary Starch","Starch","raw corn starch","2026-05-01",{"date":157,"type":39},"2026-05-07",{"date":155,"type":22},{"date":160,"type":22},"2026-11-25",{"name":45,"class":46},{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":16,"sex":17,"minAge":79,"maxAge":169,"enrollmentInfo":170,"targetDuration":4,"studyType":23,"phases":172,"briefSummary":173,"conditions":174,"keywords":179,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":4},"100636573","a1-free-vs-conventional-milk-metabolic-response-study-100636573","NCT07567443","A1-Free vs. Conventional Milk Metabolic Response Study","A Randomized Crossover Study Evaluating Postprandial Glucose and Insulin Responses to A1-Free and Conventional Milk With and Without a Delayed Lactose Challenge in Healthy Adults","Inclusion Criteria:\n\n* Ability\u002Fdesire to provide informed consent\n* Are between 18 and 65 years of age\n* Are generally healthy, with no known metabolic or gastrointestinal conditions that would affect digestion or metabolism\n* Are willing to consume milk-based beverages and lactose-containing drinks as part of the study\n* Are willing to fast overnight (approximately 10-12 hours) prior to study visits and follow study instructions (e.g., diet and activity restrictions)\n* Are willing to attend all study visits and complete all study procedures (blood draws, breath tests, urine samples, questionnaires)\n* Are able to understand and provide written informed consent in English.\n\nExclusion Criteria:\n\n* You have a known allergy to milk or dairy products\n* You are currently pregnant, planning to become pregnant, or breastfeeding\n* You currently smoke or have used tobacco or nicotine-containing products within the past 3 months\n* You have a history of excessive alcohol use within the past 30 days\n* You have been diagnosed with diabetes (Type 1 or Type 2), prediabetes, or other metabolic conditions that affect glucose or insulin responses (such as insulin resistance, metabolic syndrome, or polycystic ovary syndrome \\[PCOS\\])\n* You have a history of gastrointestinal conditions that may affect digestion or absorption (such as inflammatory bowel disease, Crohn's disease, ulcerative colitis, celiac disease, or severe irritable bowel syndrome)\n* You have had gastrointestinal surgery that alters normal digestive function (such as bariatric surgery or gastric bypass)\n* You have other medical conditions that may affect digestion or interfere with study results (such as Past or present: Organ transplant, chronic pancreatitis, pancreatic insufficiency, symptomatic biliary disease, Celiac disease, chronic constipation, diverticulosis, inflammatory bowel disease (IBD), ulcerative colitis (UC), Crohn's disease (CD), small intestine bacterial overgrowth syndrome (SIBO), gastroparesis, gastro-esophageal reflux disease (GERD), Irritable Bowel Syndrome (IBS) or any other medical condition with symptoms that could confound collection of adverse events.)\n* You have used medications or supplements known to affect glucose metabolism, digestion, or gastrointestinal function within the following timeframes prior to enrollment:\n* Within 4 weeks: insulin, metformin, GLP-1 receptor agonists, corticosteroids, digestive enzymes, fiber supplements, and all oral or IV antibiotics\n* Within 2 weeks: bismuth-containing compounds (e.g., Pepto-Bismol) and proton pump inhibitors or acid suppressors (e.g., omeprazole \\[Prilosec\\], lansoprazole \\[Prevacid\\], esomeprazole \\[Nexium\\], pantoprazole \\[Protonix\\], rabeprazole \\[Aciphex\\])\n* Within 1 week: laxatives and stool softeners (e.g., Miralax, Colace, senna, lactulose, Citrucel, Metamucil, Fibercon), probiotics and prebiotics, gastrointestinal motility agents (e.g., Reglan, Linzess, Amitiza), and antidiarrheal medications (e.g., loperamide \\[Imodium\\], Lomotil)\n* You have had a recent infection within the past 30 days\n* You have been diagnosed with Human Immunodeficiency Virus (HIV), hepatitis B, or hepatitis C\n* You are currently undergoing chemotherapy\n* Height: \\_\\_\\_ Weight: \\_\\_\\_ BMI: \\_\\_\\_ Weighing \\\u003C16.5 kg or Body mass index \\> 35 kg\u002Fm2\n* You have participated in another clinical trial or used an investigational product within the past 30 days\n* You have any other condition that, as determined by the study team, would make participation unsafe or interfere with study results","65 Years",{"count":171,"type":22},35,[25],"This study will examine how different types of milk affect blood sugar and insulin responses after eating. Specifically, the study compares milk that contains only A2 beta-casein protein (A1-free milk) to conventional milk, which contains both A1 and A2 proteins.\n\nParticipants will complete four study visits in which they will consume different milk-based beverages. These include lactose-containing milk and lactose-free milk followed by a lactose drink given later. Blood samples will be collected over several hours to measure glucose and insulin responses. Breath tests and questionnaires will also be used to assess digestion and gastrointestinal symptoms.