[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":410},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,43,71,96,119,141,165,187,213,238,260,287,309,338,371,390],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100644888","effect-of-caudal-block-on-urethrocutaneous-fistula-after-distal-hypospadias-repair-100644888",false,"NCT07675798","Effect of Caudal Block on Urethrocutaneous Fistula After Distal Hypospadias Repair","The Effect of Caudal Block on the İncidence of Urethrocutaneous Fistula After Distal Hypospadias Repair: A Multicentre, Randomized Controlled Trial","Inclusion Criteria:\n\n* Male patients aged 6-60 months\n* Diagnosed with distal hypospadias\n* Scheduled for elective hypospadias repair\n* Written informed consent obtained from parent or legal guardian\n\nExclusion Criteria:\n\n* Age \\\u003C 6 months or \\> 60 months\n* Proximal or non-distal hypospadias\n* Previous hypospadias repair\n* Skin lesions at the epidural\u002Fcaudal injection site\n* Coagulopathy\n* Known allergy to anesthetic agents, particularly bupivacaine hydrochloride\n* Spinal anomalies\n* Chronic granulomatous disease\n* Diabetes mellitus\n* Patients receiving corticosteroid therapy\n* Refusal of informed consent by parent or guardian","MALE","6 Months","60 Months",{"count":20,"type":21},80,"ESTIMATED","INTERVENTIONAL",[24],"NA","Hypospadias is one of the most common congenital urogenital anomalies in males, occurring in approximately 1 in every 200-300 male births. It is characterized by abnormal positioning of the urethral meatus on the ventral surface of the penis. Surgical repair is the standard treatment; however, urethrocutaneous fistula formation remains one of the most frequent and clinically significant postoperative complications, potentially requiring reoperation and causing considerable distress to both the patient and the family.\n\nCaudal nerve block is a widely used regional anesthesia technique in pediatric lower abdominal and genitourinary surgery, valued for its high analgesic efficacy, relative ease of application, and low complication profile. However, emerging evidence suggests that caudal block may be associated with an increased incidence of postoperative complications following hypospadias repair, including fistula formation and wound edema. Notably, Kundra et al. (2012) reported a fistula rate of 19.2% in patients who received caudal block, compared to 0% in those who received penile block, raising important questions about the routine use of caudal block in hypospadias surgery.\n\nThis prospective, multicenter, randomized controlled trial aims to evaluate the effect of caudal block on the incidence of urethrocutaneous fistula following distal hypospadias repair. A total of 80 male patients aged 6-60 months will be randomized 1:1 to either receive general anesthesia with caudal block or general anesthesia alone. The primary outcome is the incidence of urethrocutaneous fistula. Secondary outcomes include perioperative opioid consumption, postoperative pain scores, analgesic duration, and other surgical complications such as wound dehiscence and urethral stricture. Patients will be followed up for 3-6 months postoperatively. The study will be conducted across four centers in Turkey. Results are expected to provide evidence-based guidance on the role of caudal block in pediatric hypospadias repair.",[27,28,29],"Hypospadias","Caudal Block","Pediatric Anesthesia","RECRUITING","2026-06-23",{"date":33,"type":34},"2026-06-30","ACTUAL",{"date":36,"type":34},"2025-12-01",{"date":38,"type":21},"2026-08-15",{"name":40,"class":41},"Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital","OTHER",2,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},"100632290","comparison-of-laryngeal-mask-airway-versus-endotracheal-intubation-in-pediatric-laparoscopic-inguinal-hernia-repair-100632290","NCT07511764","Comparison of Laryngeal Mask Airway Versus Endotracheal Intubation in Pediatric Laparoscopic Inguinal Hernia Repair","Comparison of Laryngeal Mask Airway Versus Endotracheal Intubation in Pediatric Laparoscopic Inguinal Hernia Repair: A Multicenter, Prospective, Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* being between 1 and 10 years of age,\n* having a planned laparoscopic inguinal hernia repair,\n* being classified as ASA I-II,\n* having given informed consent from the parent.