[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"SEFA HAKTAN HATIK\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":184},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,54,89,122,156],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":34,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100630073","transcutaneous-auricular-vagus-nerve-stimulation-and-spirometry-sham-controlled-randomized-trial-100630073",false,"NCT07482930","Transcutaneous Auricular Vagus Nerve Stimulation and Spirometry: Sham-Controlled Randomized Trial","Acute Effects Transcutaneous Auricular Vagus Nerve Stimulation on Spirometric Parameters in Healthy Individuals: A Sham-Controlled Randomized Study","taVNS-SPIRO","Inclusion Criteria:\n\n* Aged 18-40 years.\n* Healthy volunteers.\n* Able to perform spirometry and follow study instructions.\n* Provided written informed consent.\n\nExclusion Criteria:\n\n* Any cardiovascular disease, cardiac arrhythmia, hypertension, or related condition.\n* Any neurological disorder (e.g., diabetes mellitus, peripheral neuropathy, epilepsy).\n* Any diagnosed psychiatric disorder.\n* Any respiratory disease (e.g., asthma, chronic obstructive pulmonary disease).\n* Pregnancy or suspected pregnancy.\n* Ear conditions that prevent stimulation (infection, open wound, pain\u002Ftenderness) or presence of a piercing at\u002Fnear the stimulation site.\n* Vigorous exercise within 24 hours prior to measurement.\n* Caffeine intake, smoking, or alcohol consumption within 4-6 hours prior to measurement.\n* Marked intolerance or hypersensitivity to the device or the procedure.\n* Inability to follow instructions during measurements or refusal to complete the session.",true,"ALL","18 Years","40 Years",{"count":22,"type":23},50,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study will examine the short-term effects of transcutaneous auricular vagus nerve stimulation (a non-invasive electrical stimulation delivered through the outer ear) on lung function measured by spirometry in healthy adults. The vagus nerve is involved in many automatic body functions, and ear-based stimulation has been used in research to explore its possible effects on different physiological systems. However, it is not clear whether a brief stimulation session can acutely influence breathing test results in people without respiratory disease.\n\nHealthy volunteers aged 18-40 will take part in one laboratory visit. Participants will be randomly assigned to one of two groups: (1) active bilateral stimulation applied to specific ear regions that are known to be innervated by the vagus nerve, or (2) sham stimulation using the same device setup but designed to minimize vagal activation. The stimulation session will last approximately 10 minutes. Before and after the stimulation, participants will perform standard spirometry (breathing) tests. Primary spirometric outcomes will include common measures of lung function such as forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and peak expiratory flow (PEF). Heart rate, heart rate variability, and blood pressure may also be recorded to monitor physiological responses and safety during the visit.\n\nParticipation is voluntary and participants may withdraw at any time. The procedure is considered minimal risk. Possible side effects are usually mild and temporary, such as tingling, warmth, or mild discomfort at the ear. Rarely, participants may feel lightheaded; if this occurs, the procedure will be stopped and the participant will be monitored until symptoms resolve. There is no guaranteed direct benefit to participants. The results may help clarify whether short-term ear-based vagus nerve stimulation can influence spirometric parameters and may inform future studies on autonomic and respiratory interactions.",[29,30,31,32,33],"Vagus Nerve Stimulations","Spirometry","Autonomic Nervous System (ANS) Functioning and Mood State","Blood Pressure Monitoring","Respiratory Function Tests",[35,36,37,38,39,40],"transcutaneous auricular vagus nerve stimulation","spirometry","autonomic nervous system","sham stimulation","pulmonary function test","blood pressure","RECRUITING","2026-03-16",{"date":44,"type":45},"2026-03-19","ACTUAL",{"date":47,"type":45},"2026-03-17",{"date":49,"type":23},"2026-04-25",{"name":51,"class":52},"SEFA HAKTAN