[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Randy Kardon\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":88},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,71],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100339064","objectively-diagnose-and-monitor-treatment-of-light-sensitivity-100339064",false,"NCT03694626","Objectively Diagnose and Monitor Treatment of Light Sensitivity","Use of Facial Feature to Objectively Diagnose and Monitor Treatment of Light Sensitivity","Healthy Control subjects:\n\nInclusion Criteria\n\n* Healthy individuals with normal eye exam in the previous year\n* Age 18-80\n\nExclusion Criteria\n\n* History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and\u002For hypertension that are not well controlled, history of head trauma, concussion, or TBI, history of cervical or spinal injury\u002Fsurgery\n* Medications or eyedrops that would confound measuring the pupil light reflex and EMG: including topical autonomic drugs that could influence pupil size, ocular pharmacologic agents, sedative agents (e.g. benzodiazepines or barbiturates), opioid narcotics\n* Must not be light sensitive or get migraine headaches\n\nTBI patients without photosensitivity or headache:\n\nInclusion Criteria\n\n* Age 18-80\n* Traumatic Brain Injury (TBI)\n\nExclusion Criteria\n\n* History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and\u002For hypertension that are not well controlled\n* Medications or eyedrops that would confound measuring the pupil light reflex and EMG: including topical autonomic drugs that could influence pupil size, ocular pharmacologic agents, sedative agents (e.g. benzodiazepines or barbiturates), opioid narcotics - Must not be light sensitive or get migraine headaches (use headache criteria from Ana if we are including headaches)\n\nPatients with photosensitivity from non-TBI causes Inclusion Criteria\n\n* Age 18-80\n* Photosensitivity: determined by patient reporting symptoms and there may or may not be an identified cause associated with their light sensitivity (i.e. history of uveitis, childhood exotropia, meningitis, radiation, tumor)\n\nExclusion Criteria\n\n* History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and\u002For hypertension that are not well controlled, history of head trauma, concussion, or TBI, history of cervical or spinal injury\u002Fsurgery\n* Medications or eyedrops that would confound measuring the pupil light reflex and EMG: including topical autonomic drugs that could influence pupil size, ocular pharmacologic agents, sedative agents (e.g. benzodiazepines or barbiturates), opioid narcotics\n\nTBI patients with photosensitivity Inclusion Criteria\n\n* Age 18-80\n* Photosensitivity: determined by patient reporting symptoms and cause associated with their light sensitivity is post TBI\n* TBI\n\nExclusion Criteria\n\n\\- History of eye or systemic disorder that affect the retina, optic nerve, visual pathway, or pupil defect: including glaucoma, optic neuropathy, or retinal disease, diabetes and\u002For hypertension that are not well controlled",true,"ALL","18 Years","80 Years",{"count":21,"type":22},120,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and autonomic nerve responses to light.",[28,29,30],"Photophobia","Traumatic Brain Injury","Migraine","RECRUITING","2025-11-18",{"date":34,"type":35},"2025-11-24","ACTUAL",{"date":37,"type":35},"2019-07-11",{"date":39,"type":22},"2028-01-01",{"name":41,"class":42},"Randy Kardon","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":23,"phases":54,"briefSummary":55,"conditions":56,"keywords":62,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":65,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":43},"100322228","new-non-invasive-modalities-for-assessing-retinal-structure-and-function-100322228","NCT03475173","New Non-invasive Modalities for Assessing Retinal Structure and Function","New Non-invasive Modalities for Assessing Retinal Structure and Function:Preliminary Investigation","Controls:\n\nInclusion:\n\nNormal eye exam in last 2 years\n\nExclusion:\n\nCataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. Any abnormalities of the retina or optic nerve that could affect metabolism of the retina outside of normal.\n\nSubjects with Inner Retina Defect:\n\nInclusion:\n\nDefined structural defect to include those with Ischemic optic neuropathy, branch retinal artery occlusion (BRAO), hemianopia or visual field defect that respects the vertical meridian, inherited mitochondrial optic neuropathies such as Leber's and Dominant Optic Neuropathy, other retinopathies or optic neuropathies.\n\nExclusion:\n\nCataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.\n\nSubjects with Outer Retinal Defect:\n\nInclusion:\n\nAZOOR (acute zonal occult outer retinopathy) or other focal or diffuse outer photoreceptor loss of function\n\nExclusion:\n\nCataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.\n\nThe 450 total is to allow for exclusion of some subjects or in the event that the enrolled subject blinks too much or cannot fixate on a visual target adequately to maintain the same eye position during the short imaging interval. We hope to have a total of 450 (50 controls and 400 patients)","99 Years",{"count":53,"type":22},500,[25],"This study investigates a new technology to assess the structure and function inside the eye. Retinal imaging of subjects with inner and outer retinal defects to detect areas of abnormal structure and function compared to other visual function tests.",[57,58,59,60,61],"Ischemic Optic Neuropathy","Branch Retinal Artery Occlusion","Hemianopia","Leber Hereditary Optic Neuropathy","Acute Zonal Occult Outer Retinopathy",[63,64],"Optic Neuropathy",", Retinopathy",{"date":34,"type":35},{"date":67,"type":35},"2019-05-06",{"date":69,"type":22},"2028-03-01",{"name":41,"class":42},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":78,"targetDuration":4,"studyType":23,"phases":79,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":83,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":87,"locationsCount":43},"100322226","smartphone-flicker-fusion-test-for-patients-with-optic-disorders-100322226","NCT03475147","Smartphone Flicker Fusion Test for Patients With Optic Disorders.","Validation of a Smartphone-Based Flicker Fusion Test","Inclusion Criteria:\n\nControl\n\n* Age matched 18-80 years of age.\n* Healthy normal controls with no known eye disorders.\n\nExclusion Criteria:\n\n* Scotoma or any other ocular disorder\n\nInclusion Criteria - Patients\n\n* Age 18-80\n* Clinically associated scotoma\n\nExclusion Criteria - Patients\n\n-Any other ocular disorder",{"count":53,"type":22},[25],"The purpose of this project is to validate a quick, easy-to-use and administer smartphone flicker fusion test. The app (called eyeFusion) can potentially be used to easily and quickly collect critical flicker fusion measurements on patients admitted with optic disorders as part of the clinical care process.",[82],"Scotoma",{"date":34,"type":35},{"date":85,"type":35},"2017-01-27",{"date":39,"type":22},{"name":41,"class":42},""]