\n\nThe goal of this study is to determine whether milk protein type influences metabolic responses and whether consuming lactose-free milk affects how the body processes lactose when it is consumed later.",[175,176,177,178],"Postprandial Glucose Response","Insulin Response","Lactose Digestion","Postprandial Metabolism",[180,181,182,183,184,185,186,187],"A1 beta-casein","A1-free milk","Postprandial glucose","Insulin response","Postprandial Glycemia","Digestive Kinetics","Lactose digestion","Metabolic response","2026-04-28",{"date":190,"type":39},"2026-05-05",{"date":192,"type":22},"2026-06-15",{"date":194,"type":22},"2027-01-31",{"name":45,"class":46},{"id":197,"slug":198,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":11,"sex":17,"minAge":203,"maxAge":204,"enrollmentInfo":205,"targetDuration":4,"studyType":23,"phases":207,"briefSummary":208,"conditions":209,"keywords":213,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":47},"100565189","phase-2-wearable-biofeedback-for-swallowing-disorders-rehabilitation-in-stroke-and-parkinson-disease-100565189","NCT06638944","Wearable Biofeedback for Swallowing Disorders Rehabilitation in Stroke and Parkinson Disease","Impact of Wearable Biofeedback for the Rehabilitation and Tele-rehabilitation of Neurogenic Dysphagia","Inclusion Criteria:\n\n* 50-90 years old\n* a confirmed (by a neurologist\u002Fphysician) diagnosis of stroke at least 3 months post event, or of PD (Hoehn and Yahr Stages II-IV)\n* score in the normal\u002Fmild range on the Montreal Cognitive Assessment (MoCA), determined during an in-house screening\n* confirmed oropharyngeal dysphagia, as evaluated during the intervention eligibility assessment by a certified and trained Speech Language Pathologist (SLP)\n* accuracy of exercise performance; as evaluated during the intervention eligibility assessment by a certified and trained SLP\n* independent (or with caregiver support) use of i-Phagia system post pre-intervention training session; as evaluated during the intervention eligibility assessment by a certified and trained SLP\n\nExclusion Criteria:\n\n* known allergy to barium or known\u002Fsuspected perforation or obstruction of the gastrointestinal (GI) tract\n* recent history of pneumonia (past 6 months)\n* head and neck surgery, radiation or trauma\n* a score in the moderate-severe range on MoCA (screened during in-house screening)\n* other neurological\u002Fneuromuscular disorders (e.g., multiple sclerosis, brain tumor, myositis, etc)\n* difficulty complying due to neuropsychological dysfunction determined during the in-house screening\n* currently enrolled in swallow or speech therapy\n* facial hair in the submental (under the chin) area and refusing to shave.\n* known allergies relating to the Ten20® Conductive Paste (this is the conductive paste used to help with sensors signal and adherence to the skin) and\u002For any of the sensor materials (gold\u002Facrylic) that come into contact with the skin\n* no oropharyngeal dysphagia; as evaluated during the intervention eligibility assessment by the certified and trained SLP\n* inability to perform the prescribed exercises accurately after a maximum of 12 practice trials; as evaluated during the intervention eligibility VFSS assessment by the certified and trained SLP\n* inability to use the system accurately post training (for i-Phagia groups); as evaluated during the intervention eligibility assessment by the certified and trained SLP\n* inability to safely swallow (without aspiration) at least one consistency; as evaluated during the intervention eligibility assessment by the certified and trained SLP","50 Years","90 Years",{"count":206,"type":22},120,[59],"Dysphagia, or difficulty swallowing, is a common symptom of many neurological diseases but its treatment is not well established or easily accessible.\n\nTo start addressing this gap, the researchers developed and validated a cost-effective wearable surface electromyography (sEMG) biofeedback sensor technology (i-Phagia), optimized to record muscle activity from the head\u002Fneck and provide biofeedback to patients and adherence data to clinicians during swallow therapy. This system has been developed with commercially available and widely used materials and the Purdue University IRB has determined that the device is non-significant risk device.\n\nThe goal of this clinical trial is to learn if this biofeedback (using this new technology\u002Fi-Phagia) when used as an adjunct to a standard swallow therapy protocol works to improve swallowing function in patients post chronic stroke or diagnosed with Parkinson's disease. It will also help the investigators learn whether this therapy protocol is equally effective when provided in-person versus via telehealth. Finally, it will determine which patient factors may influence how well the treatment works.\n\nThe main questions it aims to answer are:\n\n* Does biofeedback (using this new technology\u002Fi-Phagia) when used as an adjunct to a standard swallow therapy protocol works better than a standard of care treatment to improve swallowing function in patients post chronic stroke or diagnosed with Parkinson's disease?\n* Is completing the swallow therapy protocol at home (via telehealth) as effective as completing it in-person (in the clinic)?\n* What factors related to the patients (e.g., age, diagnosis, etc.) may influence how well the treatment works?