[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"São Paulo State University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":104},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,49,74],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100627092","effects-of-beetroot-extract-on-blood-pressure-and-exercise-in-hypertensive-older-women-100627092",false,"NCT07444138","Effects of Beetroot Extract on Blood Pressure and Exercise in Hypertensive Older Women","Acute Effects of Beetroot Extract Supplementation on Blood Pressure, Oxidative Stress, and Muscle Oxygen Saturation in Hypertensive Older Women Submitted to an Aerobic Exercise Session","Inclusion Criteria:\n\n* Female sex: Older women aged between 60 and 70 years.\n* Physical capability: Absence of health conditions that could compromise performance in the required physical exercise tests.\n\nExclusion Criteria:\n\n* Smoking: Current smokers.\n* Alcohol use: History of alcohol abuse or excessive alcohol consumption.\n* Cardiovascular Disease: Diagnosis of cardiovascular diseases (other than the primary condition of hypertension).",true,"FEMALE","60 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn about the acute effects of beetroot extract in older women with high blood pressure. The main questions it aims to answer are:\n\nDoes beetroot extract affect blood pressure during exercise? Does it change oxygen levels in the muscles? Participants will take a beetroot supplement and perform an aerobic exercise session to check how their bodies respond.",[27,28],"Hypertension","Hypertension (HTN)",[30,31,32,33,34,35],"Dietary Nitrate","Beetroot Extract","Aerobic Exercise","Nitric Oxide","Older Adults","Blood Pressure","RECRUITING","2026-02-27",{"date":39,"type":40},"2026-03-02","ACTUAL",{"date":42,"type":40},"2025-10-08",{"date":44,"type":21},"2026-07",{"name":46,"class":47},"São Paulo State University","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":4},"100624289","exercise-insulin-resistance-and-chronic-pain-in-postmenopausal-women-100624289","NCT07407699","Exercise, Insulin Resistance, and Chronic Pain in Postmenopausal Women.","Isulin Resistance as a Mediator of Chronic Pain in Postmenopausal Women: Effects of a Combined Exercise Program on Metabolic and Inflammatory Mechanisms","EX-PAIN-MENO","Inclusion Criteria:\n\n* Postmenopausal women, defined as between 12 months and 5 years since the last menstrual period.\n* Not using hormone replacement therapy.\n* Not engaged in regular physical exercise (defined as more than once per week in the last months).\n* With or without insulin resistance.\n\nExclusion Criteria:\n\n* Diagnosis of neurological diseases (e.g., Parkinson's disease, multiple sclerosis, or stroke sequelae).\n* Severe psychiatric disorders.\n* Inflammatory autoimmune diseases (e.g., rheumatoid arthritis or systemic lupus erythematosus).\n* Active neoplasms.\n* Use of systemic corticosteroids or immunosuppressive drugs within the last three months.\n* Severe decompensated cardiovascular disease.\n* Any medical condition that contraindicates participation in physical exercise.",{"count":58,"type":21},50,[24],"This study aims to investigate the effects of a combined exercise program on chronic pain in postmenopausal women, considering insulin resistance as a potential physiological mediator. The intervention will assess changes in pain intensity, metabolic and inflammatory biomarkers, psychosocial factors, and body composition. The findings may contribute to understanding the metabolic mechanisms underlying chronic pain in postmenopausal women and support exercise as a non-pharmacological therapeutic strategy.",[62,63,64],"Chronic Pain","Postmenopausal","Insulin Resistance","NOT_YET_RECRUITING","2026-02-05",{"date":68,"type":40},"2026-02-12",{"date":70,"type":21},"2026-08",{"date":72,"type":21},"2027-07",{"name":46,"class":47},{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":4,"eligibilityCriteria":80,"healthyVolunteers":16,"sex":81,"minAge":82,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":99,"completionDateStruct":101,"leadSponsor":103,"locationsCount":48},"100619405","phase-1-dual-site-transcranial-magnetic-stimulation-of-the-supplementary-motor-area-and-cerebellum-for-the-treatment-of-essential-tremor-100619405","NCT07344194","Dual-Site Transcranial Magnetic Stimulation of the Supplementary Motor Area and Cerebellum for the Treatment of Essential Tremor.","Dual-Site Transcranial Magnetic Stimulation of the Supplementary Motor Area and Cerebellum for the Treatment of Essential Tremor","Inclusion Criteria:\n\n* Male or female participants, aged 18 to 80 years; women of childbearing potential must not be pregnant.\n* Diagnosis of Essential Tremor with a score greater than 2 on items 5 or 6 of the Fahn-Tolosa-Marin Tremor Rating Scale despite optimized medical therapy.\n* Medication-refractory tremor, defined as prior use of both first-line medications (propranolol and primidone) at maximally tolerated doses without adequate tremor control.\n* Ability to provide written informed consent in accordance with institutional policies.\n* Ability to comply with all study procedures and follow-up assessments as defined by the study protocol.\n\nExclusion Criteria:\n\n* Unstable or untreated psychiatric disorders.\n* Inability to provide informed consent.\n* Uncontrolled medical conditions, including but not limited to uncontrolled diabetes mellitus, hypertension, symptomatic pulmonary disease, or symptomatic cardiac disease.\n* Concomitant participation in another investigational drug or device study.\n* Pregnancy or breastfeeding.\n* Presence of an implanted deep brain stimulation (DBS) system.\n* History of epilepsy not adequately controlled, defined as seizure-free for less than 5 years.\n* Presence of a cardiac pacemaker.\n* Presence of metallic implants in any part of the body that are contraindicated for rTMS.","ALL","18 Years",{"count":84,"type":21},36,[86,87],"PHASE1","PHASE2","Essential tremor is a common movement disorder that causes involuntary shaking, mainly during voluntary actions such as writing or holding objects. Recent research suggests that essential tremor is not caused by a single brain area, but by abnormal activity within a network that includes the cerebellum and motor areas of the brain. However, most non-invasive brain stimulation studies to date have targeted only one brain region and have shown inconsistent clinical benefits.\n\nThis randomized, double-blind, placebo-controlled clinical trial aims to evaluate the effects of a dual-site transcranial magnetic stimulation (rTMS) protocol targeting the supplementary motor area (SMA) and the cerebellum in patients with essential tremor that does not respond adequately to standard medications. The study is based on previous pilot data showing meaningful tremor reduction using combined stimulation of these two brain regions.\n\nParticipants will receive five sessions of rTMS, consisting of low-frequency stimulation over the SMA followed by high-frequency stimulation over the cerebellum. The main hypothesis is that this combined approach will lead to an immediate and sustained improvement in action tremor of the dominant upper limb, measured up to four weeks after treatment. Secondary outcomes include quality of life, safety, side effects, and changes in brain excitability associated with tremor improvement.",[90],"Essential Tremor",[92,93,94,95],"essential tremor","rTMS","movement disorders","non-invasive neuromodulation","2026-01-19",{"date":98,"type":40},"2026-01-21",{"date":100,"type":40},"2026-01-15",{"date":102,"type":21},"2027-01",{"name":46,"class":47},""]