[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Recep Tayyip Erdogan University Training and Research Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":259},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,48,72,100,125,146,168,188,214,238],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100644292","evaluation-of-the-effect-of-hyperuricemia-on-alveolar-bone-loss-100644292",false,"NCT07666126","Evaluation of the Effect of Hyperuricemia on Alveolar Bone Loss","Evaluation of the Effect of Hyperuricemia on Alveolar Bone Loss and Oxidative Stress","Inclusion Criteria:\n\n* Being between 18 and 65 years of age\n* Being systemically healthy or diagnosed with hyperuricemia\n* Having at least 20 natural teeth\n* Being periodontally healthy or diagnosed with periodontitis\n\nExclusion Criteria:\n\n* Diabetes, cardiovascular disease, osteoporosis, chronic kidney disease, metabolic syndrome, and obesity are systemic diseases that may affect purine metabolism.\n* Smoking\n* Pregnancy or lactation\n* Having received periodontal treatment within the last 3-6 months\n* Use of antibiotics, anti-inflammatory drugs, or uric acid-lowering drugs\n* Presence of systemic diseases that may affect purine metabolism",true,"ALL","18 Years","65 Years",{"count":21,"type":22},80,"ESTIMATED","OBSERVATIONAL","Periodontitis is a multifactorial disease characterized by chronic inflammation of the gum tissue and alveolar bone destruction, and is known to be associated with various systemic diseases. Hyperuricemia, on the other hand, is a metabolic condition characterized by increased serum uric acid levels and can affect inflammation, oxidative stress, and bone metabolism. In recent years, the relationship between hyperuricemia and periodontal diseases has been increasingly investigated, but the biological mechanisms of this relationship have not yet been fully elucidated. Therefore, this study aimed to determine whether there is a relationship between hyperuricemia and periodontitis and to reveal the possible pathophysiological mechanisms of this relationship, which are shaped by inflammation, oxidative stress, and bone metabolism.\n\nA total of 80 individuals aged 18-65 years will be included in this clinical observational study. The periodontal status of the participants will be assessed using clinical periodontal parameters such as probing pocket depth, clinical attachment loss, plaque index, gingival index, and bleeding on probing. Participants will be divided into four groups according to their periodontal status and the presence of hyperuricemia: individuals with periodontitis and hyperuricemia, individuals with periodontally healthy and hyperuricemia, individuals with periodontitis but without hyperuricemia, and individuals with periodontally healthy and without hyperuricemia. Gingival crevicular fluid and serum samples will be taken from the participants. In these samples, receptor-mediated nuclear factor kappa B ligand, osteoprotegerin, total antioxidant status, total oxidant status, oxidative stress index, interleukin-1 beta, interleukin-10, interleukin-18, and nucleotide-binding oligomerization domain-like receptor protein 3 levels will be analyzed. This study is considered unique because it examines the relationship between hyperuricemia and periodontitis by evaluating inflammation, oxidative stress, and bone metabolism parameters together.",[26,27,28],"Periodontal Diseases","Hyperuricemia","Oxidative Stress",[30,31,32,33,34],"periodontal disease","hyperuricemia","oxidative stress","alveolar bone loss","inflammation","RECRUITING","2026-06-23",{"date":38,"type":39},"2026-06-26","ACTUAL",{"date":41,"type":22},"2026-06-10",{"date":43,"type":22},"2026-10-01",{"name":45,"class":46},"Recep Tayyip Erdogan University Training and Research Hospital","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":19,"enrollmentInfo":56,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":47},"100615049","anti-inflammatory-nutrition-on-the-outcomes-of-non-surgical-periodontal-therapy-100615049","NCT07287540","Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy","Evaluation of the Effects of Anti-inflammatory Nutrition on the Outcomes of Non-surgical Periodontal Therapy in Individuals With Periodontitis","Inclusion Criteria:\n\n* Being systemically healthy\n* Not smoking\n* Not using anti-inflammatory drugs in the last 3 months, antibiotics, or systemic corticosteroids in the last 6 months\n* Not being pregnant or