\n\nParticipants will:\n\n* Complete a 12-week swallow treatment protocol (12 treatment visits) either in-person or at home (via telehealth)\n* Complete 3 in-person evaluations (pre-treatment; post-treatment; and at a 12-week post treatment follow-up time point)\n* Exercise at home several days per week and keep a diary\u002Flog of their home exercise\n\nThe hypothesis is that upon study completion, the efficacy of sEMG biofeedback-facilitated swallow therapy for both in-person and telehealth service delivery in two neurogenic dysphagia populations will have been established, and variables determining response to treatment will begin to be identified.",[210,211,212],"Dysphagia","Stroke","Parkinson Disease",[214,215,216,217,218,219,220],"biofeedback","dysphagia","oropharyngeal dysphagia","Parkinson disease","stroke","telehealth","wearable","2026-01-08",{"date":223,"type":39},"2026-01-12",{"date":225,"type":39},"2025-07-22",{"date":227,"type":22},"2029-04-30",{"name":45,"class":46},{"id":230,"slug":231,"hasResults":11,"nctId":232,"briefTitle":233,"officialTitle":234,"acronym":4,"eligibilityCriteria":235,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":4,"enrollmentInfo":236,"targetDuration":4,"studyType":23,"phases":238,"briefSummary":239,"conditions":240,"keywords":242,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":250,"lastUpdatePostDateStruct":251,"startDateStruct":253,"completionDateStruct":255,"leadSponsor":257,"locationsCount":47},"100615066","evaluating-a-deep-neural-noise-reduction-algorithm-for-hearing-aids-100615066","NCT07287774","Evaluating a Deep Neural Noise-Reduction Algorithm for Hearing Aids","Evaluating a Deep Neural Noise-Reduction Algorithm for Hearing Aids in Varying Signal-to-Noise Conditions","Inclusion Criteria:\n\n* A hearing aid candidate with mild-to-moderate cochlear hearing loss, based on audiometric profile (at least 20 dB of hearing loss at 2000 Hz, with progressively worse hearing levels at higher frequencies).\n\nExclusion Criteria:\n\n* Normal hearing\n* Severe or profound hearing loss\n* Conductive hearing loss\n* Neural hearing loss",{"count":237,"type":22},50,[25],"This study is designed to understand how different hearing-aid noise-reduction technologies affect a listener's ability to hear speech in noisy environments. Participants will listen to speech at several background-noise levels while trying different processing settings. By comparing performance across these conditions, the study aims to identify which types of noise reduction improve speech intelligibility the most. We expect that some noise-reduction strategies will help listeners understand speech better than others, especially in more difficult listening situations.",[241],"Hearing Loss, Cochlear",[243,244,245,246,247,248,249],"hearing aids","noise reduction","speech understanding","listening in noise","speech perception","hearing loss","background noise","2025-12-12",{"date":252,"type":39},"2025-12-17",{"date":254,"type":39},"2025-10-16",{"date":256,"type":22},"2026-04-30",{"name":45,"class":46},{"id":259,"slug":260,"hasResults":11,"nctId":261,"briefTitle":262,"officialTitle":263,"acronym":264,"eligibilityCriteria":265,"healthyVolunteers":16,"sex":17,"minAge":79,"maxAge":103,"enrollmentInfo":266,"targetDuration":4,"studyType":23,"phases":268,"briefSummary":269,"conditions":270,"keywords":272,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":277,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":47},"100556664","impact-of-native-chicory-inulin-on-change-and-persistence-of-gut-microbiota-100556664","NCT06528041","Impact of Native Chicory Inulin on Change and Persistence of Gut Microbiota","Effect of Native Chicory Inulin Supplementation on Rates of Microbial Change Between Individuals","INFLUX","Inclusion Criteria:\n\n* adults aged 18-45\n* BMI \\>18.5 - \\\u003C 30 kg\u002Fm2\n* Regular bowel movements (\\> 4 days per week)\n\nExclusion Criteria:\n\n* Self-reported sensitivity to FODMAPs and following a low FODMAP diet ((FODMAPS stands for fermentable oligosaccharides, disaccharides, monosaccharides and polyols).\n* Self-reported food allergies and sensitivities including gluten, dairy, nuts, soya and lactose etc.\n* Self-reported antibiotic treatment in the past 6 months.\n* Self-reported history of gastrointestinal disease and\u002For heart disease, cardiovascular, liver, and respiratory disorders, cancer and\u002For clinically relevant (pre) diabetes.\n* Self-reported to having undergone major surgery of the gastrointestinal tract, with the exception of cholecystectomy and appendectomy.\n* Self-reported smoking and\u002For self-reported drug or alcohol abuse.\n* Self-reported history of psychiatric and\u002For mood disorders including eating disorders.\n* Self-reported to be following a restrictive diet (i.e. ketogenic, intermittent fasting).\n* Pregnant and lactating women.",{"count":267,"type":22},52,[25],"The main aim of this study is to investigate differences in rate, extent of change and persistence of the gut microbiota in healthy adult volunteers in response to native chicory inulin. Along with investigating the impact of native chicory on bowl habits, mood and appetite. The two main questions this study aims to answer:\n\n* To what extent do differences exist in rate of change over time between individuals in gut microbiota response (Bifidobacterium growth) to native chicory inulin supplementation.\n* To what extent do differences exist between individuals in persistence of the gut microbiota upon stopping supplementation.\n\nThe effects of native chicory inulin on gut microbiota response will be compared to a maltodextrin placebo to sure changes in gut microbiota result directly from chicory inulin supplementation.