[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"STCube, Inc.\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":90},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,39,68],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":27,"whyStopped":4,"lastUpdateSubmitDate":28,"lastUpdatePostDateStruct":29,"startDateStruct":32,"completionDateStruct":34,"leadSponsor":36,"locationsCount":4},"100641085","phase-1-nelmastobart-in-combination-with-tas-102-and-bevacizumab-in-recurrentmetastatic-colorectal-cancer-100641085",false,"NCT07656038","Nelmastobart in Combination With Tas-102 and Bevacizumab in Recurrent\u002FMetastatic Colorectal Cancer","A Single-arm, Open-label, Phase Ib Clinical Trial Evaluating the Safety, Pharmacokinetics, Immunogenicity, and Preliminary Efficacy of Nelmastobart in Combination With TAS-102 and Bevacizumab in Recurrent\u002FMetastatic Colorectal Cancer","Inclusion Criteria:\n\n* Participants who participate in the study must meet all of the following inclusion criteria.\n\n  1. Adults ≥18 years old and of any gender when signing the informed consent form.\n  2. Participants with metastatic\u002Frecurrent colorectal cancer confirmed by histopathology\u002Fcytology who have not responded to or are unable to receive standard anti-cancer therapy based on oxaliplatin and irinotecan. Participants who undergo curative surgery for colorectal cancer and receive adjuvant anti-cancer therapy will be considered to have received their first palliative anti-cancer therapy if their disease recurs during or within 6 months after completion of the adjuvant anti-cancer treatment.\n  3. According to the Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, there must be at least one measurable or assessable lesion present.\n  4. Participants with ECOG performance status 0-1\n  5. Participants with adequate bone marrow and body organ functions\n\n     1. Absolute neutrophil count (ANC) ≥ 2.0 x 109\u002FL\n     2. Hemoglobin count (Hgb) ≥ 9.0 g\u002FdL\n     3. Platelet count ≥ 100 x 109\u002FL\n     4. Serum creatinine ≤ ULN x 1.5 or serum creatinine clearance \\> 30mL\u002Fmin\n     5. Total bilirubin ≤ 1.5 x ULN (Participants with biliary obstruction may be enrolled if they meet the criterion after adequate biliary drainage.)\n     6. AST and ALT ≤ 3 x ULN in the absence of liver metastasis;\n     7. or AST and ALT ≤ 5 x ULN in the presence of liver metastasis\n  6. Confirm that participants with adequate cardiac function at the screening visit QTc calculated using the Fredericia formula ≤ 480 msec (Those with QTc \\>480 msec may be enrolled if the mean of 3 consecutive QTc measurements is \\\u003C480 msec.).\n  7. A negative serum β-HCG test within 14 days prior to IP dosing for women of childbearing potential\n  8. Participants who agree, and are able to use during the study medically reliable methods of contraception as follows:\n\n     To be eligible for enrollment, women of childbearing potential (all women who can have physiological pregnancy during IP treatment and for 6 months after the end of IP treatment unless they use appropriate methods of contraception) must use the following methods of contraception.\n     1. Participants must refrain from any type of sexual intercourse, and persistent abstinence in daily life is recommended. Periodic abstinence (e.g., rhythm method, cervical mucus method, basal body temperature method, etc.) and withdrawal method are not acceptable methods of contraception.\n     2. Female sterilization procedures: Bilateral ovariectomy with or without hysterectomy; tubal ligation within 6 weeks prior to enrollment in this study. If the subject is confirmed to have childbearing potential based on the assessment of hormone level, only bilateral ovariectomy will be permitted.\n     3. Vasectomized partner (at least 6 months prior to screening). For women who participate in the study, the vasectomized partner must be the only partner during her participation in this study.\n     4. Men must use condoms during sexual intercourse during and after IP treatment (for 6 months after the last IP dose).\n  9. Life expectancy ≥3 months\n  10. Participants who consent to sampling tumor tissues or collecting tumor tissue samples obtained within 2 years prior to the screening visit.