[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Ramsay Générale de Santé\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":387},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,15,0,[8,39,64,96,120,142,170,193,216,238,260,293,314,339,362],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":27,"lastUpdatePostDateStruct":28,"startDateStruct":31,"completionDateStruct":33,"leadSponsor":35,"locationsCount":38},"100641700","preoperative-stress-assessment-in-patients-undergoing-surgery-for-rotator-cuff-tendinopathy-100641700",false,"NCT07658326","Preoperative Stress Assessment in Patients Undergoing Surgery for Rotator Cuff Tendinopathy","Tendistress","Inclusion Criteria:\n\n* Patient, male or female, over 18 years of age\n* First-line surgery for rotator cuff tendinopathy (torn and untorn)\n* Subject affiliated with or covered by a social security scheme\n* Collection of the patient's non-opposition to participate in the study\n\nExclusion Criteria:\n\n* Patients with medical history of adhesive capsulitis or complex regional pain syndrome (CRPS)\n* Patients with a history of diabetes or thyroid dysfunction\n* Patients with a history of fibromyalgia\n* Patients with a history of mental illness (PMD, schizophrenia)\n* Patients taking antidepressants or similar medications\n* Patients participating in another clinical trial\n* Protected patients: adults under guardianship, curatorship, or other legal protection, deprived of liberty by judicial or administrative decision;\n* Pregnant, breastfeeding, or parturient women;\n* Patients hospitalized without their consent.","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","OBSERVATIONAL","Orthopedic surgery of the limbs presents a unpredictable postoperative course, which can be more or less lengthy in terms of functional recovery and resumption of personal or professional activities. Not uncommon, convalescence can require many months with dramatic personal and\u002For socio-professional consequences (disability, unemployment, etc.), particularly in the postoperative development of complex regional pain syndrome (CRPS) and\u002For adhesive capsulitis.\n\nAmong the suspected contributing factors, the existence of an unfavorable preoperative psychological context in patients is often mentioned.\n\nThis research is based on the hypothesis that a high level of preoperative stress in patients could contribute to the occurrence of more significant postoperative complications in patients who have undergone shoulder surgery.\n\nThe main objective is to measure the level of preoperative stress in patients undergoing surgery for rotator cuff tendinopathy.",[24,25],"Stress","Tendinopathy Rotator Cuff","RECRUITING","2026-06-16",{"date":29,"type":30},"2026-06-22","ACTUAL",{"date":32,"type":30},"2023-09-28",{"date":34,"type":20},"2026-09",{"name":36,"class":37},"Ramsay Générale de Santé","OTHER",3,{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":43,"acronym":44,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":46,"enrollmentInfo":47,"targetDuration":4,"studyType":49,"phases":50,"briefSummary":52,"conditions":53,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":58,"completionDateStruct":60,"leadSponsor":62,"locationsCount":63},"100641470","evaluation-of-the-impact-of-self-rehabilitation-after-foot-surgery-via-a-connected-application-100641470","NCT07653828","Evaluation of the Impact of Self-rehabilitation After Foot Surgery Via a Connected Application","M-First","Inclusion Criteria:\n\n* Age \\> 18 years and \\\u003C 85 years,\n* Patient, male or female, undergoing surgery for unilateral and isolated Hallux valgus with procedure of the 1st ray,\n* First-line surgery,\n* Persistent mobility of the metatarsophalangeal joint of the hallux,\n* Patient in possession of a smartphone or tablet,\n* Patient affiliated with or beneficiary of a social security scheme,\n* Patient who has signed the free and informed consent.\n\nExclusion Criteria:\n\n* Patient not having a smartphone or tablet,\n* Rheumatoid foot,\n* Hallux rigidus\u002FMTP1 osteoarthritis,\n* Gestures on the lateral rays\n* Surgical or traumatic history influencing MTP1 mobility.\n* Minors\n* Adults under guardianship, curatorship or other legal protection, deprived of liberty by judicial decision or administrative;\n* Pregnant, breastfeeding or parturient woman; - Hospitalized without consent","85 Years",{"count":48,"type":20},188,"INTERVENTIONAL",[51],"NA","Hallux valgus is the most common forefoot deformity and primarily affects women. Surgical treatment involves an osteotomy of the first metatarsal to reduce the M1-M2 angle. Often, an osteotomy of the first phalanx of the big toe is performed in conjunction to reduce the M1-P1 angle.\n\nOnce the deformity has been corrected, the second objective is to restore the foot's function, particularly mobility and plantar flexion strength. To achieve this, rehabilitation is prescribed, but inconsistently due to the lack of clear guidelines and limited patient participation, especially outside of the physiotherapist's scheduled appointments.\n\nContinuous passive range of motion exercises can accelerate the return to standard footwear and normal joint mobility. This study is based on the hypothesis that an application connected with rehabilitation exercises to be done outside of sessions with a physiotherapist reproduces this mechanism of continuous passive mobility. In this context, it is hoped that patients benefiting from self-rehabilitation of the foot via the connected application, in addition to traditional care with a physiotherapist, will achieve better postoperative mobility of the metatarsophalangeal joint of the hallux compared to traditional care with a physiotherapist in patients undergoing hallux valgus surgery, with an isolated procedure on the first ray.