[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Raffaele Mazzolari\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":52},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":5},"100636266","exercise-intensity-and-muscle-recovery-in-statin-users-100636266",false,"NCT07563452","Exercise Intensity and Muscle Recovery in Statin Users","Investigating the Role of Mechanical Muscle Loading in the Context of Preventive Exercise for Statin Users - a Pilot Study","STN-EX","Inclusion Criteria:\n\n* Sedentary behavior (defined as \\\u003C 1 hour of planned physical activity per week)\n* Low occupational physical activity\n* Age between 30 and 65 years\n* Non-smoker\n* Medical clearance to partake in physical exercise (as determined during screening visit)\n* For statin users: Current statin medication with stable dosage for at least 8 weeks prior to enrollment\n* For controls: Statin-naïve individuals\n\nExclusion Criteria:\n\n* BMI \\\u003C 20 kg\u002Fm² or \\> 30 kg\u002Fm²\n* Smoking or smoking cessation \\\u003C 1 year ago\n* Medical conditions or musculoskeletal issues that preclude eligibility for full physical effort or interfere with outcome measures\n* Medication (other than statins) that may interfere with physical exercise or outcome measures (assessment on a case-by-case basis during screening visit)\n* Any condition identified during screening (e.g., abnormal ECG, cardiopulmonary exercise test) that, in the opinion of the physician, precludes safe participation",true,"ALL","30 Years","65 Years",{"count":22,"type":23},40,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study aims to investigate how different types and intensities of exercise affect muscle recovery in individuals taking statin medications compared to healthy controls. Statins are essential for cardiovascular prevention but are often associated with muscle-related side effects (SAMS), which can be exacerbated by physical activity.\n\nThe study will compare aerobic cycling (low muscular strain) with resistance training (RT) at increasing intensities (40%, 60%, and 80% of estimated 1-repetition maximum; e1RM). Researchers will measure markers of muscle damage, such as creatine kinase (CK) levels, and subjective recovery needs to determine which exercise modalities and intensities are best tolerated by statin users. The goal is to provide evidence for more individualized and safer exercise recommendations for this population.",[29],"Statin Adverse Reaction",[31,32,33,34,35,36,37,38,39],"Statin","Statin-associated muscle symptoms","SAMS","Resistance training","Endurance training","Muscle loading","Creatine kinase","Recovery need","Exercise intensity","RECRUITING","2026-06-19",{"date":43,"type":44},"2026-06-24","ACTUAL",{"date":46,"type":44},"2026-06-08",{"date":48,"type":23},"2027-06",{"name":50,"class":51},"Raffaele Mazzolari","OTHER",""]