lactating\n* Not having received periodontal treatment in the last 6 months\n* Having at least 20 teeth in the mouth\n* Being diagnosed with periodontitis by the investigator\n* Having a dietary inflammatory index \\>0\n\nExclusion Criteria:\n\n* Having a systemic disease\n* Smoking\n* Using anti-inflammatory drugs within the last 3 months, antibiotics within the last 6 months, or systemic corticosteroids\n* Being pregnant or lactating\n* Having received periodontal treatment within the last 6 months\n* Having fewer than 20 teeth in the mouth\n* No periodontitis","20 Years",{"count":57,"type":22},100,"This study aimed to determine the effect of anti-inflammatory nutrition on non-surgical periodontal treatment in individuals with periodontitis by evaluating gingival crevicular fluid (GCF) and serum biomarkers and clinical periodontal parameters.\n\nA total of 100 volunteers identified as having a pro-inflammatory diet (Q3 and Q4) will be included in the study. Individuals will be assigned to two groups. These groups will then be further divided into two groups based on whether or not they will receive anti-inflammatory nutrition education. Group Q3-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q3-2 (n=25) will receive only non-surgical periodontal treatment. Group Q4-1 (n=25) will receive non-surgical periodontal treatment and anti-inflammatory nutrition education. Group Q4-2 (n=25) will receive only non-surgical periodontal treatment. After the periodontal index measurements are completed, the patients will receive non-surgical periodontal treatment. GCF and serum samples, periodontal clinical parameters and Dietary Inflammatory Index will be collected 3 times: at baseline, 1.5 and 3 months after non-surgical periodontal treatment. Levels of interleukin (IL)-1β, IL-10, tumor necrosis factor (TNF)-α, total oxidant status (TOS), total antioxidant status (TAS), and C-reactive protein (CRP) will be assessed from these samples. This will investigate the role of anti-inflammatory nutrition in reducing periodontal inflammation and increasing treatment success.",[60],"Periodontitis",[62,63,64],"periodontitis","diet inflammatory index","anti-inflammatory nutrition","2026-06-18",{"date":36,"type":39},{"date":68,"type":39},"2025-11-22",{"date":70,"type":22},"2026-07-04",{"name":45,"class":46},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":89,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":47},"100643649","the-effect-of-vitamin-d-supplementation-on-the-anti-inflammatory-response-in-periodontal-diseases-100643649","NCT07636733","The Effect of Vitamin D Supplementation on the Anti-inflammatory Response in Periodontal Diseases","The Effect of Vitamin D Levels and Supplementation on Anti-inflammatory Response in Periodontal Disease: a Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Study groups will be formed according to the 2017 Periodontal Disease Classification. Accordingly:\n* Periodontally healthy; absence of bleeding on probing, erythema, edema, patient symptoms, attachment, and bone loss\n* Gingivitis; patients with an average gingival index ≥0.5 according to Löe and Silness\n* Stage I-II periodontitis; patients with CAL 1-2 or 3-4 mm and a maximum PPD ≤5 mm, showing radiographic horizontal bone loss up to the coronal third of the root (15%-33%), but without tooth loss due to periodontitis\n* Stage III-IV periodontitis; Stage 3 and 4 patients with ≥15 teeth in their mouth, with CAL ≥5 and PPD ≥6 in at least 6 areas, and radiographic bone loss extending to the middle or apical third of the root.\n\nExclusion Criteria:\n\n* Individuals who have undergone periodontal treatment in the last 6 months, have systemic diseases (such as diabetes, parathyroid and thyroid-related endocrine diseases) that may affect periodontal status, patients with chronic liver disease, hypoparathyroidism and renal failure, those who have been using medications that may affect periodontal response (aspirin, non-steroidal anti-inflammatory drugs or steroids) for a long time, those who are using additional vitamin D or calcium supplements in the pre-study phase, those who are pregnant or breastfeeding, and those with hypercalcemia and malabsorption syndrome will not be included in the study.","70 Years",{"count":81,"type":22},120,"INTERVENTIONAL",[84],"NA","A review of the literature revealed that while there are studies investigating the relationship between vitamin D and periodontal disease, there are no studies investigating