\n\nParticipants will firstly complete a one-week run-in phase to establish baseline data and will then be allocated to either native chicory inulin or maltodextrin supplementation for 6 weeks. Inulin will be delivered at 12 g\u002Fday split into 2 x 6g portions. Maltodextrin will be calorie matched at 6 g\u002Fday split into 2 x 3g portions. This will then be followed by a 6 week post-supplementation phase. Fecal and blood samples will be collected regularly throughout all phases for analysis of gut microbiota and compounds of interest. Participants will also record any changes in gastrointestinal sensation, bowel habits and mood in a diary. Changes in appetite sensation will also measured.",[271],"Healthy",[273,274,275,276],"Gut microbiota","inulin","prebiotics","Bifidobacterium","2025-12-04",{"date":279,"type":39},"2025-12-11",{"date":281,"type":39},"2024-08-01",{"date":283,"type":22},"2026-07-30",{"name":45,"class":46},{"id":286,"slug":287,"hasResults":11,"nctId":288,"briefTitle":289,"officialTitle":290,"acronym":4,"eligibilityCriteria":291,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":4,"enrollmentInfo":292,"targetDuration":4,"studyType":23,"phases":294,"briefSummary":295,"conditions":296,"keywords":302,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":4},"100608168","can-listening-to-music-improve-attention-and-language-after-post-stroke-aphasia-100608168","NCT07198048","Can Listening to Music Improve Attention and Language After Post-Stroke Aphasia?","Treating Attention and Language in Post-stroke Aphasia Using a Music-based Intervention.","Inclusion Criteria:\n\nAdults at least 18 years of age Individuals who have had a stroke and are at least 6 month post stroke Individuals are able to answer 4 questions to determine ability to consent (What is your name, what is the day\u002Fdate, where are you , and why are we having this conversation).\n\nHave normal or corrected to normal hearing Have normal or corrected to normal vision Have no issues with color blindness Individuals who have at least mild aphasia on the Western Aphasia Battery Revised Speaks American English\n\nExclusion Criteria:\n\nIndividuals who meet the inclusion criteria, but are unwilling to travel to the ABC Lab at Purdue University for in person testing and do not have a laptop or desktop with a web camera that they could participate online with, will be excluded.\n\nIndividuals who have had a dementia diagnosis or attention disorder pre stroke will be excluded.",{"count":293,"type":22},45,[25],"The goal of this clinical trial is to learn if a music-based intervention can acutely improve three types of attention (alerting, orientating, executive control) in people with aphasia following a stroke.\n\nThe main questions it aims to answer are:\n\n1. Is a music based intervention effective at improving attention with someone who has aphasia?\n2. Does music-induced changes in attention improve language abilities and quality of life with someone who has aphasia? Researchers will compare a group that listening to music, to listing to an audiobook group, to a group that serves as a control to see if there are changes in attention over time.\n\nParticipants will:\n\n1. Listen to music or an audiobook for 30 minutes a day for 8 weeks\n2. Complete a daily journal about each day's listening experience\n3. Complete three testing sessions where attention, language, and quality of life are assessed.",[297,211,298,299,300,301],"Aphasia","Stroke and Aphasia","Stroke Hemorrhagic","Stroke Ischemic","Music Intervention",[218,303,304,305,306,307],"aphasia","attention","language","music","music intervention","2025-09-25",{"date":310,"type":39},"2025-09-30",{"date":312,"type":22},"2025-10",{"date":314,"type":22},"2028-07-01",{"name":45,"class":46},{"id":317,"slug":318,"hasResults":11,"nctId":319,"briefTitle":320,"officialTitle":320,"acronym":4,"eligibilityCriteria":321,"healthyVolunteers":16,"sex":17,"minAge":322,"maxAge":323,"enrollmentInfo":324,"targetDuration":4,"studyType":23,"phases":326,"briefSummary":327,"conditions":328,"keywords":332,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":339,"completionDateStruct":341,"leadSponsor":343,"locationsCount":47},"100596663","retrieval-based-word-learning-in-developmental-language-disorder-during-book-reading-ii-100596663","NCT07048392","Retrieval-Based Word Learning in Developmental Language Disorder During Book Reading II","Inclusion Criteria:\n\n* a significant deficit in language ability (language test score below cutoff for best sensitivity\u002Fspecificity) or documented age-appropriate language ability.\n* normal hearing.\n* no evidence of neurological damage or disease.