[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Rotman Research Institute at Baycrest\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":114},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,70,90],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100609279","effect-of-accelerated-neuromodulation-of-anterior-cingulate-cortex-to-enhance-cognition-in-older-adults-with-mild-memory-problems-100609279",false,"NCT07212504","Effect of Accelerated Neuromodulation of Anterior Cingulate Cortex to Enhance Cognition in Older Adults With Mild Memory Problems","NACC-EC","Inclusion Criteria:\n\n* 55 - 85 years of age (on the day of randomization)\n* are male or post-menopausal female\n* have a diagnosis of mild cognitive impairment (MCI) based on Montreal Cognitive Assessment score \\\u003C 26 or where available, results from clinical neuropsychological assessment, OR subjective memory concerns and first degree relative, living or deceased, with a probable or confirmed diagnosis of AD\n* score 24 or higher on the Mini Mental State Examination (MMSE)\n* are willing to provide informed consent\n* are able to follow the treatment schedule\n* are stable on medications for 2 months and are not expected to change medication during the entire study period (if they are taking medications)\n* have a satisfactory safety screening questionnaire for TMS\n\nExclusion Criteria:\n\n* have a metal plate in their head(such as an ear implant, implanted brain stimulators, aneurysm clips). Dental devices and implants that are non-magnetic are safe.\n* have known increased pressure or a history of increased pressure in their brain, which may increase their risk for having seizures\n* have a cardiac pacemaker\n* have an implanted medication pump\n* have a central venous line\n* have a history of any psychotic disorder, bipolar disorder, eating disorder, obsessive compulsive disorder, post-traumatic stress disorder, or dementia\n* have a history of substance abuse in the last 6 months\n* have a history of stroke or other brain lesions\n* have a personal history of epilepsy\n* have a family history of epilepsy\n* are a pregnant or breast-feeding woman\n* have a history of abnormal MRI of the brain\n* have untreated hypo- or hyper-thyroidism\n* have unstable medical condition(s)\n* have any other known contraindications to TMS\n* are on unstable doses of any psychotropic medication such as antidepressants, antipsychotic, mood stabilizers or memory enhancing medications\n* regularly use benzodiazepines or other hypnotics within 2 weeks of randomization","ALL","55 Years","85 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to test whether an accelerated deep Transcranial Magnetic Stimulation (dTMS) protocol in combination with cognitive training can improve cognitive abilities in older adults with Subjective Cognitive Decline (SCD) or Mild Cognitive Impairment (MCI). The study will look at whether it is safe and tolerable to use accelerated dTMS to enhance the benefits of cognitive training in older adults, and will also gather early information on the effects of accelerated dTMS on memory and other cognitive abilities.",[27,28],"Mild Cognitive Impairment (MCI)","Subjective Cognitive Decline (SCD)",[30,31,32,33],"Mild Cognitive Impairment","Subjective Cognitive Decline","Transcranial Magnetic Stimulation (TMS)","Intermittent Theta Burst Stimulation","RECRUITING","2025-10-27",{"date":37,"type":38},"2025-10-28","ACTUAL",{"date":40,"type":21},"2025-11-15",{"date":42,"type":21},"2027-03-15",{"name":44,"class":45},"Rotman Research Institute at Baycrest","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":18,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":64,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":46},"100609276","accelerated-neuromodulation-of-anterior-cingulate-cortex-for-depression-100609276","NCT07212465","Accelerated Neuromodulation of Anterior Cingulate Cortex for Depression","Feasibility, Tolerability, and Preliminary Efficacy for Non-Invasive Neuromodulation of the Anterior Cingulate Cortex for Depression (NACC-D) in Older Adults Using Deep Transcranial Magnetic Stimulation With an Accelerated Intermittent Theta Burst Protocol","NACC-D","Inclusion Criteria:\n\n* are between 60- 85 years old (on the day of randomization)\n* have been diagnosed with DSM5 Major Depressive Disorder, with the current episode longer than 4 weeks but less than 5 years\n* did not respond to\u002Fdid not tolerate, or failed to achieve remission with at least one antidepressant trial of 8 week minimum duration\n* are willing to provide informed consent\n* are able to follow the treatment schedule\n* are stable on medications for 2 months