\n  11. Participants who, after being fully informed of the study, voluntarily decide to participate in the study, provide written informed consent, and agree to comply with study procedures during the study.\n\nExclusion Criteria:\n\n* Participants who meet any of the following exclusion criteria will be excluded from the study.\n\n  1. Participants who have hypersensitivity to the active ingredient of IP or any of its components (excipients)\n  2. Participants who had cytotoxic chemotherapy within 14 days prior to randomization; treatment with IP in another clinical trial with the elapse of ≤2 weeks from the last dose of that IP or ≤5 folds the half-life of that IP; or treatment with monoclonal antibody therapy within the past 4 weeks\n  3. Uncontrolled serious infection\n  4. Confirmed PD during treatment with trifluridine\u002Ftipiracil for palliative care or confirmed recurrence within 6 months after the end of such treatment\n  5. Participants requiring high-dose steroids (\\>10 mg\u002Fday prednisone or equivalent) or other immunosuppressants However, these participants may be enrolled in the following cases.\n\n     1. Short-term (\\\u003C7 days) use of systemic corticosteroids that are considered standard of care will be allowed.\n     2. Participants requiring intermittent use of bronchodilators, inhalant steroids, or local steroid injections will be allowed.\n     3. Replacement therapy (e.g., thyroxine, insulin, physiological corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered as a type of systemic treatment and will be allowed.\n  6. Pregnant or lactating women\n  7. Participants with a history of autoimmune disease requiring systemic treatment (i.e., use of disease modifying therapy, corticosteroids, or immunosuppressants) within 2 years prior to the screening visit (However, enrollment will be possible for subjects with vitiligo, psoriasis not requiring systemic treatment, type 1 diabetes mellitus, hypothyroidism stably managed with hormone replacement therapy, Sjogren's syndrome, or resolved pediatric asthma\u002Fatopy.)\n  8. Participants with active central nervous system lesions (radiologically unstable or symptomatic brain lesions). With the exception of patients with meningeal metastasis, individuals who had radiotherapy or surgical treatment may be enrolled if there is evidence that the patient's condition is maintained without steroid therapy and that the disease of the brain lesion has not progressed for ≥4 weeks.\n  9. Participants with a documented history of cerebrovascular events (stroke or transient ischemic attack), unstable angina pectoris, myocardial infarction, or cardiac symptoms consistent with New York Heart Association (NYHA) Class IV within 6 months prior to the screening visit\n  10. Participants with hypertensive encephalopathy or hypertension that is not adequately controlled with antihypertensives\n  11. Participants with a history of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, or idiopathic pneumonia; or with active pneumonia based on screening chest X-rays\n  12. Participants who received allogeneic stem cell or solid organ transplants\n  13. Participants who received live attenuated vaccines within 30 days prior to the screening visit. Examples of live vaccines include, but are not limited to measles, mumps, rubella, varicella\u002F(varicella) zoster, yellow fever, rabies, bacillus Calmette-Guerin, and typhoid vaccines. Injectable seasonal influenza vaccines are generally killed virus vaccines and will be allowed. However, intranasal influenza vaccines are live attenuated vaccines and will not be allowed.\n  14. Participants with a history of other primary cancers However, enrollment will be possible for the following cancers.\n\n      1. Adequately treated skin cancer (basal cell or squamous carcinoma) that is not melanoma, superficial cervical cancer or stage 1 bladder cancer, completely resected thyroid cancer which did not metastasize and for which all treatment is completed (Scars must have been adequately treated prior to study enrollment).