[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Riphah International University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":589},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,468,0,25,[9,40,64,96,124,150,174,199,225,245,264,287,311,332,353,377,401,419,444,464,486,508,530,552,571],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":39},"100644722","safety-and-efficacy-of-hemoglobin-f-inducers-in-patients-with-beta-thalassemia-100644722",false,"NCT07673302","Safety and Efficacy of Hemoglobin F Inducers in Patients With Beta Thalassemia","Safety and Efficacy of Hemoglobin F Inducers in Patients With Beta Thalassemia: a Prospective 12 Months Study","Inclusion criteria:\n\n* Confirmed diagnosis of Beta thalassemia Major (BTM) ascertained by Hemoglobin Electrophoresis or HPLC report performed pre-transfusion or genetic testing profile (comprising PCR or HBB gene sequencing) suggestive of β-thalassemia syndrome.\n* All ages and both genders will be included\n* Written informed consent\n\nExclusion criteria:\n\n* Pregnancy or unwilling to follow contraception or planning conception (Enrolled female patients will be strictly advised to avoid pregnancy during the study period and until 6 months after thalidomide withdrawal.\n* Hemoglobinopathies other than beta thalassemia\n* History of neurological problems\n* Inability to regularly follow up","ALL",{"count":19,"type":20},240,"ESTIMATED","INTERVENTIONAL",[23],"NA","The aim of this study is to determine the safety and therapeutic effect of HbF inducers (combination therapy: thalidomide and hydroxyurea) on beta thalassemia patients. The main objectives of this study are:\n\n* To determine the therapeutic efficacy of HbF inducers (combination therapy: thalidomide and hydroxyurea) on hemoglobin level and blood transfusion in beta thalassemia patients.\n* To determine the safety of HbF inducers (combination therapy: thalidomide and hydroxyurea) in beta thalassemia patients\n* To determine effect of HbF inducers (combination therapy: thalidomide and hydroxyurea) on quality of life of beta thalassemia patients",[26],"Thalassemia","NOT_YET_RECRUITING","2026-06-23",{"date":30,"type":31},"2026-06-29","ACTUAL",{"date":33,"type":20},"2026-06-20",{"date":35,"type":20},"2027-06-19",{"name":37,"class":38},"Riphah International University","OTHER",1,{"id":41,"slug":42,"hasResults":12,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":4,"eligibilityCriteria":46,"healthyVolunteers":12,"sex":17,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":21,"phases":51,"briefSummary":52,"conditions":53,"keywords":55,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":58,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":39},"100644666","comparative-effect-of-cimt-and-pnftechnique-on-hands-dexterity-in-cerebral-palsy-100644666","NCT07673289","Comparative Effect of CIMT and PNFTechnique on Hands Dexterity in Cerebral Palsy","Comparative Effect of Constraint Induced Movement Therapy and Proprioceptive Neuromuscular Facilitation Technique on Hands Dexterity in Cerebral Palsy","Inclusion Criteria:\n\n* 8 to 13 years of age\n* Both male and female\n* Children with moderate level of mental retardation who are able to follow commands\n\nExclusion Criteria:\n\n* Children with other musculoskeletal and neurological issues.\n* Children who have complications such as epilepsy, congenital heart condition","8 Years","13 Years",{"count":50,"type":20},26,[23],"Cerebral Palsy (CP) is a group of permanent disorders of the development of movement and posture, causing activity limitations that are attributed to non-progressive disturbances that occurred in the developing fetal or infant brain. The primary motor impairments in CP often include issues with muscle tone, reflexes, and coordination. Among the various motor disorders associated with CP, impairment of the upper extremities is particularly common and functionally debilitating. Specifically, reduced hand dexterity the ability to perform coordinated, fine motor tasks significantly impacts a child's independence in daily activities such as feeding, dressing, and school-related tasks like writing. Therefore, improving hand function is a critical goal in physiotherapy for this population The objective of this study was to compare the effectiveness of a constraint induced movement therapy ( CIMT ) and Proprioceptive neuromuscular facilitation technique on dexterous movement of hands in cerebral palsy .The study design will be Randomized Controlled Trail. The study setting will be Pediatric Rehabilitation Center or Physiotherapy Department. The duration of study will be 10 months after approval of synopsis. The sample size will be 20 which is calculated by epitools. The sampling technique will be Non-probability convenient sampling . Children who are diagnosed with cerebral palsy will be included. Children with other musculoskeletal and neurological issues will be excluded. Data Collection Tools will be Box and Block test and Pediatric Evaluation of Disability Inventory.. The data will be analyzed using SPSS 23.\n\nKeyword Cerebral Palsy, Constraint induced movement therapy (CIMT), dexterous movement, Proprioceptive neuromuscular facilitation",[54],"Cerebral Palsy",[54,56],"Constraint induced movement therapy","RECRUITING",{"date":30,"type":31},{"date":60,"type":31},"2026-01-11",{"date":62,"type":20},"2026-07-01",{"name":37,"class":38},{"id":65,"slug":66,"hasResults":12,"nctId":67,"briefTitle":68,"officialTitle":69,"acronym":4,"eligibilityCriteria":70,"healthyVolunteers":12,"sex":17,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":4,"studyType":21,"phases":75,"briefSummary":76,"conditions":77,"keywords":79,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":39},"100644866","concurrent-training-vs-soleus-push-ups-on-neurogenesis-related-biomarkers-in-diabetic-neuropathy-patients-100644866","NCT07675720","Concurrent Training vs Soleus Push-Ups on Neurogenesis-Related Biomarkers in Diabetic Neuropathy Patients","Comparative Effects of Concurrent Training and Soleus Push-Ups on Neurogenesis-Related Biomarkers in Patients With Diabetic Peripheral Neuropathy: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 40-65 years\n* Diagnosed Type 2 Diabetes Mellitus (T2DM) Confirmed diagnosis of T2DM for at least 5 years.\n* Confirmed Diabetic Peripheral Neuropathy (DPN)\n\nDiagnosis is based on clinical evaluation and scoring tools such as:\n\n* Michigan Neuropathy Screening Instrument (MNSI) Cut-off value of ≥4 for Part A (History)(104) Cut-off value of ≥2 from Part B (Examination)(105)\n* Vibration Pressure Threshold (≥25 Volts)(106)\n\n  * HbA1c between 6.5% and 9.0% Reflecting moderate glycemic control, patients with extremely poor control were excluded for safety.\n  * Stable medication regimen No changes in antidiabetic, antihypertensive, or neuropathy medications in the past 3 months.\n  * Sedentary or low physical activity level Based on standard questionnaires (International Physical Activity Questionnaire - IPAQ), not currently engaged in structured exercise programs.\n  * Ability to walk independently To ensure safety during aerobic or resistance exercise (for Group A).\n  * Able to understand and follow instructions\n  * Consent to participate and comply with study protocol\n  * Written informed consent, obtained before randomization\n\nExclusion Criteria:\n\n* History of recent cardiovascular events Includes myocardial infarction, stroke, or any cardiac intervention within the past 6 months.\n\n  * Uncontrolled hypertension Blood pressure ≥160\u002F100 mmHg at rest.\n  * Severe musculoskeletal disorders or physical disability Including joint deformities, fractures, or amputation that limit the ability to perform exercise.\n  * Severe diabetic foot ulcers or active lower limb infection Increases risk during lower limb activity or exercise.\n  * End-stage renal disease (CKD stage 4 or higher) Associated systemic complications may confound study outcomes or affect safety.\n  * Severe retinopathy or proliferative diabetic eye disease Exercise may pose risks such as retinal hemorrhage.