and are not expected to change medication during the entire study period (if they are taking medications)\n* have a satisfactory safety screening questionnaire for TMS\n\nExclusion Criteria:\n\n* have a metal plate in your head (such as an ear implant, implanted brain stimulators, aneurysm clips). Dental devices and implants that are non-magnetic are safe\n* have known increased pressure or a history of increased pressure in their brain, which may increase their risk for having seizures\n* have a cardiac pacemaker\n* have an implanted medication pump\n* have a central venous line\n* have a history of any psychotic disorder, bipolar disorder, eating disorder, obsessive compulsive disorder, post-traumatic stress disorder, or dementia\n* have a history of substance abuse in the last 6 months\n* have a history of stroke or other brain lesions\n* have a personal history of epilepsy\n* have a family history of epilepsy\n* are a pregnant or breast-feeding woman\n* have a history of abnormal MRI of the brain\n* have untreated hypo- or hyper-thyroidism\n* have unstable medical condition(s)\n* have any other known contraindications to TMS\n* are on unstable doses of any psychotropic medication such as - antidepressants, antipsychotic, mood stabilizers or memory enhancing medications\n* require daily doses of benzodiazepines or hypnotics within two weeks of randomization","60 Years",{"count":57,"type":21},24,[24],"The goal of this clinical trial is to test whether an accelerated deep Transcranial Magnetic Stimulation (dTMS) protocol can reduce depressive symptoms in older adults (ages 60-85) with Major Depressive Disorder (MDD) who have not tolerated or responded to antidepressant medications. The study will evaluate whether accelerated dTMS administered over 5 consecutive days is safe and well-tolerated in this population, and whether it produces greater reductions in depressive symptoms compared to placebo stimulation.",[61],"Major Depressive Disorder (MDD)",[32,63,33],"Treatment Resistant Depression",{"date":37,"type":38},{"date":66,"type":38},"2025-07-21",{"date":68,"type":21},"2027-02-15",{"name":44,"class":45},{"id":71,"slug":72,"hasResults":11,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":77,"enrollmentInfo":78,"targetDuration":4,"studyType":22,"phases":79,"briefSummary":80,"conditions":81,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":46},"100523390","dtms-for-subjective-cognitive-decline-100523390","NCT06095063","dTMS for Subjective Cognitive Decline","Effect of Deep Transcranial Magnetic Stimulation (dTMS) on Cognition in Older Adults With Subjective Cognitive Decline (SCD)","Inclusion Criteria:\n\n* have a family history of late onset sporadic Alzheimer's disease (AD) as defined by having a first degree relative, living or deceased, with a probable or confirmed diagnosis of AD\n* have subjective memory decline and concern about memory changes\n* score 26 or higher on the Montreal Cognitive Assessment (MoCA)\n* are willing to provide informed consent\n* are able to follow the treatment schedule\n* are stable on medications for 2 months and are not expected to change medication during the entire study period (if they are taking medications)\n* have a satisfactory safety screening questionnaire for TMS\n* have an informant\u002Fstudy partner who is able to complete study questionnaires regarding the participant\n\nExclusion Criteria:\n\n* have a metal plate in their head, except in the mouth (such as an ear implant, implanted brain stimulators, aneurysm clips)\n* have known increased pressure or a history of increased pressure in their brain, which may increase their risk for having seizures\n* have a cardiac pacemaker\n* have an implanted medication pump\n* have a central venous line\n* have a significant heart condition\n* have current depression or a history of any psychotic disorder, bipolar disorder, eating disorder, obsessive compulsive disorder, post-traumatic stress disorder, or dementia other than AD\n* have a history of substance abuse in the last 6 months\n* have a history of stroke or other brain lesions\n* have a personal history of epilepsy\n* have a family history of epilepsy\n* are a pregnant or breast-feeding woman\n* have a history of abnormal MRI of the brain\n* have significant hearing loss requiring use of hearing aids\n* have untreated hypo- or hyper-thyroidism\n* have TMS contraindications\n* have unstable medical condition(s)\n* regularly use benzodiazepines or other hypnotics within 2 weeks of randomization","70 Years",{"count":20,"type":21},[24],"Deep transcranial magnetic stimulation (dTMS) is a brain stimulation technique that involves generating a brief magnetic field in a coil