\n\nThe main objective is to compare the mobility of the metatarsophalangeal joint of the hallux 6 months after an operation for isolated hallux valgus by osteotomy in patients benefiting from optimized rehabilitation with a physiotherapist using a connected application compared to patients receiving standard care with a physiotherapist.",[54],"Hallux Valgus","2026-06-12",{"date":57,"type":30},"2026-06-17",{"date":59,"type":30},"2021-06-28",{"date":61,"type":20},"2026-12",{"name":36,"class":37},1,{"id":65,"slug":66,"hasResults":11,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":70,"eligibilityCriteria":71,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":49,"phases":74,"briefSummary":75,"conditions":76,"keywords":79,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":63},"100640495","combined-distal-femoral-nerve-block-for-pain-control-after-knee-replacement-100640495","NCT07629388","Combined Distal Femoral Nerve Block for Pain Control After Knee Replacement","Comparative Study Assessing the Efficacy of a Combined Distal Femoral Nerve Block for Postoperative Analgesia Following Total Knee Arthroplasty (TKA)","FEM-COMB","Inclusion Criteria:\n\n* Adult patients aged over 18 years.\n* Scheduled for total knee arthroplasty with multimodal analgesia.\n* Affiliated with or benefiting from a social security system.\n* Able to understand the study information and provide written informed consent.\n\nExclusion Criteria:\n\n* Emergency surgery.\n* Weight under 50 kg.\n* Body mass index over 40 kg\u002Fm².\n* Contraindication to nefopam, non-steroidal anti-inflammatory drugs, local anesthetics, or morphine.\n* Preoperative opioid use.\n* Antidepressant or gabapentinoid treatment.\n* Other planned surgical or medical procedures during the study period.\n* Participation in another clinical trial, or currently in an exclusion period from another trial.\n* Inability to understand study information for linguistic, psychological, cognitive, or literacy reasons.\n* Pregnancy, possible pregnancy without effective contraception, or breastfeeding.\n* Protected adults, including those under guardianship, curatorship, legal protection, detention, or otherwise unable to give informed consent.",{"count":73,"type":20},240,[51],"The goal of this clinical trial is to see whether a combined distal femoral nerve block improves pain relief after total knee replacement in adults having planned surgery. The main questions it aims to answer are:\n\n* Does the combined distal femoral nerve block reduce the amount of opioid needed in the post-anesthesia recovery room?\n* Does it preserve quadriceps muscle strength while improving postoperative pain control?\n\nResearchers will compare the combined distal femoral nerve block to a saphenous nerve block alone to see if the combined block provides better analgesia without reducing leg strength.\n\nParticipants will:\n\n* Receive either the combined distal femoral nerve block or the saphenous nerve block alone before surgery.\n* Also receive standard multimodal pain management, including anesthesia, surgical site infiltration, and postoperative pain medications.\n* Be assessed for pain, opioid use, nausea and vomiting, quadriceps strength, time to first standing, hospital stay length, and patient satisfaction from surgery until discharge.",[77,78],"Pain After Total Knee Arthroplasty","Pain Management",[80,81,82,83,84,85,86],"total knee arthroplasty","distal femoral nerve block","saphenous nerve block","femoral triangle block","postoperative pain","opioid consumption","regional anesthesia","NOT_YET_RECRUITING","2026-06-04",{"date":90,"type":30},"2026-06-05",{"date":92,"type":20},"2026-05-25",{"date":94,"type":20},"2027-05-25",{"name":36,"class":37},{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":104,"minAge":17,"maxAge":105,"enrollmentInfo":106,"targetDuration":4,"studyType":49,"phases":107,"briefSummary":108,"conditions":109,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":63},"100629004","impact-of-surgery-for-deep-posterior-endometriosis-on-ovarian-reserve-endoro-100629004","NCT07469007","Impact of Surgery for Deep Posterior Endometriosis on Ovarian Reserve (ENDORO)","Impact of Surgery for Deep Posterior Endometriosis on Ovarian Reserve","ENDORO","Inclusion Criteria:\n\n* Female, aged 18 to 39 years old;\n* Suspected severe deep posterior pelvic endometriosis on reference pelvic MRI (ovarian kissing, obliteration of the pouch of Douglas) with concordant clinical examination, or confirmed severe deep posterior pelvic endometriosis during exploratory laparoscopy;\n* Patient affiliated with or covered by a social security plan;\n* Patient having been informed and having given her free, informed, and written consent\n\nExclusion Criteria:\n\n* Presence of ovarian involvement defined by the presence of at least one endometrioma \\>5 mm;\n* History of surgery for severe deep endometriosis;\n* Severe preoperative premature ovarian insufficiency (defined by AMH \\\u003C1ng\u002FmL and antral follicle count \\\u003C8);\n* Concurrent use of GnRH agonist therapy at or within the preceding 3 months of enrollment;\n* BMI \\>35 kg\u002Fm²;\n* Menopausal status;\n* Patient participating in another trial with an exclusion period that has not yet expired at the time of screening;\n* Protected patient: adult under guardianship, curatorship, or other legal protection, deprived of liberty by judicial or administrative decision;\n* Pregnant, breastfeeding, or postpartum woman.","FEMALE","39 Years",{"count":19,"type":20},[51],"Endometriosis is a chronic condition typically affecting women of reproductive age and often responsible for chronic pelvic pain and\u002For infertility.\n\nIts prevalence is estimated at 10% of the female population. Deep endometriosis is a specific phenotype of the disease, defined histologically by infiltration of the peritoneum exceeding 5 mm or by fibromuscular plaques infiltrating the muscularis propria of the abdominopelvic organs. It affects approximately 12 to 20% of patients with endometriosis.\n\nSurgery is one of the treatment options. Its aim is anatomical restoration, notably through complete macroscopic resection of the lesions and the release of adhesions, particularly those affecting the adnexa. While the negative impact of cystectomies on ovarian reserve is well known, the impact of surgery for severe deep endometriosis without ovarian involvement has never been studied. Yet, these procedures are regularly performed, and in the vast majority of cases on women of reproductive age. Moreover, the impression gathered in routine practice suggests a decrease in reserve parameters of around 5%. Therefore, understanding the actual impact of the procedure on ovarian reserve would, if it were concrete, allow for expanding the indications for preoperative fertility preservation to this subgroup of patients.