\n\nExclusion Criteria:\n\n* Obesity (body weight \\>95th percentile),\n* symptomatic gastroesophageal reflux,\n* high risk of aspiration,\n* upper airway anomalies,\n* history of difficult intubation,\n* acute respiratory tract infection,\n* emergency surgical indication,\n* need for conversion from laparoscopy to open surgery,\n* presence of additional systemic risks such as immunodeficiency\u002Fmalignancy.","ALL","1 Year","10 Years",{"count":54,"type":21},266,[24],"Inguinal hernia is one of the most common conditions requiring surgical intervention in childhood, with a reported lifetime prevalence of 1-4%. With the increasing use of minimally invasive techniques such as PIRS (Percutaneous Internal Ring Suturing) among laparoscopic surgical procedures, perioperative anesthesia and airway management have become a critical area of clinical decision-making. The traditional approach in pediatric laparoscopic surgery is endotracheal intubation (ETT). Although ETT provides reliable airway control, it carries certain disadvantages. In contrast, the laryngeal mask airway (LMA) is less invasive and is associated with faster recovery. Systematic reviews and meta-analyses conducted in recent years have shown that the LMA may be safe for ventilation in pediatric laparoscopy, reduces peak airway pressure, and shortens recovery time. No well-designed, multicenter study with an adequate sample size comparing the LMA and ETT in pediatric laparoscopic inguinal hernia surgery has yet been conducted. This gap limits evidence-based decision-making in a clinical setting that directly impacts practice. Therefore, the aim of this study is to compare LMA and ETT in pediatric laparoscopic inguinal hernia repair. In this regard, the study is unique and necessary from both clinical and academic perspectives for determining the optimal airway strategy in pediatric laparoscopy.",[58],"Inguinal Hernia Repair",[60,61,62],"inguinal hernia","laparoscopy","laryngeal mask airway","2026-06-19",{"date":65,"type":34},"2026-06-24",{"date":36,"type":34},{"date":68,"type":21},"2026-09-15",{"name":40,"class":41},1,{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":50,"minAge":78,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":22,"phases":81,"briefSummary":82,"conditions":83,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":4},"100642447","remifentanil-vs-nicardipine-for-controlled-hypotension-in-elective-nasal-surgery-100642447","NCT07660562","Remifentanil vs. Nicardipine for Controlled Hypotension in Elective Nasal Surgery","Comparison of Remifentanil and Nicardipine Infusions for Controlled Hypotension in Elective Nasal Surgery Where Bleeding Control is Critical: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Age \\> 18 years\n* ASA physical status I-II\n* Scheduled for elective nasal surgery\n* No known serious cardiovascular, respiratory, renal, or hepatic disease\n* No known allergy to remifentanil or nicardipine\n* No chronic use of beta-blockers, calcium channel blockers, or antihypertensive agents\n* Not pregnant or breastfeeding\n* BMI ≤ 35 kg\u002Fm²\n* No emergency surgical indication\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* ASA III or above\n* Known serious cardiovascular, respiratory, renal, or hepatic disease\n* Known allergy to remifentanil or nicardipine\n* Chronic use of beta-blockers, calcium channel blockers, or antihypertensive agents\n* Pregnancy or breastfeeding\n* Morbid obesity (BMI \\> 35 kg\u002Fm²)\n* Emergency surgery\n* Refusal to participate","18 Years",{"count":80,"type":21},44,[24],"This study compares remifentanil infusion versus nicardipine infusion for controlled hypotension during elective nasal surgery. Both agents are standard clinical methods. The study evaluates hemodynamic stability, surgical field quality (Fromme-Boezaart score), tissue perfusion, intraoperative blood loss, surgeon satisfaction, and perioperative adverse effects.",[84,85,86],"Nasal Surgery","Anesthesia","Controlled Hypotension for Nasal Surgeries","NOT_YET_RECRUITING","2026-06-16",{"date":90,"type":34},"2026-06-22",{"date":92,"type":21},"2026-06-25",{"date":94,"type":21},"2026-07-15",{"name":40,"class":41},{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":11,"sex":103,"minAge":78,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":22,"phases":107,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":114,"startDateStruct":116,"completionDateStruct":117,"leadSponsor":118,"locationsCount":70},"100639105","serratus-posterior-superior-intercostal-plane-block-for-postoperative-analgesia-in-mastectomy-100639105","NCT07579650","Serratus