that is placed on the scalp. The magnetic field passes through the skull and induces a weak electrical current in the brain that briefly activates neural circuits at the stimulation site. The Brainsway dTMS H7-Coil is able to target an area of the brain that has been shown in studies to be linked to greater resilience to cognitive decline. In this study, the investigators will combine dTMS with cognitive training in older adults with subjective cognitive decline (SCD) and examine the effect of this treatment on memory, other cognitive abilities, and mood. In addition, the investigators will examine the combined effects of dTMS and cognitive training on brain activity as measured using electroencephalography (EEG).\n\nApproximately 30 older adults from ages 55 to 70 with SCD and a positive family history of Alzheimer's disease will be enrolled in this study.",[82,31],"Alzheimer Disease","2025-10-23",{"date":35,"type":38},{"date":86,"type":38},"2023-11-15",{"date":88,"type":21},"2026-11-15",{"name":44,"class":45},{"id":91,"slug":92,"hasResults":11,"nctId":93,"briefTitle":94,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":97,"targetDuration":4,"studyType":22,"phases":99,"briefSummary":100,"conditions":101,"keywords":103,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":108,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":46},"100336854","deep-tms-for-comorbid-depression-and-cognitive-impairment-in-older-adults-100336854","NCT03665831","Deep TMS for Comorbid Depression and Cognitive Impairment in Older Adults","Treatment of Comorbid Depression and Cognitive Impairment in Older Adults With Neurocognitive Disorders Using Deep Transcranial Magnetic Stimulation (dTMS)","Inclusion Criteria:\n\n* meet DSM 5 criteria for Major or Mild Neurocognitive Disorder due to Alzheimer's disease with Clinical Dementia Rating Scale (CDR) score of at least 0.5\n* have been diagnosed with DSM5 Major Depressive Disorder, with the current episode longer than 4 weeks but less than 5 years\n* did not respond to or did not tolerate antidepressant treatment\n* are willing to provide informed consent\n* are able to follow the treatment schedule\n* are stable on medications for 2 months and are not expected to change medication during the entire study period (if they are taking medications)\n* have a satisfactory safety screening questionnaire for TMS\n* have an informant\u002Fstudy partner who is able to complete study questionnaires regarding the participant\n\nExclusion Criteria:\n\n* have a metal plate in their head, except in the mouth (such as an ear implant, implanted brain stimulators, aneurysm clips)\n* have known increased pressure or a history of increased pressure in their brain, which may increase their risk for having seizures\n* have a cardiac pacemaker\n* have an implanted medication pump\n* have a central venous line\n* have a significant heart disease or history of stroke\n* Modified Hachinski Score (MHIS) \\> 3 (to exclude those with significant vascular component to memory loss)\n* have a history of any psychotic disorder, bipolar disorder, eating disorder, obsessive compulsive disorder, post-traumatic stress disorder, or dementia other than AD\n* have a history of substance abuse in the last 6 months\n* have a history of stroke or other brain lesions\n* have a personal history of epilepsy\n* have a family history of epilepsy\n* are a pregnant or breast-feeding woman\n* are taking psychotropic medications including antidepressant medications, antipsychotics or mood stabilizing medications due to increased risk of seizure\n* are taking memantine\n* have a history of abnormal MRI of the brain\n* have significant hearing loss requiring use of hearing aids\n* have untreated hypo- or hyper-thyroidism",{"count":98,"type":21},28,[24],"In this study, the investigators will be examining the effects of the deep repetitive transcranial magnetic stimulation (rTMS) using the H1 coil in patients over the age of 60 diagnosed with mild to early-moderate Alzheimer's disease (AD) or mild cognitive impairment (MCI) and comorbid Major Depressive Disorder (MDD) who have been unable to tolerate or failed to respond to antidepressant medications. The coil was designed to stimulate deeper regions of the left dorsolateral prefrontal cortex (DLPFC). Based on prior research, the investigators propose that active stimulation with the H1 coil for 4 weeks may result in significant remission rates and will be tolerable and safe.",[102,82,30],"Major Depressive Disorder",[104,105,106,107],"dTMS","depression","magnetic","iTBS",{"date":35,"type":38},{"date":110,"type":38},"2018-10-23",{"date":112,"type":21},"2026-09-15",{"name":44,"class":45},""]