[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Region Östergötland\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":147},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,44,70,88,120],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100499386","chronic-coronary-syndrome-in-swedish-primary-care-100499386",false,"NCT05782582","Chronic Coronary Syndrome in Swedish Primary Care","COSPRI","Inclusion Criteria:\n\n• People who seek primary care for symptoms judged to be compatible with a medium probability (PTP\\> 15) for symptomatic chronic coronary artery disease.\n\nExclusion Criteria:\n\n* Suspicion of acute coronary syndrome when care is sought.\n* Previously diagnosed acute myocardial infarction\n* Revascularization with PCI\u002FCABG\n* Proven reversible ischemia according to myocardial scintigraphy.\n* Left Bundle Branch Block (LBBB).\n* Ventricular pacemaker\n* People whose meaning due to illness, mental disorder, weakened state of health or any other similar condition cannot be obtained, to be included in a research project.\n* Insufficient understanding of spoken and written Swedish language.","ALL","18 Years",{"count":19,"type":20},500,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this clinical trial is to learn about a new procedure for investigation of possible coronary heart disease and to see if it is faster, cheaper or more expensive, promotes healthier behavior, mental well-being, adherence to drugs for heart protection and the risk for cardiac events like acute myocardial infarction over years to come. The novelty in the procedure is that a myocardial perfusion scan to assess blood flow to areas of the heart muscle, echocardiography i.e., heart ultrasound and heart CT scan comes as a \"package investigation\" performed on the same day. According to existing routines, \"standard investigation\" an exercise stress bicycle test is done, as well as an echocardiography and if needed the work up is completed by a myocardial perfusion scan. The main questions the trial aims to answer are:\n\n* are the results from the procedure given to the patient faster with package investigation as compared to standard investigation?\n* does the cost differ between the package and standard investigation group?\n* does self-reported physical activity, physical fitness, dietary habits and mental well-being differ between the package and standard investigation group at start and after one, three and five years?\n* does prescription of drugs taken for heart protection and adherence to the prescribed drugs differ between the package and standard investigation group after two and five years?\n* does the risk for heart events like acute heart infarction differ between package and standard investigation after two and five years?\n\nPrimary health care centers in Region Östergötland are randomly assigned to use either the new or existing procedure for investigation of possible coronary heart disease a so called cluster randomization. Patients who consult a physician at any of these primary health care centers are potential participants in the trial and are informed about the trial by written information, as they get their appointment for the medical investigation at either of two hospitals in the Region Östergötland. When the patient comes to the hospital for the investigations, he or she is asked to give written consent to the research i.e., to answer questionnaires now after one, three and five years, to let the researchers take part of the medical records, investigational results and data from medical registries over time.",[26],"Coronary Artery Disease",[28,29,30],"Primary Health Care","Diagnostic Imaging","Myocardial Perfusion Imaging","RECRUITING","2026-01-28",{"date":34,"type":35},"2026-01-30","ACTUAL",{"date":37,"type":35},"2023-05-01",{"date":39,"type":20},"2032-12-31",{"name":41,"class":42},"Region Östergötland","OTHER",3,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":50,"eligibilityCriteria":51,"healthyVolunteers":52,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},"100542720","primecog-primary-care-cognitive-testing-100542720","NCT06346535","PrimeCog: Primary Care Cognitive Testing","PrimeCog: Cognitive Profile, Psychosocial Characteristics, Brain MRI and Biomarkers for Stress and Neurodegeneration in Patients With Depression or Stress Induced Exhaustion Disorder in Primary Care.","PrimeCog","Inclusion Criteria:\n\n1. adults 18 to 65 years old;\n2. fluent in Swedish;\n3. corrected to normal vision and hearing;\n4. (for cases), newly diagnosed with MDD or SED (i.e., received as new diagnosis at the visit to the physician) according to the diagnostic criteria from DSM-V (MDD) and the Swedish Board of Health and Welfare (SED)\n\nExclusion Criteria:\n\n1. already ongoing treatment for MDD\u002FSED or previous diagnosis of MDD\u002FSED within the last year;\n2. history of serious mental illness (defined as mental illness that has required psychiatric in-patient care);\n3. acute cerebrovascular event or severe head trauma in the last 6 months;\n4. known cognitive impairment;\n5. substance dependence, ongoing or past;\n6. motor disability or impairment affecting interaction with the digital tests;\n7. photosensitive epilepsy or -migraines.