\n      2. Treated solid tumor with no evidence of recurrent disease at least 36 months prior to screening\n  15. Side effects of prior anticancer therapy that did not recover to Grade ≤1 (with the exception of alopecia)\n  16. Participants who had radiotherapy in an extensive lesion involving ≥30 % of the bone marrow within 4 weeks prior to the screening visit or limited range radiotherapy for palliative care within 2 weeks\n  17. Participants who had major surgery within 4 weeks prior to the screening visit or who have not recovered from side effects of surgery\n  18. Participants who are unable to take drugs orally or who have a past history, or pathological findings of major gastrointestinal surgery that may affect the absorption of IP\n  19. Participants who have evidence of active infection including hepatitis B, hepatitis C, and human immunodeficiency virus (HIV) However, enrollment will be possible for the following cases.\n  20. Participants with positive hepatitis B surface antigen (HBsAg) may be enrolled if HBV DNA is negative based on a local test.\n\n      1. Participants with positive hepatitis B core antibody (IgG anti-HBc) and a history of HBV infection may be enrolled if HBV DNA is negative.\n      2. Participants with positive anti-HCV Ab may be enrolled if HCV RNA is negative.\n      3. Participants with hereditary problems such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption\n  21. Participants with medical, psychiatric, or cognitive disorders or impaired ability to understand information, provide prior consent, comply with protocol procedures, or complete the study\n  22. Those whom the investigator deems inappropriate for participation in this clinical trial","ALL","18 Years",{"count":19,"type":20},45,"ESTIMATED","INTERVENTIONAL",[23],"PHASE1","Nelmastobart（hSTC810） is a novel humanized monoclonal antibody that fuses on IgG4 and targets a novel immune checkpoint protein, BTN1A1+.This is an phase Ib bridging trial conducted in China to assess the safety, tolerability, and pharmacokinetic characteristics of Nelmastobart in combined with TAS-102 and Bevacizumab in Chinese participants with mCRC, and to verify that the safety results align with those from the Korean STCUBE-003 phase Ib trial. The phase Ib trial will also provide supportive data for conducting a randomized, double-blind, controlled Phase II study in China.",[26],"Colonrectal Cancer (CRC)","NOT_YET_RECRUITING","2026-06-12",{"date":30,"type":31},"2026-06-18","ACTUAL",{"date":33,"type":20},"2026-06-30",{"date":35,"type":20},"2028-07-31",{"name":37,"class":38},"STCube, Inc.","INDUSTRY",{"id":40,"slug":41,"hasResults":11,"nctId":42,"briefTitle":43,"officialTitle":44,"acronym":4,"eligibilityCriteria":45,"healthyVolunteers":11,"sex":16,"minAge":46,"maxAge":4,"enrollmentInfo":47,"targetDuration":4,"studyType":21,"phases":49,"briefSummary":51,"conditions":52,"keywords":54,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":67},"100616516","phase-2-nelmastobart-in-combination-with-docetaxel-in-non-small-cell-lung-cancer-100616516","NCT07306624","Nelmastobart in Combination With Docetaxel in Non Small Cell Lung Cancer","A Multicenter, Phase 2 Clinical Trial Based on an Adaptive Design to Evaluate the Safety and Efficacy of Nelmastobart in Combination With Docetaxel in Patients With Advanced\u002FMetastatic Non-Small Cell Lung Cancer Who Are Resistant or Intolerant to Platinum-based Chemotherapy and\u002For Immunotherapy","Inclusion Criteria:\n\n* Histologically or cytologically confirmed stage IIIb, IIIc, or IV 4 recurrent non-squamous NSCLC\n* BTN1A1 TPS score ≥50\n* Subjects with positive AGA must have progressed after At least 1 platinum-based chemotherapy and\u002For immunotherapy AND at least 1 locally approved targeted therapy appropriate to the AGA\n* Subjects with negative AGA must have progressed after prior PD1\u002F (PDL therapy and\u002For platinum-based chemotherapy\n* Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 0- 1.\n* Adequate organ function as described in the protocol\n* Adequate cardiac function as described in the protocol\n* For female or male patients with reproductive potential: Agree to use contraception throughout the study and at least 5 months after the last dose.\n* Life expectancy of at least 3 months\n* Has agreed to provide archival tissue\n\nExclusion Criteria:\n\n* Known hypersensitivity to the active ingredients or excipients of the study drug.\n* History of using Docetaxel for palliative therapy.\n* Prior treatment with Cytotoxic chemotherapy or oral targeted therapy within 14 days.\n* Investigational drugs within 5 half-lives.\n* Monoclonal antibodies or ADCs within 4 weeks.