[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Rong Zhang\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":82},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,52],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100464703","phase-2-impact-of-intensive-treatment-of-sbp-on-brain-perfusion-amyloid-and-tau-ipat-study-100464703",false,"NCT05331144","Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study)","Impact of Intensive Treatment of Systolic Blood Pressure on Brain Perfusion, Amyloid, and Tau in Older Adults (IPAT Study)","IPAT","Inclusion Criteria:\n\n* Age 60-85, all races\u002Fethnicities, and both sexes are eligible;\n* Mini-Mental State Exam (MMSE) ≥ 26 to exclude gross dementia; based on clinical judgment, may be rescreened in ≥ 7 days;\n* Individuals with SBP ≥ 130 and SBP ≤ 180 if on 0 or 1 antihypertensive medications; ≥130 and ≤170 on up to 2 medications; ≥130 and ≤160 on up to 3 medications; ≥130 and ≤150 on up to 4 medications. Those on antihypertensives are eligible. If an individual, not treated for hypertension (HTN), has a SBP ≥ 125 mmHg, consider rescreening after 24 hours;\n* Willingness to be randomized into the treatment groups and ability to return to clinic for follow-up visits over 24 months;\n* Fluency in English or Spanish or both, adequate visual and auditory acuity to allow neuropsychological testing;\n* Participants must have a regular healthcare provider.\n\nExclusion Criteria:\n\n* Clinically documented history of stroke, focal neurological signs or other major cerebrovascular diseases based on clinical judgment or MRI\u002FCT scans such as evidence of infection, infarction, or other brain lesions;\n* Diagnosis of AD or other type of dementia, or significant neurologic diseases such as Parkinson's disease, seizure disorder, multiple sclerosis, history of severe head trauma or normal pressure hydrocephalus;\n* Evidence of severe major depression (GDS ≥ 12, may be rescreened after 12 weeks or longer if evidence of reactive depression or temporary mood disturbances) or clinically significant psychopathology, (e.g., psychosis and schizophrenia); if hospitalized in past year, can be rescreened in 6 months; or presence of a major psychiatric disorder that in the investigator's opinion, could interfere with adherence to research assessments or procedures.\n* Unstable heart disease based on clinical judgment (e.g., heart attack\u002Fcardiac arrest, cardiac bypass procedures within previous 6 months and congestive heart failure), or other severe medical conditions;\n* History of atrial fibrillation and evidence on ECG with any of the following: active symptoms of persistent palpitation, dizziness, history of syncope, chest pain, dyspnea, orthopnea, shortness of breath at rest, or paroxysmal nocturnal dyspnea within the past 6 months; resting heart rate of \\\u003C 30 or \\> 110 bpm; taking class I or III antiarrhythmic drugs including flecainide, propafenone, dronedarone, sotalol, dofetilide, and amiodarone; or clinical concerns for safely participating in lowering blood pressure.\n* Systolic BP equal or greater than 180 mmHg and\u002For diastolic BP equal or greater than 110 mmHg, may be rescreened in 1 week.\n* Orthostatic hypotension, defined as the third standing SBP \\\u003C 100mmHg, may be rescreened after 2 weeks;\n* History of significant autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis or polymyalgia rheumatica;\n* Significant history of alcoholism or drug abuse within the last five years;\n* Uncontrolled diabetes mellitus, defined as hemoglobin A1C \\> 7.5%, or requiring insulin treatment;\n* Regularly smoking cigarettes within the past year;\n* Pacemaker or other medical device of metal that precludes performing MRI;\n* Women with a potential for pregnancy, lactation\u002Fchildbearing (2 year post-menopausal or surgically sterile to be considered not childbearing potential);\n* Participant enrolled in another investigational drug or device study, either currently or within the past 2 months;\n* Severe obesity with BMI \\> 40 ; clinical judgment should be applied in all cases to assess patient safety and anticipated compliance;\n* Allergy to angiotensin receptor blockers (ARBs), i.e., drugs that have a suffix \"-sartan\"; allergy to amlodipine;\n* Abnormal screening laboratory tests (e.g., liver ALT and AST \\> 3 x ULN, GFR \\\u003C 30 or Hct \\\u003C 28%); may be rescreened after 2 weeks or longer;\n* A medical condition likely to limit survival to less than 3 years;\n* Participant has any condition(s) judged by the study investigator to be medically