the anti-inflammatory effect of vitamin D on periodontal disease. Investigators hypothesized that the increased incidence of periodontal disease in individuals with vitamin D deficiency might be due not only to pro-inflammatory effects but also to impaired bone metabolism and a decrease in the anti- inflammatory mechanism. Investigators aimed to determine this by comparing serum and DOS levels of 1,25-dihydroxyvitamin D (1,25(OH)2D), 25-hydroxyvitamin D (25(OH)D3), Receptor activator nuclear kappa B ligand (RANKL), osteoprotegerin (OPG), Tumor Necrosis Factor Related Apoptosis induced Ligand (TRAIL), Developmental endothelial locus (Del)-1, Lipoxin, Resolvin, interleukin (IL)-10, and transforming growth factor-β (TGF-β).\n\nThe study will include 120 individuals who are systemically healthy based on clinical and radiographic examinations and diagnosed with Stage I-II periodontitis, Stage III-IV periodontitis, chronic gingivitis, and periodontally healthy. Periodontal clinical parameters (Probing pocket depth (PPD), Clinical attachment level (CAL), Bleeding on probing (BOP), Plaque index (PI), Gingival index (GI)) will be recorded three times: before treatment, and 6 and 12 weeks after treatment. Gingival crevicular fluid (GCF) and serum samples will be collected from participants at baseline and 12 weeks later for biochemical analysis.",[26,87,88],"Gingivitis","Vitamin D Deficiency",[62,90,91,92],"gingivitis","Vitamin D","anti-inflammatory","2026-06-08",{"date":41,"type":39},{"date":96,"type":39},"2026-06-03",{"date":98,"type":22},"2026-10-16",{"name":45,"class":46},{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":105,"acronym":4,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":107,"targetDuration":108,"studyType":23,"phases":4,"briefSummary":109,"conditions":110,"keywords":113,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":47},"100628474","metabolic-syndrome-associated-diet-100628474","NCT07462104","Metabolic Syndrome Associated Diet","Pro-İnflammatory Diet as a Modifying Factor in Periodontal Tissue Destruction Associated With Metabolic Syndrome","Inclusion Criteria:\n\n* Being between 18 and 65 years of age\n* Presence of at least three of the following parameters: (For MetS diagnosis) Waist circumference: ≥ 94 cm for men, ≥ 88 cm for women Blood pressure ≥ 130\u002F85 mmHg or taking antihypertensive medication Fasting blood glucose ≥ 100 mg\u002Fdl or diagnosed with Type 2 Diabetes Triglycerides ≥ 1.7 mmol\u002FL HDL \\\u003C 1.29 mmol\u002FL\n* Having at least 20 teeth\n* Not having received periodontal therapy in the last 6 months\n* Not having taken antibiotics, steroids, and\u002For nonsteroidal anti-inflammatory drugs in the last 3 weeks\n* Not having any autoimmune disease, osteoporosis, or cancer\n* Not taking immunosuppressive medications, oral contraceptives, Not taking bisphosphonates\n* Not being pregnant\n* Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS)\n* Not taking chronic medications that affect periodontal tissues (cyclosporine A, phenytoin)\n* Not taking antioxidant supplements in the last 6 months\n\nExclusion Criteria:\n\n* Patients with an active infectious disease,\n* Those taking medications that could affect periodontal tissues,\n* History of endocarditis,\n* Recent antibiotic use (within 4 months),\n* Alcohol\u002Fdrug use,\n* Psychological disorders,\n* Eating disorders,\n* Dementia,\n* Pregnancy and breastfeeding,\n* Patients who did not sign the informed consent form",{"count":57,"type":22},"1 Day","The goal of this observational study is to examine the relationship between metabolic syndrome (MetS) and periodontitis, and to evaluate the role of the Dietary Inflammatory Index (DII) in this association.\n\nThe main question it aims to answer is:\n\nDoes a pro-inflammatory diet, as measured by the DII, increase the risk or severity of periodontitis in individuals with metabolic syndrome?