[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Research Center of Periodontal-Systemic Interactions\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":41},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100630759","oral-periodontal-evaluation-and-assessment-of-oral-fluid-biomarkers-in-patients-with-hepatitis-bd-100630759",false,"NCT07491848","Oral-Periodontal Evaluation and Assessment of Oral Fluid Biomarkers in Patients With Hepatitis B+D","Oral-Periodontal Evaluation and Assessment of Biomarkers in Oral Fluids in Patients With Hepatitis B+D Treated With Bulevirtide","Inclusion Criteria:\n\n* Adults (≥18 years old) capable of providing informed consent.\n* For Hepatitis B+D groups: confirmed hepatitis B and D co-infection.\n* Bulevirtide group: receiving bulevirtide therapy as prescribed.\n* No Bulevirtide group: not receiving bulevirtide.\n* For Healthy Control group: systemically healthy adults without hepatitis B or D infection.\n* Willingness to undergo oral-periodontal examination, saliva and gingival crevicular fluid collection, and oral cavity photography.\n\nExclusion Criteria:\n\n* Patients with other systemic diseases that could influence periodontal health (e.g., uncontrolled diabetes, autoimmune diseases).\n* Patients currently receiving other experimental therapies that may affect oral or systemic inflammation.\n* Pregnancy or lactation.\n* Inability or unwillingness to provide informed consent.\n* History of oral or periodontal surgery within the last 6 months that could affect measurements.",true,"ALL","18 Years",{"count":20,"type":21},25,"ESTIMATED","OBSERVATIONAL","Periodontal disease is a chronic inflammatory condition associated with systemic diseases, highlighting the concept of periodontal medicine. This study aims to investigate the relationship between periodontal inflammation, oral lesions, and hepatitis B+D infection, with or without bulevirtide treatment. Oral-periodontal clinical parameters and targeted inflammatory biomarkers in saliva and gingival crevicular fluid will be evaluated in three groups: patients with hepatitis B+D receiving bulevirtide, patients with hepatitis B+D not receiving bulevirtide, and healthy controls.",[25,26,27],"HEPATITIS B CHRONIC","Hepatitis D","Periodontitis","RECRUITING","2026-03-19",{"date":31,"type":32},"2026-03-25","ACTUAL",{"date":34,"type":32},"2026-02-15",{"date":36,"type":21},"2027-02-15",{"name":38,"class":39},"Research Center of Periodontal-Systemic Interactions","OTHER",2,""]