inappropriate, risky or likely to cause poor study compliance. For example:\n\n  1. Plans to move outside the clinic catchment area in the next 2 years;\n  2. Significant concerns about participation in the study from spouse, significant other, or family members;\n  3. Lack of support from primary health care provider;\n  4. Residence too far from the study clinic site such that transportation is a barrier including persons who require transportation assistance provided by the study clinic funds for screening or randomization visits;\n  5. Residence in a nursing home; persons residing in an assisted living or retirement community are eligible if they meet the other criteria;\n  6. Other medical, psychiatric, or behavioral factors that, in the judgment of the site PI or clinician, may interfere with study participation or the ability to follow the study Protocol.\n  7. Couples or significant partners who live together cannot be enrolled or participate simultaneously in the study.","ALL","60 Years","85 Years",{"count":21,"type":22},180,"ESTIMATED","INTERVENTIONAL",[25],"PHASE2","The purpose of this study is to determine if intensive lowering of systolic blood pressure (SBP), using FDA approved medications (antihypertensive), reduces Alzheimer's Disease pathology (i.e., excessive brain amyloid and tau protein deposition) in older adults at high risk for memory decline or dementia.",[28,29,30,31],"Cognitively Normal Older Adults","Hypertension","Subjective Cognitive Decline","Family History of Dementia",[33,34,35,36,37,38],"Dementia","Alzheimer's Disease","Cognitive Function","Blood Pressure","Amyloid","Tau","RECRUITING","2025-07-31",{"date":42,"type":43},"2025-08-05","ACTUAL",{"date":45,"type":43},"2022-10-25",{"date":47,"type":22},"2027-12-31",{"name":49,"class":50},"Rong Zhang","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":58,"sex":17,"minAge":59,"maxAge":60,"enrollmentInfo":61,"targetDuration":4,"studyType":23,"phases":63,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":51},"100549531","construction-of-a-risky-sexual-behaviour-intervention-programme-for-college-students-based-on-bcw-theory-100549531","NCT06435234","Construction of a Risky Sexual Behaviour Intervention Programme for College Students Based on BCW Theory","Inclusion Criteria:\n\n1. aged ≥16 years;\n2. full-time undergraduate college students;\n3. engaged in risky sexual behaviors (including multiple sexual partners, unprotected sex, and casual sex, and one of them is considered to have engaged in risky sexual behaviors) during their college years;\n4. able to clearly recall and describe the incident;\n5. signed an informed consent form\n\nExclusion Criteria:\n\n1. not wanting to be asked sex-related questions;\n2. being screened at the beginning of the semester using the Mental Health Survey and diagnosed by a psychiatrist as having a mental illness (schizophrenia, major depressive disorder, bipolar disorder)",true,"16 Years","24 Years",{"count":62,"type":22},40,[64],"NA","Using the intervention functions of Behavior Change Wheel (BCW) and BCTs, we constructed an intervention program for college students' risky sexual behaviors by combining literature analysis, qualitative research, Delphi's expert correspondence, and pre-experiment (20 students in the test group and 20 students in the control group). Before the intervention (T0) and at the end of the intervention (12 weeks, T1), we measured students' psychosexual health, social support, and sexual self-efficacy using relevant scales to ensure the effectiveness of the intervention. By clarifying the influencing factors of college students' risky sexual behaviors, the proposed intervention program for college students' risky sexual behaviors can effectively reduce the incidence of college students' risky sexual behaviors, improve the level of college students' psychosexual health, increase the level of social support, improve the sense of sexual self-efficacy, improve the level of risk perception, enhance the ability of risky decision-making, reduce the risky behaviors, and reduce the occurrence of adverse outcomes, thus providing a reference and reference for the prevention and control of college students' risky sexual behaviors. This will provide reference for the prevention and control of risky sexual behaviors among college students.",[67],"Unsafe Sex",[69,70,71,72,73],"Risky sexual behavior","BCW","college students","intervention program","unsafe sex","2024-10-08",{"date":76,"type":43},"2024-10-10",{"date":78,"type":43},"2024-09-29",{"date":80,"type":22},"2025-04",{"name":49,"class":50},""]