HATIK","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":24,"phases":65,"briefSummary":66,"conditions":67,"keywords":74,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":53},"100614033","frequency-dependent-effects-of-auricular-vagus-nerve-stimulation-on-autonomic-and-cardiovascular-parameters-100614033","NCT07274332","Frequency-Dependent Effects of Auricular Vagus Nerve Stimulation on Autonomic and Cardiovascular Parameters","Acute Effects of Different Frequencies of Auricular Vagus Nerve Stimulation on HRV, Blood Pressure, and Respiratory Rate: A Sham-Controlled, Randomized, Crossover Dose-Response Study","AVNS-DRC","Inclusion Criteria:\n\n* 18-30 years\n* Healthy (self-reported)\n* No cardiovascular, neurological, metabolic or psychiatric disorders\n* No regular medication affecting autonomic function\n* Non-smoker\n* BMI 18-29.9\n\nExclusion Criteria:\n\n* Pregnancy\n* Cardiac arrhythmia\n* Hypertension or hypotension\n* Chronic respiratory disorders\n* Active infection\n* Metal implants in cervical area\n* Epilepsy\n* Syncope history\n* Prior vagus stimulation experience","30 Years",{"count":64,"type":23},36,[26],"This randomized, sham-controlled, crossover study investigates the acute autonomic effects of transcutaneous cervical vagus nerve stimulation (tcVNS) applied at five different frequencies (0 Hz\u002Fsham, 10 Hz, 25 Hz, 50 Hz, 100 Hz) in healthy adults. The primary objective is to determine how stimulation frequency modulates heart rate variability (HRV), blood pressure, and respiratory rate. The study aims to establish a frequency-specific dose-response model using validated physiological measurements.",[68,69,70,71,72,73],"Vagus Nerve Stimulation","Autonomic Nervous System","Heart Rate","Blood Pressure","Respiration","Healthy Volunteers",[75,76,77,78,79],"Transcutaneous Cervical Vagus Nerve Stimulation","Neuromodulation","Non-invasive Vagus Stimulation","Parasympathetic Activation","Heart Rate Variability","NOT_YET_RECRUITING","2025-11-27",{"date":83,"type":45},"2025-12-10",{"date":85,"type":23},"2025-12-22",{"date":87,"type":23},"2026-03-15",{"name":51,"class":52},{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":97,"enrollmentInfo":98,"targetDuration":4,"studyType":24,"phases":100,"briefSummary":101,"conditions":102,"keywords":108,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":53},"100598223","effects-of-thumb-manipulation-on-hand-grip-strength-function-and-sensation-100598223","NCT07068698","Effects of Thumb Manipulation on Hand Grip Strength, Function, and Sensation","The Effects of Thumb Manipulation on Hand Grip Strength, Hand Function, and Sensory Parameters","THUMBFUN","Inclusion Criteria:\n\n* Aged between 18 and 50\n* Willing to participate in the study\n* Have signed the informed consent form\n* Able to use verbal and written communication skills\n\nExclusion Criteria:\n\n* Having contraindications that may prevent manipulation\n* Having a history of congenital or acquired orthopedic or neurological conditions affecting the upper extremity\n* Having a history of rheumatological diseases\n* Having a history of trauma or surgery affecting the upper extremity","50 Years",{"count":99,"type":23},60,[26],"This randomized controlled study will aim to investigate the effects of thumb manipulation on hand grip strength, function, and sensation in healthy individuals. A total of 60 volunteers aged between 18 and 50 years will be recruited from Ortadağ Special Education and Rehabilitation Center. Participants will be randomly assigned to either a chiropractic manipulation group (n=30) or a control group (n=30), with an equal distribution of males and females in each group. The intervention group will receive thumb manipulation twice weekly for 4 weeks, while the control group will not receive any intervention. Outcome measures will include two-point discrimination (assessed with a discriminator), hand grip strength (measured using a dynamometer), pinch strength (evaluated with a pinch meter), and hand function (measured by the Duruöz Hand Index). Statistical analyses will be performed with a significance level set at p\\\u003C0.05. It is expected that participants in the manipulation group will show greater improvements in all measured parameters compared to the control group, suggesting a positive effect of thumb manipulation on hand-related sensorimotor functions in healthy individuals.",[103,104,105,106,107],"Thumb Manipulation","Hand Grip Strength","Hand Sensory Function","Hand Function in Healthy Individuals","Sensory