\n\nThe main objective is to evaluate the impact of complete macroscopic resection of severe deep posterior pelvic endometriosis on the change in AMH levels at 12 months compared to an unexposed group.",[110,111],"Endometriosis","Ovarian Reserve","2026-03-09",{"date":114,"type":30},"2026-03-13",{"date":116,"type":30},"2025-02-11",{"date":118,"type":20},"2028-02-11",{"name":36,"class":37},{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":49,"phases":130,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":141,"locationsCount":63},"100620087","prognostic-profile-of-dupuytrens-disease-a-cohort-study-product-100620087","NCT07353060","Prognostic Profile of Dupuytren's Disease: a Cohort Study (PRODUCT)","Prognostic Profile of Dupuytren's Disease: a Cohort Study","PRODUCT","Inclusion Criteria:\n\n* Patient, male or female, over 18 years of age\n* Patient with Dupuytren's disease confirmed by clinical examination: nodule or cord arising from the superficial palmar aponeurosis, visible or palpable\n* Aponeurotic cord causing an MCP or PIP joint flexion contracture of at least 20°\n* Indication for percutaneous needle ablation (flexion contracture of at least 20°, functionally impaired according to the patient)\n* Acceptance of percutaneous needle ablation by the patient\n* Patient affiliated with or covered by a social security scheme\n* Patient having been informed and having signed a free and informed written consent\n* Negative urine pregnancy test for women of childbearing age\n\nExclusion Criteria:\n\n* Minor patient,\n* Patient with another condition, infection, or wound of the hand,\n* Patient participating in another clinical trial,\n* Protected patient: adult under guardianship, curatorship, or other legal protection, deprived of liberty by judicial or administrative decision,\n* Person unable to express their consent,\n* Pregnant, breastfeeding, or parturient woman",{"count":129,"type":20},305,[51],"Dupuytren's disease is characterized by retractile fibrosis of the superficial palmar aponeurosis, which can lead to irreversible flexion contractures of the fingers and lasting functional impairment. Widespread throughout the world, it has a particularly high prevalence in northern European countries. This has been estimated at between 3.5% and 11% in England and Denmark. This prevalence is expected to increase over time due to the aging population. Risk factors for the disease include age, male sex, heredity, diabetes, smoking, and alcohol consumption. The resulting disability is not spontaneously reversible. It affects various aspects of daily life, most notably personal care, nutrition, and social interaction.\n\nTreatment for Dupuytren's disease, whether medical or surgical, remains symptomatic to date and does not preclude the possibility of recurrence. In France, it is based on percutaneous needle aponeurotomy and surgical aponeurectomy. Its objectives are to reduce the flexion contracture of the fingers and the functional disability caused by the disease. Enzymatic aponeurosis with collagenase is also possible, but it is less well tolerated than percutaneous needle aponeurotomy. It is more expensive and not covered by health insurance.\n\nThe widespread adoption of a medical-surgical strategy that positions percutaneous needle aponeurotomy as the first-line treatment could improve the acceptability of Dupuytren's disease treatment and significantly reduce its cost to healthcare systems. However, the impact of this strategy depends on the extent to which second-line surgery is required. This use has been little studied. The proportion of patients requiring surgical treatment after percutaneous needle aponeurotomy is estimated to be 10 to 18%. These data are based on small sample sizes observed over varying follow-up periods. They need to be verified in large populations using a prospective study. Moreover, the factors associated with the need for surgery after percutaneous needle ablation for Dupuytren's disease are currently poorly understood. Understanding these factors would be beneficial for optimizing medical and surgical management. It could allow for better tailoring of treatment options to the patient's individual profile.",[133],"Dupuytren's Disease","2026-01-13",{"date":136,"type":30},"2026-01-20",{"date":138,"type":20},"2026-02-04",{"date":140,"type":20},"2031-02-04",{"name":36,"class":37},{"id":143,"slug":144,"hasResults":11,"nctId":145,"briefTitle":146,"officialTitle":146,"acronym":147,"eligibilityCriteria":148,"healthyVolunteers":11,"sex":149,"minAge":17,"maxAge":4,"enrollmentInfo":150,"targetDuration":4,"studyType":49,"phases":152,"briefSummary":153,"conditions":154,"keywords":156,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":169},"100615702","targeted-and-perilesional-or-systematic-biopsy-in-prostate-cancer-100615702","NCT07296042","Targeted And Perilesional Or Systematic Biopsy In Prostate Cancer","TARGET","Inclusion Criteria:\n\n* Adult men (≥ 18 years old)\n* Clinical suspicion of PCa (based on digital rectal examination, family history, PSA and PSA density values) and prescribed prostate biopsy\n* Detection by multi-parametric MRI of the prostate of a PI-RADS 4 or 5 index lesion, or a PI-RADS 3 index lesion with a PSA density ≥ 0.15 ng\u002Fml\u002Fcc\n* Patient eligible for prostate biopsy under local or general anesthesia\n* PSA ≤ 20 ng\u002FmL\n* Patient who agreed to participate in the study and signed the consent form\n\nExclusion Criteria:\n\n* History of prostate cancer\n* History of negative prostate biopsy\n* MRI negative (PI-RADS 1 or 2) or equivocal (PI-RADS 3) with PSA density \\\u003C 0.15 ng\u002Fml\u002Fcc\n* Patient unable to understand the terms of the study or unable to give informed consent (neurological or psychiatric disorders, non-French speaker, etc.)\n* Patient under full or partial legal guardianship.","MALE",{"count":151,"type":20},456,[51],"Magnetic Resonance Imaging (MRI) improves the detection of clinically significant prostate cancer (PCa) by guiding biopsies of MRI-visible lesions (targeted biopsies) in patients suspected with having PCa. This strategy increases the detection of clinically significant PCa, however, while also increasing the detection of insignificant prostate cancer, often synonymous of \"overdiagnosis\".