\n* Use or expected use of strong CYP3A4 inhibitors (e.g., ketoconazole) within 14 days prior to the first dose.\n* Uncontrolled severe infection requiring IV treatment, or suspected infectious complications\u002Ffever.\n* Requirement for continuous high-dose steroids (\\>10 mg\u002Fday prednisone equivalent) or immunosuppressants within 7 days (excluding Docetaxel premedication; intermittent\u002Freplacement therapies allowed).\n* Pregnant or breastfeeding women.\n* History of autoimmune disease requiring systemic treatment within the last 2 years\n* Known active symptomatic or radiologically unstable CNS lesions\n* History of stroke, unstable angina, MI, or NYHA Class III-IV symptoms within 6 months, or current Class II.\n* Systolic BP 160 mmHg or Diastolic BP 100 mmHg, or hypertensive encephalopathy.\n* History of ILD, organizing\u002Fdrug-induced pneumonia, or active pneumonia on screening (mild asymptomatic fibrosis requires consultation).\n* Recipients of allogeneic stem cell or solid organ transplants.\n* Vaccination with live or attenuated live vaccines within 30 days.\n* Maligancies other than NSCLC\n* Failure to recover from prior anti-cancer therapy side effects to CTCAE Grade 1\n* Wide-field bone marrow radiation (\\>30%) within 4 weeks, or limited palliative radiation within 2 weeks.\n* Major surgery within 4 weeks or incomplete recovery from surgical side effects.\n* Evidence of active HBV, HCV, or HIV infection (carriers with negative viral loads\u002FRNA may be eligible).\n* Clinically unstable pleural or peritoneal effusion (stable cases after intervention are allowed).","19 Years",{"count":48,"type":20},62,[50],"PHASE2","A Multicenter, Phase 2 Clinical Trial Based on an Adaptive Design to Evaluate the Safety and Efficacy of Nelmastobart in Combination with Docetaxel in Patients with Advanced\u002FMetastatic Non-Small Cell Lung Cancer Who Are Resistant or Intolerant to Platinum-based Chemotherapy and\u002For Immunotherapy",[53],"Non Small Cell Lung Cancer",[55,56,57],"BTN1A1","nsclc","immune check point inhibitor","RECRUITING","2026-01-13",{"date":61,"type":31},"2026-01-15",{"date":63,"type":20},"2026-01-10",{"date":65,"type":20},"2027-08-31",{"name":37,"class":38},5,{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":4,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":46,"maxAge":4,"enrollmentInfo":75,"targetDuration":4,"studyType":21,"phases":77,"briefSummary":78,"conditions":79,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":67},"100583241","phase-1-nelmastobart-in-combination-with-trifluridine-tipiracil-and-bevacizumab-in-metastatic-recurrent-colorectal-cancer-100583241","NCT06873763","Nelmastobart in Combination With Trifluridine\u002F Tipiracil and Bevacizumab in Metastatic\u002F Recurrent Colorectal Cancer","A Single-arm, Phase Ib\u002F2 Study of Nelmastobart in Combination With Trifluridine\u002FTipiracil and Bevacizumab in Metastatic\u002FRecurrent Colorectal Cancer Patients With Resistance or Intolerance to Oxaliplatin and Irinotecan-based Chemotherapy","Inclusion Criteria:\n\nSubjects who participate in the study must meet all of the following inclusion criteria.\n\n1. Adults ≥19 years old at the time of written informed consent\n2. Patients with histologically\u002Fcytologically confirmed metastatic\u002Frecurrent colorectal cancer after failure of, or not eligible for oxaliplatin and irinotecan-based standard anticancer therapy (If a subject had a radical surgery for colorectal cancer followed by adjuvant anticancer therapy, and the disease recurred during the adjuvant anticancer therapy or within 6 months from the end of the adjuvant anticancer therapy, the adjuvant anticancer therapy will be considered primary palliative therapy.)\n3. Subjects with at least one evaluable lesion, or non-measurable but evaluable lesion according to RECIST v1.1\n4. Subjects with ECOG performance status 0-1\n5. Subjects with adequate bone marrow and body organ functions\n\n   * Absolute neutrophil count (ANC) ≥ 1.5 x 109\u002FL\n   * Hemoglobin count (Hgb) ≥ 9.0 g\u002FdL\n   * Platelet count ≥ 100 x 109\u002FL\n   * Serum creatinine ≤ ULN x 1.5 or serum creatinine clearance \\> 30mL\u002Fmin\n   * Total bilirubin ≤ 1.5 x ULN (Subjects with biliary obstruction may be enrolled if they meet the criterion after adequate biliary drainage.)