\n\nParticipants will include adults who meet the diagnostic criteria for metabolic syndrome. Their periodontal health will be assessed through standard clinical parameters, and dietary data will be collected using a validated food frequency questionnaire to calculate individual DII scores. The study will observe and analyze these factors to explore potential links between diet-induced inflammation, systemic metabolic health, and periodontal outcomes.",[111,60,112],"Metabolic Syndrome (MetS)","Diet, Food and Nutrition",[114,62,115,34],"metabolic syndrome","diet","NOT_YET_RECRUITING","2026-03-04",{"date":119,"type":39},"2026-03-10",{"date":121,"type":22},"2026-03-23",{"date":123,"type":22},"2026-11-23",{"name":45,"class":46},{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":132,"targetDuration":108,"studyType":23,"phases":4,"briefSummary":133,"conditions":134,"keywords":136,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":139,"startDateStruct":141,"completionDateStruct":143,"leadSponsor":145,"locationsCount":47},"100625779","chronic-kidney-disease-associated-diet-100625779","NCT07427069","Chronic Kidney Disease Associated Diet","The Role of Pro-Inflammatory Diet in Periodontal Tissue Destruction in Chronic Kidney Disease","Inclusion Criteria:\n\n* Being between 18 and 65 years of age\n* Being diagnosed with Chronic Kidney Disease (having an eGFR below 60 ml\u002Fmin\u002F1.73 m² for at least 3 months or a urine albumin-to-creatinine ratio above 30 mg\u002Fg (proteinuria))\n* Having at least 20 teeth\n* Not having received periodontal therapy in the last 6 months\n* Not having taken antibiotics, steroids, and\u002For nonsteroidal anti-inflammatory drugs in the last 3 weeks\n* Not having any autoimmune disease, osteoporosis, or cancer\n* Not taking immunosuppressive medications, oral contraceptives, Not taking bisphosphonates\n* Not being pregnant\n* Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS)\n* Not taking chronic medications that affect periodontal tissues (cyclosporine A, phenytoin)\n* Not taking antioxidant supplements in the last 6 months\n\nExclusion Criteria:\n\n* Patients with an active infectious disease,\n* Those taking medications that could affect periodontal tissues,\n* History of endocarditis,\n* Recent antibiotic use (within 4 months),\n* Alcohol\u002Fdrug use,\n* Psychological disorders,\n* Eating disorders,\n* Dementia,\n* Pregnancy and breastfeeding,\n* Patients who did not sign the informed consent form",{"count":57,"type":22},"The goal of this observational study is to investigate the relationship between chronic kidney disease (CKD) and periodontitis, and to evaluate the potential mediating role of dietary inflammatory potential, measured by the Dietary Inflammatory Index (DII), in this association.\n\nThe main question it aims to answer is:\n\nDoes a pro-inflammatory diet, as reflected by a higher DII score, exacerbate periodontal inflammation in individuals with chronic kidney disease?\n\nParticipants will include adults diagnosed with CKD at various stages. Periodontal status will be assessed through clinical parameters such as probing depth, clinical attachment loss, and bleeding on probing. Dietary intake will be evaluated using a validated food frequency questionnaire, and DII scores will be calculated accordingly. The study will aim to observe and analyze whether dietary inflammation contributes to increased periodontal disease severity in CKD patients, potentially offering insight into modifiable risk factors relevant to both systemic and oral health.",[135,60,112],"Chronic Kidney Disease",[137,62,115,34],"Chronic kidney disease","2026-02-21",{"date":140,"type":39},"2026-02-24",{"date":142,"type":22},"2026-04-20",{"date":144,"type":22},"2026-11-16",{"name":45,"class":46},{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":153,"targetDuration":108,"studyType":23,"phases":4,"briefSummary":155,"conditions":156,"keywords":158,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":138,"lastUpdatePostDateStruct":162,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":47},"100625781","the-relationship-between-ultra-processed-food-consumption-and-oral-health-100625781","NCT07427095","The Relationship Between Ultra-Processed Food Consumption and Oral Health","Investigating the Relationship Between Ultra-Processed Food Consumption and Caries and Periodontal Disease","Inclusion Criteria:\n\n* Individuals between the ages of 18 and 65,\n* Individuals with at least 20 teeth,\n* Not having received periodontal treatment in the last 6 months,\n* Not having taken antibiotics, steroids, and\u002For nonsteroidal anti-inflammatory drugs in the last 3 weeks,\n* Not having any autoimmune disease, osteoporosis, or cancer,\n* Not using immunosuppressive drugs, oral contraceptives, or bisphosphonates,\n* Not being pregnant,\n* Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS),\n* Not using chronic medications that affect periodontal tissues (cyclosporine A, Phenytoin),\n* Not having taken antioxidant supplements in the last 6 months.