\n\nIt is well known that insignificant PCa has a very low risk of local and distant progression, and active surveillance with a deferred curative treatment protocol based on clear indicators of disease progression is now recommended for all insignificant PCa. However, higher detection of insignificant PCa can lead to patient anxiety about inclusion in an active surveillance protocol, potential further damage from repeated surveillance biopsies and higher healthcare costs.\n\nThus, there is a need for a new biopsy scheme that maintains clinically significant PCa's detection while reducing the diagnosis of insignificant PCa. In recent years, an alternative approach has been to add additional cores close to the target lesion, this is defined as regional biopsies. The hypothesis is that most clinically significant PCa missed in the target are found close to the target. Whereas most cancers found on systematic biopsies outside the MRI target probably correspond to insignificant PCa. This strategy aims to maintain the detection of clinically significant PCa, while reducing the detection of insignificant PCa.\n\nThis proposed multicenter diagnostic study aims to demonstrate the effectiveness of the experimental biopsy scheme (targeted + regional) in detecting clinically significant PCa, compared with a conventional scheme (targeted + systematic). We also aim to compare the detection of insignificant PCa by both schemes.",[155],"Prostate Cancer",[157,158,159,160],"MRI","biopsy","prostate cancer detection","clinically significant prostate cancer","2025-12-16",{"date":163,"type":30},"2025-12-22",{"date":165,"type":20},"2026-03",{"date":167,"type":20},"2028-03",{"name":36,"class":37},5,{"id":171,"slug":172,"hasResults":11,"nctId":173,"briefTitle":174,"officialTitle":175,"acronym":176,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":104,"minAge":17,"maxAge":178,"enrollmentInfo":179,"targetDuration":4,"studyType":49,"phases":180,"briefSummary":181,"conditions":182,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":63},"100611841","randomized-study-evaluating-the-treatment-of-vulvovaginal-gaping-by-plication-of-the-puborectalis-muscles-versus-perineorrhaphy--transverse-myorrhaphy-of-the-puborectalis-muscles-at-12-months-hera-100611841","NCT07245823","Randomized Study Evaluating the Treatment of Vulvovaginal Gaping by Plication of the Puborectalis Muscles Versus Perineorrhaphy ± Transverse Myorrhaphy of the Puborectalis Muscles at 12 Months. (HERA)","Randomized Study Evaluating the Treatment of Vulvovaginal Gaping by Plication of the Puborectalis Muscles Versus Perineorrhaphy ± Transverse Myorrhaphy of the Puborectalis Muscles at 12 Months.","HERA","Inclusion Criteria:\n\n* Female patient between 18 and 80 years-old.\n* Genital hiatus at rest ≥ 4 cm by POP-Q\n* Sexually active woman without pain (never\u002Frarely scored) during penetration and who has stopped sexual activity due to vulvovaginal incompetence without pain (never\u002Frarely scored) during penetration\n* Prolapse\n* Candidate for surgery for anatomical reconstruction of the vulvovaginal incompetence\n* Patient affiliated with a social security scheme or beneficiary of such a scheme, according to Article L.1124-1 of the Public Health Code\n* Free, informed and signed consent\n\nExclusion Criteria:\n\n* Resting GH \\\u003C 4 cm (POP-Q classification)\n* Women not sexually active and not planning to become sexually active\n* Chronic perineal pain syndrome\n* Anal sphincter injury with concomitant indication for sphincterorrhaphy\n* Cognitive or language impairment of the patient unable to complete the study questionnaires\n* Contraindications to surgery or anesthesia\n* Adult under guardianship, curatorship, or other legal protection, deprived of liberty by judicial or administrative decision, hospitalized without consent\n* Pregnant, breastfeeding, or parturient woman\n* Patient planning to become pregnant during the study period\n* Immediate postpartum","80 Years",{"count":19,"type":20},[51],"Vulvovaginal incompetence is generally associated with prolapse and contributes to the pathogenesis of the latter. The perineum and the perineal body (PB) are structures frequently injured throughout life, leading to vesicourethral and rectoanal dysfunction, which are the main focus of study. Other symptoms, such as periorificial dyspareunia and vulvovaginal incompetence, appear to be less verbalized by women. The resulting sexual discomfort is linked, on the one hand, to physical anatomical trauma, with, in some cases, vulvovaginal incompetence contributing to a vaginal sensitivity decreased, and, on the other hand, to psychological trauma with damage to self-image. Vulvoperineoplasty is a surgical repair procedure that aims to optimally reconstruct the introital anatomy by correcting the vulvovaginal incompetence in order to restore normal anatomy, restore self-image, and treat the symptoms of vaginal laxity (feeling of a vagina that is too large and loss of vaginal sensitivity).\n\nConventional surgical techniques for treating vulvar incompetence, such as levator myorrhaphy and perineorrhaphy, are currently being questioned because they cause functional sequelae, particularly regarding to sexual quality of life. The pubo-rectal muscle plication (PPR) technique is based on the anatomical observation of puborectalis muscle lengthening (PMR) observed on MRI scans in patients with vaginal incompetence. This technique could be an interesting alternative in the surgical treatment of vulvovaginal incompetence.