[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Reproductive & Genetic Hospital of CITIC-Xiangya\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":43},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100633972","prospective-international-multi-center-clinical-trial-of-pgt-a-upgrade-100633972",false,"NCT07533630","Prospective International Multi-center Clinical Trial of PGT-A Upgrade","Efficacy of PGT-A Upgrade in Preimplantation Genetic Testing of Embryos: An International Multicenter Prospective Clinical Study","Inclusion Criteria:\n\n(1) Any one of the following conditions being met is sufficient:\n\n1. advanced maternal age (AMA, age ≥35 years),\n2. recurrent implantation failure (RIF),\n3. recurrent miscarriage (RM),\n4. severe male factor (SMF). (2) And at least one blastocyst is available.\n\nExclusion Criteria:\n\n1. Couples undergoing PGT-SR due to chromosomal structural abnormalities carried by either one or both members, such as balanced translocations, Robertsonian translocations, inversions, complex chromosomal rearrangements, and pathogenic microdeletions or microduplications;\n2. Couples undergoing PGT-M;\n3. Conditions with established impact on uterine morphology or endometrial receptivity, including untreated uterine malformations (septate uterus, unicornuate uterus, didelphic uterus, etc.) and untreated hydrosalpinx;\n4. Embryos coming from oocyte or sperm (gametes) donation;\n5. Individuals with contraindications to pregnancy or assisted reproduction technology.","FEMALE","20 Years","46 Years",{"count":20,"type":21},1700,"ESTIMATED","OBSERVATIONAL","The goals of this international multicenter cross-sectional study are:\n\n1. To provide patients with a comprehensive PGT solution capable of simultaneously detecting embryonic chromosomal aneuploidy, mosaicism, microdeletions\u002F microduplications, heteroploidy, and heterozygosity (LOH) in a single assay, thereby reducing miscarriage and birth defects;\n2. To perform PGT analysis on abnormally fertilized embryos, select euploid embryos with normal ploidy, and calculate embryo utilization rates;\n3. To reduce the false-positive rate through confirmation of mosaic embryos and subsequent analysis of its origin, thereby minimizing embryo wastage;\n4. To provide molecular genetic evidence for expert consensus on clinical management of atypically fertilized embryos, of pathogenic\u002Flikely pathogenic small CNVs, optimize mosaic embryo transfer strategies, and inform preconception intervention;\n5. To enhance international PGT testing standards through international multi-center collaboration.\n\nThe study will enroll patients undergoing PGT-A from seven domestic and international centers, with patient enrollment expected to be completed within one year. PGT-A upgrade testing will be performed on embryos from enrolled patients, and the incidence rates of Incidence of microdeletions\u002Fmicroduplications, heteroploidy, LOH will be statistically analyzed. All patients who undergo embryo transfer will be followed up for clinical outcomes and birth defects.",[25],"Infertility Assisted Reproductive Technology",[27,28,29],"Preimplantation Genetic Testing for Aneuploidies","Mosaic embryos","Microdeletions\u002Fmicroduplications","NOT_YET_RECRUITING","2026-04-09",{"date":33,"type":34},"2026-04-16","ACTUAL",{"date":36,"type":21},"2026-05",{"date":38,"type":21},"2028-08",{"name":40,"class":41},"Reproductive & Genetic Hospital of CITIC-Xiangya","OTHER",7,""]