\n  * Current Smoker, tobacco or alcohol consumer. That may affect the blood biomarkers.\n  * Cognitive impairment or psychiatric disorders That may affect understanding, compliance, or safety during exercise.\n  * Participation in a structured exercise program within the last 3 months To avoid training-induced bias and ensure a sedentary baseline.\n  * Chronic inflammatory or autoimmune conditions Conditions like rheumatoid arthritis or lupus may alter neurotrophic biomarkers.\n  * Use of medications affecting neurogenesis or metabolism Such as corticosteroids, antipsychotics, or immunosuppressants.\n  * Diagnosed sleep disorder\n  * That may affect the outcomes of the intervention.\n  * Pregnancy or lactation Due to altered physiology and ethical concerns.","40 Years","65 Years",{"count":74,"type":20},99,[23],"This study will examine how two types of exercise programs affect nerve health in people with diabetic peripheral neuropathy. Diabetic peripheral neuropathy is a common complication of type 2 diabetes that can cause numbness, pain, balance problems, and reduced quality of life. Exercise is often recommended for people with diabetes, but it is not yet clear which types of exercise are most effective for improving nerve function.\n\nIn this randomized controlled trial, participants with type 2 diabetes and confirmed peripheral neuropathy will be assigned to one of three groups. One group will perform a combined program of aerobic and resistance exercises (concurrent training). Another group will perform soleus push-up exercises, a seated ankle movement designed to activate the soleus muscle and improve glucose metabolism. The third group will continue with standard diabetes care and general lifestyle advice without a structured exercise program.\n\nThe study will evaluate whether these exercise interventions influence biological markers related to nerve repair and neuroplasticity, including brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and the Schwann cell marker S100B. In addition, the study will assess changes in neuropathy symptoms, balance and postural stability, blood sugar control, and quality of life.\n\nParticipants will complete assessments before the intervention and again during follow-up after the exercise program. The findings of this study may help identify effective and feasible exercise strategies to support nerve health, improve physical function, and reduce the impact of diabetic peripheral neuropathy.",[78],"Diabetic Peripheral Neuropathy Type 2",[80,81,82,83,84,85,86,87,88],"Diabetic Neuropathies","Exercise Therapy","Neurogenesis","Diabetes Mellitus, Type 2","Resistance Training","Aerobic Exercise","Brain-Derived Neurotrophic Factor","Nerve Growth Factor","Quality of Life",{"date":90,"type":31},"2026-06-30",{"date":92,"type":20},"2026-09",{"date":94,"type":20},"2027-12",{"name":37,"class":38},{"id":97,"slug":98,"hasResults":12,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":12,"sex":17,"minAge":103,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":107,"phases":4,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":123},"100638064","rehabilitation-assessment-of-motor-function-in-cerebral-palsy-using-explainable-ai-100638064","NCT07629024","Rehabilitation Assessment of Motor Function In Cerebral Palsy Using Explainable AI","Rehabilitation Assessment of Motor Function in Ambulatory Children With Cerebral Palsy Using Explainable Machine Learning","Inclusion Criteria:\n\n* Age 4 to18 years\n* Diagnosed any motor type of cerebral palsy (spastic, dyskinetic, ataxic, mixed),)\n* GMFCS levels I -III (able to walk with or without an assistive device).\n* All participants must be able to ambulate at least 10 meters with or without an assistive device.\n* Capable of following simple verbal instructions.\n* Parental informed consent and child assent\n\nExclusion Criteria:\n\n* Recent orthopedic or neurosurgical interventions (\\\u003C6 months).\n* Uncontrolled seizures affecting gait.\n* Non-ambulatory (GMFCS IV-V) or cognitive impairments preventing cooperation.","4 Years","18 Years",{"count":106,"type":20},200,"OBSERVATIONAL","The goal of this observational study is to develop and validate an AI-based prediction model for functional mobility and gait outcomes in children with cerebral palsy using low-cost clinical and gait data collected in rehabilitation settings in Pakistan. The study aims to determine whether machine learning models can accurately predict mobility status, gait symmetry, and functional independence in ambulatory and non-ambulatory children with cerebral palsy.\n\nThe main questions it aims to answer are:\n\n* Can clinical and gait-related variables accurately predict functional mobility and gait outcomes in children with spastic cerebral palsy?\n* Can video-based assessment tools provide clinically useful data for AI-based rehabilitation assessment in low-resource settings?\n\nResearchers will analyze clinical, functional, and gait data to identify patterns associated with mobility limitations and rehabilitation outcomes.\n\nParticipants will:\n\n* Undergo clinical and functional assessments, including measures of balance, mobility, posture, and functional independence.\n* Perform gait and movement tasks while data are collected using AI-based video analysis tools.\n* Participate in routine rehabilitation sessions while their movement and functional performance are recorded for analysis.\n* Provide demographic and clinical information relevant to cerebral palsy severity and functional status.",[110],"Cerebral Palsy Children",[112,113,114,115],"CP Assesment","Explainable machine learning","Gait symmetry","Functional independence",{"date":117,"type":31},"2026-06-26",{"date":119,"type":20},"2026-06-10",{"date":121,"type":20},"2027-12-30",{"name":37,"class":38},4,{"id":125,"slug":126,"hasResults":12,"nctId":127,"briefTitle":128,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":12,"sex":131,"minAge":71,"maxAge":132,"enrollmentInfo":133,"targetDuration":4,"studyType":21,"phases":135,"briefSummary":136,"conditions":137,"keywords":139,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":143,"lastUpdatePostDateStruct":144,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":39},"100644366","moderate-intensity-vs-high-intensity-interval-training-in-women-with-heart-failure-100644366","NCT07662876","Moderate Intensity vs High Intensity Interval Training in Women With Heart Failure","Effects of Moderate Intensity Exercise vs High Intensity Interval Training on Functional Capacity and Quality of Life in Women With Heart Failure","Inclusion Criteria:\n\n* Women aged 40-70 years, diagnosed with Stable Heart Failure (NYHA class II or III).\n* Clinically stable patients referred for exercise-based cardiac rehabilitation by the physician.\n* Able to perform exercise testing (able to walk 150 meters on the six-minute walk test) before starting the program.\n* Women willing to participate and provide informed consent.\n\nExclusion Criteria:\n\n* Unstable Heart failure or myocardial infarction (\\\u003C 4 weeks).\n* Severe arrhythmias, uncontrolled hypertension, or ongoing chest pain during exercise.\n* Orthopedic, neurological, or cognitive limitations preventing safe exercise participation.\n* Any medical contraindication to exercise testing.