Posterior Superior Intercostal Plane Block for Postoperative Analgesia in Mastectomy","Mastectomy and Axillary Dissection: Evaluation of the Effect of Serratus Posterior Superior Intercostal Plane Block on Postoperative Analgesia: A Multicenter, Randomized, Placebo-Controlled Trial","Inclusion Criteria:\n\n* Female patients aged 18-65 years\n* ASA physical status I-III\n* Scheduled for elective unilateral mastectomy with axillary lymph node dissection under general anesthesia\n* Able to understand and use the Numeric Rating Scale (NRS) for pain assessment\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to local anesthetics (e.g., bupivacaine)\n* Coagulopathy, thrombocytopenia (\\\u003C100,000\u002Fmm³), or ongoing anticoagulant\u002Fantiplatelet therapy that cannot be discontinued\n* Infection or skin lesion at the injection site\n* Planned bilateral surgery or additional major surgical procedures\n* Chronic pain conditions or regular use of opioids, gabapentinoids, or centrally acting analgesics\n* Neurological or psychiatric conditions interfering with pain assessment\n* History of previous major thoracic or chest wall surgery on the same side\n* Pregnancy or breastfeeding\n* Refusal to participate or inability to provide informed consent","FEMALE","65 Years",{"count":106,"type":21},50,[24],"This study aims to evaluate the effect of serratus posterior superior intercostal plane (SPSIP) block on postoperative pain, opioid consumption, and analgesic requirements in patients undergoing mastectomy and axillary lymph node dissection",[110],"Breast Cancer",[112],"mastectomy","2026-05-16",{"date":115,"type":34},"2026-05-19",{"date":113,"type":34},{"date":33,"type":21},{"name":40,"class":41},{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":11,"sex":50,"minAge":78,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":22,"phases":129,"briefSummary":130,"conditions":131,"keywords":134,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":113,"lastUpdatePostDateStruct":136,"startDateStruct":137,"completionDateStruct":138,"leadSponsor":140,"locationsCount":70},"100638675","serratus-posterior-superior-intercostal-plane-block-in-minimally-invasive-cardiac-surgery-100638675","NCT07588230","Serratus Posterior Superior Intercostal Plane Block in Minimally Invasive Cardiac Surgery","Preoperative Serratus Posterior Superior Intercostal Plane Block for Analgesia and Opioid Sparing in Patients Undergoing Minimally Invasive Cardiac Valve Surgery Via Mini-Thoracotomy: A Randomized, Double-Blind, Placebo-Controlled Trial","Inclusion Criteria:\n\n* Adult patients aged 18-75 years\n* ASA physical status I-III\n* Scheduled for elective minimally invasive cardiac valve surgery via mini-thoracotomy\n* Able to understand and use the Numeric Rating Scale (NRS)\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Age \\>75 years\n* Known allergy or hypersensitivity to local anesthetics (e.g., bupivacaine)\n* Coagulopathy or ongoing anticoagulant therapy that cannot be discontinued\n* Infection at the planned block site\n* Chronic opioid use or chronic pain conditions\n* Severe pulmonary disease affecting respiratory assessment\n* Neurological or psychiatric disorders interfering with pain assessment\n* Emergency surgery\n* Pregnancy or breastfeeding\n* Refusal to participate","75 Years",{"count":128,"type":21},90,[24],"This randomized, double-blind, placebo-controlled study aims to evaluate the effect of the serratus posterior superior intercostal plane (SPSIP) block on postoperative pain and opioid consumption in patients undergoing minimally invasive cardiac valve surgery via mini-thoracotomy.",[132,133],"Heart Valve Disease","Postoperative Pain",[135,133],"Cardiac Surgery",{"date":115,"type":34},{"date":113,"type":34},{"date":139,"type":21},"2026-10-26",{"name":40,"class":41},{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":4,"eligibilityCriteria":147,"healthyVolunteers":11,"sex":50,"minAge":148,"maxAge":52,"enrollmentInfo":149,"targetDuration":4,"studyType":22,"phases":151,"briefSummary":152,"conditions":153,"keywords":156,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":70},"100636394","intranasal-dexmedetomidine-vs-oral-midazolam-for-premedication-in-pediatric-surgery-100636394","NCT07565116","Intranasal