\n\nThe main objective of this study is to evaluate the effectiveness of anatomical reconstruction of vulvovaginal incompetence by sagittal plication of the puborectalis muscles vs. by perineorrhaphy ± transverse myorrhaphy of the puborectalis muscles at 12 months.",[183,184],"Prolapse Genital","Vulvovaginal Disease","2025-11-17",{"date":187,"type":30},"2025-11-24",{"date":189,"type":20},"2025-11-20",{"date":191,"type":20},"2029-04-25",{"name":36,"class":37},{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":201,"targetDuration":4,"studyType":49,"phases":203,"briefSummary":204,"conditions":205,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":63},"100608559","evaluation-of-the-impact-of-an-alteration-of-nad-metabolism-on-the-renal-prognosis-of-patients-admitted-to-intensive-care-ni-aki-100608559","NCT07203131","Evaluation of the Impact of an Alteration of NAD+ Metabolism on the Renal Prognosis of Patients Admitted to Intensive Care (NI-AKI)","Evaluation of the Impact of an Alteration of NAD+ Metabolism on the Renal Prognosis of Patients Admitted to Intensive Care","NI-AKI","Inclusion Criteria:\n\n* Patient, male or female aged over 18,\n* Patient admitted to intensive care for a reason with a high risk of ARI: shock, sepsis, cardio-circulatory arrest, post-operative unscheduled surgery, post-operative cardiac surgery,\n* Patient with normal renal function on admission,\n* Patient affiliated to or beneficiary of a social security scheme,\n* Patient having been informed and having given his\u002Fher free, informed and written consent\n\nExclusion Criteria:\n\n* Minor patient,\n* History of chronic kidney disease,\n* History of kidney transplant,\n* Admission for a reason with a low risk of ARI (neuroresuscitation, voluntary drug intoxication with anxiolytics - antidepressants - psychotropic drugs),\n* Acute non-infectious respiratory failure, (scheduled surgery other than cardiac surgery)\n* Patient hospitalized without consent,\n* Patient in a period of exclusion due to another research still in progress at the time of inclusion,\n* Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision,\n* Pregnant, breastfeeding or parturient woman.",{"count":202,"type":20},150,[51],"Among all patients admitted to intensive care, it is estimated that more than half of them are exposed during their stay to acute renal failure (ARF). Impacting the vital prognosis to short term, the occurrence of renal failure is not without consequences in intensive care survivors, presenting an increased risk of death mainly mediated by an excess risk with regard to chronic kidney disease and\u002For certain cardiovascular pathologies.\n\nMalnutrition, particularly vitamin deficiency, has already been reported as a risk factor for AKI. Studies on two models (animal and human) have recently highlighted the importance of NAD+ production failure in the onset of renal failure.\n\nNAD+ synthesis can be done from tryptophan or via a salvage pathway from vitamin PP.\n\nIn a phase 2 study in patients undergoing cardiac surgery, vitamin B3 supplementation was accompanied by a reduction in the occurrence of AKI and a limitation of the duration \u002F intensity of renal dysfunction.\n\nThis innovative research aims to identify an alteration in the metabolic pathway of NAD+ production as a risk factor for AKI in intensive care patients. This would be the first study to address this issue in this specific population.\n\nThe main objective of this research is to describe the association between the urinary Quinolinate\u002FTryptophan ratio on admission and the occurrence of acute renal failure in patients admitted to intensive care unit.",[206,207],"Acute Renal Insufficiency","NAD","2025-09-29",{"date":210,"type":30},"2025-10-02",{"date":212,"type":30},"2025-03-17",{"date":214,"type":20},"2025-12-05",{"name":36,"class":37},{"id":217,"slug":218,"hasResults":11,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":222,"eligibilityCriteria":223,"healthyVolunteers":11,"sex":104,"minAge":17,"maxAge":4,"enrollmentInfo":224,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":226,"conditions":227,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":234,"leadSponsor":236,"locationsCount":237},"100448207","comparison-of-changes-in-the-quality-of-life-of-patients-operated-on-breast-cancer-at-the-drme-ardche-breast-institute-according-to-access-to-supportive-oncological-care-idsein-100448207","NCT05116449","Comparison of Changes in the Quality of Life of Patients Operated on Breast Cancer at the Drôme Ardèche Breast Institute According to Access to Supportive Oncological Care (IDSein)","Comparison of Changes in the Quality of Life of Patients Operated on Breast Cancer at the Drôme Ardèche Breast Institute According to Access to Supportive Oncological Care","IDSein","Inclusion Criteria:\n\n* Woman with histologically confirmed invasive breast cancer for whom surgery is scheduled\n* Age\\> 18 years old\n* Performance status ECOG \\\u003C2\n* Patient speaking and understanding French and able to complete questionnaires\n* Patient affiliated or beneficiary of a social security scheme\n* Patient having read the information note and not objecting to the use of the data collected\n\nExclusion Criteria:\n\n* male\n* Patient with metastatic breast cancer\n* Patient with bilateral breast cancer\n* History of cancer of less than 5 years\n* Active infection or other serious underlying condition that may prevent the patient from receiving treatment\n* History or progressive psychiatric illness\n* Person deprived of liberty or under guardianship\n* Inability to undergo medical monitoring for geographical, social or psychological reasons Indication of emergency amputation\n* Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision\n* Pregnant, breastfeeding or parturient woman\n* Patient hospitalized without consent",{"count":225,"type":20},310,"The aim of this study is to explore the quality of life of cancer patients, in particular women operated on breast cancer, throughout their care journey, taking into account their access to supportive oncological care within and outside the establishment care.",[228],"Breast Cancer Female","2025-09-11",{"date":231,"type":30},"2025-09-17",{"date":233,"type":30},"2021-02-22",{"date":235,"type":20},"2026-01-22",{"name":36,"class":37},2,{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":244,"eligibilityCriteria":245,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":246,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":248,"conditions":249,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":63},"100603885","evaluation-of-atherectomy-in-the-management-of-occlusive-lesions-of-the-common-femoral-arteries-100603885","NCT07142330","Evaluation of Atherectomy in the Management of Occlusive Lesions of the Common Femoral Arteries","Evaluation of Atherectomy in the Management of Occlusive Lesions of the Common Femoral Arteries (RAFAL)","RAFAL","Inclusion Criteria:\n\n* Male or female patient over 18 years of age\n* Non-emergency\n* Claudicating patient