\n   * AST and ALT ≤ 3 x ULN in the absence of liver metastasis; or AST and ALT ≤ 5 x ULN in the presence of liver metastasis\n6. Subjects with adequate cardiac function at the screening visit\n\n   * QTc calculated using the Fredericia formula ≤ 480 msec (Those with QTc \\>480 msec may be enrolled if the mean of 3 consecutive QTc measurements is \\\u003C480 msec.)\n7. A negative serum β-HCG test within 14 days prior to IP dosing for women of childbearing potential\n8. Subjects who agree, and are able to use during the study medically reliable methods of contraception as follows\n\n   * To be eligible for enrollment, women of childbearing potential (all women who can have physiological pregnancy during IP treatment and for 6 months after the end of IP treatment unless they use appropriate methods of contraception) must use the following methods of contraception.\n   * Subjects must refrain from any type of sexual intercourse, and persistent abstinence in daily life is recommended. Periodic abstinence (e.g., rhythm method, cervical mucus method, basal body temperature method, etc.) and withdrawal method are not acceptable methods of contraception.\n   * Female sterilization procedures: Bilateral ovariectomy with or without hysterectomy; tubal ligation within 6 weeks prior to enrollment in this study. If the subject is confirmed to have childbearing potential based on the assessment of hormone level, only bilateral ovariectomy will be permitted.\n   * Vasectomized partner (at least 6 months prior to screening). For women who participate in the study, the vasectomized partner must be the only partner during her participation in this study.\n   * Men must use condoms during sexual intercourse during and after IP treatment (for 6 months after the last IP dose).\n9. Life expectancy ≥3 months\n10. Subjects who consent to sampling tumor tissues or collecting tumor tissue samples obtained within 2 years prior to the screening visit\n11. Subjects who, after being fully informed of the study, voluntarily decide to participate in the study, provide written informed consent, and agree to comply with study procedures during the study\n\n    \\[Inclusion criteria for the phase 2 study\\] Subjects who participate in the phase 2 study must meet all of the following criteria.\n12. Subjects with Tumor Proportion Score (TPS) ≥50 based on immunohistochemistry (IHC) at the screening visit\n\nExclusion Criteria:\n\nIndividuals who meet any of the following exclusion criteria will be excluded from the study.\n\n1. Patients who have hypersensitivity to the active ingredient of IP or any of its components (excipients)\n2. Individuals who had cytotoxic chemotherapy within 14 days prior to randomization; treatment with IP in another clinical trial with the elapse of ≤2 weeks from the last dose of that IP or ≤5 folds the half-life of that IP; or treatment with monoclonal antibody therapy within the past 4 weeks\n3. Uncontrolled serious infection\n4. Confirmed PD during treatment with trifluridine\u002Ftipiracil for palliative care or confirmed recurrence within 6 months after the end of such treatment\n5. Individuals requiring high-dose steroids (\\>10 mg\u002Fday prednisone or equivalent) or other immunosuppressants\n\n   * However, these individuals may be enrolled in the following cases.\n   * Short-term (\\\u003C7 days) use of systemic corticosteroids that are considered standard of care will be allowed.\n   * Subjects requiring intermittent use of bronchodilators, inhalant steroids, or local steroid injections will be allowed.\n   * Replacement therapy (e.g., thyroxine, insulin, physiological corticosteroid replacement therapy for adrenal or pituitary insufficiency) is not considered as a type of systemic treatment and will be allowed.\n6. Pregnant or lactating women\n7. Individuals with a history of autoimmune disease requiring systemic treatment (i.e., use of disease modifying therapy, corticosteroids, or immunosuppressants) within 2 years prior to the screening visit (However, enrollment will be possible for subjects with vitiligo, psoriasis not requiring systemic treatment, type 1 diabetes mellitus, hypothyroidism stably managed with hormone replacement therapy, Sjogren's syndrome, or resolved pediatric asthma\u002Fatopy.)