\n\nExclusion Criteria:\n\n* Patients with endocrine or genetic disorders such as hypothyroidism, type 1 diabetes mellitus, or Cushing's syndrome\n* Patients with active infectious disease\n* Patients taking medications that may affect periodontal tissues\n* Patients who have recently taken antibiotics (within 4 months)\n* Patients with alcohol\u002Fdrug use\n* Patients with psychological disorders\n* Patients with eating disorders, dementia\n* Patients who are pregnant or breastfeeding\n* Patients with any food allergies\n* Patients who do not sign the informed consent form",{"count":154,"type":22},200,"The goal of this observational study is to examine the potential relationship between ultra-processed food consumption and the presence of dental caries and periodontal disease, and to evaluate the role of the Ultra-Processed Food Index (UPFI) in this association.\n\nThe main question it aims to answer is:\n\nDoes increased consumption of ultra-processed foods raise the risk or severity of dental caries and periodontal disease in individuals?\n\nParticipants will include individuals within a specified age range who voluntarily agree to participate in the study. Oral health status will be assessed through standard clinical parameters, including the presence of caries, plaque index, probing pocket depth, clinical attachment loss, and bleeding on probing. Dietary habits will be evaluated using a validated food frequency questionnaire, and individual UPFI scores will be calculated. The study will aim to observe and analyze the effects of ultra-processed food consumption on oral health outcomes.",[157],"Ultra-processed Food",[159,160,30,161],"Ultra-Processed Food","tooth decay","oral health",{"date":140,"type":39},{"date":164,"type":22},"2026-04-27",{"date":166,"type":22},"2026-10-26",{"name":45,"class":46},{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":175,"targetDuration":108,"studyType":23,"phases":4,"briefSummary":176,"conditions":177,"keywords":178,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":180,"lastUpdatePostDateStruct":181,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":47},"100620222","metabolic-syndrome-associated-periodontal-inflammatory-surface-area-100620222","NCT07354815","Metabolic Syndrome-Associated Periodontal Inflammatory Surface Area","Determination of the Level of Correlation Between Periodontal Inflammatory Surface Area and Metabolic Syndrome-Associated Periodontal Tissue Destruction","Inclusion Criteria:\n\n* Being between 18 and 65 years of age\n* Presence of at least three of the following parameters: (For MetS diagnosis) Waist circumference: ≥ 94 cm for men, ≥ 88 cm for women Blood pressure ≥ 130\u002F85 mmHg or taking antihypertensive medication Fasting blood glucose ≥ 100 mg\u002Fdl or diagnosed with Type 2 Diabetes Triglycerides ≥ 1.7 mmol\u002FL HDL \\\u003C 1.29 mmol\u002FL\n* Having at least 20 teeth\n* Not having received periodontal therapy in the last 6 months\n* Not having taken antibiotics, steroids, and\u002For nonsteroidal anti-inflammatory drugs in the last 3 weeks\n* Not having any autoimmune disease, osteoporosis, or cancer\n* Not taking immunosuppressive medications, oral contraceptives, Not taking bisphosphonates\n* Not being pregnant\n* Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS)\n* Not taking chronic medications that affect periodontal tissues (cyclosporine A, phenytoin)\n* Not taking antioxidant supplements in the last 6 months\n\nExclusion Criteria:\n\n* Patients with active infectious disease,\n* Those taking medications that may affect periodontal tissues,\n* Those who did not sign the informed consent form.",{"count":57,"type":22},"This study aims to examine the potential of metabolic syndrome (MetS), a systemic, inflammatory disease, to influence the relationship between periodontal inflammatory surface area (PISA) and diabetes and obesity parameters. The primary question addressed by the study is:\n\nCan PISA be used as a significant parameter in the relationship between periodontal disease and MetS? In this context, the relationship between PISA and periodontal clinical parameters and serum parameters directly related to the diagnosis of MetS will be examined.",[111,60],[114,62,179],"periodontal inflammatory surface