[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Research Center Borstel\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":179},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,42,70,98,128,153],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":22,"conditions":23,"keywords":25,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100645123","tuberculosis-clinical-registry-in-europe-100645123",false,"NCT07677904","Tuberculosis Clinical Registry in Europe","Tuberculosis Clinical Registry in Europe - the TBnet Registry","Inclusion Criteria:\n\n* Diagnosis of Tuberculosis\n* Age ≥ 18 years\n* Capacity to provide informed consent\n* Written informed consent to participate in the study\n\nExclusion Criteria:\n\n* Lack of capacity to provide informed consent\n* Age \\\u003C 18 years","ALL","18 Years",{"count":19,"type":20},1000,"ESTIMATED","OBSERVATIONAL","The TBnet registry is a multinational, prospective tuberculosis registry established by the Tuberculosis Network European Trialsgroup (TBnet e.V.) to collect and analyze long-term data from TB patients across Europe. Its purpose is to centralize data on TB epidemiology, prevention, diagnosis, and treatment to improve care, support research, and ultimately help eliminate TB. The registry captures risk factors, diagnostic details (e.g., microbiology, imaging, drug resistance), treatment data, side effects, outcomes, and late complications.",[24],"Tuberculosis",[26,27,28],"registry","extrapulmonary tuberculosis","PTLD","NOT_YET_RECRUITING","2026-06-24",{"date":32,"type":33},"2026-07-01","ACTUAL",{"date":35,"type":20},"2026-07",{"date":37,"type":20},"2040-12",{"name":39,"class":40},"Research Center Borstel","OTHER",2,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":51,"conditions":52,"keywords":57,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":41},"100622691","investigation-of-the-effects-of-oxidized-antigens-on-the-t-cell-response-and-the-epigenetic-reprogramming-of-neutrophils-in-lung-diseases---oxigene---100622691","NCT07386912","Investigation of the Effects of Oxidized Antigens on the T-Cell Response and the Epigenetic Reprogramming of Neutrophils in Lung Diseases - OXIGENE -","OXIGENE","Inclusion Criteria:\n\n* Diagnosis of an acute or chronic inflammatory lung disease, infectious or non-infectious, including asthma, COPD, pneumonia, tuberculosis, or viral pulmonary infection (e.g., COVID-19, influenza).\n* Age ≥ 18 years at the time of informed consent.\n* Ability to provide informed consent and consent to the collection and processing of clinical and laboratory data, as well as to the analysis of blood samples as part of study participation.\n* Sufficient physical condition to undergo a single venous blood draw (approximately 50 mL), as assessed by the treating physician.\n\nExclusion Criteria:\n\n* Active malignant disease or ongoing cancer therapy (e.g., chemotherapy or immunotherapy), due to potential immunological confounding.\n* Immunosuppressive therapy or known severe immunodeficiency that could interfere with the interpretation of cellular immune responses.\n* Pregnancy or breastfeeding, for general research-ethical reasons and to protect vulnerable populations.\n* Acute unstable clinical condition that, in the opinion of the treating physician, makes study participation unreasonable.\n* Known intolerance to blood sampling or relevant hematological disorders that could compromise the safety or feasibility of venipuncture.\n* Lack of capacity to provide informed consent or insufficient understanding of the study content despite supportive explanation.",{"count":50,"type":20},100,"The OXIGENE study is a research project that aims to better understand how the immune system behaves in people with lung diseases such as asthma, COPD, pneumonia, tuberculosis, and viral lung infections. By analyzing a single blood sample, the study examines how certain immune cells react during inflammation and infection, and whether lasting changes in these cells influence how strongly the body responds to disease. Although participants do not receive direct medical benefit, the results may help improve future diagnosis and treatment of lung diseases by providing deeper insight into immune responses.",[53,54,55,56,24],"Asthma","COPD","Bacterial Pneumonia","Viral Pneumonia",[58,59,60,61],"neutrophil granulocytes","epigenome","oxidation","antigens","2026-01-27",{"date":64,"type":33},"2026-02-04",{"date":66,"type":20},"2026-02-01",{"date":68,"type":20},"2030-12",{"name":39,"class":40},{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":79,"conditions":80,"keywords":85,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":97,"locationsCount":41},"100621345","environmental-reservoirs-of-non-tuberculous-mycobacteria-in-cystic-fibrosis-households-a-case-control-study-of-exposure-risk-at-home-100621345","NCT07369414","Environmental Reservoirs of Non-tuberculous Mycobacteria in Cystic Fibrosis Households: A Case-control Study of Exposure Risk at Home","NTMecoCF","Inclusion Criteria:\n\n* Confirmed diagnosis of cystic fibrosis (CF)\n* No age restriction (including minors with consent from legal guardians)\n* Written informed consent to participate in the study (or consent provided by a legal guardian for minors)\n* In the case of an NTM infection: diagnosis according to ATS\u002FIDSA criteria and availability of a clinical NTM isolate\n\nExclusion Criteria:\n\n* Lack of capacity to provide informed consent, refusal to participate, or withdrawal of informed consent",{"count":78,"type":20},120,"This multicenter, non-interventional case-control study investigates whether household environmental reservoirs, particularly water systems, are associated with non-tuberculous mycobacterial (NTM) infections in people with cystic fibrosis. Environmental samples from the homes of CF patients with and without NTM infection will be analyzed and genetically compared with available clinical isolates, alongside assessment of environmental risk factors, to