with significant de novo calcified stenosis affecting the common femoral artery, technically eligible for revascularization by thromboendarterectomy or rotational atherectomy\n* Surgery planned with either technique\n* Patient's consent to participate in the study must be obtained,\n\nExclusion Criteria:\n\n* Patient contraindicated for either technique (for surgical or anesthesiological reasons)\n* Patient with asymptomatic lesions of the common femoral artery\n* Patient with a history of surgery or angioplasty\u002Fstenting of the femoral stump\n* Patient with occlusion of the ipsilateral common femoral artery or external iliac artery\n* Patient with an indication for additional aortofemoral, iliofemoral, femoral-popliteal, or hamstring bypass\n* Patient with severe trophic disorders for which a major amputation is considered immediately in addition to revascularization\n* Patient objecting to the use of their data",{"count":247,"type":20},120,"Thromboendarterectomy is the standard technique for the treatment of symptomatic occlusive lesions of the common femoral artery. It consists of surgically controlling the artery and interrupting circulation, opening the vessel and removing the atherosclerotic plaque. However, this technique is associated with healing difficulties, postoperative infections, and debilitating incisional pain. The rise of endovascular therapies, particularly at the coronary level, has led to the emergence of new deocclusion techniques, including rotational atherectomy. This technique relies on the use of an intravascular catheter that reams out the atherosclerotic plaque while re-aspirating the resulting debris. A few studies have examined the use of rotational atherectomy for occlusive lesions of the common femoral arteries, but have not evaluated its results compared to the standard treatment. The aim of this multicenter cohort is to describe the efficacy and safety of rotational atherectomy and the standard treatment, thromboendarterectomy, in symptomatic occlusive lesions affecting the common femoral artery.",[250,251],"Femoral Artery Occlusion","Atheromatous Plaques","2025-08-19",{"date":254,"type":30},"2025-08-26",{"date":256,"type":20},"2025-09-01",{"date":258,"type":20},"2026-09-01",{"name":36,"class":37},{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":264,"acronym":265,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":16,"minAge":267,"maxAge":268,"enrollmentInfo":269,"targetDuration":4,"studyType":49,"phases":270,"briefSummary":271,"conditions":272,"keywords":274,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":285,"lastUpdatePostDateStruct":286,"startDateStruct":288,"completionDateStruct":290,"leadSponsor":292,"locationsCount":63},"100603739","diagnostic-interest-of-bone-tomoscintigraphy-in-the-search-for-cervical-pseudarthrosis-100603739","NCT07140432","Diagnostic Interest of Bone Tomoscintigraphy in the Search for Cervical Pseudarthrosis","BOSCAR","Inclusion Criteria:\n\n* Patients over 21 years of age\n* Patients who have undergone cervical arthrodesis and are being treated at Clinique de la Sauvegarde or Clinique Convert\n* Patients with a NDI clinical score at 1 year greater than 5\n* Patient affiliated to\u002F or beneficiary of a Social Security scheme as definied by the law\n\nExclusion Criteria:\n\n* Patients whose clinical condition requires rapid treatment that can't wait for examinations to be carried out\n* Pregnancy and breastfeeding\n* Protected person (curatorship, guardianship, safeguard of justice)\n* History of hypersensitivity to the active substance ( sodium oxidronate) or to any of its constituents","21 Years","99 Years",{"count":19,"type":20},[51],"Cervical pseudarthrosis is a classic complication and a challenge for challenge for spine surgeons. The rate of pseudarthrosis can range from 3 to 15%, and depend greatly on the patient, the approach the number of levels operated on.\n\nAlthough some patients remain asymptomatic, most require revision surgery instability, cervical or radicular pain. Diagnosis of cervical pseudarthrosis remains difficult. The clinical presentation is non-specific, and there is no consensus on the imaging imaging. Radiographic evaluation lacks sensitivity. The dynamic images require prior calibration and anatomical landmarks difficult to visualize. Angle measurement lacks reproducibility and sensitivity. CT scans, currently considered the gold standard as the gold standard, provides valuable morphological data but does not provide information on the functional nature of bone bridges the functional nature of bone bridges and apparent consolidation, particularly incomplete.\n\nAt the same time, functional imaging using bone scintigraphy has been historically limited by lack of spatial resolution, absence of anatomical and radiation attenuation for deep structures.The advent of hybrid imaging makes it possible to these limitations. Recently, the 6 to 16 scanners fitted to gamma cameras enable a detailed study correlations between functional and anatomical data.\n\nInterpretation criteria remain unestablished, however, and only one study reports the use of hydric bone imaging in the study of cervical pseudarthrosis. All patients were positive on scintigraphy. However, given the absence of \"healthy\" patients and the small number of patients the diagnostic value of bone scintigraphy in this indication.",[273],"Cervical Pseudarthrosis",[275,276,277,278,279,280,281,282,283,284],"cervical pseudarthrosis","imagining","hydric bone imagining","bone bridges","CT scans","diagnosis","cervical pain","bone scintigraphy","clinical presentation","diagnostic value","2025-08-18",{"date":287,"type":30},"2025-08-24",{"date":289,"type":30},"2024-12-31",{"date":291,"type":20},"2027-02-28",{"name":36,"class":37},{"id":294,"slug":295,"hasResults":11,"nctId":296,"briefTitle":297,"officialTitle":298,"acronym":299,"eligibilityCriteria":300,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":301,"targetDuration":4,"studyType":49,"phases":303,"briefSummary":304,"conditions":305,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":313,"locationsCount":63},"100583562","determination-of-scapulothoracic-and-glenohumeral-angles-by-imaging-in-patients-after-shoulder-arthroplasty-scap-imag-100583562","NCT06877936","Determination of Scapulothoracic and Glenohumeral Angles by Imaging in Patients After Shoulder Arthroplasty (SCAP-imag)","Determination of Scapulothoracic and Glenohumeral Angles by Imaging in Patients After Shoulder Arthroplasty","SCAP-imag","Inclusion Criteria:\n\n* Major\n* Reverse total shoulder arthroplasty surgery performed by Dr. Lionel Neyton (Jean Mermoz Private Hospital,69008 Lyon) 24±3 months prior to inclusion in the study.\n* Have had a CT scan of the operated shoulder prior to the operation\n* Patient having signed informed consent\n* Patient affiliated to a social security scheme or beneficiary of such a scheme, according to Article L.1124-1 of the Public Health Code\n\nExclusion Criteria:\n\n* Contraindication to the EOS® examination\n* Anthropometry incompatible with the production of EOS images\n* Pregnant, parturient, breastfeeding women\n* Have a history of fracture at the level of the humerus, scapula or clavicle\n* Have a history of surgery on the shoulder or contralateral upper limb to the limb with the prosthesis\n* Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision",{"count":302,"type":20},25,[51],"The shoulder is a site particularly affected by osteoarthritis since it affects up to 7% of the population aged over 65. To deal with osteoarthritis, total shoulder prosthesis is an increasingly used solution. Among the different types of total shoulder prostheses, the majority of surgical procedures involve the use of a reverse total shoulder prosthesis. This type of prosthesis modifies the anatomy of the shoulder in order to ensure better stability and mobility of the shoulder in patients while also compensating for potential significant lesions of certain deep muscles of the shoulder joint (i.e., rotator cuff).\n\nReverse prostheses have good short-term results but these are impaired in longer term with a Constant functional score of around 70% at 10 years and a survival rate of 70% after 20 years. Problems of bone conflicts between the scapula and the humerus can also be observed on these reverse total shoulder prostheses with variable rates from 4.6% to 47.3% depending on the position of the prosthesis.\n\nIn order to minimize the risk of complications, several tools are available to surgeons to optimize the positioning of the prosthesis. Planning software can be used to plan the kinematics of the shoulder after arthroplasty and quantify shoulder movements by 1\u002F estimating the scapulothoracic and glenohumeral angles, and 2\u002F determining the scapulohumeral rhythm (i.e., joint coordination index evaluating the relative contribution of these two joints to the total elevation of the arm). This prediction allows the surgeon to adapt the size, shape and position of the implants to each patient in order to ensure optimal shoulder kinematics, namely a maximum amplitude without bone conflicts (contacts) between the scapula and the humerus.\n\nThe main objective of this study is to evaluate the influence of a reverse shoulder arthroplasty on shoulder kinematics at 2 years postoperatively in comparison with the non-operated contralateral limb.",[306],"Arthropathy Shoulder","2025-03-10",{"date":309,"type":30},"2025-03-14",{"date":311,"type":30},"2025-01-29",{"date":291,"type":20},{"name":36,"class":37},{"id":315,"slug":316,"hasResults":11,"nctId":317,"briefTitle":318,"officialTitle":318,"acronym":319,"eligibilityCriteria":320,"healthyVolunteers":321,"sex":16,"minAge":17,"maxAge":322,"enrollmentInfo":323,"targetDuration":4,"studyType":49,"phases":325,"briefSummary":326,"conditions":327,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":331,"lastUpdatePostDateStruct":332,"startDateStruct":334,"completionDateStruct":336,"leadSponsor":338,"locationsCount":63},"100562403","ability-of-rotator-cuff-muscle-strength-levels-assessed-by-isokinetic-dynamometry-to-predict-return-to-sport-after-shoulder-stabilization-surgery-by-open-latarjet-procedure-100562403","NCT06602713","Ability of Rotator Cuff Muscle Strength Levels, Assessed by Isokinetic Dynamometry, to Predict Return to Sport After Shoulder Stabilization Surgery by Open Latarjet Procedure","ISO-LAT","Inclusion Criteria:\n\nPatient group:\n\n* Be aged between 18 and 45\n* Occurrence of the injury during the practice of a sporting activity\n* Post-traumatic anterior glenohumeral subluxation\u002Fdislocation\n* Contralateral shoulder with no history of injury\n* No other associated shoulder pathology\n* Patient scheduled for shoulder stabilizing surgery using an open Latarjet procedure performed by one of the surgeons at the Santy Orthopedic Center (Lyon)\n* No contraindication to isokinetic assessment\n* Patient having signed informed consent\n* Subject affiliated or beneficiary of a social security scheme\n\nHealthy volunteers:\n\n* Be aged between 18 and 45\n* Regularly practice a sporting activity\n* No contraindication to isokinetic assessment\n* Person having signed informed consent\n* Subject affiliated or beneficiary of a social security scheme\n\nExclusion Criteria:\n\nPatient group:\n\n* Contraindication from the sports clinician or surgeon\n* Have another pathology in the upper limbs.\n* Have constitutional hyperlaxity\n* Protected subject: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision\n\nHealthy volunteer group (athletes without a history of shoulder pathology):\n\n* Declare a history of pain\u002Finjury in the upper limbs in the last 6 months\n* Declare a history of orthopedic surgery in the upper limbs\n* Protected subject: adult under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision",true,"45 Years",{"count":324,"type":20},210,[51],"The stabilization surgical treatment by open Latarjet procedure is one of the reference treatments after anterior glenohumeral dislocation in athletes. This surgical technique allows low recurrence rates and high return to sport rates. Indeed, more than 90% of athletes return to sport after this type of surgery, but only 60% are able to resume the same activity as a preinjury level of performance. Therefore, adaptations in the postoperative management of athletes patients seem necessary. Isokinetic dynamometry is considered the gold standard to provide an objective assessment of muscle strength abilities, particularly in the clinical setting. Although rehabilitation exercises are prescribed early after the