area","2026-01-12",{"date":182,"type":39},"2026-01-21",{"date":184,"type":22},"2026-02-23",{"date":186,"type":22},"2026-06-30",{"name":45,"class":46},{"id":189,"slug":190,"hasResults":11,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":4,"eligibilityCriteria":194,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":195,"targetDuration":108,"studyType":23,"phases":4,"briefSummary":197,"conditions":198,"keywords":200,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":209,"completionDateStruct":211,"leadSponsor":213,"locationsCount":47},"100605100","pathogenesis-of-periodontal-disease-in-individuals-with-psoriasis-100605100","NCT07158125","Pathogenesis of Periodontal Disease in Individuals With Psoriasis","Role of Th17 and Stress-related Neuroendocrine Markers in the Pathogenesis of Periodontal Disease in Individuals With Psoriasis","Inclusion Criteria:\n\n* Being between the ages of 18 and 65\n* Being diagnosed with psoriasis by a dermatologist\n* Having at least 20 teeth\n* Not having received periodontal treatment in the last 6 months\n* Not having taken antibiotics, steroids, and\u002For nonsteroidal anti-inflammatory drugs in the last 3 weeks\n* Not having any autoimmune disease, osteoporosis, or cancer\n* Not using immunosuppressive drugs, oral contraceptives, or bisphosphonates\n* Not being pregnant\n* Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS)\n* Not using chronic medications that affect periodontal tissues (cyclosporine A, phenytoin)\n* Not having taken antioxidant supplements in the last 6 months\n\nExclusion Criteria:\n\n* \\\u003C20 teeth\n* Any significant oral infection (i.e., herpes or candidiasis)\n* Oral injuries or bleeding unrelated to periodontitis\n* Periodontal therapy and antibiotic therapy within the past 3 months\n* Salivary gland dysfunction\n* Acute illness (fever, sore throat)\n* Systemic illness, mental illness, immunosuppressive drugs or immunodeficiency\n* Pregnancy or breastfeeding\n* Use of antidepressants",{"count":196,"type":22},60,"The aim of this study is to evaluate the levels of Th17 cell-associated cytokines (IL-17, IL-21, IL-23) and the salivary stress biomarkers cortisol, dehydroepiandrosterone, and Chromogranin A in the pathogenesis of periodontal disease in individuals with psoriasis, thereby revealing immunological and neuroendocrine interactions.\n\nThe fundamental question it aims to answer is:\n\nWhat are the biological mechanisms that may increase the risk of periodontal disease in individuals with psoriasis?\n\nIn this context, the periodontal status of individuals with psoriasis will be clinically assessed, followed by analysis of the levels of Th17-associated cytokines and stress biomarkers in gingival crevicular fluid and saliva samples. Additionally, patients will be asked questions from the Social Appearance Anxiety Scale. The periodontal status of individuals with psoriasis will be determined cross-sectionally, and the resulting biomarker levels will be examined. In addition, the data obtained will be evaluated with statistical analysis in relation to disease severity and clinical parameters.",[199],"Psoriasis",[201,62,202,203,204,205],"psoriasis","Th17","cortisol","dehydroepiandrosterone","chromogranin A","2025-08-28",{"date":208,"type":39},"2025-09-05",{"date":210,"type":22},"2025-09-15",{"date":212,"type":22},"2026-04-06",{"name":45,"class":46},{"id":215,"slug":216,"hasResults":11,"nctId":217,"briefTitle":218,"officialTitle":219,"acronym":4,"eligibilityCriteria":220,"healthyVolunteers":11,"sex":17,"minAge":221,"maxAge":18,"enrollmentInfo":222,"targetDuration":108,"studyType":23,"phases":4,"briefSummary":224,"conditions":225,"keywords":227,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":231,"lastUpdatePostDateStruct":232,"startDateStruct":234,"completionDateStruct":235,"leadSponsor":237,"locationsCount":47},"100602763","relationship-between-malocclusion-severity-and-periodontitis-risk-100602763","NCT07127744","Relationship Between Malocclusion Severity and Periodontitis Risk","Determination of the Relationship Between Orthodontic Malocclusion Severity and Periodontitis Risk Using RANKL, OPG and Oxidative Stress Markers","Inclusion Criteria:\n\n* Patients between the ages of 12 and 18,\n* Patients with all permanent teeth,\n* Not having taken antibiotics, steroids, and\u002For nonsteroidal anti-inflammatory drugs in the last 3 weeks,\n* Not having an active infectious disease,\n* Not having chronic medication use that affects periodontal tissues (cyclosporine A, Phenytoin),\n* Not having taken antioxidant supplements in the last 6 months.