improve understanding of exposure pathways and inform future prevention strategies.",[81,82,83,84],"Cystic Fibrosis (CF)","Mucoviscidosis","Non-Tuberculous Mycobacteria","Mycobacterium Abscessus Infection",[86,87,88,89,90],"Environmental reservoirs","Household water systems","Microbial exposure","Whole-genome sequencing","Environmental risk factors","RECRUITING","2026-01-16",{"date":62,"type":33},{"date":95,"type":20},"2026-01",{"date":68,"type":20},{"name":39,"class":40},{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":107,"conditions":108,"keywords":109,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":127},"100602573","sputum-free-diagnostis-of-tb-100602573","NCT07125274","Sputum-free Diagnostis of TB","Biomarker-guided Diagnosis of Tuberculosis","TB_Diagnostics","Inclusion Criteria:\n\n* Suspected pulmonary or extrapulmonary tuberculosis, or confirmed pulmonary or extrapulmonary tuberculosis with less than 7 days of anti-tuberculosis treatment, OR other pulmonary infection (control group).\n* Age ≥ 18 years\n* Ability to provide informed consent\n* Willingness to participate in the study\n\nExclusion Criteria:\n\n* Lack of ability to provide informed consent\n* Age \\\u003C 18 years\n* Pregnancy",{"count":50,"type":20},"The aim of this study is to identify new biomarkers that enable reliable, non-invasive diagnosis of tuberculosis (TB), including in patients who are unable to produce sputum. The study analyzes biomaterials (blood, urine, stool, sputum) collected from patients with suspected TB. Various diagnostic methods are applied to assess the feasibility of individual and combined biomarker tests.\n\nParticipating patients will provide biomaterial samples (blood, urine, stool, sputum) once. No additional examinations or invasive procedures will be performed. Routine diagnostic procedures remain unaffected.\n\nThis is a single-center, prospective observational study. Patients are enrolled as part of their clinical care at the University Medical Center Hamburg-Eppendorf.",[24],[110,111,112,113,114,115,116,117,118],"TB","diagnostics","sputum","sputum-free","transcriptomic","pathfast","CRISPR","stool","PCR","2025-08-12",{"date":121,"type":33},"2025-08-15",{"date":123,"type":33},"2025-06-06",{"date":125,"type":20},"2026-12",{"name":39,"class":40},1,{"id":129,"slug":130,"hasResults":11,"nctId":131,"briefTitle":132,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":136,"targetDuration":4,"studyType":21,"phases":4,"briefSummary":138,"conditions":139,"keywords":141,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":152},"100603073","treatment-monitoring-for-ntm-infections-with-a-symptom-diary-100603073","NCT07131774","Treatment Monitoring for NTM Infections With a Symptom Diary","Evaluation of a Diary for Assessing Treatment Outcomes in Patients With Pulmonary Infections Caused by Nontuberculous Mycobacteria (NTM)","NTMdiary","Inclusion Criteria:\n\n* Pulmonary NTM infection according to ATS\u002FIDSA criteria (1)\n* Age ≥ 18 years\n* Ability to provide informed consent\n* Willingness to participate in the study AND\n* Clinical decision to initiate antimicrobial therapy as part of routine care\n\n  * Cohort 1 OR\n* Clinical decision against antimicrobial therapy as part of routine care\n\n  * Cohort 2\n\nExclusion Criteria:\n\n* Lack of ability to provide informed consent\n* Language barriers that prevent completion of the diary\n* Antimicrobial therapy for the NTM infection already initiated",{"count":137,"type":20},200,"The primary aim of the study is to investigate the correlation between patient-reported symptoms recorded in the diary and the microbiological and radiological disease course in patients with pulmonary infections caused by nontuberculous mycobacteria (NTM).",[140],"Non-Tuberculous Mycobacterial (NTM) Infections",[142,143,144],"symptom diary","microbiology","radiology",{"date":146,"type":33},"2025-08-20",{"date":148,"type":33},"2025-07-11",{"date":150,"type":20},"2026-06",{"name":39,"class":40},3,{"id":154,"slug":155,"hasResults":11,"nctId":156,"briefTitle":157,"officialTitle":157,"acronym":158,"eligibilityCriteria":159,"healthyVolunteers":160,"sex":16,"minAge":161,"maxAge":162,"enrollmentInfo":163,"targetDuration":164,"studyType":21,"phases":4,"briefSummary":165,"conditions":166,"keywords":167,"overallStatus":91,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":127},"100578768","improving-the-outcomes-of-children-with-tuberculosis-through-innovative-diagnostics-and-treatment-monitoring-100578768","NCT06815588","Improving the Outcomes of Children With Tuberculosis Through Innovative Diagnostics and Treatment Monitoring","RoGer Pedi","Inclusion criteria\n\n* Children under 15 years evaluated for respiratory TB.\n* Signature of the informed consent form by the parent\u002Fguardian and assent form by the child if applicable.\n\nExclusion criteria\n\n\\- Refusal to sign informed consent",true,"0 Years","14 Years",{"count":50,"type":20},"9 Months","This study aims at identifying and evaluating novel diagnostic methods for children evaluated for respiratory tuberculosis. The investigators will use alternative samples like stool, urine, and masks to diagnose children with respiratory tuberculosis. Once diagnosed, the investigators will use target next generation sequencing to determine if the bacillus is resistant to any of the drugs used for treatment. Additionally, children initiated under TB treatment will be followed-up during treatment to measure blood biomarkers for outcome prediction. Finally, spirometry will be performed longitudinally until 3 months after the end of treatment to assess the lung capacity of children treated for respiratory TB. All children initiated on TB treatment will fill in a quality of life questionnaire.",[24],[168,169,170],"pediatric TB","non-sputum diagnosis","post TB lung disease","2025-02-03",{"date":173,"type":33},"2025-02-07",{"date":175,"type":33},"2024-09-15",{"date":177,"type":20},"2026-03-30",{"name":39,"class":40},""]