\n8. Individuals with active central nervous system lesions (radiologically unstable or symptomatic brain lesions). With the exception of patients with meningeal metastasis, individuals who had radiotherapy or surgical treatment may be enrolled if there is evidence that the patient's condition is maintained without steroid therapy and that the disease of the brain lesion has not progressed for ≥4 weeks.\n9. Individuals with a documented history of cerebrovascular events (stroke or transient ischemic attack), unstable angina pectoris, myocardial infarction, or cardiac symptoms consistent with New York Heart Association (NYHA) Class IV within 6 months prior to the screening visit\n10. Patients with hypertensive encephalopathy or hypertension that is not adequately controlled with antihypertensives\n11. Individuals with a history of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced pneumonitis, or idiopathic pneumonia; or with active pneumonia based on screening chest X-rays\n12. Individuals who received allogeneic stem cell or solid organ transplants\n13. Individuals who received live attenuated vaccines within 30 days prior to the screening visit. Examples of live vaccines include, but are not limited to measles, mumps, rubella, varicella\u002F(varicella) zoster, yellow fever, rabies, bacillus Calmette-Guerin, and typhoid vaccines. Injectable seasonal influenza vaccines are generally killed virus vaccines and will be allowed. However, intranasal influenza vaccines are live attenuated vaccines and will not be allowed.\n14. Individuals with a history of other primary cancers\n\n    * However, enrollment will be possible for the following cancers.\n    * Adequately treated skin cancer (basal cell or squamous carcinoma) that is not melanoma, superficial cervical cancer or stage 1 bladder cancer, completely resected thyroid cancer which did not metastasize and for which all treatment is completed (Scars must have been adequately treated prior to study enrollment).\n    * Treated solid tumor with no evidence of recurrent disease at least 36 months prior to screening\n15. Side effects of prior anticancer therapy that did not recover to Grade ≤1 (with the exception of alopecia)\n16. Individuals who had radiotherapy in an extensive lesion involving ≥30 % of the bone marrow within 4 weeks prior to the screening visit or limited range radiotherapy for palliative care within 2 weeks\n17. Patients who had major surgery within 4 weeks prior to the screening visit or who have not recovered from side effects of surgery\n18. Patients who are unable to take drugs orally or who have a past history, or pathological findings of major gastrointestinal surgery that may affect the absorption of IP\n19. Patients who have evidence of active infection including hepatitis B, hepatitis C, and human immunodeficiency virus (HIV)\n\n    * However, enrollment will be possible for the following cases.\n    * Patients with positive hepatitis B surface antigen (HBsAg) may be enrolled if HBV DNA is negative based on a local test.\n    * Patients with positive hepatitis B core antibody (IgG anti-HBc) and a history of HBV infection may be enrolled if HBV DNA is negative.\n    * Patients with positive anti-HCV Ab may be enrolled if HCV RNA is negative.\n20. Patients with hereditary problems such as galactose intolerance, Lapp lactase deficiency, or glucose-galactose malabsorption\n21. Individuals with medical, psychiatric, or cognitive disorders or impaired ability to understand information, provide prior consent, comply with protocol procedures, or complete the study\n22. Those whom the investigator deems inappropriate for participation in this clinical trial",{"count":76,"type":20},52,[23,50],"The objective of this multi-center, single-group, open-label Phase Ib\u002FII study is to evaluate the safety, pharmacokinetics, and efficacy of nelmastobart in combination with trifluridine\u002Ftipiracil and bevacizumab in metastatic or recurrent colorectal cancer patients with resistance or intolerance to oxaliplatin- and irinotecan-based chemotherapy, and to determine the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D), and the efficacy and safety of the combination therapy in BTN1A1-positive patients.",[80,81],"Metastatic Colorectal Cancer (CRC)","Recurrent Colorectal Cancer","2025-07-08",{"date":84,"type":31},"2025-07-11",{"date":86,"type":31},"2025-06-09",{"date":88,"type":20},"2027-03",{"name":37,"class":38},""]