\n* scores on tests of nonverbal intelligence above the intellectual disability range\n* not within Autistic range on Autism screening test\n* native English speaker (can be bilingual)\n\nExclusion Criteria:\n\n* failed hearing screening\n* known neurological damage or disease\n* scores on tests of nonverbal intelligence below the intellectual disability range (standard score less than 75)\n* autism spectrum disorder\n* non-native English speaker","48 Months","71 Months",{"count":325,"type":22},32,[25],"Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that is longstanding and harmful to the children's academic, social, and eventual economic well-being. Word learning is one of the principal weaknesses in these children. This project focuses on the word learning abilities of four- and five-year-old children with DLD. The goal of the project is to build on the investigators' previous work to determine whether, as has been found thus far, special benefits accrue when these children must frequently recall newly introduced words during the course of learning. In this study, the investigators seek to replicate the advantage that repeated retrieval holds over simple exposure to the words appearing in the context of a story book by increasing the degree to which the words are integrated into the story line.",[329,330,331],"Developmental Language Disorder and Language Impairment","Specific Language Impairment","Language Development",[333,334,335],"word learning","word retrieval","preschool-aged children","2025-07-03",{"date":338,"type":39},"2025-07-04",{"date":340,"type":39},"2025-03-01",{"date":342,"type":22},"2026-07-31",{"name":45,"class":46},{"id":345,"slug":346,"hasResults":11,"nctId":347,"briefTitle":348,"officialTitle":349,"acronym":4,"eligibilityCriteria":350,"healthyVolunteers":16,"sex":17,"minAge":79,"maxAge":103,"enrollmentInfo":351,"targetDuration":4,"studyType":23,"phases":353,"briefSummary":354,"conditions":355,"keywords":356,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":364,"lastUpdatePostDateStruct":365,"startDateStruct":367,"completionDateStruct":369,"leadSponsor":370,"locationsCount":47},"100583198","impact-of-soluble-arabinoxylan-and-rice-bran-fiber-on-the-gut-microbiome-in-healthy-adults-100583198","NCT06873204","Impact of Soluble Arabinoxylan and Rice Bran Fiber on the Gut Microbiome in Healthy Adults","RDA Cereal Fiber Clinical","Inclusion Criteria:\n\n* Men or women.\n* Aged between 18-45 years.\n* Body mass index between 18.5 and 25 kg\u002Fm².\n* Able to read\u002Fspeak English.\n\nExclusion Criteria:\n\n* Gastrointestinal disorders (inflammatory bowel disease, irritable bowel syndrome, gluten sensitivity\u002Fintolerance, etc.).\n* Those who took antibiotics 3 months before the study.\n* Individuals taking regular medication or supplements that might affect the gut microbiota.\n* Individuals undertaking weight-loss diets.\n* Unstable body weight (±3 kg in the past 3 months), and individuals below 110 lb.\n* Heavy drinkers (for men, consuming more than 4 drinks on any day or more than 14 drinks per week; for women, consuming more than 3 drinks on any day or more than 7 drinks per week).\n* Smokers (those who have smoked 100 cigarettes in their lifetime and who currently smoke cigarettes, even every day or occasionally).\n* Breastfeeding or pregnant women.",{"count":352,"type":22},25,[25],"The importance of the gut microbiota for general health has been recently elucidated, but little is known about the impact of different types of nutrients on the gut microbiota. The soluble fiber in cereal by-products, arabinoxylan (AX), is known to be beneficial for generally promoting gut health. However, it is unclear whether consuming rice bran (RB), the source of AX, is equally helpful or better than consuming the extracted form of AX. This study aims to reveal the potential benefit of insoluble cereal bran fiber ingredients by comparing the effect of soluble arabinoxylan fiber alone and the mostly insoluble rice bran fiber, containing arabinoxylan, on intestinal health and gut microbiota. A placebo (maltodextrin) will be used as a control, with no significant changes expected in this group for the evaluated outcomes.\n\nParticipants will:\n\n* Consume two different fiber supplements (soluble arabinoxylan or stabilized rice bran) as well as a placebo (maltodextrin) for 3 weeks each, separated by a 2-week washout period.\n* Provide blood and stool samples at six different time points.\n* Complete a food and gastrointestinal symptom diary during the intervention periods.",[271],[273,357,358,359,360,361,362,363],"Dietary fiber","Soluble arabinoxylan","Rice bran fiber","Intestinal health","Butyrate-producing bacteria","Clostridium cluster IVa","Short-Chain Fatty Acids","2025-06-25",{"date":366,"type":39},"2025-06-29",{"date":368,"type":22},"2025-07",{"date":312,"type":22},{"name":45,"class":46},{"id":372,"slug":373,"hasResults":11,"nctId":374,"briefTitle":375,"officialTitle":375,"acronym":4,"eligibilityCriteria":321,"healthyVolunteers":16,"sex":17,"minAge":322,"maxAge":323,"enrollmentInfo":376,"targetDuration":4,"studyType":23,"phases":377,"briefSummary":378,"conditions":379,"keywords":381,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":385,"lastUpdatePostDateStruct":386,"startDateStruct":388,"completionDateStruct":390,"leadSponsor":392,"locationsCount":47},"100592560","retrieval-based-word-learning-in-developmental-language-disorder-adaptive-retrieval-schedule-100592560","NCT06995014","Retrieval-based Word Learning in Developmental Language Disorder: Adaptive Retrieval Schedule",{"count":325,"type":22},[25],"Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that is longstanding and harmful to the children's academic, social, and eventual economic wellbeing. Word learning is one of the principal weaknesses in these children. This project focuses on the word learning abilities of four- and five-year-old children with DLD. The goal of the project is to determine whether special benefits accrue when these children must frequently recall newly introduced words during the course of learning. In the current study, the