[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Rawalpindi Institute of Cardiology\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":70},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100640579","phase-4-dexmedetomidine-vs-lignocaine-for-reducing-intubation-induced-hemodynamic-responses-in-cardiac-surgery-a-randomized-controlled-trial-100640579",false,"NCT07611890","Dexmedetomidine vs Lignocaine for Reducing Intubation-Induced Hemodynamic Responses in Cardiac Surgery: A Randomized Controlled Trial","Comparison of Intravenous Dexmedetomidine and Lignocaine in Reducing Hemodynamic Responses During Laryngoscopy and Endotracheal Intubation In Patients Undergoing Cardiac Surgery at Rawalpindi Institute Of Cardiology- A Randomized Controlled Trial","Inclusion Criteria:\n\nAmerican Society of Anesthesiologists (ASA) physical status III-IV. Patients who are at risk of cardiovascular events\n\nExclusion Criteria:\n\n1. Patients with known hypersensitivity to dexmedetomidine and Lignocaine.\n2. Patients on medications that could interfere with the study (e.g., beta-blockers, calcium channel blockers).\n3. Pregnant or lactating women.\n4. Patients with a history of airway anomalies or difficult intubation.","ALL","18 Years","65 Years",{"count":20,"type":21},70,"ESTIMATED","INTERVENTIONAL",[24],"PHASE4","After confirming eligibility, written informed consent will be obtained by a trained team member who is not involved in assigning treatment or giving the study medication. Each participant will receive a unique study number to protect privacy. Participants will be randomly assigned to receive one of the study medications using a chance-based method.The study medication will be administered through a vein before placement of the breathing tube. Blood pressure and pulse rate will be measured before the procedure and at several time points after the breathing tube is inserted.",[27,28,29],"Laryngoscopic Stress Response","Dexmedetomidine","Lignocaine",[31,28,29,32],"Laryngoscopic stress response","Cardiac surgery","RECRUITING","2026-05-21",{"date":36,"type":37},"2026-05-28","ACTUAL",{"date":34,"type":37},{"date":40,"type":21},"2026-08-21",{"name":42,"class":43},"Rawalpindi Institute of Cardiology","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":62,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":69,"locationsCount":44},"100626415","phase-4-effect-of-nalbuphine-versus-fentanyl-on-hemdoynamic-effects-of-laryngoscopy-100626415","NCT07435337","Effect of Nalbuphine Versus Fentanyl on Hemdoynamic Effects of Laryngoscopy","COMPARISON OF HEMODYNAMIC EFFECTS OF NALBUPHINE VERSUS FENTANYL: A RANDOMIZED, DOUBLE-BLINDED INTERVENTIONAL STUDY IN PATIENTS ON CARDIOPULMONARY BYPASS AT RAWALPINDI INSTITUTE OF CARDIOLOGY, RAWALPINDI","Inclusion Criteria:\n\n* Weighing 40-70kg\n\n  * ASA III of either sex\n  * Undergoing cardiac surgery with CPB\n\nExclusion Criteria:\n\n• History of Drug Allergy • Pre-existing Asthma • Renal or Hepatic dysfunction • Extreme obesity • Pregnant \u002F lactating patients • Difficult intubation\u002Fprolonged intubation",true,"40 Years","60 Years",{"count":56,"type":21},98,[24],"Participants will undergo routine pre-operative evaluation. An intravenous line will be placed in the recovery area. On arrival in the operating room, standard monitoring (blood pressure, heart rate, oxygen saturation, ECG, breathing monitor, and temperature) will be applied. A central venous catheter and an arterial line will be inserted under local anesthesia using sterile technique.\n\nBefore anesthesia induction, patients will receive premedication including midazolam and an opioid pain-relief injection given slowly through the vein. General anesthesia will then be induced with etomidate. After adequate sedation, a muscle relaxant (atracurium) will be administered, and the patient will be ventilated with 100% oxygen using a face mask. The breathing tube will then be inserted and correct placement confirmed.\n\nDuring surgery, anesthesia will be maintained with oxygen, sevoflurane gas, and a continuous atracurium infusion. Hemodynamic parameters such as heart rate and blood pressure will be monitored throughout the peri-intubation and intraoperative period.",[60,61],"Laryngoscopy","Hemodynamic Changes",[31],"2026-02-20",{"date":65,"type":37},"2026-02-27",{"date":67,"type":37},"2026-02-21",{"date":34,"type":21},{"name":42,"class":43},""]