\n* Refusal or inability to provide informed consent or comply with the rehabilitation program.","FEMALE","70 Years",{"count":134,"type":20},64,[23],"* To determine the effects of moderate intensity exercise vs high intensity interval training on functional capacity in women with heart failure\n* To determine the effects of moderate intensity exercise vs high intensity interval training on quality of life in women with heart failure",[138],"Heart Failure",[140,141,142],"Heart failure","Moderate Intensity","High Intensity Interval Training","2026-06-17",{"date":28,"type":31},{"date":146,"type":20},"2026-07",{"date":148,"type":20},"2026-12",{"name":37,"class":38},{"id":151,"slug":152,"hasResults":12,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":12,"sex":17,"minAge":104,"maxAge":157,"enrollmentInfo":158,"targetDuration":4,"studyType":21,"phases":160,"briefSummary":161,"conditions":162,"keywords":164,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":166,"lastUpdatePostDateStruct":167,"startDateStruct":169,"completionDateStruct":171,"leadSponsor":173,"locationsCount":4},"100641360","effects-of-sahrmanns-versus-mcgill-exercise-in-patients-with-non-specific-low-back-pain-100641360","NCT07659327","Effects Of Sahrmann's Versus McGill Exercise In Patients With Non-Specific Low Back Pain","Effects Of Sahrmann's Versus McGill Exercise On Pain, Disability, And Range Of Motion In Patients With Non-Specific Low Back Pain","Inclusion Criteria:\n\n* Diagnosed patients of non-specific low back pain Adults between 18-35 years. Both male and female included Low back pain for minimum of three months NPRS score 3-7 will be recruited in this study.\n\nExclusion Criteria:\n\nHistory of any trauma and spinal injury History of previous lumbar surgery History of cancer, spinal infection, rheumatologic diseases, spine fracture, red flag signs.\n\nCongenital anomly (scoliosis, kyphosis) Systemic diseases affecting bones \\& joints such as rheumatoid arthritis","35 Years",{"count":159,"type":20},42,[23],"The goal of this clinical trial is to learn whether Sahrmann exercises or McGill exercises are more effective for reducing pain and improving function in adults with non-specific low back pain. It will also evaluate which exercise program is more effective in improving spinal range of motion.\n\nThe main questions it aims to answer are:\n\nDo Sahrmann exercises reduce pain more effectively than McGill exercises? Do Sahrmann exercises improve disability more effectively than McGill exercises? Do Sahrmann exercises improve lumbar range of motion more effectively than McGill exercises?\n\nResearchers will compare a Sahrmann exercise program with a McGill exercise program to determine which approach produces better outcomes in patients with non-specific low back pain.\n\nParticipants will:\n\nBe randomly assigned to either a Sahrmann exercise group or a McGill exercise group.\n\nReceive standard physical therapy treatment, including heat therapy and transcutaneous electrical nerve stimulation (TENS).\n\nPerform the assigned exercise program under the supervision of a physiotherapist.\n\nAttend exercise sessions 3-5 times per week during the study period. Complete assessments of pain, disability, and lumbar range of motion before and after the intervention.\n\nHave pain measured using the Numeric Pain Rating Scale (NPRS), disability measured using the Oswestry Disability Index (ODI), and lumbar range of motion measured using a Baseline Bubble Inclinometer.",[163],"Non-specific Low Back Pain (NSLBP)",[165],"non-specific low back pain, pain management, Disability Evaluation, Exercise Therapy, Rehabilitation, sahrmann' exercise, McGill exercise","2026-06-16",{"date":168,"type":31},"2026-06-22",{"date":170,"type":20},"2026-07-30",{"date":172,"type":20},"2026-12-30",{"name":37,"class":38},{"id":175,"slug":176,"hasResults":12,"nctId":177,"briefTitle":178,"officialTitle":179,"acronym":4,"eligibilityCriteria":180,"healthyVolunteers":12,"sex":17,"minAge":71,"maxAge":181,"enrollmentInfo":182,"targetDuration":4,"studyType":21,"phases":184,"briefSummary":185,"conditions":186,"keywords":188,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":196,"leadSponsor":198,"locationsCount":39},"100643601","effects-of-sahrmanns-approach-versus-conventional-treatment-oin-patients-with-knee-osteoarthritis-100643601","NCT07642258","Effects of Sahrmann's Approach Versus Conventional Treatment Oin Patients With Knee Osteoarthritis","Effects of Sahrmann's Approach Versus Conventional Treatment on Pain, Valgus Angle and Functional Disability in Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* Males and females between 40 to 60 years of age.\n* Diagnosed patients of knee Osteoarthritis with grade 2.\n* Valgus angle of knee \\> 10°.\n\nExclusion Criteria:\n\n* Any other inflammatory conditions.\n* Rheumatoid arthritis, ankylosing spondylitis or any other auto immune disorder","60 Years",{"count":183,"type":20},40,[23],"Osteoarthritis (OA) of the knee, also referred to as degenerative joint disease, is normally due to wear and tear and progressive cartilage loss in the articular cartilage. Osteoarthritis is most prevalent condition among older adults. The objective of the study will be to compare the effects of Sahrmann's approach versus conventional treatment on pain, valgus angle and functional disability in patients with knee osteoarthritis.",[187],"Knee Osteoarthritis",[189,190,191],"pain","functional disability","VALGUS ANGLE","2026-06-08",{"date":194,"type":31},"2026-06-11",{"date":62,"type":20},{"date":197,"type":20},"2026-10-01",{"name":37,"class":38},{"id":200,"slug":201,"hasResults":12,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":4,"eligibilityCriteria":205,"healthyVolunteers":12,"sex":17,"minAge":104,"maxAge":206,"enrollmentInfo":207,"targetDuration":4,"studyType":21,"phases":208,"briefSummary":209,"conditions":210,"keywords":213,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":222,"leadSponsor":224,"locationsCount":39},"100642898","low-volume-nose-resistance-breathing-exercise-with-incentive-spirometer-in-patient-with-cervical-spinal-cord-injuries-100642898","NCT07645027","Low Volume Nose Resistance Breathing Exercise With Incentive Spirometer in Patient With Cervical Spinal Cord Injuries","Effect of Low Volume Nose Resistance Breathing Exercise With Incentive Spirometer on Pulmonary Function Test, Dyspnea, Cough and Sputum in Patient With Cervical Spinal Cord Injuries","Inclusion Criteria:\n\n* Diagonosed cervical spine injury C4-C7\n* Age 18-38 years\n* Undergoing in-patient rehabilitation\n* No previous history of severe pulmonary disease\n* Disease duration \\\u003C1 year\n* Ability to give informed consent\n* Road Accident\n\nExclusion Criteria:\n\n* Uncontrolled hypertension\n* Other Neuromuscular disease\n* Stage 3-4 pressure wound\n* Clinical instability\n* Traumatic Brain injury","38 Years",{"count":159,"type":20},[23],"This randomized clinical trial aims to evaluate the effectiveness of combining Low Volume Nose Resistance Breathing Exercises (LVNRBE) with Incentive Spirometry (IS) on respiratory outcomes in patients with cervical spinal cord injury (SCI). Respiratory complications are a major concern in cervical SCI due to impaired respiratory muscle function, leading to reduced lung volumes, dyspnea, ineffective cough, and sputum retention. The study will recruit 42 inpatients aged 18-38 years with cervical SCI (C4-C7), randomly divided into two groups: Data Analysis: Statistical tests (paired and independent t-tests) will determine intra- and intergroup differences using SPSS v25, with significance set at p \\\u003C 0.05.\n\n* Group A (Intervention): Receives LVNRBE using an Acapella device plus IS for 20 minutes, three times daily, five days a week for four weeks.\n* Group B (Control): Receives conventional respiratory physiotherapy with the same frequency and duration.