investigators compare a \"standard\" repeated spaced retrieval schedule, with fixed spacing between hearing a word and attempting to retrieve it, to an \"adaptive\" repeated spaced retrieval schedule in which opportunities to retrieve a given word are tailored to the individual child's current knowledge state. The goal of the study is to determine whether the adaptive schedule can increase children's absolute levels of learning while maintaining the advantages of repeated spaced retrieval.",[380,330,331],"Developmental Language Disorder",[382,383,384],"Word learning","Word retrieval","Preschool-aged children","2025-05-28",{"date":387,"type":39},"2025-06-03",{"date":389,"type":39},"2024-08-15",{"date":391,"type":22},"2025-12-31",{"name":45,"class":46},{"id":394,"slug":395,"hasResults":11,"nctId":396,"briefTitle":397,"officialTitle":398,"acronym":4,"eligibilityCriteria":399,"healthyVolunteers":16,"sex":17,"minAge":400,"maxAge":4,"enrollmentInfo":401,"targetDuration":4,"studyType":23,"phases":403,"briefSummary":404,"conditions":405,"keywords":410,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":415,"lastUpdatePostDateStruct":416,"startDateStruct":418,"completionDateStruct":420,"leadSponsor":422,"locationsCount":47},"100454378","maximizing-nutrition-education-to-meet-dietary-and-food-security-of-children-and-parents-100454378","NCT05196763","Maximizing Nutrition Education to Meet Dietary and Food Security of Children and Parents","Maximizing the Impact of Nutrition Education to Meet the Dietary Quality and Food Security Needs of Children and Parents","Inclusion Criteria:\n\n* households in Indiana\n* households with children\n* English speaking\n* eligible to receive SNAP (≥18 years and household income at or below 130% of the poverty guideline)\n* willing to allow a child 5-18 years to participate\n* willing to participate in the study and wait 1 year to receive SNAP-Ed\n\nExclusion Criteria:\n\n* not have received SNAP-Ed lessons in the past year\n* not pregnant or lactating (due to inherent dietary changes)","5 Years",{"count":402,"type":22},300,[25],"Food insecurity and low diet quality are persistent problems linked with chronic disease and poor health among limited-resource children and adults using Supplemental Nutrition Assistance Program (SNAP). We have shown nutrition education via adult-focused, direct SNAP-Education (SNAP-Ed) improved household food security by 25% but not adult dietary quality among SNAP-eligible households using a randomized, controlled, longitudinal SNAP-Ed intervention in Indiana. Households experiencing food insecurity often reserve food considered \"healthful\" for children, so child dietary quality improvement may precede that observed among adults when household food security improves. This study will determine the effect of adult-focused direct SNAP-Ed on child dietary quality and household food security using a longitudinal randomized, controlled SNAP-Ed intervention. Assessment will include repeated 24-hour dietary recalls to determine usual intake, the U.S. Household Food Security Survey Module, and behavior data from before and after the 10-week \"intervention period,\" and 1 year later, after which the control group will receive the intervention. Low-income participants (n=275) from Indiana will be recruited following SNAP-Ed protocol. Results of the study will inform the creation of supplementary on-demand SNAP-Ed educational material focused on improving healthful dietary intake for children and adults in situations of food insecurity in households with children. Education on modeling healthy attitudes and behaviors, planning and preparing family meals, and dietary shortfalls as informed by the results and previous evidence will be included and evaluated. The study aligns with the goals of USDA to increase food security and this RFP to improve healthful behaviors, food quality and nutrition.",[406,407,408,409],"Nutrition, Healthy","Hunger","Diet, Healthy","Food Habits",[411,412,413,414],"food security","food insecurity","dietary quality","nutrition","2025-05-27",{"date":417,"type":39},"2025-05-31",{"date":419,"type":39},"2022-11-01",{"date":421,"type":22},"2027-12",{"name":45,"class":46},{"id":424,"slug":425,"hasResults":11,"nctId":426,"briefTitle":427,"officialTitle":428,"acronym":4,"eligibilityCriteria":429,"healthyVolunteers":11,"sex":17,"minAge":79,"maxAge":430,"enrollmentInfo":431,"targetDuration":4,"studyType":23,"phases":433,"briefSummary":434,"conditions":435,"keywords":439,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":446,"lastUpdatePostDateStruct":447,"startDateStruct":449,"completionDateStruct":451,"leadSponsor":453,"locationsCount":47},"100502264","addressing-tetrachloroethylene-exposure-in-an-impacted-community-100502264","NCT05819996","Addressing Tetrachloroethylene Exposure in an Impacted Community","Addressing Tetrachloroethylene Exposure in an Impacted Community: Residents' Concerns, Neurotoxic Effects, and Exposure Reduction","Inclusion Criteria:\n\n* Residents of Martinsville, Indiana\n* 18 years or older","99 Years",{"count":432,"type":22},510,[25],"Groundwater in Martinsville, IN, is contaminated by volatile organic compounds (VOCs), tetrachloroethylene (PCE) and trichloroethylene (TCE). Indoor air in some residential and commercial buildings is also contaminated with PCE and TCE. This study is being conducted to better understand the impact of low-level exposures to these compounds on community members' health. Data collected in this study will be used to help the community identify a course of action.",[436,437,438],"Vapors; Inhalation","Cancer","Volatile Organic Compounds",[440,441,442,443,444,445],"Tetrachloroethylene","Trichloroethylene","PCE","TCE","Community environmental contamination","Chlorinated volatile organic compounds","2025-03-15",{"date":448,"type":39},"2025-03-18",{"date":450,"type":39},"2023-02-17",{"date":452,"type":22},"2028-05-31",{"name":45,"class":46},{"id":455,"slug":456,"hasResults":11,"nctId":457,"briefTitle":458,"officialTitle":459,"acronym":460,"eligibilityCriteria":461,"healthyVolunteers":16,"sex":462,"minAge":79,"maxAge":4,"enrollmentInfo":463,"targetDuration":4,"studyType":23,"phases":465,"briefSummary":466,"conditions":467,"keywords":471,"overallStatus":88,"whyStopped":4,"lastUpdateSubmitDate":484,"lastUpdatePostDateStruct":485,"startDateStruct":487,"completionDateStruct":488,"leadSponsor":490,"locationsCount":47},"100577460","how-does-perimenopausal-menorrhagia-affect-womens-quality-of-life-and-cognitive-function-100577460","NCT06798584","How Does Perimenopausal Menorrhagia Affect Women's Quality of Life and Cognitive Function?","Rough Journey to Menopause: How Does Perimenopausal Menorrhagia Affect Women's Quality of Life and Cognitive Function?","MENO","Inclusion Criteria:\n\n* Undergoing natural perimenopause\n* English-speaking\n* In general good health as documented by each woman's personal report that the participant is without any past history of a chronic health condition\n\nExclusion Criteria:\n\n* Taking psychoactive drugs\n* A history of hematological disorders","FEMALE",{"count":464,"type":22},240,[25],"The goal of this clinical trial is to investigate how iron status and heavy bleeding during the menopausal transition affect women's cognitive function and quality of life. The main questions it aims to answer are:\n\n* What is the association between iron status, cognitive function, mood, quality of family relationships, and quality of life in perimenopausal women?\n* How does iron repletion, via supplementation, affect cognitive function, mood, quality of family relationships, and quality of life in perimenopausal women?\n\nThe investigators will compare the effect of iron supplements to a placebo (gelatin capsule) to see if iron supplements could improve iron status, cognitive function, mood, quality of family relationships, and quality of life of iron-deficient and\u002For anemic women undergoing the menopausal transition.\n\nEach participant will:\n\n* Make 2 visits (about 2 hours each - baseline and endline) to the Clinical Research Center at Purdue\n* Make a very brief visit at midpoint (about 10 minutes) for a checkup\n* Take a daily study supplement or placebo for 4 months",[468,469,470],"Iron Deficiency Anemia Treatment","Iron Deficiency","Iron Deficiency (Without Anemia)",[472,473,474,469,475,476,477,478,479,480,481,482,483],"Iron","Perimenopause","Iron Deficiency Anemia","Cognitive Function","Quality of Life","Mood","Quality of Family Relationships","Menopause","Perimenopausal Menorrhagia","Abnormal Uterine Bleeding","Menopause Transition","Women's Health","2025-02-12",{"date":486,"type":39},"2025-02-13",{"date":340,"type":22},{"date":489,"type":22},"2025-12",{"name":45,"class":46},{"id":492,"slug":493,"hasResults":11,"nctId":494,"briefTitle":495,"officialTitle":496,"acronym":4,"eligibilityCriteria":497,"healthyVolunteers":16,"sex":17,"minAge":498,"maxAge":499,"enrollmentInfo":500,"targetDuration":4,"studyType":23,"phases":502,"briefSummary":503,"conditions":504,"keywords":505,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":510,"lastUpdatePostDateStruct":511,"startDateStruct":513,"completionDateStruct":515,"leadSponsor":517,"locationsCount":47},"100471179","sentence-production-training-in-aphasia-100471179","NCT05415501","Sentence Production Training in Aphasia","Structural Priming as a Treatment Component in Aphasia","Inclusion Criteria:\n\n* Individuals with post-stroke aphasia\n* At least 6 months post-onset of eft hemisphere stroke\n* Native speaker of English\n* Normal or corrected to normal hearing and vision\n* High-school educated\n* Difficulty communicating in sentences, with some ability to use words independently\n\nExclusion Criteria:\n\n* Severe apraxia of speech\n* Other neurological conditions affecting communication (e.g., dementia)\n* Uncontrolled psychiatric\u002Fpsychological conditions affecting thinking and communication\n* Active alcohol\u002Fsubstance abuse","21 Years","85 Years",{"count":501,"type":22},104,[25],"This project focuses on developing a novel treatment for sentence production and comprehension in aphasia, using implicit priming. First set of experiments will aim examine which learning conditions are most effective in creating maximal training gains. Then, in a later study, the investigators will develop and test the efficacy of a novel treatment study based on findings from the first set of the studies.",[297],[506,507,508,509],"aphasia training","aphasia treatment","sentences","grammar","2024-12-14",{"date":512,"type":39},"2024-12-18",{"date":514,"type":39},"2021-08-01",{"date":516,"type":22},"2026-05-30",{"name":45,"class":46},{"id":519,"slug":520,"hasResults":11,"nctId":521,"briefTitle":522,"officialTitle":523,"acronym":4,"eligibilityCriteria":524,"healthyVolunteers":11,"sex":17,"minAge":525,"maxAge":4,"enrollmentInfo":526,"targetDuration":4,"studyType":23,"phases":528,"briefSummary":529,"conditions":530,"keywords":532,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":535,"lastUpdatePostDateStruct":536,"startDateStruct":538,"completionDateStruct":540,"leadSponsor":542,"locationsCount":47},"100561961","phase-1-heat-therapy-in-type-2-diabetes-100561961","NCT06596967","Heat Therapy in Type 2 Diabetes","Home-based Heat Therapy in Older Adults with Type 2 Diabetes: a Pilot Trial","Inclusion Criteria:\n\n1. age 55 and older\n2. Type 2 Diabetes (documented by chart review, presence of treatment for type 2 Diabetes, fasting plasma glucose equal or greater than 126 mg\u002FdL or A1C equal or greater than 6.5%).