Function",[109,110,111,112,113],"Thumb manipulation","Chiropractic","Hand grip strength","Hand function","Healthy individuals","2025-07-07",{"date":116,"type":45},"2025-07-16",{"date":118,"type":23},"2025-07-06",{"date":120,"type":23},"2025-09-06",{"name":51,"class":52},{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":126,"acronym":127,"eligibilityCriteria":128,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":24,"phases":130,"briefSummary":131,"conditions":132,"keywords":138,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":148,"lastUpdatePostDateStruct":149,"startDateStruct":151,"completionDateStruct":153,"leadSponsor":155,"locationsCount":53},"100596283","comparison-of-the-immediate-effects-of-mobilization-and-manipulation-versus-sham-manipulation-on-plantar-pressure-in-patients-with-hallux-valgus-100596283","NCT07043439","Comparison of the Immediate Effects of Mobilization and Manipulation Versus Sham Manipulation on Plantar Pressure in Patients With Hallux Valgus","HALLPRESS","Inclusion Criteria:\n\n* Be over 18 years of age\n* Volunteer to participate in the study\n* Have hallux valgus (those with a hallux valgus angle greater than 15 and a Manchester Scale score of B or higher)\n\nExclusion Criteria:\n\n* Having undergone surgery on the foot or ankle area within the last 6 months\n* Having any neurological or psychiatric problems",{"count":99,"type":23},[26],"The aim of this study is to examine the immediate effects of mobilization and manipulation versus sham manipulation on plantar pressure, quality of life, and pain in patients with hallux valgus. Participants will be assessed using a sociodemographic data form, the Manchester-Oxford Foot Questionnaire (MOXFQ), the Manchester Scale, goniometric measurements, the Multidimensional Nil Hallux Valgus Scale, the SF-36 Health Survey, the Numeric Pain Rating Scale (NPRS), and plantar pressure analysis via a pedobarographic device. The study will be conducted on a total of 60 feet, with 30 feet assigned to the manipulation group and 30 feet to the sham manipulation group.",[133,134,135,136,137,110],"Hallux Valgus","Foot Deformities","Musculoskeletal Manipulations","Plantar Pressure","Manuel Therapy",[133,139,140,141,142,143,144,145,146,147],"First Metatarsal Mobilization","HVLA Manipulation","Sham Manipulation","Plantar Pressure Analysis","Pedobarography","Manual Therapy","Chiropractic Mobilization","Pain","Quality of Life","2025-06-20",{"date":150,"type":45},"2025-06-29",{"date":152,"type":23},"2025-06-25",{"date":154,"type":23},"2025-08-25",{"name":51,"class":52},{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":162,"eligibilityCriteria":163,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":164,"enrollmentInfo":165,"targetDuration":4,"studyType":24,"phases":167,"briefSummary":168,"conditions":169,"keywords":173,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":176,"lastUpdatePostDateStruct":177,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":53},"100595568","chiropractic-care-for-neck-pain-comparing-diversified-technique-and-drop-table-method-100595568","NCT07034144","Chiropractic Care for Neck Pain: Comparing Diversified Technique and Drop Table Method","Comparison of Chiropractic Diversified Technique and Drop Table Application in Patients With Neck Pain","CDTDTM","Inclusion Criteria:\n\n* Sign a voluntary informed consent form.\n* Be between 18 and 65 years of age.\n* Have previously consulted an orthopedist or physical therapist for neck pain.\n* Have no contraindications to chiropractic interventions.\n* Have no history of cervical surgery.\n* Report neck pain lasting longer than 7 days.\n\nExclusion Criteria:\n\n* Are under 18 or over 65 years of age.\n* Have experienced cervical trauma within the last month.\n* Have any systemic illness.\n* Have any contraindication for chiropractic intervention (e.g., brain tumor, cervical fracture).","65 Years",{"count":166,"type":23},45,[26],"This study aims to compare the effects of two different chiropractic techniques, Diversified and Drop Table, on pain levels, cervical joint range of motion, and neck muscle strength in individuals with non-specific neck pain.",[170,171,172,110],"Spinal Manipulation","Neck Pain","Non Specific Neck Pain",[110,174,175,170],"Neck pain","Drop Table","2025-06-13",{"date":178,"type":45},"2025-06-24",{"date":180,"type":23},"2025-06-14",{"date":182,"type":23},"2025-08-14",{"name":51,"class":52},""]