[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Ramos Mejía Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":66},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,44],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":21,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100530865","ventilatory-parameters-in-acute-neurological-injury-100530865",false,"NCT06192342","Ventilatory Parameters in Acute Neurological Injury","Baseline Ventilatory Parameters in Patients With Acute Neurological Injury","Inclusion Criteria:\n\nAcute neurological injury in patients ≥ 16 years of age with requiring mechanical ventilation for neurological causes and without baseline lung injury, defined as: normal chest x-ray and adequate oxygenation; PaO2\u002FFiO2 ≥ 300.Neumovent TS and Neumovent Advance respirators will be used.\n\n\\-\n\nExclusion Criteria:\n\nPneumothorax, or a pleural drainage tube. Hemodynamic instability (mean blood pressure ≤ 65 mmHg) or high doses of inotropes (Norepinephrine \\> 0.5 gammas\u002Fkilo\u002Fminute or equivalent).\n\nPaO2\u002FFiO2 \\\u003C 80 mmHg. Chronic obstructive pulmonary disease (COPD). Pregnant","ALL","16 Years",{"count":19,"type":20},19,"ESTIMATED","2 Years","OBSERVATIONAL","The goal of this observational study is to test the association between baseline ventilatory parameters (in particular mechanical power (MP), mechanical power normalized to predicted body weight (MP\u002FPBW) and driving pressure (DP) with the baseline neurological status (assessed through the Glasgow coma score) in adults patients under mechanical ventilation with acute neurological injury secondary to stroke, brain trauma or subarachnoid hemorrhage.\n\nThe main question\\[s\\]it aims to answer are:\n\n1. In patients with acute neurological injury under mechanical ventilation, is there a correlation between the acute neurological injury, assessed using the Glasgow scale on admission, and baseline ventilatory parameters?\n2. In patients with acute neurological injury under mechanical ventilation, are the baseline ventilatory parameters altered at baseline?",[25,26,27,28],"Neurologic Decompensation, Acute","Traumatic Brain Injury","Stroke","Subarachnoid Hemorrhage",[30],"acute neurological injury, mechanical ventilation","RECRUITING","2026-03-25",{"date":34,"type":35},"2026-03-30","ACTUAL",{"date":37,"type":35},"2024-05-01",{"date":39,"type":20},"2027-05-30",{"name":41,"class":42},"Ramos Mejía Hospital","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":58,"lastUpdatePostDateStruct":59,"startDateStruct":61,"completionDateStruct":63,"leadSponsor":65,"locationsCount":4},"100606137","components-of-mechanical-power-on-the-functional-lung-in-ards-100606137","NCT07171632","Components of Mechanical Power on the Functional Lung in ARDS","Assessment of Mechanical Power Components on the Functional Lung in Patients With Acute Respiratory Distress Syndrome (ARDS)","Inclusion Criteria:\n\n* Patients ≥ 18 years\n* Diagnosis of acute respiratory distress syndrome\n* Receiving invasive mechanical ventilation (volume control mode) for at least 48 consecutive hours.\n\nExclusion Criteria:\n\n* Patients spontaneously breathing\n* Patients under non-invasive support therapies\n* Patients receiving ventilation through a tracheostomy cannula at any time during the first 48 h\n* Patients that receiving pressure-controlled ventilation or any modality other than volume-controlled\n* Patients with missing data for calculating mechanical power (MP).\n* Patients with chronic pulmonary disease\n* Patients with a high risk of death within 3 months for reasons other than ARDS\n* Patients having made the decision to withhold life-sustaining treatment.","18 Years",{"count":53,"type":20},184,"Mechanical power (MP) is a composite variable that integrates static and dynamic respiratory parameters and has been associated with ventilator-induced lung injury (VILI). MP is predominantly delivered to the reduced functional lung size, commonly referred to as the \"baby lung\" (BL). Functional lung size, in turn, is closely related to respiratory system compliance (Crs). Previous studies have demonstrated an association between MP normalized to compliance (MP\u002FCrs) and mortality. Moreover, evidence suggests that VILI associated with MP\u002FCrs results primarily from the combined effect of its components rather than from any single component in isolation.\n\nThe objective of this study is to evaluate both the overall and the relative contribution of each component of mechanical power, normalized to compliance (MP\u002FCrs), to in-hospital mortality in patients with acute respiratory distress syndrome (ARDS).",[56],"Respiratory Distress Syndrome (RDS)","NOT_YET_RECRUITING","2025-11-26",{"date":60,"type":35},"2025-12-04",{"date":62,"type":20},"2025-12-01",{"date":64,"type":20},"2027-03-10",{"name":41,"class":42},""]