[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Roskamp Institute Inc.\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":95},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,42,65],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":5},"100495818","validating-gulf-war-illness-blood-biomarkers-100495818",false,"NCT05736146","Validating Gulf War Illness Blood Biomarkers","Validating Blood Biomarkers of Brain Immune and Metabolic Dysfunction in Gulf War Illness","Inclusion Criteria:\n\n1. Age 35 years or older.\n2. For GWI cases, served in the 1990-1991 Gulf War as active duty, national guard, or reserves and meet criteria for the CDC Chronic Multisymptom Illness (CMI) GWI definition or Kansas GWI definition.\n3. For controls, must be a veteran in the same age range as those veterans with GWI as defined above.\n4. Ability to understand written and spoken English or availability of a legal representative who can understand written or spoken English. Participants and caregiver\u002Finformants must be able to read, write and speak the language in which psychometric tests are provided with visual and auditory acuity (corrected) sufficient to allow for accurate testing.\n\nExclusion Criteria:\n\n1. Diagnosed or being treated by a physician for any of the following (Steele et al, 2000) and deemed clinically significant per the discretion of the PI:\n\n   1. Cancer (except for non-melanoma skin cancers)\n   2. Chronic infectious disease\n   3. Problems resulting from postwar injuries.\n   4. Liver disease\n   5. Lupus\n   6. Multiple sclerosis\n   7. Stroke\n   8. Serious psychiatric condition (those associated with psychosis and\u002For for which the respondent had been hospitalized since 1991).\n   9. Dementia or any type of Parkinson's disease (PD).\n2. Hospitalized in the last 5 years for alcohol or drug dependence, depression, or post-traumatic stress disorder (PTSD).\n3. Female subject is either pregnant or nursing.",true,"ALL","35 Years",{"count":20,"type":21},100,"ESTIMATED","OBSERVATIONAL","The investigators goals are to identify blood lipids\u002Fmetabolites that correlate with cognitive decline in the presence of the APOE ε4 allele among veterans with GWI. To determine the effect of dietary, medical and biological factors that influence lipid and metabolites in blood from GW veterans. To identify blood lipid\u002Fmetabolite profiles that correlate with bioenergetics deficits and glial activation in the brains of GWI. To validate blood biomarker signatures of GWI using APOE genotyping and blood lipids\u002Fmetabolites that correlate with the CNS dysfunction in GWI.",[25,26],"Gulf War Syndrome","Gulf War Illness",[28,29],"Gulf War","APOE","RECRUITING","2025-07-21",{"date":33,"type":34},"2025-07-24","ACTUAL",{"date":36,"type":34},"2022-06-30",{"date":38,"type":21},"2026-03-01",{"name":40,"class":41},"Roskamp Institute Inc.","OTHER",{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":17,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":58,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":64},"100457951","nicotinamide-riboside-clinical-trial-for-gwi-100457951","NCT05243290","Nicotinamide Riboside Clinical Trial for GWI","A Randomized Double-blind Placebo-controlled Clinical Trial of Nicotinamide Riboside for Restoring Mitochondrial Bioenergetics in Gulf War Illness","Inclusion Criteria:\n\n* Both sexes, all ethnic groups, and ages 47 to 70 years.\n* Subject willing and able to give informed consent.\n* Medically stable as per the investigator's discretion.\n* Negative urine pregnancy test for females of childbearing potential. A woman is considered of childbearing potential unless she is surgically sterile (hysterectomy or tubal ligation) or is postmenopausal (no menstrual cycle for 2 years or more).\n* If female of childbearing potential, must be willing to use adequate birth control during the study and for 30 days after the last dose. Females agreeing to take an acceptable form of birth control per investigator discretion (where relevant). Females must prevent pregnancy or otherwise be unable to conceive.