Dexmedetomidine vs Oral Midazolam for Premedication in Pediatric Surgery","Comparison of Intranasal Dexmedetomidine and Oral Midazolam for Premedication in Pediatric Patients Undergoing Elective Inguinal and Urological Surgery: A Prospective, Randomized, Double-Blind, Controlled Trial","Inclusion Criteria:\n\n* Pediatric patients aged 2-10 years\n* ASA physical status I-II\n* Scheduled for elective inguinal or urological surgery under general anesthesia\n* Both male and female patients\n* Written informed consent obtained from parents or legal guardians\n\nExclusion Criteria:\n\n* Known allergy or hypersensitivity to dexmedetomidine or midazolam\n* Presence of significant systemic disease or organ dysfunction\n* Cardiac arrhythmia or congenital heart disease\n* Neurological or behavioral disorders, including developmental delay\n* Chronic use of analgesics or other medications that may affect study outcomes\n* Anticipated difficult airway\n* Nasal pathology that may interfere with intranasal drug administration\n* Emergency surgery\n* Inability to obtain written informed consent from parents or legal guardians","2 Years",{"count":150,"type":21},84,[24],"This study aims to compare the effects of intranasal dexmedetomidine and oral midazolam as premedication in pediatric patients undergoing elective inguinal and urological surgery under general anesthesia.\n\nPremedication plays a critical role in reducing preoperative anxiety, facilitating parent-child separation, and improving cooperation during anesthesia induction in pediatric patients. While oral midazolam is widely used, it has several limitations, including variable bioavailability and the risk of paradoxical reactions. Intranasal dexmedetomidine has emerged as a promising alternative due to its sedative, anxiolytic, and minimal respiratory depressant effects.\n\nIn this prospective, randomized, double-blind, controlled study, patients aged 2-10 years will be assigned to receive either intranasal dexmedetomidine or oral midazolam prior to anesthesia induction. The primary outcome is the proportion of patients achieving adequate sedation at induction, defined as a Ramsay Sedation Score (RSS) ≥2.\n\nSecondary outcomes include perioperative hemodynamic stability, parent-child separation anxiety, mask acceptance during induction, postoperative emergence agitation, recovery time, and the need for rescue sedation.",[29,154,155],"Preoperative Anxiety","Emergence Agitation",[29,154,155],"2026-05-11",{"date":159,"type":34},"2026-05-14",{"date":161,"type":34},"2026-05-05",{"date":163,"type":21},"2026-09-26",{"name":40,"class":41},{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":50,"minAge":78,"maxAge":126,"enrollmentInfo":171,"targetDuration":4,"studyType":22,"phases":173,"briefSummary":174,"conditions":175,"keywords":177,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":4},"100640016","the-effect-of-different-volumes-of-ilioinguinal-iliohypogastric-nerve-block-on-postoperative-analgesia-in-inguinal-hernia-surgery-100640016","NCT07579975","The Effect of Different Volumes of Ilioinguinal-Iliohypogastric Nerve Block on Postoperative Analgesia in Inguinal Hernia Surgery","Inclusion Criteria:\n\n* Patients aged between 18 and 75 years\n* American Society of Anesthesiologists (ASA) physical status I, II, or III\n* Diagnosis of unilateral inguinal hernia\n* Scheduled for elective open inguinal hernia repair under spinal anesthesia\n\nExclusion Criteria:\n\n* Age under 18 or over 75 years\n* ASA physical status IV or higher\n* Body mass index (BMI) greater than 35 kg\u002Fm²\n* Pregnancy or suspected pregnancy\n* Emergency surgery\n* Refusal to provide informed consent\n* Known or suspected coagulopathy\n* Local infection at the site of the nerve block\n* Known allergy to local anesthetics\n* History of chronic opioid use or substance abuse\n* Cognitive impairment or inability to cooperate with study procedures (e.g., inability to use the visual analog scale)",{"count":172,"type":21},70,[24],"The primary objective of this study is to evaluate and compare the efficacy of different volumes of local anesthetics, administered at the same total dose, for ilioinguinal and iliohypogastric (II\u002FIH) nerve blocks in patients undergoing unilateral inguinal hernia repair.