\n\nOutcomes will be assessed pre- and post-intervention using:\n\n* Pulmonary Function Tests (FVC, FEV1),\n* Modified Borg Dyspnea Scale,\n* Cough Frequency Scale,\n* Sputum Grading Scale.",[211,212],"Cervical Spinal Cord Injury","Cervical Cord Injuries Spinal",[214,215,216,217],"Cervical cord injury","Dyspnea","Incentive spirometer","Low volume nose resistance breathing exercise",{"date":219,"type":31},"2026-06-12",{"date":221,"type":31},"2026-05-01",{"date":223,"type":20},"2026-08-01",{"name":37,"class":38},{"id":226,"slug":227,"hasResults":12,"nctId":228,"briefTitle":229,"officialTitle":230,"acronym":4,"eligibilityCriteria":231,"healthyVolunteers":12,"sex":17,"minAge":71,"maxAge":181,"enrollmentInfo":232,"targetDuration":4,"studyType":21,"phases":234,"briefSummary":235,"conditions":236,"keywords":238,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":240,"startDateStruct":241,"completionDateStruct":242,"leadSponsor":244,"locationsCount":39},"100642382","effects-of-myofascial-trigger-point-release-versus-neil-asher-technique-oin-patients-with-rotator-cuff-syndrome-100642382","NCT07645963","Effects of Myofascial Trigger Point Release Versus Neil Asher Technique Oin Patients With Rotator Cuff Syndrome","Effects of Myofascial Trigger Point Release Versus Neil Asher Technique on Pain, Range of Motion, and Disability in Patients With Rotator Cuff Syndrome","Inclusion Criteria:\n\n* Age 40-60 years\n* Positive Neer's and Hawkins Kennedy test (27)\n* Grade 1 or 2 rotator cuff syndrome (non-surgical)\n\nExclusion Criteria:\n\n* Cardiac issues (e.g., myocardial infarction)\n* Fibromyalgia\n* Pregnancy\n* Trauma-related shoulder pain\n* History of shoulder surgery\n* Numbness, tingling\n* Corticosteroid injections",{"count":233,"type":20},36,[23],"Rotator cuff syndrome is a common cause of shoulder pain and functional limitation, often associated with myofascial trigger points. Myofascial Trigger Point Release (MFTR) and the Neil Asher Technique (NAT) are manual therapies aimed at reducing pain and improving mobility. This study compares their effects on pain, range of motion, and disability in individuals with rotator cuff syndrome.",[237],"Rotator Cuff Syndrome",[189,190,239],"range of motion",{"date":219,"type":31},{"date":90,"type":20},{"date":243,"type":20},"2026-10-30",{"name":37,"class":38},{"id":246,"slug":247,"hasResults":12,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":4,"eligibilityCriteria":251,"healthyVolunteers":12,"sex":17,"minAge":71,"maxAge":181,"enrollmentInfo":252,"targetDuration":4,"studyType":21,"phases":254,"briefSummary":255,"conditions":256,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":258,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":263,"locationsCount":4},"100642602","effects-of-deltoid-strengthening-exercises-in-patients-with-adhesive-capsulitis-100642602","NCT07644884","Effects of Deltoid Strengthening Exercises in Patients With Adhesive Capsulitis","Effects of Deltoid Strengthening Exercises on Pain, Range of Motion, Muscle Strength and Disability in Patients With Adhesive Capsulitis","Inclusion Criteria:\n\n* • Both male and female gender\n\n  * Subjects with age ranging from 40 to 60 years\n  * Subjects with stage II and III adhesive capsulitis\n\nExclusion Criteria:\n\n* • Subjects with rotator cuff tears\n\n  * Subjects with glenohumeral arthritis",{"count":253,"type":20},48,[23],"Adhesive capsulitis, also known as frozen shoulder, is a musculoskeletal condition that causes significant shoulder pain and restricted joint mobility. It affects the glenohumeral joint and is commonly seen in individuals between the ages of 40 and 60 year. It affects 3 to 5% of the general population with a higher prevalence among females and patients with diabetes or thyroid disorders. Adhesive capsulitis progresses in four stages: painful, freezing, frozen, and thawing, and the condition may persist for 1 to 2 years. This study aims to determine the effects of Deltoid Strengthening Exercises on pain, range of motion, muscle strength and disability in patients with Adhesive Capsulitis.",[257],"Frozen Shoulder",{"date":219,"type":31},{"date":260,"type":20},"2026-06-06",{"date":262,"type":20},"2026-11-06",{"name":37,"class":38},{"id":265,"slug":266,"hasResults":12,"nctId":267,"briefTitle":268,"officialTitle":269,"acronym":4,"eligibilityCriteria":270,"healthyVolunteers":12,"sex":17,"minAge":271,"maxAge":71,"enrollmentInfo":272,"targetDuration":4,"studyType":21,"phases":273,"briefSummary":274,"conditions":275,"keywords":277,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":282,"startDateStruct":283,"completionDateStruct":284,"leadSponsor":286,"locationsCount":39},"100642068","comparative-effects-of-post-isometric-relaxation-and-reciprocal-inhibition-techniques-inpiriformis-syndrome-100642068","NCT07646314","Comparative Effects of Post-Isometric Relaxation and Reciprocal Inhibition Techniques inPiriformis Syndrome","Comparative Effects of Post-Isometric Relaxation and Reciprocal Inhibition Muscle Energy Techniques on Pain, ROM and Function in Piriformis Syndrome","Inclusion Criteria:\n\n\\- Piriformis syndrome clinically confirmed via special tests (e.g., FAIR test, Freiberg sign, Pace test)\n\n* Both gender male and female.\n* Age between 25 and 40 years.\n* Presence of antalgic gait due to pain.\n* Moderate to severe pain (e.g., NPRS score ≥ 4)\n* Voluntary consent to participate in the study.\n* Medically stable, no acute or unstable medical conditions that would interfere with participation.\n\nExclusion Criteria:\n\n* Lumber disc herniation or radiculopathy confirmed by imaging or neurological signs\n\n  * History of hip or pelvis surgery.\n  * Other neuromuscular or musculoskeletal disorders e.g., stroke, multiple sclerosis, or rheumatoid arthritis\n  * Recent lower limb fracture or injury within the last 6 months.\n  * Pregnancy due to potential risks and altered biomechanics.\n  * Inability to follow instruction\n  * Ongoing physiotherapy or alternative treatments","25 Years",{"count":159,"type":20},[23],"Piriformis Syndrome (PS) is a condition which is characterized by pain, numbness, and limited range of motion (ROM) due to compression or irritation of the sciatic nerve by the piriformis muscle. It often leads to discomfort in the buttock region, radiating pain along the posterior thigh, and functional limitations in daily activities. Manual therapy techniques, particularly Muscle Energy Techniques (METs), have been widely used for the management of musculoskeletal dysfunctions, including piriformis syndrome.",[276],"Piriformis Syndrome",[278,279,280,281],"Piriformis","Pain","Disability","Manual Therapy",{"date":219,"type":31},{"date":143,"type":20},{"date":285,"type":20},"2026-11-20",{"name":37,"class":38},{"id":288,"slug":289,"hasResults":12,"nctId":290,"briefTitle":291,"officialTitle":292,"acronym":4,"eligibilityCriteria":293,"healthyVolunteers":12,"sex":17,"minAge":294,"maxAge":132,"enrollmentInfo":295,"targetDuration":4,"studyType":21,"phases":296,"briefSummary":297,"conditions":298,"keywords":300,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":305,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":39},"100643389","combined-effects-of-lirt-bfr-therapy-in-post--stroke-patients-100643389","NCT07646418","Combined Effects of LIRT-BFR Therapy in Post- Stroke Patients","Combined Effects of Low Intensity Resistance Training With Blood Flow Restriction Therapy on Upper Limb Strength, Forward Reach and Sensorimotor Function in Post-Stroke Patients","Inclusion Criteria:\n\n* • 50 to 70 year of age (5)\n\n  * Both males and females (5)\n  * Generalized stroke population (both ischemic and hemorrhagic stroke) (9).\n  * Post stroke patient after 1 month (5)\n  * Barthel index scores ≥ 20 (10)\n  * Spasticity level according to Modified Ashworth scale should be 1\u002F+1 grade in the affected upper limb(7)\n  * Muscle strength at grade 3 according to MMT of affected upper limb (7)\n\nExclusion Criteria:\n\n* • People with a history of mental\u002Fcognitive illness (9)\n\n  * History of transient ischemic attack (TIA) or recurrent stroke (8)\n  * Diabetes with peripheral neuropathy (5)\n  * Having resting blood pressure above 160\u002F100 mmHg even after taking medications\n  * Cardiovascular comorbidity (heart failure, unstable angina, aortic stenosis)","50 Years",{"count":134,"type":20},[23],"Stroke is a focal neurological deficit of sudden onset, with symptoms lasting more than 24 hours leading to consequences like impacting physical abilities, cognitive functions and emotional well-being, speech and language difficulties. Among various rehabilitation program, Blood flow restriction (BFR) therapy with low intensity resistance training has shown its promising results. Blood flow restriction training, also called Kaatsu, originated in Japan. So this study aims to determine the combined effects of Low Intensity Resistance Training with Blood Flow Restriction Therapy on Upper Limb Strength, Forward Reach and Sensorimotor function in Post-Stroke Patients.",[299],"Stroke",[301,302,303,304],"Balance","BFR