[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"RAND\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":252},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,40,65,90,115,135,164,196,223],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100528091","community-care-intervention-to-decrease-covid-19-vaccination-inequities-100528091",false,"NCT06156254","Community Care Intervention to Decrease COVID-19 Vaccination Inequities","Impact of a Community Care Intervention to Address Inequities in COVID-19 and Influenza Vaccination Among Adults Suffering From Disproportionate Chronic Disease","Inclusion Criteria:18 years or older AND speak English or Spanish AND have no obvious physical or cognitive impairment that would make them unable to complete the assessment (as indicated by confusion or inability to understand the questions).\n\nExclusion Criteria: not willing to consent OR acutely sick OR have high suicide risk\n\nEligibility criteria: Have received a COVID-19 vaccine but not received an updated COVID-19 vaccine at the time of recruitment AND self-report being told by a physician they have one of the following health conditions; high blood pressure\u002Fhypertension OR diabetes OR asthma OR overweight\u002Fobese OR a one of the following mental health condition (probable depression, probable generalized anxiety, or probable PTSD)\n\n\\-","ALL","18 Years",{"count":19,"type":20},800,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this study is to find out if a community health workers (CHW) intervention conducted in Federally Qualified Health Centers (FQHCs) can increase the number of adults with chronic illnesses who are up-to-date with their COVID-19 and influenza vaccines.",[26],"COVID-19 Vaccination","RECRUITING","2026-05-12",{"date":30,"type":31},"2026-05-15","ACTUAL",{"date":33,"type":31},"2023-09-21",{"date":35,"type":20},"2026-06-01",{"name":37,"class":38},"RAND","OTHER",4,{"id":41,"slug":42,"hasResults":11,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":16,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":21,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":57,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":64},"100456118","testing-alert-with-gto-in-middle-schools-100456118","NCT05219422","Testing ALERT With GTO in Middle Schools","Improving the Implementation of Evidence-based Drug Prevention Programs in Schools","GTO-ALERT","Inclusion Criteria:\n\n* Eligibility for student participants: all students in 7th grade, primarily aged 12-14, attending school at one of the enrolled schools in the study.\n* Eligibility for school staff participants: all educators interested in enrolling in the study at each of the enrolled schools.\n\nExclusion Criteria:\n\n* Not meeting eligibility criteria\n\nNote: the age range is from 11 to 70 to account for both the student AND teacher populations.",true,"11 Years","70 Years",{"count":52,"type":20},42,[23],"To test the efficacy of Project ALERT with the support enhancement tool, Getting To Outcomes.",[56],"Substance Abuse",{"date":58,"type":31},"2026-05-13",{"date":60,"type":31},"2022-08-30",{"date":62,"type":20},"2027-03-31",{"name":37,"class":38},1,{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":70,"acronym":4,"eligibilityCriteria":71,"healthyVolunteers":48,"sex":16,"minAge":72,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":21,"phases":75,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":64},"100550250","the-impact-of-pre-emptive-home-delivery-of-ors--zinc-on-treatment-for-child-diarrhea-100550250","NCT06444633","The Impact of Pre-emptive Home Delivery of ORS + Zinc on Treatment for Child Diarrhea","The Impact of Pre-emptive Home Delivery of ORS + Zinc on Treatment for Child Diarrhea: a Cluster Randomized Controlled Trial in Bauchi, Nigeria","Inclusion Criteria:\n\n* At least 15 years old\n* Has at least one child under 5 at baseline\n* Proficiency in English or Hausa\n\nExclusion Criteria:\n\n* Living in a temporary home (nomadic population)\n* Does not speak English or Hausa\n* Unable to give informed consent","15 Years",{"count":74,"type":20},103920,[23],"The aim of this clustered randomized controlled trial is to evaluate whether free and pre-emptive distribution of Oral Rehydration Salts (ORS) and Zinc at home increases the use of ORS to treat diarrhea cases among children under the age of 5 in Bauchi, Nigeria. The primary research questions for the study are:\n\n* RQ1a: Does pre-emptive home delivery with free distribution of ORS and zinc coupled with information about the importance of proper treatment (henceforth referred to as \"the intervention\") result in greater use of ORS to treat child diarrhea (for children under the age of 5) over the 6 months following the deliveries, relative to the status quo (i.e., in the absence of such an intervention)?\n* RQ1b: Does the intervention result in greater use of ORS to treat child diarrhea (for children under the age of 5) over the 12 months following the deliveries, relative to the status quo?\n* RQ1.1: How much does the effect of the intervention on use of ORS to treat child diarrhea (for children under the age of 5) change over time?\n\nAll wards in Bauchi state will be randomly assigned to one of two groups:\n\n* treatment, where all households with at least one child under the age of 5 will receive free pre-emptive ORS and zinc co-packs - with two ORS sachets and 10 zinc tablets per child - coupled with information about the importance of proper treatment\n* delayed-start control, with care as usual during the evaluation period and intervention delivery post evaluation) groups.\n\nA total of 1,732 enumeration areas (EAs) will be sampled across all wards for the study period. Within each EA, 20 eligible households will be randomly sampled for surveys during each wave of data collection: baseline, endline wave 1 (over 1-6 months post intervention), and endline wave 2 (over 7-12 months post intervention). The primary outcomes for the study include the use of ORS to treat child diarrhea over 6 months post-intervention, over 12 months post-intervention, and over each month until 12 months post-intervention.",[78],"Diarrhea Toddler",[80,81,82],"Oral Rehydration Salts","Child Diarrhea","Zinc","2026-05-08",{"date":58,"type":31},{"date":86,"type":31},"2024-09-04",{"date":88,"type":20},"2027-04",{"name":37,"class":38},{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":48,"sex":16,"minAge":97,"maxAge":98,"enrollmentInfo":99,"targetDuration":4,"studyType":21,"phases":101,"briefSummary":102,"conditions":103,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":114},"100569823","effectiveness-of-brief-intervention-in-primary-care-for-diverse-young-people-chat-100569823","NCT06699251","Effectiveness of Brief Intervention in Primary Care for Diverse Young People (Chat)","Effectiveness of Brief Intervention in Primary Care for Diverse Young People","Inclusion Criteria:\n\n* receive health care at one of two participating health systems\n* aged 12-17\n* screen positive for being at risk for alcohol or cannabis use using the CRAFFT\n\nExclusion Criteria:\n\n* if they don't meet the inclusion criteria, they will be excluded","12 Years","19 Years",{"count":100,"type":20},500,[23],"Brief motivational interviewing intervention to address alcohol use among diverse teens 12-17.",[104,105],"Adolescent Drinking","Cannabis Use","2026-03-04",{"date":108,"type":31},"2026-03-06",{"date":110,"type":31},"2025-04-28",{"date":112,"type":20},"2029-02-28",{"name":37,"class":38},2,{"id":116,"slug":117,"hasResults":11,"nctId":118,"briefTitle":119,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":122,"targetDuration":4,"studyType":21,"phases":123,"briefSummary":124,"conditions":125,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":64},"100579668","adaptive-interventions-for-emergency-department-patients-with-opioid-use-disorder-100579668","NCT06827288","Adaptive Interventions for Emergency Department Patients With Opioid Use Disorder","ADAPT-ED","Inclusion Criteria:\n\n* Presented for ED care at ARMC\n* Age 18 or older\n* Probable OUD diagnosis\n* Speak and understand English or Spanish\n* Have capacity to give informed consent\n* Provide a signed and dated informed consent form",{"count":100,"type":20},[23],"The ADAPT-ED study is a two-stage, sequential multiple assignment randomized trial (SMART) to inform the development of an adaptive intervention that is optimally effective in increasing long-term buprenorphine use for adults presenting to the ED with probable opioid use disorder (OUD).",[126],"Opioid Use Disorder","2026-02-17",{"date":129,"type":31},"2026-02-19",{"date":131,"type":31},"2024-10-04",{"date":133,"type":20},"2028-03-31",{"name":37,"class":38},{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":48,"sex":143,"minAge":17,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":21,"phases":147,"briefSummary":150,"conditions":151,"keywords":153,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":4},"100519805","phase-1-game-changers-for-family-planning-peer-advocacy-program-100519805","NCT06048328","Game