\n\nThe investigators aim to determine whether varying the injectate volume-while keeping the total drug amount constant-influences the quality and duration of postoperative analgesia. By monitoring pain scores and opioid consumption, this research seeks to identify the optimal volume-to-dose ratio for enhancing patient recovery and pain management following inguinal surgery.",[176],"Inguinal Hernia Postoperative Pain Acute Pain",[178],"Unilateral inguinal hernia Ilioinguinal-iliohypogastric nerve block Postoperative analgesia Local anesthetic volume","2026-05-06",{"date":181,"type":34},"2026-05-12",{"date":183,"type":21},"2026-04-14",{"date":185,"type":21},"2026-11-14",{"name":40,"class":41},{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":50,"minAge":78,"maxAge":194,"enrollmentInfo":195,"targetDuration":4,"studyType":197,"phases":4,"briefSummary":198,"conditions":199,"keywords":203,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":70},"100634958","serum-electrolytes-and-contrast-induced-nephropathy-in-acute-ischemic-stroke-patients-undergoing-endovascular-treatment-100634958","NCT07546448","Serum Electrolytes and Contrast-Induced Nephropathy in Acute Ischemic Stroke Patients Undergoing Endovascular Treatment","The Impact of Serum Electrolyte Levels on the Risk of Contrast-Induced Nephropathy in Patients With Acute Ischemic Stroke Undergoing Endovascular Therapy","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Patients diagnosed with acute ischemic stroke\n* Patients who underwent endovascular therapy for acute ischemic stroke between 2018 and 2026\n* Patients with a baseline NIHSS score of 6 or higher\n* Patients who received iodinated contrast medium during the endovascular procedure\n* Patients managed under general anesthesia\n* Patients with available pre-procedural and post-procedural serum creatinine measurements sufficient to assess contrast-induced acute kidney injury\n\nExclusion Criteria:\n\n* Age younger than 18 years\n* Pre-existing acute kidney injury or chronic kidney disease meeting KDIGO stage 1-3 before endovascular therapy\n* APACHE score greater than 25 at the time of the procedure\n* Known allergy or hypersensitivity to iodinated contrast media\n* Exposure to iodinated contrast media within the previous 2 weeks\n* Use of nephrotoxic medications within the previous 2 weeks\n* History of myocardial infarction or previous stroke\n* Use of vasopressor\u002Finotropic agents such as dopamine at the time of the procedure\n* Systemic steroid use at the time of the procedure\n* Incomplete medical records or missing laboratory data required for evaluation of CI-AKI","100 Years",{"count":196,"type":21},250,"OBSERVATIONAL","This study aims to evaluate the relationship between serum electrolyte levels and the development of contrast-induced acute kidney injury (CI-AKI) in patients with acute ischemic stroke undergoing endovascular therapy (EVT).\n\nContrast-induced nephropathy remains a significant complication associated with endovascular procedures and is linked to increased morbidity and mortality. While several risk factors have been identified, the role of serum electrolyte imbalances in the development of CI-AKI has not been fully elucidated.\n\nIn this retrospective cohort study, patients treated with EVT between 2018 and 2026 will be analyzed. Patients will be classified based on the presence or absence of CI-AKI according to changes in serum creatinine levels. Demographic data, comorbidities, laboratory parameters-including serum electrolytes-and procedural variables will be compared between groups.\n\nThe primary objective is to determine whether serum electrolyte levels are associated with the risk of CI-AKI. Secondary objectives include evaluating 90-day mortality and dialysis dependency in patients who develop CI-AKI.",[200,201,202],"Acute Ischemic Stroke","Contrast-induced Nephropathy","Acute Kidney Injury",[200,204],"Contrast-Induced Acute Kidney