[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Rebecca E Kotcher, MD\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":77},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,49],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100564219","blue-light-as-an-anti-inflammatory-and-analgesic-strategy-in-thoracic-trauma-100564219",false,"NCT06626334","Blue Light as an Anti-inflammatory and Analgesic Strategy in Thoracic Trauma","Blue Light as an Anti-inflammatory and Analgesic Strategy in Thoracic Trauma: A Randomized Controlled Trial in Adults With Rib Fractures","BLAASTT","Inclusion Criteria:\n\n* Age greater than or equal to 18 years\n* Admitted to a single large academic level I trauma center (Presbyterian\u002FMontefiore hospital) within the first 48 hours of traumatic injury\n* Greater than or equal to 1 acute rib fracture\n* Pain related to rib fracture(s), by one or more of the following criteria: 1. Pain \\>\u002F= 4\u002F10 at rest, 2. Pain \\>\u002F= 4\u002F10 with incentive spirometer (IS) use, and\u002For 3. Inspiratory volume \\\u003C 1000 cc\n* Anticipated length of stay greater than or equal to 48 hours\n* Alert, with capacity to provide informed consent\n\nExclusion Criteria:\n\n* Mechanical ventilation\\* or non-invasive positive pressure ventilation administered for respiratory insufficiency prior to the time of informed consent\n* Delirium (positive CAM screening) at the time of informed consent\n* Ocular trauma, which may interfere with the mechanism of action\n* Traumatic brain injury (TBI) or history of TBI or stroke, which may interfere with the mechanism of action\n* Splenectomy upon admission or history of splenectomy, which may interfere with the mechanism of action\n* History of significant ocular dysfunction\\*\\* (i.e., macular degeneration, glaucoma, cataracts), which may interfere with the mechanism of action\n* History of cataract surgery, due to the possibility of blue light filtering intraocular lens placement\n* History of bipolar disorder or schizophrenia, which could increase the risk of an adverse reaction to light exposure (i.e., acute mania)\n* History of dementia, which would compromise the reliability of pain intensity and delirium measures\n\n  * Or other condition in which a patient cannot open eyes to receive light intervention or report a pain score \\*\\*Myopia, hyperopia, and\u002For astigmatism corrected for with contact lenses or spectacle corrective eyeglasses will NOT be a criterion for exclusion","ALL","18 Years",{"count":20,"type":21},75,"ESTIMATED","INTERVENTIONAL",[24],"NA","The main goal of this clinical trial is to learn if light therapy improves pain and inflammation in adults with painful rib fractures. The main question it aims to answer is:\n\n\\- Does bright blue light therapy in addition to standard pain treatments improve pain with breathing in adults with painful rib fractures?\n\nResearchers will compare participants who receive bright blue light therapy to participants who receive white light therapy and participants who receive only usual lighting conditions to look for differences in their pain control. In addition to their assigned light treatment, all participants will receive standard pain control treatments.\n\nParticipants will be assigned randomly to one of three groups: one-third will be assigned to bright blue light therapy, one-third will be assigned to bright white light therapy, and one-third will be assigned to usual light only. They will receive their assigned light treatment for 4 hours during the morning\u002Fearly afternoon for up to 3 days while they are in the hospital. On each day they receive the light treatment and on the day after their final light treatment:\n\n* They will be asked twice to rate their pain at rest and with taking a deep breath.\n* They will be tested to confirm that they are not experiencing delirium, or confusion related to being in the hospital.\n* Blood samples will be collected to look for changes in inflammation and the circadian clock, the body's natural 24-hour cycle.",[27,28],"Rib Fractures","Pain, Acute",[30,31,32,33,34,35],"Light Therapy","Blue Light Therapy","Pain Control","Analgesia","Immunomodulation","Bright Light Therapy","RECRUITING","2026-03-02",{"date":39,"type":40},"2026-03-04","ACTUAL",{"date":42,"type":40},"2024-10-23",{"date":44,"type":21},"2026-08",{"name":46,"class":47},"Rebecca E Kotcher, MD","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":48},"100609723","green-light-for-post-operative-wellness-100609723","NCT07218289","Green Light for Post-Operative Wellness","Green Light Therapy to Reduce Pain and Promote Wellness After Surgery: A Randomized Controlled Trial in Adult Post-Operative Patients","GLOW","Inclusion Criteria:\n\n* Age \\>\u002F= 18 years\n* Planned to undergo laparoscopic or robotic surgery at UPMC Shadyside Hospital\n* Anticipated post-operative length of stay \\>\u002F= 48 hours\n* Able to speak and read English fluently, with the capacity to provide informed consent and complete the associated surveys independently\n\nExclusion Criteria:\n\n* Pregnancy\n* History of significant ocular issues\u002Fdysfunction (†‡ ) (e.g., glaucoma, ocular trauma, macular degeneration, cataracts) that would interfere with the ocular mechanism of action\n* History of significant neurological disease (‡) (e.g., traumatic brain injury, stroke, neurodegenerative disease) that would compromise the reliability of pain screening and\u002For interfere with the central mechanism of action\n* History of bipolar disorder or schizophrenia, which could increase the risk of an adverse reaction to light exposure (i.e., acute mania)\n* History of splenectomy, which would interfere with the mechanism of action\n\n  * Ocular issues corrected with contact lenses or spectacle corrective eyeglasses will NOT be considered a criterion for exclusion ‡Unclear cases will be at the discretion of the PI",{"count":58,"type":21},60,[24],"This is an unblinded, parallel group randomized controlled trial to evaluate bright green light as an adjunct therapy after surgery at UPMC Shadyside. The primary outcome measure will be pain intensity with secondary outcome measures including opioid requirements, sleep quality, mood, and overall post-operative recovery. Specific aims\u002Fhypotheses for this study are as follows:\n\nAim 1: To assess bright green light therapy's potential as a complementary post-operative analgesic strategy in patients recovering from surgery Hypothesis 1: Participants exposed to bright green light, in comparison to dim white (ambient) light, will have improved postoperative pain scores and lower opioid use.\n\nAim 2: To examine the impact of bright green light therapy on patient-centered measures of post-operative recovery that may be related to improved circadian function.\n\nHypothesis 2: Participants exposed to bright green light, in comparison to dim white (ambient) light, will have improved quality of post-operative recovery, enhanced sleep, and reduced anxiety and depression.",[62],"Surgery",[64,65,66,67,68],"light therapy","post-operative pain","depression","anxiety","post-operative recovery","2026-02-09",{"date":71,"type":40},"2026-02-12",{"date":73,"type":40},"2026-01-14",{"date":75,"type":21},"2026-12-01",{"name":46,"class":47},""]