\n* Veterans deployed to the Gulf War between August 1990 and August 1991.\n* Veteran meets criteria for the CDC Chronic Multisymptom Illness (CMI) GWI definition or Kansas GWI definition.\n* Weight of 50.0kg - 200.0kg (110 lbs. - 440 lbs.).\n\nExclusion Criteria:\n\n* Diagnosed by a physician with medical or psychiatric conditions that would account for their symptoms or interfere with their ability to report their symptoms, as per investigator discretion.\n* Female subject is either pregnant or nursing; or if female subject is of childbearing age is not currently on or is unwilling and\u002For unable to use birth control.\n* Have contraindications, allergy, or sensitivity to NR, vitamin B3, or excipients (microcrystalline cellulose, silicon dioxide, magnesium stearate, hypromellose, and\u002For titanium dioxide).\n* Any significant medical condition that could interfere with study conduct, as per investigator discretion. These may include but are not limited to the following: untreated chronic hypertension (defined as systolic \\> 180 mmHg; diastolic \\>110 mmHg), myocardial infarction within 6 months of screening, renal failure, hepatic failure, and\u002For receiving chemotherapy.\n* Clinically significant lab values for clinical laboratory assessments, as per investigator discretion.\n* Poor venous access.\n* Current use of any NR supplement products (such as nicotinamide, nicotinamide mononucleotide (NMN), vitamin B3\u002FNiacin, vitamin B complex, etc.) within 30 days of screening.\n* Participation in another clinical trial involving dietary or pharmaceutical intervention within 90 days of screening.","47 Years","70 Years",{"count":52,"type":21},52,"INTERVENTIONAL",[55],"NA","In this multi-site trial, we will use a randomized, double-blind, placebo-controlled study design to test whether 300 mg of Nicotinamide Riboside (NR) can achieve the primary objective of increasing plasma NAD+ levels in participants with Gulf War Illness (GWI).",[26],{"date":33,"type":34},{"date":60,"type":34},"2022-04-13",{"date":62,"type":21},"2025-12-31",{"name":40,"class":41},2,{"id":66,"slug":67,"hasResults":11,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":4,"eligibilityCriteria":70,"healthyVolunteers":16,"sex":17,"minAge":71,"maxAge":4,"enrollmentInfo":72,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":74,"conditions":75,"keywords":79,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":86,"lastUpdatePostDateStruct":87,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},"100583968","investigating-health-impacts-of-exposure-to-harmful-algal-blooms-100583968","NCT06883227","Investigating Health Impacts of Exposure to Harmful Algal Blooms","Inclusion Criteria:\n\n1. Subject should be able to provide written informed consent.\n2. Adult aged 18 or older.\n3. Resident (temporary or permanent) of one of the following five southwest Florida counties (Lee, Collier, Charlotte, Sarasota, or Manatee).\n4. Any race or ethnicity.\n5. Willing to return for at least a total of four study visits and participate in all required procedures for the duration of the study.\n\nExclusion Criteria:\n\n1. Inability to speak or write in English.\n2. Any medical condition for which the study investigator believes enrollment is medically inappropriate.\n3. Unwilling\u002Funable to provide biological samples or poor venous access.","18 Years",{"count":73,"type":21},400,"The goals of this project are to study the biological effects of environmental toxins (ET), in particular aquatic toxins such as brevetoxins (PbTx) and microcystin or their metabolites. This study is designed to examine the effects of the body from harmful algae blooms (HAB) as well as possibility of an association between exposure to the marine toxin, brevetoxin (PbTx), which is released from K. brevis during the red tide bloom, and the prevalence of neurological illnesses.",[76,77,78],"Red Tide","Neurologic Disorder","Florida",[80,76,81,82,83,84,85],"Brain fog","respiratory","coughing","neurotoxin","beach","florida","2025-03-19",{"date":88,"type":34},"2025-03-24",{"date":90,"type":34},"2024-10-14",{"date":92,"type":21},"2030-10-14",{"name":40,"class":41},1,""]