[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Rotherham Doncaster and South Humber NHS Foundation Trust\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":85},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,55],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":5},"100571632","trial-of-an-online-group-psychotherapy-intervention-for-common-mental-health-disorders-100571632",false,"NCT06722781","Trial of an Online Group Psychotherapy Intervention for Common Mental Health Disorders","UpLift-X Trial 1: A Cluster Factorial Randomised Controlled Trial of Digitally-enabled Group Psychotherapy for Common Mental Disorders","UpLift-X","Inclusion Criteria:\n\n* 17 years old and over\n* Literate and fluent in the English language, which would enable group interactions and learning via online materials\n* With access to an internet-connected device (e.g., computer, phone) and confidential space\n* Referred to NHS-TT services\n* Assessed by a qualified psychological professional and deemed to be eligible for high intensity CBT (this includes low risk of harm to self or others)\n* Currently on waiting list for high intensity CBT and not accessing any other psychological interventions. This includes patients accessing pharmacotherapy but who are additionally seeking psychological treatment\n* Presenting symptoms of one or more internalizing disorders (major depressive disorder, generalised anxiety disorder, panic disorder, agoraphobia, specific phobias, somatoform disorder, obsessive-compulsive and related disorders, body dysmorphic disorder, post-traumatic stress and related disorders)\n\nExclusion Criteria:\n\n* 16 years old and under\n* Not able to speak or read English fluently, which would require more individualised support with interpreters\n* No access to internet-connected device or confidential space to engage with digital intervention\n* Not involved with NHS-TT services\n* Assessed by a qualified psychological professional and not deemed to be eligible for high intensity CBT on the basis of mental health condition and\u002For risk assessment (e.g., acute risk of suicide at the time of assessment)\n* Already accessing a high intensity psychotherapy or other forms of psychological treatment (e.g., private therapy, counselling)\n* Presenting with symptoms of eating disorders, substance use disorders, psychotic disorders, personality disorders, bipolar disorders identified at the time of initial assessment.","ALL","17 Years",{"count":20,"type":21},660,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to understand how to deliver online group therapy for adults with common mental health problems in a personalised way. This study will test a new online group therapy program for various common mental health problems like anxiety and depression. The therapy is based on an approach called the Unified Protocol, which includes eight modules teaching different coping skills. The therapy will be delivered via a video call and a website, which will also have helpful videos and information about coping skills.\n\nAims:\n\n1. Does changing the order of the therapy modules affect how well treatment works or how many patients drop-out of treatment?\n2. Do some modules work better for different patients based on their individual features and if patients receive the therapy module that is most likely to be helpful for them first, does it mean they have a better chance of feeling better by the end of treatment?\n3. Does online group therapy work as well to treat common mental health problems as standard care (individual cognitive behavioural therapy \\[CBT\\])?\n\nHypotheses:\n\n1. Changing the order of therapy modules will not change how well therapy works or how many people drop-out.\n2. Patients with specific profiles (based on their individual characteristics) will benefit more from some treatment modules and will see greater improvements in their symptoms if they received their best therapy module before other modules\n3. There will be no differences in overall treatment outcome or dropout rates when comparing online group therapy vs. individual CBT\n\nResearchers will compare whether delivering the modules in different orders, with five different versions of the treatment, to see if changing the order of therapy modules affects how well it works or drop-out rates. Researchers will test how best to match patients to the most helpful parts of treatment for them. The group therapy outcomes and costs will also be compared to data from patients who have had individual CBT to see how the intervention compares to standard care.\n\nParticipants will:\n\n* Complete online symptom questionnaires before treatment starts and before each therapy session\n* Attend 12 weekly group therapy sessions delivered by a video call on a website (called Uplift-X).\n* Access online resources like videos and practice exercises to use between therapy sessions.\n* Complete the online symptom questionnaires again at the end of treatment and 6 months later.",[27,28,29],"Common Mental Health Problems","Anxiety","Depression Disorders",[31,32,33,34,35,36,37,38,39,40,41,42],"Psychological interventions","Internalizing disorders","High intensity CBT","Common mental health problems","Unified Protocol","Digitally-enabled therapy","Group therapy","Digital Health Technology","NHS Talking Therapies","Personalised treatment","Pragmatic clinical trial","Transdiagnostic","RECRUITING","2025-07-07",{"date":46,"type":47},"2025-07-10","ACTUAL",{"date":49,"type":47},"2025-04-30",{"date":51,"type":21},"2026-09-30",{"name":53,"class":54},"Rotherham Doncaster and South Humber NHS Foundation Trust","OTHER_GOV",{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":62,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},"100559684","stratcare-trial-2-evaluating-the-clinical-and-cost-effectiveness-of-ai-driven-stratified-care-for-depression-100559684","NCT06567340","StratCare Trial 2: Evaluating the Clinical and Cost-effectiveness of AI-driven Stratified Care for Depression","StratCare-2","Inclusion criteria:\n\n* 18 years of age or older.\n* Patients who consent to share their de-identified clinical records for research purposes.\n* Patients assessed as eligible for psychological care in Talking Therapies based on clinical guidelines.\n* Patients with case-level depression symptoms (PHQ-9 ≥ 10).\n\nExclusion Criteria:\n\n• Those who are ineligible for treatment in Talking Therapies services according to standard treatment guidelines.","18 Years",{"count":64,"type":21},1252,[24],"Depression and anxiety are common mental health problems affecting around one in six adults. Treatments include therapy, telephone or group-based activities delivered by therapists. Treatment uses a \"stepped care\" model where most patients start with very brief treatments. If they remain unwell after this, they access longer and more intensive therapy. This model does not always work, as only one out of two patients fully recover.\n\nThe researchers have developed an artificial intelligence tool called \"StratCare\". It is designed to help health services to offer the best available treatment for each patient. StratCare is a computerised system that guides therapists on how to assess new patients. It asks a few questions about their symptoms, personality, and background. The system makes a recommendation about which treatment might be most effective for that person. This is either starting with brief therapy or starting with intensive therapy. The treatments are already used with depression in the National health Service (NHS). The patient can discuss with their therapist and decide whether to accept the recommendation. Otherwise, they can discuss trying other options. Previous research found that StratCare can help more people to recover from depression compared to the usual stepped care model.\n\nThe researchers will investigate if the StratCare tool works on a large scale in the NHS and if it helps patients in the long-term. The researchers will run a trial involving 1252 participants using NHS Talking Therapies services. Half will use the StratCare tool to make a treatment recommendation. The other half will follow the stepped care approach. The researchers will contact participants in the trial after 6, 12 and 18 months to see if their mood and quality of life has improved. The researchers will also interview therapists and participants to see what they think about treatment being guided by the StratCare tool.\n\nHypotheses:\n\n* Stratified care will result in lower mean depression scores compared to usual stepped care (USC).\n* Stratified care will result in a statistically significant higher proportion of cases with reliable and clinically significant improvement in depression symptoms, compared to USC.\n\nPrimary Outcome:\n\nDepressive symptoms, as measured by change on the Patient Health Questionnaire (PHQ-9), at 12 months post-enrolment.",[68],"Depression",[70,71,72,28,73,74,75,76],"Software","Medical Devices","Mental Health","Psychotherapy","Cognitive Behavioural Therapy","Mood Disorders","Mental Health Services","NOT_YET_RECRUITING",{"date":79,"type":47},"2025-07-08",{"date":44,"type":21},{"date":82,"type":21},"2026-11-30",{"name":53,"class":54},1,""]