[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Rawda Hesham Abd ElAziz\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":70},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,45],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100602179","clinical-effectiveness-of-episodic-use-of-bioactive-silica-based-versus-in-management-of-dentin-hypersensitivity-a-6m-randomized-clinical-trial-100602179",false,"NCT07120139","Clinical Effectiveness of Episodic Use of Bioactive Silica Based Versus in Management of Dentin Hypersensitivity (A 6m Randomized Clinical Trial)","Clinical Effectiveness of Episodic Use of Bioactive Silica Based Versus Continuous Use of Fluoride Desensitizing Toothpastes in Management of Dentin Hypersensitivity (A 6m Randomized Clinical Trial)","Inclusion Criteria:\n\nPatients with DH, VAS ≥ 3 and Schiff sensitivity score needed to be ≥2, indicating that application of a jet of air makes the patient respond and move or requests discontinuation of the stimuli application.\n\n• Teeth with DH related to Non- carious Cervical lesions (abrasion, abfracture, erosion).\n\n• Teeth with gingival recession and exposed root dentin.\n\n\\-\n\nExclusion Criteria:\n\n* Patients with known allergies or adverse reactions to any ingredient of the tested materials.\n\nSystematic disease and\u002F or physical disabilities that may affect participation. • Patients who did any periodontal surgeries within the previous 3 months.\n\n• Patients with orthodontic appliances, or restorative work that might interfere with evaluation.\n\n• Patient who frequently use analgesics or any drugs that could affect the pain level.\n\n• Home or in-office bleaching and\u002F or in office fluoride application for 6 months before beginning of treatment.\n\n• Pregnant females with frequent vomiting attacks.\n\n• Smokers.\n\n• Systemic conditions that cause or predispose patients to develop dentin hypersensitivity (for example, gastroesophageal reflux disease, GERD).\n\n• Excessive dietary or environmental exposure to acids.",true,"ALL","22 Years","45 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","The aim of the study to compare the clinical effectiveness of Episodic use of Bioactive Silica Based versus continuous use of fluoride based desensitizing toothpastes in management of dentin hypersensitivity (DH) of adult patients over 6m follow up and evaluating patient satisfaction regarding the treatment provided. Episodic use will be tested as it reflects the effectiveness in a clinical scenario regarding patient compliance and adherence to the treatment where some of the Egyptian patients stop the treatment once improvement occurs due to financial constraints",[28],"Dentin Hypersensitivity",[30,31],"Bioactive Silica Based with calcium booster (Refix technology) toothpaste","Dentin hypersensitivity.","NOT_YET_RECRUITING","2025-08-12",{"date":35,"type":36},"2025-08-13","ACTUAL",{"date":38,"type":22},"2025-08-20",{"date":40,"type":22},"2026-02-28",{"name":42,"class":43},"Rawda Hesham Abd ElAziz","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":4},"100602187","clinical-effectiveness-of-bioactive-silica-based-with-calcium-toothpaste-100602187","NCT07120243","Clinical Effectiveness of Bioactive Silica Based With Calcium Toothpaste","Clinical Effectiveness of Bioactive Silica Based With Calcium Toothpaste, Sodium Fluoride Varnish in Management of White Spot Lesions (A 6m Randomized Clinical Trial).","Inclusion Criteria:\n\n* Patient with non cavitated carious WSL in at least one upper or lower tooth.\n* Teeth with active non cavitated white spot carious lesions on the cervical one third of the facial or lingual surfaces.\n\nTeeth with initial carious lesions with score 1 or 2 according to The International Caries Detection and Assessment System (ICDAS).\n\n• Teeth with Diagnodent values between 14-20 that refers to early enamel caries.\n\nExclusion Criteria:\n\nPatients with known allergies or adverse reactions to any ingredient of the tested materials.\n\n• Systematic disease and\u002F or physical disabilities that may affect participation.\n\n• Patients with white spots due to congenital reasons e.g. enamel hypomineralization.\n\n• Pregnant females with frequent vomiting attacks.\n\n• Smokers.\n\n• Excessive dietary or environmental exposure to acids.\n\n* Presence of surface cavitation or restorations .","55 Years",{"count":54,"type":22},20,[25],"This study will be conducted to Clinically evaluate Bioactive Silica Based with calcium booster (Refix technology) toothpaste and Sodium Fluoride varnish versus conventional fluoride toothpastes in management of white spot lesions of adult patients over 6m follow up and evaluating patient perception regarding the treatment provided.",[58,59],"Caries; Initial","Caries Active",[30,61,62],"Caries Prevention","white spot carious lesions","2025-08-06",{"date":35,"type":36},{"date":66,"type":22},"2025-08-15",{"date":68,"type":22},"2026-03-01",{"name":42,"class":43},""]