\n\nFor the MRI subgroup, any contraindication to MRI is an exclusion criterion.",true,"65 Years",{"count":55,"type":20},300,"OBSERVATIONAL","The PrimeCog study aims to describe the symptomatology and pathophysiology of stress-induced exhaustion disorder (SED) and major depressive disorder (MDD) compared to healthy controls (HC). The participants will be recruited at primary care centers, and samples of blood, saliva, and hair will be collected. Digital questionnaires covering psychosocial variables and screening instruments for the detection of depression, anxiety, etc., along with a digital cognitive test battery, will be performed at home. Subsequently, an MRI of the brain will be performed, and analysis of biomarkers for stress, inflammation, and neurodegeneration will be conducted. These procedures will be repeated after twelve and twenty-four months. The study will investigate differences in the biomarkers, neuroimaging findings, and cognitive abilities between patients with SED, MDD, and controls over time. Associations between the symptom severity of MDD\u002FSED and psychosocial variables, cognition, MRI, and the biomarkers will also be examined. The aim is to provide new diagnostic tools for differentiation between MDD and SED and guide individualized treatment based on underlying pathophysiology and cognitive function. All necessary competences for conducting this extensive study are represented within the research group. The PrimeCog study is unique in its comprehensive design, addressing knowledge gaps, and directly comparing these diagnoses over time in primary care, where patients are typically treated.",[59,60,28],"Mental Health Issue","Cognitive Symptom","2024-04-19",{"date":63,"type":35},"2024-04-23",{"date":65,"type":35},"2024-04-01",{"date":67,"type":20},"2029-04-01",{"name":41,"class":42},1,{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":76,"targetDuration":4,"studyType":21,"phases":77,"briefSummary":78,"conditions":79,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":82,"startDateStruct":83,"completionDateStruct":85,"leadSponsor":87,"locationsCount":69},"100487963","the-effects-of-primary-care-behavioral-health-in-primary-care-in-sweden-100487963","NCT05633940","The Effects of Primary Care Behavioral Health in Primary Care in Sweden","Patients:\n\nInclusion Criteria, one of following:\n\n* Adult patients who seek care for mental health problems at a participating centre,\n* Adult patients who have received any following International Classification of Diseases diagnose: F00-F99, Z56, Z73\n* Adult patients who are prescribed any psychotropic drugs with ATC codes: N05A-C, N06A) at a participating centre.\n* Adult patients who has an appointment to a behavioral health consultant at a participating centre.\n\nExclusion Criteria:\n\n• Not capable to leave informed consent.\n\nMedical staff:\n\nInclusion Criteria:\n\n• Health care professionals employed at a participating centre.\n\nExclusion Criteria:\n\n• Temporarily hired personnel, e.g. hired doctors or nurses on weekly basis.",{"count":19,"type":20},[23],"The novel multi-professional service delivery model \"Primary Care Behavioural Health\" (PCBH) has been suggested as an effective way to integrate behavioural health services into routine primary care to overcome the growing problems with psychosocial and mental health problems in primary care. In this multicenter mixed-methods pragmatic clinical trial, the implementation of PCBH in routine primary health care in a region in Sweden is investigated.",[28,80,81],"Mental Disorder","Behavioral Symptoms",{"date":63,"type":35},{"date":84,"type":35},"2021-01-01",{"date":86,"type":20},"2026-12-31",{"name":41,"class":42},{"id":89,"slug":90,"hasResults":11,"nctId":91,"briefTitle":92,"officialTitle":93,"acronym":94,"eligibilityCriteria":95,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":96,"targetDuration":4,"studyType":21,"phases":98,"briefSummary":99,"conditions":100,"keywords":104,"overallStatus":111,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":69},"100537312","digital-physiotherapy-treatment-for-patients-with-subacromial-pain-compared-to-usual-physiotherapy-in-primary-care-100537312","NCT06276192","Digital