\n\nExclusion Criteria:\n\n(1) HbA1c \\<6.5% or \\>9.0%, (2) body mass index \\> 40 kg\u002Fm2, (3) insulin-dependent Type 1 Diabetes Mellitus, (4) incident cardiovascular events in the last year (heart attack, stroke), (5) symptomatic coronary artery disease and\u002For heart failure, (6) uncontrolled hypertension (systolic blood pressure \\>150 mmHg and\u002For diastolic blood pressure \\>110 mmHg), (7) hypotension (resting systolic BP \\< 90 mmHg), (8) use of walking aid other than a cane, (9) active cancer, (10) impaired thermal sensation in the legs, (11) unable to fit into water-circulating garments, (12) orthopedic complications that preclude completion of physical function tests, (13) contraindications or inability to undergo a DXA scan, including implants, devices, or other foreign material, and inability to attain correct position and\u002For remain motionless for the measurement.","55 Years",{"count":527,"type":22},24,[58],"This study aims to test whether home-based heat therapy (HT) can improve the health of older adults with type 2 diabetes (T2D). T2D is common in older adults and can lead to severe issues such as heart disease, disability, and early death. While regular exercise is known to help manage T2D, many people with the condition find it difficult to stay active. This study explores HT as a simple, non-invasive treatment that may offer similar benefits.\n\nParticipants will wear special leg sleeves that deliver heat to their legs for 90 minutes each day at home over 12 weeks. The study\\'s primary goal is to assess whether HT treatment at home is feasible and safe to use. We hypotesize that people with diabetes who receive heat therapy will have better blood sugar control, stronger legs, less body fat, and improved ability to walk, along with lower blood pressure.\n\nIf successful, HT could offer a new option for people with T2D to manage their condition, especially for those who struggle with regular exercise. This research could lead to larger studies and help provide a practical way to improve health and quality of life for older adults with diabetes.",[531],"Type 2 Diabetes",[533,534],"heat therapy","type 2 Diabetes","2024-09-11",{"date":537,"type":39},"2024-09-19",{"date":539,"type":39},"2024-09-03",{"date":541,"type":22},"2025-07-31",{"name":45,"class":46},{"id":544,"slug":545,"hasResults":11,"nctId":546,"briefTitle":547,"officialTitle":547,"acronym":4,"eligibilityCriteria":548,"healthyVolunteers":16,"sex":17,"minAge":498,"maxAge":549,"enrollmentInfo":550,"targetDuration":4,"studyType":23,"phases":551,"briefSummary":552,"conditions":553,"keywords":558,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":569,"lastUpdatePostDateStruct":570,"startDateStruct":572,"completionDateStruct":574,"leadSponsor":576,"locationsCount":47},"100542208","health-effects-of-grain-foods-in-adults-100542208","NCT06339879","Health Effects of Grain Foods in Adults","Inclusion Criteria:\n\n* male and female; 21 to 60 years old; Hemoglobin A1c concentration between 5.7 and 6.4%\n* Prefer no use of medications, but if on medication, must have been on a stable dose for 3 months and plan to remain at the same dose for the duration of the trial.\n* low customary intake of whole grain foods (less than 2 servings per day) and high energy from added sugar (greater than 10% energy).\n\nExclusion Criteria:\n\n* Grain or dairy sensitivities or allergies or celiac disease; sensitivity or allergy to other foods that would result in refusal to eat a class of foods.\n* smoker\n* intended weight loss or gain during the study period; intended change of activity level during the study period\n* use of blood thinners\n* prior gastrointestinal surgery.","60 Years",{"count":206,"type":22},[25],"This study will assess the effects of eating whole grain foods versus refined grain foods with different amounts of added sugar. It is hypothesized that a diet including grain products will have beneficial effects on taste hedonics, appetite, food\u002Fenergy intake, body weight, blood pressure, acute and chronic glycemia and acute and chronic lipemia compared to customary diets controlling for added sugars, saturated fats and sodium.",[554,555,556,557],"High Whole Grain and Low Sugar","Medium Whole Grain and Low Sugar","Low Whole Grain and Low Sugar","Low Whole Grain and High Sugar",[559,560,561,562,563,564,565,566,567,568],"whole grain","refined grain","glycemia","appetite","food intake","microbiome","body weight","blood pressure","lipemia","hedonics","2024-07-11",{"date":571,"type":39},"2024-07-15",{"date":573,"type":39},"2024-01-18",{"date":575,"type":22},"2026-12-31",{"name":45,"class":46},""]