Injury","2026-04-16",{"date":207,"type":34},"2026-04-22",{"date":209,"type":21},"2026-04-20",{"date":211,"type":21},"2026-05-10",{"name":40,"class":41},{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":219,"eligibilityCriteria":220,"healthyVolunteers":11,"sex":50,"minAge":78,"maxAge":4,"enrollmentInfo":221,"targetDuration":223,"studyType":197,"phases":4,"briefSummary":224,"conditions":225,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":230,"lastUpdatePostDateStruct":231,"startDateStruct":233,"completionDateStruct":235,"leadSponsor":237,"locationsCount":70},"100622559","defining-ileorectal-syndrome-a-prospective-observational-study-100622559","NCT07385196","Defining Ileorectal Syndrome: a Prospective Observational Study","Trying to Define Ileorectal Syndrome: a Prospective Observational Study","DEFINE-IRS","Inclusion Criteria: Age ≥18 years\n\nHistory of ileorectal anastomosis or preserved rectum following colorectal surgery\n\nAbility to understand the study procedures and provide written informed consent\n\nWillingness to participate in prospective follow-up assessments -\n\nExclusion Criteria:\n\nAge \\\u003C18 years\n\nPermanent stoma\n\nTotal rectal excision\n\nInability to complete follow-up assessments\n\n\\-",{"count":222,"type":21},30,"10 Days","1. Study Title: Trying to Define Ilorectal Syndrome: A Prospective Observational Study\n2. Study Objective and Significance:\n\n   Primary Objective:\n\n   To prospectively evaluate the frequency, symptom severity, and impact on quality of life of ileorectal syndrome developing in patients who have undergone total colectomy and ileorectal anastomosis.\n\n   Secondary Objectives:\n   * To examine the relationship between postoperative bowel dysfunction and quality of life\n   * To investigate clinical factors affecting symptom severity This study aims to contribute to postoperative follow-up and management strategies by revealing patient-centered outcomes of ileorectal syndrome.\n3. Expected Benefits and Risks of the Study:\n\n   Expected Benefits\n   * Prospective and systematic evaluation of ileorectal syndrome\n   * Identification of factors affecting the quality of life of these patients\n   * Increased awareness in clinical follow-up Potential Risks\n   * The study is observational and questionnaire-based and does not involve additional medical risks\n   * No invasive procedures will be performed on the patients\n4. Type, scope, and design of the planned study:\n\n   * Type: Prospective, observational\n   * Scope: Single-center\n   * Design: Questionnaire-based clinical trial\n5. Number of patients and volunteers to be included in the study, their qualifications, and the rationale for selection:\n\n   * Total number of patients: 30\n   * Age range: ≥18 years\n   * Gender: Female and male This number was determined based on the appropriate patient population followed in our center.\n6. Parameters to be examined:\n\n   Demographic data (age, gender, BMI) Surgical indication Whether the surgery was performed openly or laparoscopically Level of anastomosis Maximum daily bowel movement frequency and duration Feeling of urgency Nocturnal bowel movements Fluid\u002Fgas incontinence - soiling Ileus in ADBG Whether electrolyte abnormalities developed Length of hospital stay Need for re-hospitalization Severity of symptoms based on patient reports and questionnaire questions\n7. Where and by whom the parameters will be examined\n\n   Data will be collected by the responsible investigator at the relevant clinic.\n8. Which parameters to be used in the study are routine for that disease group and which are specific to the study?\n\n   Routine: Demographic data, surgical information, laboratory results Study-Specific: Postoperative bowel functionality, symptom questionnaire\n9. Estimated study duration, start and end dates:\n\n   Start date: 1\u002F1\u002F2026 End date: 31\u002F12\u002F2026 Total duration: 12 months\n10. Inclusion, exclusion, and withdrawal criteria:\n\n    Inclusion Criteria\n    * Having undergone total colectomy and ileorectal anastomosis\n    * 18 years of age and older\n    * Providing written informed consent Exclusion Criteria\n    * Serious neurological disease affecting bowel function\n    * Patients with incomplete follow-up data Withdrawal\n    * At the patient's request\n    * If follow-up cannot be completed\n11. Termination criteria:\n\n    By the ethics committee Termination decision Unforeseen circumstances preventing the conduct of the study\n12. Statistical methods to be used in the evaluation of the data to be obtained as a result of the research:\n\n    * Descriptive statistics (mean, median, percentage)\n    * Parametric and non-parametric tests\n    * Analysis of the relationship between symptom severity and quality of life\n    * p \\\u003C 0.05 statistical significance level",[226,227,228,229],"Total Colectomy","Diarrhea","Urgency Incontinence","Soilings, Fecal","2026-01-27",{"date":232,"type":34},"2026-02-03",{"date":234,"type":34},"2025-12-19",{"date":236,"type":21},"2027-02-15",{"name":40,"class":41},{"id":239,"slug":240,"hasResults":11,"nctId":241,"briefTitle":242,"officialTitle":242,"acronym":243,"eligibilityCriteria":244,"healthyVolunteers":245,"sex":50,"minAge":78,"maxAge":104,"enrollmentInfo":246,"targetDuration":4,"studyType":22,"phases":248,"briefSummary":249,"conditions":250,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":252,"lastUpdatePostDateStruct":253,"startDateStruct":255,"completionDateStruct":257,"leadSponsor":259,"locationsCount":70},"100622052","effect-of-intraoperative-salbutamol-administration-on-mechanical-power-and-respiratory-mechanics-in-obese-patients-undergoing-laparoscopic-bariatric-surgery-100622052","NCT07378605","Effect of Intraoperative Salbutamol Administration on Mechanical Power and Respiratory Mechanics in Obese Patients Undergoing Laparoscopic Bariatric Surgery","Bariatric","Inclusion Criteria:\n\n* Age: 18-65 years\n\nBMI ≥35 kg\u002Fm² (candidates for obesity surgery)\n\nScheduled for elective laparoscopic bariatric surgery\n\nASA physical status I-III\n\nSigned informed consent\n\nExclusion Criteria:\n\nKnown allergy or contraindication to salbutamol\n\nSevere cardiovascular disease (e.g., recent MI, uncontrolled arrhythmia)\n\nPre-existing severe pulmonary disease (e.g., severe COPD, asthma exacerbation)\n\nPregnancy or lactation\n\nEmergency surgery\n\nUse of β-agonists or bronchodilators within 24 hours prior to surgery\n\nPatients with inability to provide informed consent\n\n\\-",true,{"count":247,"type":21},66,[24],"The primary objective of this study is to evaluate the effect of intraoperative salbutamol administration on mechanical power in obese patients undergoing laparoscopic bariatric surgery under general anesthesia. Mechanical power will be measured at predefined intraoperative time points (T0, T1, and T2), and changes over time will be compared to determine the impact of salbutamol on the overall energy delivered to the respiratory system during mechanical ventilation.\n\nSecondary objectives include the assessment of intraoperative respiratory mechanics, including peak airway pressure (Ppeak), plateau pressure (Pplat), driving pressure (Pdrive), airway resistance (Raw), and lung compliance, as well as gas exchange parameters (SpO₂, EtCO₂) and hemodynamic variables (mean arterial pressure). Postoperative pulmonary outcomes will be evaluated using the Melbourne Group Scale (MGS), with a score greater than 4 indicating the presence of postoperative pulmonary complications. The study aims to investigate whether improvement in intraoperative mechanical power and respiratory mechanics is associated with a reduction in postoperative pulmonary complications in this high-risk population.",[251],"Bariatric Surgery","2026-01-22",{"date":254,"type":34},"2026-01-30",{"date":256,"type":21},"2026-01-01",{"date":258,"type":21},"2026-03-15",{"name":40,"class":41},{"id":261,"slug":262,"hasResults":11,"nctId":263,"briefTitle":264,"officialTitle":265,"acronym":4,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":50,"minAge":78,"maxAge":4,"enrollmentInfo":267,"targetDuration":4,"studyType":197,"phases":4,"briefSummary":269,"conditions":270,"keywords":274,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":280,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":286,"locationsCount":70},"100617905","impact-of-intraoperative-hemodynamic-instability-on-outcomes-in-cardiac-surgery-100617905","NCT07324694","Impact of Intraoperative Hemodynamic Instability on Outcomes in Cardiac Surgery","Impact of Intraoperative Hemodynamic Instability on Postoperative Major Adverse Events in Cardiac Surgery Patients: A Prospective Cohort Study","Inclusion Criteria:\n\n* Patients aged 18 years or older.\n* Scheduled for elective cardiac surgery (CABG, Valve replacement\u002Frepair, or combined procedures).\n* Surgery performed under cardiopulmonary bypass (CPB).\n* Preoperative sinus rhythm.\n* Signed informed consent form.\n\nExclusion Criteria:\n\n* