[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Rady Pediatric Genomics & Systems Medicine Institute\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":142},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,42,67,91,117],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100566545","immunogenomic-analyses-of-pediatric-catatonia-100566545",false,"NCT06656572","Immunogenomic Analyses of Pediatric Catatonia","Inclusion Criteria:\n\n* Individual in whom one of the following criteria is met:\n\n  1. Child\u002Fadolescent Ages 0-17 (2) with a diagnosis of catatonia.\n\n     OR\n  2. Biological parents of child\u002Fadolescent enrolled in this study for the purposes of reflex testing. Family members are eligible for participation in this study if they are presumed to be genetically related to a patient participant\n\nExclusion Criteria:\n\n* Child\u002Fadolescents patients who do not meet any of the inclusion criteria, or those who:\n\n  1. Already received any prior whole genome sequencing or exome sequencing.\n  2. Unable to approach the family or patient for enrollment.\n  3. Unable to obtain informed consent.\n  4. Family members are ineligible for participation in this study if:\n\n     1. They are known to not be genetically related to the child\u002Fadolescent patient participant","ALL","0 Years","17 Years",{"count":19,"type":20},120,"ESTIMATED","INTERVENTIONAL",[23],"NA","Rady Children's Institute for Genomic Medicine seeks to understand the genomes and immune systems in 40 children and adolescents who are admitted to Rady Children's Hospital San Diego with a catatonia diagnosis. Cutting-edge genome and protein sequencing technology will be used to better understand how immunological and genetic assessments may improve the ability to identify the cause of catatonia and impact care. The investigator also hopes to identify new genetic and\u002For autoimmune causes of catatonia that may inform new treatment for future patients.",[26],"Catatonia",[28,29],"Genomics","Pediatric","NOT_YET_RECRUITING","2024-11-12",{"date":33,"type":34},"2024-11-14","ACTUAL",{"date":36,"type":20},"2024-12-01",{"date":38,"type":20},"2030-09-01",{"name":40,"class":41},"Rady Pediatric Genomics & Systems Medicine Institute","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":15,"minAge":49,"maxAge":17,"enrollmentInfo":50,"targetDuration":4,"studyType":21,"phases":52,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":60,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":66},"100474379","multiomic-diagnostics-in-youth-with-psychosis-100474379","NCT05457140","Multiomic Diagnostics in Youth With Psychosis","Multiomic Diagnostics in Child and Adolescent Psychosis","Inclusion Criteria:\n\nIndividual in whom one of the following criteria is met:\n\n1. Child\u002Fadolescent admitted to the Rady Children's CAPS with symptoms of first break psychosis\n\n   OR\n2. Biological parents of child\u002Fadolescent enrolled in this study for the purposes of reflex testing. Family members are eligible for participation in this study if they are presumed genetically related to a patient participant.\n\nExclusion Criteria:\n\nChild\u002FAdolescent patients who do not meet any of the inclusion criteria, or those who:\n\n1. Already received any prior whole genome sequencing or exome sequencing.\n2. Unable to approach the family or patient for enrollment.\n3. Unable to obtain informed consent.\n4. Family members are ineligible for participation in this study if:\n\n   1. They are known to not be genetically related to the child\u002Fadolescent patient participant\n   2. They are a member of a protected research population","7 Years",{"count":51,"type":20},15,[23],"Rady Children's Institute for Genomic Medicine seeks to understand the genomes and immune systems in 15 children and adolescents who are admitted to Rady Children's Hospital Child and Adolescent Psychiatry Service with psychotic symptoms or schizophrenia. Cutting-edge genome and protein sequencing technology will be used to better understand how immunological and genetic assessments may improve our ability to identify the cause of psychosis and impact care. The investigator also hopes to identify new genetic and\u002For autoimmune causes of psychosis that may inform new treatment for future patients.",[55],"Psychosis",[57,29,58],"Genomic","Rady Children's Hospital","RECRUITING",{"date":33,"type":34},{"date":62,"type":34},"2022-10-10",{"date":64,"type":20},"2026-08",{"name":40,"class":41},1,{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":4,"eligibilityCriteria":73,"healthyVolunteers":11,"sex":15,"minAge":49,"maxAge":17,"enrollmentInfo":74,"targetDuration":4,"studyType":76,"phases":4,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":66},"100475461","mental-health-crises-in-youth-with-idds-100475461","NCT05471232","Mental Health Crises in Youth With IDDs","Understanding Mental Health Crises in Youth With Intellectual and Developmental Disabilities","Inclusion Criteria:\n\nChild\u002Fadolescents admitted to the RCHSD ED with an IDD presenting in a MHC that includes, but is not limited to:\n\n* Aggression towards others\n* Severe agitation\n* Self-injury\n* Elopement\n\nOR\n\nBiological parents of child\u002Fadolescent enrolled in this study for the purposes of reflex testing. (Family members are eligible for participation in this study if they presumed genetically related to a participant).