Physiotherapy Treatment for Patients With Subacromial Pain Compared to Usual Physiotherapy in Primary Care","Digital Physiotherapy Treatment for Patients With Subacromial Pain Compared to Traditional Physiotherapy Treatment in Primary Care - a Non-Inferiority Randomised Controlled Trial","diSAID","Inclusion Criteria:\n\n* \\>18 years old\n* Pain duration \\>2 weeks\n* Lateral shoulder pain (C5 dermatome)\n\nAt least three positive tests as follows:\n\n* Painful arc\n* External rotation resistance test\n* Jobe's test\n* Neer's impingement sign\n* Hawkin's-Kennedy's impingement test\n\nExclusion Criteria:\n\n* Symptoms are related to a traumatic event in the last 6 months with suspected rotator cuff tear, dislocation or fracture.\n* Clinical features of cervical radiculopathy\n* Clinical features of Adhesive capsulitis\n* The patient does not understand or can not read Swedish\n* The patient has no access to BankID",{"count":97,"type":20},120,[23],"The goal of this clinical trial is to test a digital treatment for patients with subacromial pain using the digital Shoulder Aid (diSAID) strategy. The participants in this study will be randomly assigned to digital treatment (diSAID) or to receive the treatment that is currently available in primary care, i.e. continue according to usual practice.\n\nThe main question this clinical trial aims to answer are:\n\n\\- Can the diSAID improve shoulder function and reduce pain for patients with subacromial pain in primary care?",[101,102,103],"Subacromial Pain Syndrome","Shoulder Pain","Rotator Cuff Syndrome",[105,106,107,108,109,110],"Shoulder pain","Subacromial pain","Digital care","Digital health intervention","Physiotherapy","Primary care","NOT_YET_RECRUITING","2024-02-18",{"date":114,"type":35},"2024-02-23",{"date":116,"type":20},"2024-02-26",{"date":118,"type":20},"2028-03-26",{"name":41,"class":42},{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":130,"conditions":131,"keywords":133,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":139,"lastUpdatePostDateStruct":140,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":69},"100524927","cardiac-hemodynamics-during-left-ventricular-assist-100524927","NCT06115096","Cardiac Hemodynamics During Left Ventricular Assist","Exploration of Intracardiac Geometry and Hemodynamics During HeartMate 3 Therapy: A Novel Approach Using Photon-Counting CT and Computational Fluid Dynamics","FlowVAD","Inclusion Criteria:\n\n* Connected to Linköping University Hospital ((situated in the Swedish Southeastern healthcare region)\n* Treatment with HeartMate 3 and implanted for \\> 6 months ago\n* Age \\>18 years.\n\nExclusion Criteria:\n\n* Reduced kidney function (eGFR below 45 ml\u002Fmin\u002F1.73m2).\n* Known iodine contrast allergy\n* In case of untreated manifest hyperthyroidism\n* In case of suspected\u002Fnewly diagnosed thyroid cancer where radioiodine examination\u002Ftreatment may be relevant\n* Myasthenia Gravis\n* Ongoing pregnancy",{"count":129,"type":20},35,"The goal of this observational study is to exploratively investigate intracardiac geometry and hemodynamics in patients with ongoing HeartMate 3-therapy in the Swedish Southeast Healthcare region. The main question it aims to answer is:\n\n\\- How do different flow levels in the HeartMate 3 left ventricular assist system influence intracardiac geometry and hemodynamics?\n\nParticipating research subjects are called upon to undergo three followed photon-counting CT scans, as well as certain echocardiographic imaging, all in one session. The research subject's HeartMate device is connected to software that allows for variations in the pump's flow between these image collections. Analyzed variables includes three-dimensional geometry, CFD-computed parameters such as blood velocity, pressure, turbulence, and blood stasis. The variables are related with device settings and, alongside, selected echocardiographic measurements and patient details such as age, BMI, and diagnostic codes for both method validation and comprehensive perspective.",[132],"Heart Failure",[134,135,136,137,138],"Left ventricular assist device (LVAD)","Computed tomography (CT)","Photon-counting Computed tomography (PCCT)","Hemodynamics","Computational fluid dynamics (CFD)","2023-10-30",{"date":141,"type":35},"2023-11-02",{"date":143,"type":35},"2023-03-01",{"date":145,"type":20},"2030-01-01",{"name":41,"class":42},""]