Latarjet procedure, muscle deconditioning occurs during the postoperative phase, limiting the abilities of the rotator cuff muscles to provide stability to the glenohumeral joint. Therefore, recovery of all components of strength, i.e. maximal strength, power, and strength endurance of the rotator cuff muscles appears crucial for the athletes to return to their sport at the pre-injury level. However, at present, the strength levels to be recovered remain to be defined.",[328,329,330],"Latarjet","Shoulder Injuries","Rotator Cuff Injuries","2024-09-17",{"date":333,"type":30},"2024-09-19",{"date":335,"type":20},"2024-10-01",{"date":337,"type":20},"2028-10-01",{"name":36,"class":37},{"id":340,"slug":341,"hasResults":11,"nctId":342,"briefTitle":343,"officialTitle":343,"acronym":344,"eligibilityCriteria":345,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":346,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":348,"conditions":349,"keywords":4,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":354,"lastUpdatePostDateStruct":355,"startDateStruct":357,"completionDateStruct":359,"leadSponsor":361,"locationsCount":63},"100484348","study-of-markers-of-iron-metabolism-and-their-relationship-with-phosphocalcic-and-hepatic-metabolism-and-inflammation-in-hemodialysis-patients-100484348","NCT05586867","Study of Markers of Iron Metabolism and Their Relationship With Phosphocalcic and Hepatic Metabolism and Inflammation in Hemodialysis Patients","MARMEFE","Inclusion Criteria:\n\n* Adult dialysis patient\n* Patient able to understand the information necessary for the study and having signed his written consent to participate\n* Affiliated patient or beneficiary of a social security scheme.\n\nExclusion Criteria:\n\n* Medically unstable or frail patient\n* Patient with hemoglobin less than 7g\u002Fdl\n* Patient with HIV+ or AIDS, patient with replicating hepatitis B or C\n* Patient participating in another clinical study requiring an additional blood sample\n* Patient benefiting from legal protection measures (guardianship, guardianship, etc.) adult under guardianship, guardianship or other legal protection, deprived of freedom by judicial or administrative decision\n* Pregnant, breastfeeding or parturient woman",{"count":347,"type":20},200,"From a scientific point of view and for publication purposes, it therefore seems important to study the metabolism of iron and in particular to define its conditions of absorption, metabolism, elimination and storage in the body at course of advanced renal failure.\n\nThe study will follow the evolution of hormones regulating iron metabolism and put into perspective their links with phosphocalcic and hepatic metabolisms as well as inflammation in hemodialysis patients.\n\nThe main objective of this program is to study the evolution of hepcidin and erythroferrone levels in hemodialysis patients. These two biomarkers regulating iron metabolism are not performed routinely in dialysis centers and are not listed in the nomenclature.",[350,351,352,353],"Iron Metabolism Disorders","Calcium Phosphate Metabolism","Hepatic Metabolic Disorders","Hemodialysis Complication","2022-10-17",{"date":356,"type":30},"2022-10-19",{"date":358,"type":30},"2021-12-01",{"date":360,"type":20},"2031-12-01",{"name":36,"class":37},{"id":363,"slug":364,"hasResults":11,"nctId":365,"briefTitle":366,"officialTitle":366,"acronym":367,"eligibilityCriteria":368,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":369,"enrollmentInfo":370,"targetDuration":4,"studyType":49,"phases":372,"briefSummary":373,"conditions":374,"keywords":376,"overallStatus":26,"whyStopped":4,"lastUpdateSubmitDate":379,"lastUpdatePostDateStruct":380,"startDateStruct":382,"completionDateStruct":384,"leadSponsor":386,"locationsCount":63},"100464285","assessment-of-personalized-follow-up-in-prevention-of-type-2-diabetes-100464285","NCT05325710","Assessment of Personalized Follow-up in Prevention of Type 2 Diabetes","Proxipart","Inclusion Criteria:\n\n* Patient, male or female, over the age of 18\n* Patient with a FINDRISC score ≥10 points\n* Beneficiary of a French health insurance system\n* Patient having been informed and having given their consent free, enlightened and written\n\nExclusion Criteria:\n\n* Patient over 75 years old\n* Patient already diagnosed with type 2 diabetes\n* Patient whose physical and\u002For psychological health is severely impaired, which according to the investigator may affect the compliance of the study participant.\n* Patient participating in another research\n* Patient in period of exclusion from another research always in progress at the time of inclusion.\n* Protected patient: adult under guardianship, curatorship or other legal protection, deprived of liberty by court order or administration.\n* Pregnant, breastfeeding or parturient women.\n* Patient hospitalized without consent","75 Years",{"count":371,"type":20},230,[51],"In France, the overall prevalence of diabetes was estimated at 5% of population in 2016, type 2 diabetes (T2DM) corresponding to 90% of cases. However, this figure is greatly underestimated,since it does not take into account people who are untreated or not diagnosed. However,it is estimated that 20 to 30% of adults with diabetes do not are not diagnosed. Conclusions presented during the annual meeting of the european Association for the Study of diabetes (EASD-Berlin) from 2019 suggest that signs precursors of the disease would be present up to 20 years before the diagnosis.\n\nThe Diagnosis is usually made around 40-50 years. The main factor of risk of T2D is the lifestyle, in particular a diet too rich for a too sedentary daily life.\n\nFrom a medico-economic point of view, chronic pathologies (including diabetes) account for 60% of insurance expenditure illness even though they concern 35% of insured persons, i.e. 20 million patients. The average annual repayment of a type 2 diabetic patient is 4890 euros.\n\nThis study is part of this context as the starting point a reflection on a different, coordinated management, to know a preventive rather than a curative approach.",[375],"Diabete Type 2",[377,378],"diabete type 2","preventive approach","2022-04-05",{"date":381,"type":30},"2022-04-13",{"date":383,"type":30},"2022-03-20",{"date":385,"type":20},"2028-04-01",{"name":36,"class":37},""]