\n\nExclusion Criteria:\n\nChild\u002FAdolescents participants who do not meet any of the inclusion criteria, or those who:\n\n* Already received any prior whole genome sequencing or exome sequencing\n* Unable to approach the family or patient for enrollment\n* Unable to obtain informed consent\n* family members are ineligible for participation in this study if they are known to not be genetically related to the child\u002Fadolescent participant and\u002For if they are a member of a protected research population.",{"count":75,"type":20},150,"OBSERVATIONAL","This study is an unmatched, case-control study of 150 youth (Ages 7-17) with a parent reported Intellectual Developmental Disability (IDD) who present to Rady Children's Hospital Emergency Department with a Mental Health Crisis (MHC). Rady Children's Institute for Genomic Medicine (RCIGM) will collect biological samples (such as blood) of these participants to study their genomes, medical and psychiatric profiles to better understand specific characteristics that may predispose them to MHC's. The 150 youth will be compared to historical, publicly available cohorts of youth with IDD's",[79],"Intellectual Disability",[57,81,82,29,58],"Intellectual and Developmental Disability","Mental Health Crisis","2024-08-06",{"date":85,"type":34},"2024-08-09",{"date":87,"type":34},"2023-03-29",{"date":89,"type":20},"2027-07-01",{"name":40,"class":41},{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":96,"eligibilityCriteria":97,"healthyVolunteers":98,"sex":15,"minAge":99,"maxAge":100,"enrollmentInfo":101,"targetDuration":4,"studyType":21,"phases":103,"briefSummary":104,"conditions":105,"keywords":107,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":66},"100539644","an-adaptive-clinical-trial-of-beginngs-newborn-screening-for-hundreds-of-genetic-diseases-by-genome-sequencing-100539644","NCT06306521","An Adaptive Clinical Trial of BeginNGS Newborn Screening for Hundreds of Genetic Diseases by Genome Sequencing","BeginNGS","Inclusion Criteria:\n\n1. Neonates (\\\u003C28 days old) at enrollment sites.\n2. Parents must have identified a primary care provider (or group).\n\nExclusion Criteria:\n\n1. Neonates whose mother is less than 18 years of age.\n2. Neonates who are wards of the state.\n3. Neonates whose parent\u002Flegal guardian is unable to provide consent.\n4. Parents with a home address outside the US or jurisdiction of the enrollment sites.\n5. Neonates or fetuses who are ill and in whom enrollment or sampling is anticipated to interfere with healthcare provision at delivery. For example, fetuses or neonates who are likely to require transfer to a higher level of care, such as to a Level IV NICU upon delivery.\n6. Neonates who are under consideration for a rapid diagnostic genome sequence or other diagnostic genetic testing.\n7. Neonates who are not expected to survive the neonatal period.",true,"1 Day","28 Days",{"count":102,"type":20},10000,[23],"The goal of this clinical trial is to test a new method for newborn screening using whole genome sequencing, called BeginNGS. Parents will be approached to provide informed consent to enroll their newborns in prenatal, postnatal, and outpatient settings. The main questions this study aims to answer are:\n\nWhat is the utility of BeginNGS as compared to state newborn screening? What is the acceptability and feasibility of BeginNGS as compared to state newborn screening? What is the cost effectiveness of BeginNGS as compared to state newborn screening?\n\nEnrolled newborns will have a blood sample taken and will receive the BeginNGS test. Newborns will have also had the state newborn screening test.",[106],"Genetic Disease",[108],"newborn screening","2024-03-05",{"date":111,"type":34},"2024-03-12",{"date":113,"type":34},"2024-02-29",{"date":115,"type":20},"2029-02",{"name":40,"class":41},{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":122,"acronym":4,"eligibilityCriteria":123,"healthyVolunteers":98,"sex":15,"minAge":4,"maxAge":4,"enrollmentInfo":124,"targetDuration":4,"studyType":21,"phases":126,"briefSummary":127,"conditions":128,"keywords":130,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":66},"100279444","rady-childrens-institute-genomic-biorepository-100279444","NCT02917460","Rady Children's Institute Genomic Biorepository","Genomic Biorepository: Protocol for the Collection, Storage, Analysis, and Distribution of Biological Samples, Genomic and Clinical Data","Inclusion Criteria:\n\n* All ages, races, genders, ethnicities, and health status will be eligible for participation. Enrollment will include that following vulnerable populations: pregnant women, neonates, fetuses, those with cognitive disabilities, pediatric patients, minorities, and employees.\n\nExclusion Criteria:\n\n* None",{"count":125,"type":20},102000,[23],"Rady Children's Institute for Genomic Medicine (RCI) will collect biological samples (such as blood), derived genomic sequences (from DNA and RNA), and clinical features in a Biorepository as a standardized resource for future research studies. The purpose of the Genomic Institute Biorepository is to provide consented samples and data for basic and clinical research related to the genomic cause and treatment of childhood disease, and, in the future, as reference (Quality Control) data to improve the ability to make clinical diagnoses or clinical decisions.\n\nIn addition, the Biorepository will provide a mechanism for making a diagnosis of a genetic disease. That is, once genomic sequences have been derived from biological samples, they will be immediately analyzed. If a genetic disease is identified that appears to explain an affected child's clinical features, then those results will be confirmed by the medically accepted standard, and placed in the electronic health record.",[129],"Genetic Diseases",[131,29,57,132,133],"Rady","Precision medicine","Biorepository","2022-12-08",{"date":136,"type":34},"2022-12-12",{"date":138,"type":34},"2016-07",{"date":140,"type":20},"2050-12",{"name":40,"class":41},""]