Therapy","Low intensity Resistance Training","Muscle Strength",{"date":219,"type":31},{"date":307,"type":31},"2025-06-01",{"date":309,"type":20},"2026-07-05",{"name":37,"class":38},{"id":312,"slug":313,"hasResults":12,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":12,"sex":17,"minAge":104,"maxAge":318,"enrollmentInfo":319,"targetDuration":4,"studyType":21,"phases":321,"briefSummary":322,"conditions":323,"keywords":325,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":328,"startDateStruct":329,"completionDateStruct":330,"leadSponsor":331,"locationsCount":39},"100643537","perturbation-training-vs-functional-activities-on-pain-rom-balance-and-function-post-acl-100643537","NCT07642752","Perturbation Training vs Functional Activities on Pain, ROM, Balance, and Function Post-ACL","Effects of Perturbation Training Versus Task-oriented Functional Activities on Pain, Range of Motion, Balance and Function in Post-anterior Cruciate Ligament Reconstruction","Inclusion Criteria:\n\n* Age range: 18-45 years\n\nMale participants only\n\nHistory of Anterior Cruciate Ligament Reconstruction (ACLR) of 3 to 12 months\n\nNo prior ACL surgery on the affected knee\n\nACL reconstruction with autograft of hamstrings tendon\n\nKnee flexion range of motion less than 120°\n\nExtension lag less than or equal to 10°\n\nPain during functional activities\n\nExclusion Criteria:\n\n* Any type of fracture\n\nConcurrent ligamentous injury or repairable meniscus\n\nOsteochondral defect\n\nAny systemic and\u002For neurological illness\n\nRheumatoid arthritis\n\nOsteomyelitis or any neurological disorders\n\nSpinal disorders\n\nInflammatory conditions such as ankylosing spondylitis","45 Years",{"count":320,"type":20},54,[23],"Anterior cruciate ligament (ACL) injuries are among the most common and functionally disabling knee injuries, particularly in physically active individuals. Despite advancements in surgical techniques, optimal post-operative rehabilitation remains critical for successful functional recovery, minimizing re-injury risk, and restoring pre-injury performance levels",[324],"Anterior Cruciate Ligament Injuries",[326,280,327,301],"Knee","Range of motion",{"date":194,"type":31},{"date":33,"type":20},{"date":262,"type":20},{"name":37,"class":38},{"id":333,"slug":334,"hasResults":12,"nctId":335,"briefTitle":336,"officialTitle":337,"acronym":4,"eligibilityCriteria":338,"healthyVolunteers":12,"sex":17,"minAge":339,"maxAge":294,"enrollmentInfo":340,"targetDuration":4,"studyType":21,"phases":341,"briefSummary":342,"conditions":343,"keywords":345,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":347,"startDateStruct":348,"completionDateStruct":350,"leadSponsor":352,"locationsCount":39},"100642978","effects-of-spinal-mobilization-with-leg-movement-with-and-without-neural-flossing-technique-in-lumbar-radiculopathy-100642978","NCT07646379","Effects of Spinal Mobilization With Leg Movement With and Without Neural Flossing Technique in Lumbar Radiculopathy","Effects of Spinal Mobilization With Leg Movement With and Without Neural Flossing Technique on Pain, Disability, and Range of Motion in Patients With Lumbar Radiculopathy","Inclusion Criteria:\n\n* • Patients aged between 30-50 years (9)\n\n  * Both male and female genders\n  * Patient should have lower back pain radiating to one side with numbness, tingling, and muscle weakness (12)\n  * Positive Lasegue \\& slump test\n\nExclusion Criteria:\n\n* Any fracture or other injury\n\n  * Any systemic illness\n  * Any inflammatory disease (Rheumatoid arthritis, gout)\n  * Disc herniation\n  * Piriformis syndrome\n  * Lumbar instability\n  * Scoliosis","30 Years",{"count":233,"type":20},[23],"Lumbar radiculopathy is a spinal condition caused by compression or irritation of the lumbar nerve roots, leading to radiating leg pain, sensory changes, and functional disability. It commonly affects middle-aged and older adults, impairing daily activities and quality of life. Conservative treatments include medication, physiotherapy, and exercise. Spinal Mobilization with Leg Movement (SMWLM), a Mulligan technique, uses passive vertebral mobilization with active leg motion to reduce nerve compression and improve mobility. Neural flossing, or neurodynamic mobilization, enhances nerve mobility by promoting gliding of nerve roots, especially in cases of restricted neural movement. This study aims to evaluate the effects of spinal mobilization with leg movement (SMWLM) with and without neural flossing technique on pain, disability, and range of motion in patients with lumbar radiculopathy.",[344],"Lumbar Radiculopathy",[346],"pain, radiculopathy, range of motion, spinal mobilization",{"date":219,"type":31},{"date":349,"type":20},"2026-05-30",{"date":351,"type":20},"2026-08-30",{"name":37,"class":38},{"id":354,"slug":355,"hasResults":12,"nctId":356,"briefTitle":357,"officialTitle":357,"acronym":4,"eligibilityCriteria":358,"healthyVolunteers":12,"sex":17,"minAge":71,"maxAge":181,"enrollmentInfo":359,"targetDuration":4,"studyType":21,"phases":361,"briefSummary":362,"conditions":363,"keywords":365,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":371,"startDateStruct":373,"completionDateStruct":375,"leadSponsor":376,"locationsCount":39},"100643372","effects-of-laura-mitchells-and-benson-relaxation-technique-on-anxiety-sleep-quality-and-fatigue-among-copd-patients-100643372","NCT07635446","Effects of Laura Mitchell's and Benson Relaxation Technique On Anxiety, Sleep Quality and Fatigue Among COPD Patients","Inclusion Criteria:\n\n\\- Gender: Male and Female\n\n* Age: 40 to 60 years\n* Patients diagnosed with COPD\n* Willing to participate\n\nExclusion Criteria:\n\n* Patients with Exacerbations within past 4 weeks\n\n  * Cardiac Diseases (Acute MI, Congestive Heart Failure)\n  * Neuromuscular Disorder\n  * Recent lung diseases\n  * Hemodynamic instability\n  * Respiratory failure",{"count":360,"type":20},38,[23],"Chronic Obstructive Pulmonary Disease (COPD) is a progressive lung condition characterized by persistent respiratory symptoms and airflow limitation. Patients with COPD often experience not only physical symptoms like breathlessness and fatigue but also psychological issues such as anxiety and poor sleep quality, which further compromise their quality of life. Non-pharmacological interventions, especially relaxation techniques, have shown promise in improving psychological well-being and physiological outcomes in COPD patients. Among these, Laura Mitchell's relaxation technique and Benson's relaxation response have gained attention for their simplicity and effectiveness.\n\nThe primary objective of this study is to assess and compare the effects of Laura Mitchell's relaxation technique and Benson's relaxation technique on anxiety, sleep quality, and fatigue levels in patients diagnosed with moderate to severe COPD. By evaluating these parameters, the study aims to determine which method provides greater benefits in managing psychological and physical symptoms associated with COPD. The study will use a randomized experimental design. Participants will be randomly assigned into two groups: Group A will receive Laura Mitchell's relaxation training, and Group B will receive Benson's technique. Both interventions will be practiced daily for 15-20 minutes over a 6-weeks period. Baseline and post-intervention (week 6) data will be collected. Outcome measures will include anxiety (GAD-7), fatigue (FSS) and sleep quality (PSQI). Data will be analyzed using paired and independent t-tests to assess within-group and between-group differences, with significance set at p \\\u003C 0.05. The data will be analyzed using SPSS v 25.",[364],"COPD",[366,367,368,369,370],"Anxiety","Benson relaxation","Fatigue","Laura Mitchell's relaxation technique","Sleep