[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Reuth Rehabilitation Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":77},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100605747","symptom-exacerbation-following-mental-imagery-in-patients-with-persistent-post-concussive-symptoms-100605747",false,"NCT07166536","Symptom Exacerbation Following Mental Imagery in Patients With Persistent Post-Concussive Symptoms","Characterization of Headache and Dizziness Exacerbation Following Mental Imagery in Patients With Persistent Post-Concussive Symptoms","Inclusion Criteria:\n\n1. Current patients of Reut Rehabilitation Hospital or individuals who were discharged from the hospital within the past 12 months.\n2. Diagnosis of mild Traumatic Brain Injury, concussion, blast injury, or cervical whiplash injury.\n3. More than 3 months since the event.\n4. Presence of headaches and\u002For dizziness that began after the injury and have persisted continuously or intermittently.\n5. Exclusion of other potential causes of headaches, such as non-healed fractures, chronic inflammation\u002Finfection, increased intracranial pressure, or meningeal injury.\n6. Headache intensity of at least 3\u002F10 on the VAS scale.\n\nExclusion Criteria:\n\n1. Significant cognitive impairment preventing informed consent (Mini-Mental State Examination score \\\u003C20 or Montreal Cognitive Assessment score \\\u003C20, as per IRB requirements).\n2. Diagnosed central neurological conditions such as multiple sclerosis, Parkinson's disease, stroke, or brain tumor.\n3. Presence of known pyramidal or extrapyramidal neurological signs.\n4. Significant language impairment interfering with communication.\n5. Psychiatric disorders significantly affecting communication.\n6. Use of vestibular-suppressant medication (e.g., Cinnarizine) with an inability or unwillingness to discontinue treatment 24 hours prior to testing.\n\nWithdrawal Criteria:\n\n1\\. Oculomotor dysfunction affecting multiple oculomotor functions.","ALL","18 Years","70 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","Background: Mild Traumatic Brain Injury (mTBI) often results in persistent emotional, cognitive, and somatic symptoms-such as headaches and dizziness. These symptoms impose a significant burden, yet their underlying mechanisms remain unclear.\n\nPredictive processing theories suggest that persistent symptoms may result from learned perceptual errors, particularly in individuals with high negative affectivity. This framework may help explain ongoing persistent post-concussive symptoms (PPCS) in the absence of identifiable pathology, which have been linked to various psychological factors.\n\nMental imagery (MI) is thought to engage similar predictive processes. There is evidence that MI of symptom-triggering movements may exacerbate symptoms in individuals with chronic somatic conditions. However, this phenomenon has not been studied in PPCS patients. Investigating symptom provocation through MI may yield novel insights into the neuropsychological mechanisms sustaining PPCS and potentially contribute to the development of therapeutic tools for this population.\n\nObjectives:\n\n1. Documenting the exacerbation of headache and dizziness following provocative mental imagery (imagery of movements or scenarios that elicit these symptoms in real life) in patients with PPCS.\n2. Comparing changes in headache and dizziness after provocative MI versus neutral MI (imagery of movements or scenarios that do not elicit these symptoms in real life).\n3. Comparing patients who experience symptom exacerbation following mental imagery to those who do not.\n4. Describing associations between symptom exacerbation and negative affectivity, anxiety, depression, catastrophizing, and lower daily functioning.\n\nMethods: A cross-sectional study will be conducted on adult patients experiencing PPCS following mTBI. Participants will be recruited through convenience sampling from a computerized hospital database of Reuth Rehabilitation Hospital, based on inclusion and exclusion criteria.\n\nAfter signing an informed consent form, participants will be invited to attend 2 to 3 sessions, each lasting 1 to 2 hours. During these sessions, a licensed physiotherapist will conduct a comprehensive clinical assessment, including: Completion of self-report questionnaires; A vestibular examination; Anamnestic interview and clinical assessment of individual movement- and scenario-related triggers for dizziness and headaches; Symptom provocation testing using mental imagery of the identified triggers.",[27,28,29],"Mild Traumatic Brain Injury, Concussion","Post Concussive Syndrome, Chronic","Post Traumatic Headache",[31,32,33,34],"mild traumatic brain injury","Persistent Post-Concussion Symptoms","mental imagery","concussion","RECRUITING","2026-04-09",{"date":38,"type":39},"2026-04-14","ACTUAL",{"date":41,"type":39},"2025-09-07",{"date":43,"type":21},"2026-12-31",{"name":45,"class":46},"Reuth Rehabilitation Hospital","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":16,"minAge":54,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":47},"100626912","efficacy-and-safety-of-6degrees-mymove-interactive-virtual-reality-compared-to-passive-virtual-reality-in-subacute-stroke-and-traumatic-brain-injury-rehabilitation-a-randomized-controlled-trial-100626912","NCT07441798","Efficacy and Safety of 6Degrees MyMove Interactive Virtual Reality Compared to Passive Virtual Reality in Subacute Stroke and Traumatic Brain Injury Rehabilitation: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Time since neurological event: At least 2 weeks post-stroke or post-head injury.\n2. Motor impairment: Upper extremities: Presence of hemiparesis without complete paralysis. Participants receiving rehabilitation focused on functional transfer to the contralateral hand using compensatory or adaptive motor learning strategies will also be eligible. Lower extremities: Presence of partial voluntary movement sufficient to allow participation in rehabilitation training.\n3. Cognitive ability: Sufficient cognitive capacity to understand instructions and engage with VR-based training, as determined by the principal investigator and\u002For treating physician.\n4. Medical stability: Medically stable condition allowing participation in the training.\n5. Informed consent: Ability to provide written informed consent personally or via a legal guardian.\n6. Final eligibility will be determined by the principal investigator\u002F treating physician.\n\nExclusion Criteria:\n\n1. Severe cognitive or language impairment: Cognitive deficits or language comprehension impairments that prevent safe and meaningful participation.\n2. Neurological deficits interfering with VR: Severe hemispatial neglect or visual field deficits that interfere with VR use. Moderate neglect may be permitted at the investigator's discretion.\n3. Medical contraindications:\n\n   * Uncontrolled epilepsy\n   * Severe vestibular or vertigo disorders","40 Years",{"count":20,"type":21},[24],"Stroke and traumatic brain injury frequently result in persistent upper and lower limb motor impairment. While conventional rehabilitation improves outcomes, patient adherence and training intensity remain limiting factors. Immersive virtual reality (VR)-based therapy may enhance neuroplasticity by delivering high-intensity, task-oriented motor practice with enriched sensory feedback.\n\nThis randomized controlled trial evaluates the efficacy and safety of the 6Degrees MyMove interactive VR system compared to passive VR exposure in individuals undergoing subacute inpatient rehabilitation after stroke or traumatic brain injury. Sixty participants will be randomized 1:1 to receive either interactive VR-based motor training or passive VR viewing, in addition to standard rehabilitation care, three times weekly for eight weeks.\n\nThe primary objective is to determine whether interactive VR leads to greater improvement in motor function compared to passive VR. Secondary outcomes include dexterity, gait speed, functional independence, psychological status, adherence, usability, and safety.",[59,60],"TBI Traumatic Brain Injury","CVA (Cerebrovascular Accident)",[62,63,64,65,66,67],"Virtual Reality Therapy","Upper Limb Rehabilitation","Stroke Rehabilitation","Fugl-Meyer Assessment","Neurorehabilitation","Wearable Motion Sensors","NOT_YET_RECRUITING","2026-02-24",{"date":71,"type":39},"2026-03-02",{"date":73,"type":21},"2026-03-18",{"date":75,"type":21},"2028-12-31",{"name":45,"class":46},""]