Changers for Family Planning Peer Advocacy Program","Pilot of a Peer Advocacy Training Intervention to Reduce Unmet Need for Contraception in Uganda","GC-FP","Index participants:\n\nInclusion Criteria:\n\n* MC user for past year\n\nSocial network member participant:\n\nInclusion Criteria:\n\n* Not using MC, but reports trying to prevent pregnancy\n* Know about the MC use of their referring index participant","FEMALE","49 Years",{"count":146,"type":20},192,[148,149],"PHASE1","PHASE2","This study will adapt the Game Changers peer advocacy training model for family planning context and pilot test the feasibility, acceptability and preliminary efficacy of the intervention to empower female contraception users to advocate for contraception use among women in their social networks who have unmet need for contraception.",[152],"Family Planning",[154],"contraception","NOT_YET_RECRUITING","2025-12-23",{"date":158,"type":31},"2025-12-31",{"date":160,"type":20},"2027-11-15",{"date":162,"type":20},"2031-07-01",{"name":37,"class":38},{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":168,"acronym":169,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":143,"minAge":17,"maxAge":171,"enrollmentInfo":172,"targetDuration":4,"studyType":21,"phases":174,"briefSummary":175,"conditions":176,"keywords":181,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":191,"completionDateStruct":193,"leadSponsor":195,"locationsCount":64},"100615525","the-impact-of-virtual-doula-services-on-birth-outcomes-in-rural-communities-100615525","NCT07293741","The Impact of Virtual Doula Services on Birth Outcomes in Rural Communities","RIVER","Inclusion Criteria:\n\n* 18-45 years of age\n* pregnant (second or early third trimester) with their first child\n* reside in a rural zip codes in the U.S.\n\nExclusion Criteria:\n\n* non-singleton pregnancy\n* police custody or incarceration\n* infant to be separated from mother (e.g., placed for adoption, protective custody)\n* working with a doula prior to enrollment.","45 Years",{"count":173,"type":20},614,[23],"This study will assess the impact of virtual doula care on birth and postnatal outcomes among rural mothers. The goal of virtual doula services is to improve access to care in underserved communities and decrease urban-rural differences in key maternal health outcomes including mode of birth (cesarean vs vaginal) and birth satisfaction. By implementing a digital randomized controlled trial, the study team will efficiently recruit a national sample of rural pregnant women to provide evidence of the effectiveness of virtual doula care, the appropriateness of virtual visits for different care and support needs, and the role of virtual care in improving maternal health.",[177,178,179,180],"Birth","Telehealth","Pregnancy","Maternal Health",[182,183,184,185,186,187],"telehealth","virtual","doula","pregnancy","birth","maternal health","2025-12-18",{"date":190,"type":31},"2025-12-22",{"date":192,"type":20},"2026-09",{"date":194,"type":20},"2029-12",{"name":37,"class":38},{"id":197,"slug":198,"hasResults":11,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":202,"eligibilityCriteria":203,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":204,"targetDuration":4,"studyType":21,"phases":206,"briefSummary":207,"conditions":208,"keywords":212,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":64},"100589081","incentives-and-reminders-to-improve-long-term-medication-adherence-inmind-100589081","NCT06949774","INcentives and ReMINDers to Improve Long-term Medication Adherence (INMIND)","INcentives and ReMINDers to Improve Long-term Medication Adherence","INMIND","Inclusion Criteria:\n\n* Male and female clients age 18 and older.\n* Started ART at Mildmay or another clinic within the preceding 2 months\n* Able to speak and understand either English or Luganda.\n* Have their own cell phone or have consistent access to someone else's phone.\n* Willing to receive daily text messages for the 6 months of intervention duration.\n* Willing and able to use the WisePill device distributed for adherence verification for the duration of the study.\n\nExclusion Criteria:\n\n* Not mentally fit to consent.\n* Language other than Luganda or English.