quality",{"date":372,"type":31},"2026-06-09",{"date":374,"type":31},"2026-06-01",{"date":223,"type":20},{"name":37,"class":38},{"id":378,"slug":379,"hasResults":12,"nctId":380,"briefTitle":381,"officialTitle":382,"acronym":4,"eligibilityCriteria":383,"healthyVolunteers":12,"sex":131,"minAge":384,"maxAge":71,"enrollmentInfo":385,"targetDuration":4,"studyType":21,"phases":387,"briefSummary":388,"conditions":389,"keywords":391,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":395,"startDateStruct":396,"completionDateStruct":398,"leadSponsor":400,"locationsCount":39},"100642994","effects-of-pilates-and-moderate-intensity-aerobic-exercise-on-postpartum-weight-loss-and-body-composition-100642994","NCT07642245","Effects of Pilates and Moderate-Intensity Aerobic Exercise on Postpartum Weight Loss and Body Composition","Effects of Pilates Versus Moderate Intensity Aerobic Exercises on Weight Loss, Body Mass Index and Waist to Hip Ratio in Postpartum Period.","Inclusion Criteria:\n\n* Women aged 20 to 40 years\n* BMI \\> 25kg\u002Fm2 at baseline\n* Medically cleared by a health professional to perform physical activity\n* Women 6 to 24 weeks postpartum\n\nExclusion Criteria:\n\n* Women with complications during delivery (Cesarean complications, perineal tears grade 3 or 4)\n* Presence of chronic disorders (diabetes mellitus, cardiovascular disorders, severe anemia)\n* Neuromusculoskeletal disorders affecting physical activity\n* Currently participating in another fitness program\n* Postpartum depression or other psychological disorders that may affect adherence","20 Years",{"count":386,"type":20},30,[23],"After childbirth, many women experience difficulty losing pregnancy-related weight, which can affect their health, self-esteem, and physical activity. Regular exercise, including Pilates and moderate-intensity aerobic exercises, is considered a safe and natural method to improve fitness and support weight loss during the postpartum period. This study aims to compare the effects of Pilates and aerobic exercise on body weight, Body Mass Index (BMI), and waist-to-hip ratio in postpartum women over 8 weeks. Participants will be randomly assigned to either a Pilates group or an aerobic exercise group, with both groups exercising three times weekly for 45-60 minutes. The results will then be compared to determine which exercise method is more effective.",[390],"Postpartum Period",[392,393,81,394],"Aerobic Exerciser","Body Mass Index","Pilates",{"date":194,"type":31},{"date":397,"type":31},"2025-04-02",{"date":399,"type":20},"2026-10-15",{"name":37,"class":38},{"id":402,"slug":403,"hasResults":12,"nctId":404,"briefTitle":405,"officialTitle":406,"acronym":4,"eligibilityCriteria":407,"healthyVolunteers":12,"sex":17,"minAge":104,"maxAge":71,"enrollmentInfo":408,"targetDuration":4,"studyType":21,"phases":409,"briefSummary":410,"conditions":411,"keywords":413,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":415,"startDateStruct":416,"completionDateStruct":417,"leadSponsor":418,"locationsCount":39},"100643618","effects-of-sahrmanns-versus-janda-approach-in-lower-crossed-syndrome-patients-100643618","NCT07642271","Effects of Sahrmann's Versus Janda Approach in Lower Crossed Syndrome Patients","Effects of Sahrmann's Versus Janda Approach on Pain, Pelvic Tilt and Lumbar Lordosis in Lower Crossed Syndrome Patients","Inclusion Criteria:\n\n* • Gender (both)\n\n  * Age (18 to 40)\n  * Participants who fulfilled the criteria of lower cross syndrome\n\nExclusion Criteria:\n\n* • Any serious pathology i.e. Neoplasm\n\n  * Any history of trauma\n  * Spinal malalignment i.e. Scoliosis\n  * Receiving any other form of Physical therapy treatment",{"count":320,"type":20},[23],"Muscular imbalance due to prolonged sitting or standing posture leads to a condition lower cross syndrome(LCS) or lumbopelvic syndrome. Several stretching and strengthening regimens are used to treat cross pattern of muscular tightness and weakness in LCS. This study aims to compare the effects of Sahrmann's versus Janda's approach on pain, pelvic tilt and lumbar lordosis in lower crossed syndrome patients.",[412],"Lower Cross Syndrome",[189,414],"pelvic tilt",{"date":194,"type":31},{"date":349,"type":20},{"date":351,"type":20},{"name":37,"class":38},{"id":420,"slug":421,"hasResults":12,"nctId":422,"briefTitle":423,"officialTitle":424,"acronym":4,"eligibilityCriteria":425,"healthyVolunteers":426,"sex":131,"minAge":104,"maxAge":157,"enrollmentInfo":427,"targetDuration":4,"studyType":21,"phases":429,"briefSummary":430,"conditions":431,"keywords":433,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":439,"startDateStruct":440,"completionDateStruct":442,"leadSponsor":443,"locationsCount":39},"100643227","comparative-effects-of-hypopressive-and-transverses-abdominis-focused-core-training-in-postpartum-100643227","NCT07576283","Comparative Effects of Hypopressive and Transverses Abdominis Focused Core Training in Postpartum","Comparative Effects of Hypopressive and Transverses Abdominis Focused Core Training on Urinary Incontinence, Pelvic Floor Function and Quality of Life in Postpartum","Inclusion Criteria:\n\n* Multiparous women with urinary incontinence\n* Who had undergone normal vaginal delivery\n* Free from any medical and gynecological risk factors and \u002For conditions\n* Stress urinary incontinence test is positive: Pad test\n\nExclusion Criteria:\n\n* Had neurological impairments or connective tissue disorders\n* Active urinary or vaginal infection in the past 3 months\n* Had known detrusor instability\n* Had undergone previous surgery to alleviate SUI\n* Had pelvic organ prolapse",true,{"count":428,"type":20},60,[23],"The study aims to compare the effectiveness of these two core training approaches in improving urinary incontinence, pelvic floor function, and quality of life in postpartum women.",[432],"Postpartum",[434,435,436,437,438],"urinary incontinence","pelvic floor function","quality of life","postpartum","female",{"date":372,"type":31},{"date":441,"type":31},"2025-10-01",{"date":223,"type":20},{"name":37,"class":38},{"id":445,"slug":446,"hasResults":12,"nctId":447,"briefTitle":448,"officialTitle":449,"acronym":4,"eligibilityCriteria":450,"healthyVolunteers":12,"sex":131,"minAge":339,"maxAge":181,"enrollmentInfo":451,"targetDuration":4,"studyType":21,"phases":453,"briefSummary":454,"conditions":455,"keywords":457,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":459,"startDateStruct":460,"completionDateStruct":461,"leadSponsor":463,"locationsCount":39},"100642734","combined-effects-of-pelvic-floor-retraining-and-hypopressive-exercises-in-uterine-prolapse-outcomes-100642734","NCT07642180","Combined Effects of Pelvic Floor Retraining and Hypopressive Exercises in Uterine Prolapse Outcomes","Combined Effects of Pelvic Floor Functional Movement Retraining and Hypopressive Exercises on Pain, Urogynecological Symptoms, and Quality of Life in Uterine Prolapse","Inclusion Criteria:\n\n* Females aged 30-60 years.\n* Diagnosed with stage I and II uterine prolapse.\n* women with ≥1 parity\n* women who have had a vaginal delivery\n\nExclusion Criteria:\n\n* Recent pelvic surgery (\\\u003C6 months).\n* Pregnancy or postpartum within 6 months.\n* Neurological conditions affecting muscle control.\n* Participation in pelvic floor rehab in the past 6 months.",{"count":452,"type":20},32,[23],"One common pelvic floor condition, particularly in postpartum or later life, is uterine prolapse. It is caused by weak pelvic floor muscles and connective tissues and often presents with pain, urinary incontinence, and reduced quality of life. Although pelvic floor muscle training (PFMT) is commonly used, newer methods such as Hypopressive Exercises (HE) and Pelvic Floor Functional Movement Retraining (PFFMR) offer promising approaches. HE focuses on posture and breathing strategies to reduce intra-abdominal pressure, while PFFMR retrains pelvic stability and function through integrated movement patterns. This study aims to evaluate the combined effects of HE and PFFMR on pain, urogynecological symptoms, and quality of life in women with uterine prolapse, compared to single interventions.