[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Richard Fatica\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":46},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":5},"100627864","metabolic-impacts-of-ren-nu-a-dietary-program-for-polycystic-kidney-disease-100627864",false,"NCT07454174","Metabolic Impacts of Ren-Nu: A Dietary Program for Polycystic Kidney Disease","Short-Term Metabolic Impacts of Ren-Nu: A Dietary Program for Individuals With Polycystic Kidney Disease","PKD-KETO","Inclusion Criteria:\n\n* Adult (18 years or older)\n\n  * Diagnosis of ADPKD by a physician.\n  * Estimated glomerular filtration rate (eGFR) ≥ 30 mL\u002Fmin\u002F1.73 m2 at screening using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.\n  * Appropriate control of blood pressure (i.e. entry reading \\\u003C140\u002F90) including the use of BP medications for diagnosis of hypertension.\n  * BMI ≥ 25 (accounting for muscle mass)\n  * Own an at-home blood pressure monitor (no brand requirements)\n  * Able to complete study-related activities (e.g., attend online classes, complete questionnaires, and proper use of medical devices)\n\nExclusion Criteria:\n\n* Intolerance or allergy to any of the ingredients in the provided medical food\n\n  * Severe or rare underlying health conditions may cause a safety risk when taking the medical food. Those underlying health conditions will be assessed by the enrolling physician and include but are not limited to:\n\n    * History of hyperkalemia\n    * Heart failure\n    * Liver cirrhosis\n    * Chronic kidney disease stage 4 or greater, or other renal condition that severely impairs bone mineral homeostasis.\n    * HIV infection\n    * Chronic drug or alcohol abuse\n    * Chronic malabsorption syndrome\n    * Malignancy (non-melanoma skin cancer exempted)\n    * Autoimmune disease\n    * Pregnant, planning to be pregnant, or nursing during the course of the study\n    * Chronic history of recurrent urinary tract infections (UTI) (≥ 3 UTIs per year)\n    * Diagnosis of aneurysm\n    * Indigestion due to hypochlorhydria (low stomach acid)\n    * Any other condition, that in the opinion of the enrolling physician, makes the subject an unsuitable candidate for the study.\n  * Current use of any of the following medications or supplements which could affect safety or compliance with this study:\n\n    * The medical food, KetoCitra®.\n    * Urine alkalizing agents such as sodium bicarbonate or potassium citrate\n    * Citrate treatments\n    * Immunosuppressive treatment\n    * Tolvaptan\n    * Potassium-sparing diuretics\n    * Somatostatin analogs\n    * Aluminum-containing supplements or medications such as aluminum antacids (e.g. Maalox) or aluminum-based phosphate binders.\n    * SGLT2 inhibitors\n  * Participation in another therapeutic intervention trial.\n  * Following a highly specialized or extreme diet that is incompatible with the interventional nutrition program (e.g. carnivore, very high protein diet for elite athletes, etc.)\n  * Food sensitivities or allergies that are incompatible with the interventional nutrition program.\n  * The subject is already adhering to a form of a ketogenic diet or related fasting regimen.\n  * Current or past history of disordered eating or feeding behaviors.\n  * History of gastric bypass.\n  * Active diagnosis of ulcerative colitis, Irritable Bowel Syndrome, Crohn's, or Gallbladder Disease.","ALL","18 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","This is a 16 week pilot study of the impact of a nutritionist led ketogenic diet (Ren-Nu) supplemented with the medical food KetoCitra on autosomal dominant polycystic kidney disease.",[27],"Autosomal Dominant Polycystic Kidney Disease (ADPKD)",[29,30,31,32,33],"ADPKD","polycystic kidneys","Ren-Nu","KetoCitra","Keto diet","RECRUITING","2026-03-03",{"date":37,"type":38},"2026-03-06","ACTUAL",{"date":40,"type":38},"2026-02-25",{"date":42,"type":21},"2028-02",{"name":44,"class":45},"Richard Fatica","OTHER",""]