\n\nExclusion Criteria:\n\n* Presence of any congenital craniofacial deformity (cleft lip and palate or any other craniofacial syndrome or deformity),\n* Patients who have previously started or completed orthodontic treatment,\n* Patients who have received periodontal treatment in the last 6 months,\n* Acute illness,\n* Systemic illness, mental illness, immunosuppressive medications, or immunodeficiency.","12 Years",{"count":223,"type":22},70,"The goal of this observational study is to examine the potential relationship between the severity of orthodontic malocclusion and the risk of developing periodontitis in individuals by evaluating salivary and gingival crevicular levels of RANKL, osteoprotegerin (OPG), and oxidative stress biomarkers.\n\nThe main question it aims to answer is:\n\nDoes increasing severity of orthodontic malocclusion contribute to a higher risk of periodontitis through changes in RANKL\u002FOPG balance and oxidative stress levels?\n\nParticipants with different levels of tooth misalignment (malocclusion) will be examined to assess the condition of their teeth and gums. During this examination, information such as dental plaque, gum bleeding, and the depth of gum pockets will be recorded. In addition, fluid samples collected from the gums will be tested in the laboratory to measure certain biological substances and chemical markers related to the body's balance between harmful and protective effects. These measurements will be done using special laboratory tests.",[226],"Malocclusion",[228,62,229,230,32],"malocclusion","RANKL","Osteoprotegerin","2025-08-16",{"date":233,"type":39},"2025-08-22",{"date":210,"type":22},{"date":236,"type":22},"2026-01-19",{"name":45,"class":46},{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":243,"acronym":4,"eligibilityCriteria":244,"healthyVolunteers":11,"sex":17,"minAge":221,"maxAge":18,"enrollmentInfo":245,"targetDuration":108,"studyType":23,"phases":4,"briefSummary":246,"conditions":247,"keywords":248,"overallStatus":116,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":256,"leadSponsor":258,"locationsCount":47},"100601885","salivary-stress-markers-associated-with-malocclusion-severity-100601885","NCT07116317","Salivary Stress Markers Associated With Malocclusion Severity","Determination of the Relationship Between Orthodontic Malocclusion Severity and Salivary Cortisol, Dehydroepiandrosterone and Chromogranin A Levels","Inclusion Criteria:\n\n* Patients between the ages of 12 and 18,\n* Patients with all permanent teeth,\n* Patients with the ability to read and understand,\n* Patients with a cephalometric evaluation file and maxillary and mandibular impression dental models before diagnostic orthodontic treatment.\n\nExclusion Criteria:\n\n* Presence of any congenital craniofacial deformity (cleft lip and palate or any other craniofacial syndrome or deformity),\n* Patients who have previously initiated or completed orthodontic treatment,\n* Patients with a history of psychiatric illness, the presence of caries, facial asymmetry, and any skin deformity affecting facial aesthetics.",{"count":81,"type":22},"The aim of this observational study is to evaluate the relationship between the severity of orthodontic malocclusion and psychophysiological stress levels in individuals aged 12 to 18 years. The study will investigate the association between malocclusion severity and both stress-related salivary biomarkers and psychosocial factors.\n\nThe primary research question is as follows:\n\nAs the severity of orthodontic malocclusion increases, do levels of salivary stress biomarkers (cortisol, DHEA, and chromogranin A), self-esteem, and social appearance anxiety significantly change in adolescent individuals?\n\nMethod:\n\nThe study will include participants between the ages of 12 and 18. The severity of malocclusion will be assessed through clinical examination. Psychological assessments will be conducted using structured questionnaires to measure self-esteem and social appearance anxiety. In addition, saliva samples collected in the morning will be analyzed using the ELISA method to determine levels of cortisol, DHEA, and chromogranin A (CgA). The data will be statistically analyzed to identify the potential relationship between orthodontic malocclusion and biological and psychosocial indicators of stress.",[226],[228,249,203,250,251],"stress","Dehydroepiandrosterone","Chromogranin A","2025-08-08",{"date":254,"type":39},"2025-08-11",{"date":254,"type":22},{"date":257,"type":22},"2026-02-09",{"name":45,"class":46},""]