\n\nThis randomized clinical trial will include 32 women aged 30-60 years with stage I-II uterine prolapse at Ganga Ram Hospital, Lahore. Participants will undergo an 8-week program with supervised sessions three times per week. Outcomes will be assessed using the Pelvic Floor Bother Questionnaire (PFBQ), Numeric Pain Rating Scale (NPRS), and Prolapse Quality of Life Questionnaire (P-QoL), and analyzed using SPSS version 25.0.",[456],"Uterine Prolapse",[81,88,458],"urogynecological symptoms",{"date":194,"type":31},{"date":397,"type":31},{"date":462,"type":20},"2026-08-15",{"name":37,"class":38},{"id":465,"slug":466,"hasResults":12,"nctId":467,"briefTitle":468,"officialTitle":469,"acronym":4,"eligibilityCriteria":470,"healthyVolunteers":12,"sex":17,"minAge":471,"maxAge":472,"enrollmentInfo":473,"targetDuration":4,"studyType":21,"phases":475,"briefSummary":476,"conditions":477,"keywords":479,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":481,"startDateStruct":482,"completionDateStruct":484,"leadSponsor":485,"locationsCount":39},"100642348","obstacle-course-versus-neuromotor-task-training-in-children-with-dcd-100642348","NCT07575178","Obstacle Course Versus Neuromotor Task Training in Children With DCD","Comparison of Obstacle Course Training and Neuromotor Task Training on Motor Planning and Functional Mobility in Children With Developmental Coordination Disorder","Inclusion Criteria:\n\n* • Diagnosis of DCD based on DSM4\u002F5 criteria.\n\n  * Children aged 7-10.\n  * Gender male and female.\n  * Mini-Mental State Examination (MMSE) score \\>24 .\n  * Cognitive development appropriate for chronological age.\n  * Raven Intelligence Test Scale (IQ \\> 75) .\n  * Developmental Coordination Questionnaire ≤48 points: likely DCD (≤ 10th percentile).\n  * BOT-2 score ≤ 40.\n\nExclusion Criteria:\n\n* History of surgery and lower limb injuries over the past 12 months.\n* Use of assistive devices to balance and walk.\n* Severe ADHD, Autism Spectrum Disorder (if it significantly interferes with participation), or major psychiatric disorders.\n* Taking neuroleptics or any other medications that significantly alter muscle tone, coordination, or attention.","7 Years","10 Years",{"count":474,"type":20},28,[23],"Developmental Coordination Disorder (DCD) affects motor planning and functional mobility in children, leading to long-term functional and psychosocial difficulties. This randomized clinical trial will compare the effectiveness of Obstacle Course Training (OCT) and Neuromotor Task Training (NTT) in improving motor planning and functional mobility in children aged 7-10 years diagnosed with DCD. Participants will be randomly allocated to either OCT or NTT for 9 weeks (two sessions per week). Outcomes will be assessed using standardized motor performance measures to determine the more effective intervention.",[478],"Developmental Coordination Disorder (DCD)",[480],"DCD, Motor coordination, Neuromotor training,",{"date":119,"type":31},{"date":483,"type":20},"2026-06",{"date":223,"type":20},{"name":37,"class":38},{"id":487,"slug":488,"hasResults":12,"nctId":489,"briefTitle":490,"officialTitle":491,"acronym":4,"eligibilityCriteria":492,"healthyVolunteers":12,"sex":131,"minAge":104,"maxAge":157,"enrollmentInfo":493,"targetDuration":4,"studyType":21,"phases":494,"briefSummary":495,"conditions":496,"keywords":498,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":504,"startDateStruct":505,"completionDateStruct":506,"leadSponsor":507,"locationsCount":39},"100642028","comparative-effects-of-neurodynamic-stretch-and-myofascial-pain-release-in-polycystic-ovarian-syndrome-100642028","NCT07645014","Comparative Effects of Neurodynamic Stretch and Myofascial Pain Release in Polycystic Ovarian Syndrome.","Comparative Effects of Neurodynamic Stretch and Myofascial Pain Release in Dysmenorrhea, Quality Of Sleep And Stress In Polycystic Ovarian Syndrome.","Inclusion Criteria:\n\n* • Age 18-35 years\n\n  * Diagnosed cases of PCOS\n  * Irregular periods until 3 months.\n  * Presence of dysmenorrhea (Check WaLIDD Questionnaire)\n  * BMI\n  * Age of Menarche (13 years)\n\nExclusion Criteria:\n\n* • History of endocrine disorders\n\n  * Endometriosis\n  * Tumour\n  * Any major surgeries\n  * Marital Status (un married)",{"count":360,"type":20},[23],"The study will be a non-blinded randomized controlled trial, consisting of two groups. Non-probability Convenience sampling will be used to recruit participants who will meet the inclusion criteria. Group allocation will be performed using the sealed envelope method to ensure randomization of participants into experimental and control groups. The sample size will be 38 (19 in each group). Group A will receive neurodynamic stretches while Group B will receive myofascial pain release technique.",[497],"Polycystic Ovarian Syndrome",[499,500,501,502,503],"Dysmenorrhea","Myofascial pain release Neurodynamic stretch","Polycystic ovarian syndrome","Quality of sleep","Stress",{"date":219,"type":31},{"date":441,"type":31},{"date":62,"type":20},{"name":37,"class":38},{"id":509,"slug":510,"hasResults":12,"nctId":511,"briefTitle":512,"officialTitle":513,"acronym":4,"eligibilityCriteria":514,"healthyVolunteers":12,"sex":17,"minAge":294,"maxAge":72,"enrollmentInfo":515,"targetDuration":4,"studyType":21,"phases":517,"briefSummary":518,"conditions":519,"keywords":521,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":525,"startDateStruct":526,"completionDateStruct":528,"leadSponsor":529,"locationsCount":39},"100643603","comparison-between-ll-sesorimotor-training-and-wbb-therapy-on-ps-db-and-fof-in-post-stroke-patients-100643603","NCT07642154","Comparison Between LL Sesorimotor Training and WBB Therapy on PS, DB and FOF in Post Stroke Patients","Comparison Between Lower Limb Sensorimotor Training and Whole-Body Vibration Therapy on Postural Stability, Dynamic Balance and Fear of Fall in Post Stroke Patients.","Inclusion Criteria:\n\n* Both male and female ranging from 50-65 years.\n* Definitive diagnosis of stroke .\n* Having sensory issues due to stroke in lower extremities.\n* Those who did not have a problem with walking due to other diseases other than stroke.\n* Having score less than 45 on berg balance scale.\n* Having no wounds, infections, and skin diseases in the feet, not taking medications such as nitroglycerin, dopamine, and dobutamine.\n* Having no history of mental illness, no suffering from osteoporosis, and not having neurological diseases. (7)\n\nExclusion Criteria:\n\n* Vestibular problems.\n* Severe cognitive decline and aphasia\n* Systemic diseases.\n* Cerebellar-related diseases.\n* Having acute and critical conditions during the intervention. (14)",{"count":516,"type":20},52,[23],"Stroke is a neurological disorder causing 70-80 percent deaths in the low income and developing countries. Patients commonly present with common impairments associated with balance, proprioception, poor gait, speech impairment and posture which affect the activities of daily living along with increased risk and fear of fall. This negatively impacts patients' mobility, confidence and role in the society. Lower limb sensorimotor training targets the integration of sensory and motor systems enhancing tactile stimulation, balance and proprioception; whereas whole body vibration stimulates muscle spindles and mechanoreceptors via mechanical oscillations that may promote reflexive muscle contractions, improve muscle tone, and enhance postural responses. The aim of this study is to find the comparative effects of lower limb sensorimotor training and whole-body vibration therapy on balance, posture and fear of fall in post stroke patients.