\n* Not willing to consistently use the Wisepill device for adherence measurement.",{"count":205,"type":20},550,[23],"Low medication adherence when initiating antiretroviral treatment (ART) is a key barrier to HIV virologic suppression, resulting in avoidable cases of drug resistance, death, and viral transmission. Routinized pill-taking can lead to successful long-term ART adherence, and short-term behavioral economics-based supports are a novel way to overcome the limited success of existing routinization interventions. This study proposes to test this combined approach for promoting long-term ART adherence using a Stage III Sequential, Multiple Assignment, Randomized Trial (SMART) design in one of the largest HIV clinics in Uganda to identify the most cost-effective adaptive intervention that if found effective is generalizable to other settings and other chronic diseases.",[209,210,211],"HIV\u002FAIDS","Medication Adherence","Habits",[213,214],"Behavioral: Daily Text Messages","Behavioral: Incentivization based on","2025-09-04",{"date":217,"type":31},"2025-09-11",{"date":219,"type":31},"2025-04-02",{"date":221,"type":20},"2029-10-31",{"name":37,"class":38},{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":230,"targetDuration":4,"studyType":21,"phases":232,"briefSummary":233,"conditions":234,"keywords":239,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":249,"leadSponsor":251,"locationsCount":39},"100581780","families-left-behind-100581780","NCT06854757","Families Left Behind","Families Left Behind: Addressing Prolonged Grief and Substance Use Disorders Among People Bereaved by Drug Overdose Deaths","Inclusion Criteria:\n\n* people who lost a loved one to an unintentional drug overdose death within the past year\n* age 18 and older\n* fluently understand English or Spanish\n* have the capacity to give consent (e.g., excluding those with severe cognitive impairment, those in active psychosis, and those with developmental disabilities).\n\nExclusion Criteria:\n\n* people who need hospitalization for psychiatric symptoms or substance use disorders. (Note, people who use drugs but who do not require hospitalization will be included.)\n* people have active suicidal ideation\n* people who lost someone to a drug overdose death more than one year ago\n* people who lost someone to a drug overdose death that was suicidal in nature or of undetermined intent",{"count":231,"type":20},340,[23],"The United States is facing unprecedented rates of drug overdose deaths, profoundly impacting millions of families who are left to navigate their grief. Those bereaved by overdose experience a unique form of grief characterized by feelings of guilt, shame, and blame, which can worsen their suffering and deter them from seeking help. Individuals coping with overdose loss often endure more severe health consequences compared to those grieving non-drug related deaths, including prolonged grief disorder, substance use disorders, PTSD, depression, and suicidal thoughts. Moreover, bereaved individuals, particularly those with a history of substance use, may engage in risky behaviors as a means of coping, further exacerbating the risk of overdose and mortality within this vulnerable population. Peer grief support interventions have emerged as a promising approach to assist those experiencing such losses. To combat these outcomes, we are collaborating with Peer Community Support Partners (PSCP) in a novel practice-research partnership to implement the RIVER peer grief support model. Though RIVER has shown success in community settings, it has yet to be rigorously evaluated. In a three-aim approach, this study aims to assess the effectiveness of the RIVER model while also enhancing and engaging grievers with support resources via medical examiner offices (MEOs), which routinely contact families during death investigations. This research represents a pivotal advancement in addressing the needs of the overlooked bereaved community, aligning with the NIH's Helping to End Addiction Long-term (HEAL) initiative to develop effective strategies against the opioid crisis. Together, community engagement and rigorous research efforts aim to enhance support for those affected by the tragedy of drug overdose.",[235,236,237,238],"Grief","Grief Disorder, Prolonged","Overdose Accidental","Substance Use Disorders",[240,241,242,243],"overdose","grief","bereavement","prolonged grief disorder","2025-08-15",{"date":246,"type":31},"2025-08-21",{"date":248,"type":31},"2025-06-13",{"date":250,"type":20},"2030-10",{"name":37,"class":38},""]