\n\nThis study will be a randomized clinical trial. Non probability convenience sampling will be used to recruit 42 patients of either gender, aged 50-65 years, and diagnosed with stroke. This study will be carried out in Saira Memorial Hospital, Lahore. The participants will be randomly allocated to Group A and Group B through computerized table generator method. Each group will be given conventional physical therapy treatment as a baseline which includes range of motion exercises, balance and gait training. Group A will receive lower limb sensorimotor training, whereas group B will receive whole body vibration therapy. Each group will perform their respective exercises 45 minutes, three times a week for 8 weeks. The participants will be evaluated at the start and end of the exercise program through Berg Balance scale for dynamic balance, falls efficacy scale for risk of fall and Nottingham sensory assessment scale for sensory assessment. Data will be analyzed by SPSS version 26.",[299,520],"Stroke Rehabilitation",[299,522,523,524],"Sensorimotor training","Whole body vibration therapy","Berg balance scale",{"date":194,"type":31},{"date":527,"type":31},"2026-04-07",{"date":62,"type":20},{"name":37,"class":38},{"id":531,"slug":532,"hasResults":12,"nctId":533,"briefTitle":534,"officialTitle":535,"acronym":4,"eligibilityCriteria":536,"healthyVolunteers":12,"sex":131,"minAge":537,"maxAge":339,"enrollmentInfo":538,"targetDuration":4,"studyType":21,"phases":540,"briefSummary":541,"conditions":542,"keywords":544,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":548,"startDateStruct":549,"completionDateStruct":550,"leadSponsor":551,"locationsCount":39},"100642320","combined-effects-of-hypopressive-exercises-and-abdominal-bracing-on-diastasis-recti-outcomes-100642320","NCT07642141","Combined Effects of Hypopressive Exercises and Abdominal Bracing on Diastasis Recti Outcomes","Combined Effects of Hypopressive Exercises and Abdominal Bracing on Interrecti Distance, Lumbopelvic Pain, and Abdominal Muscle Strength in Diastasis Recti","Inclusion Criteria:\n\n* Age group of 23 to 30 years\n\n  * Inter recti distance \\> 2 to 5 cm\n  * A women who had undergone a vaginal delivery at least 8 weeks before the first measurement\n  * A postpartum female with the presence of diastasis rectus abdominis\n  * BMI under or equal to 29kg\u002Fm2\n\nExclusion Criteria:\n\n* Pregnant females (29)\n\n  * Subjects who underwent any recent abdominal surgeries\n  * Patient diagnosed with a Fibroid uterus\n  * Patient diagnosed with abdominal hernia\n  * Cesarean section (C-section)\n  * Chronic medical conditions such as diabetes, uncontrolled hypertension, cardiovascular disease, or thyroid disorders.","23 Years",{"count":539,"type":20},34,[23],"Diastasis Recti Abdominis (DRA) is the separation of the rectus abdominis muscles along the linea alba, commonly seen after childbirth due to the mechanical and hormonal changes that occur during pregnancy. DRA can negatively affect posture, trunk stability, and breathing patterns, and may result in persistent lumbopelvic pain and weakened core muscles if not properly managed. Although hypopressive exercises and abdominal bracing have individually demonstrated positive effects in reducing inter-recti distance and improving core function, limited research exists regarding their combined effects. This randomized clinical trial aims to evaluate the combined impact of hypopressive exercises and abdominal bracing on inter-recti distance, lumbopelvic pain, and abdominal muscle strength in postpartum women with DRA. The study will include 34 postpartum women recruited from Jinnah Hospital, Lahore, who will be randomly assigned into two groups. Group A will receive both hypopressive exercises and abdominal bracing, while Group B will receive only hypopressive exercises along with standard postpartum physiotherapy. Outcome measures will include pain intensity, lumbopelvic disability, abdominal muscle strength, and inter-recti distance, with data analyzed using SPSS version 25.",[543],"Diastasis Recti",[545,546,547],"Lumbopelvic pain","Hypopresive Exercise","Abdominal Bracing",{"date":194,"type":31},{"date":397,"type":31},{"date":462,"type":20},{"name":37,"class":38},{"id":553,"slug":554,"hasResults":12,"nctId":555,"briefTitle":556,"officialTitle":557,"acronym":4,"eligibilityCriteria":558,"healthyVolunteers":426,"sex":131,"minAge":104,"maxAge":157,"enrollmentInfo":559,"targetDuration":4,"studyType":21,"phases":560,"briefSummary":561,"conditions":562,"keywords":564,"overallStatus":57,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":567,"startDateStruct":568,"completionDateStruct":569,"leadSponsor":570,"locationsCount":39},"100643070","effects-of-static-stretching-and-strength-training-on-antenatal-restless-leg-syndrome-100643070","NCT07642089","Effects of Static Stretching and Strength Training on Antenatal Restless Leg Syndrome","Effects of Statics Stretching With and Without Strength Training on Symptom Severity, Fatigue and Sleep Quality in Antenatal Restless Leg Syndrome","Inclusion Criteria:\n\n* Pregnant women aged 18-35 years.\n* Gestational age between 24 and 32 weeks.\n* Diagnosed with RLS based on the International Restless Legs Syndrome Study Group (IRLSSG) criteria.\n* Experiencing sleep disturbances and fatigue related to RLS.\n\nExclusion Criteria:\n\n* High-risk pregnancies or obstetric complications.\n* Pre-existing neurological or musculoskeletal disorders.\n* Engagement in regular exercise routines prior to the study.\n* Contraindications to exercise as determined by a healthcare provider.",{"count":386,"type":20},[23],"Restless Legs Syndrome (RLS) is a prevalent sensorimotor disorder affecting pregnant women, particularly in the third trimester, and is associated with sleep disturbances, fatigue and reduced quality of life. Non-pharmacological strategies such as stretching and strength training offer promising alternatives during pregnancy. This randomized controlled trial aims to compare the effects of static stretching alone and static stretching combined with strength training on sleep quality, symptom severity and fatigue in antenatal women with RLS.\n\nThirty pregnant women meeting the diagnostic criteria for RLS will be recruited from National Hospital and medical center and randomly assigned into two groups. Group A will receive static stretching exercises, while Group B will receive static stretching and lower limb strength training exercises for 6 weeks, three sessions per week. Data will be analyzed using SPSS, with a p-value \\\u003C 0.05 considered statistically significant.",[563],"Restless Leg Syndrome",[565,370,566],"Resistance training","Muscle Stretching Exercise",{"date":194,"type":31},{"date":397,"type":31},{"date":462,"type":20},{"name":37,"class":38},{"id":572,"slug":573,"hasResults":12,"nctId":574,"briefTitle":575,"officialTitle":576,"acronym":4,"eligibilityCriteria":577,"healthyVolunteers":12,"sex":17,"minAge":104,"maxAge":157,"enrollmentInfo":578,"targetDuration":4,"studyType":21,"phases":579,"briefSummary":580,"conditions":581,"keywords":583,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":585,"startDateStruct":586,"completionDateStruct":587,"leadSponsor":588,"locationsCount":39},"100642029","effects-of-cervical-stabilization-exercises-with-and-without-reverse-natural-apophyseal-glides-in-text-neck-syndrome-100642029","NCT07646392","Effects of Cervical Stabilization Exercises With and Without Reverse Natural Apophyseal Glides in Text Neck Syndrome","Effects of Cervical Stabilization Exercises With and Without Reverse Natural Apophyseal Glides on Pain, Range of Motion and Disability Among Patients With Text Neck Syndrome","Inclusion Criteria:\n\n* • Both male and female are taken\n\n  * Age between 18-35 years\n  * Craniovertebral angle less than 50 degree\n\nExclusion Criteria:\n\n* • Trauma\n\n  * Patient undergoes cervical surgery.\n  * Disc prolapse, herniation, spondylolisthesis\n  * Osteoporosis\n  * Torticullis\n  * Pregnancy\n  * Psychological Problems\n  * Cervical radiculopathy",{"count":159,"type":20},[23],"Text neck syndrome is one such disorder within that group, increasingly affecting individuals worldwide across various age groups. The phenomenon of text neck may occur in individuals who frequently and for prolonged periods adopt a forward-flexed neck and head position while looking at the screens of mobile electronic devices. This posture puts stress on the neck muscles and spine, leading to various symptoms like neck pain, stiffness, and headaches.",[582],"Text Neck Syndrome",[584],"Neck pain, disability, Range of motion",{"date":219,"type":31},{"date":349,"type":20},{"date":351,"type":20},{"name":37,"class":38},""]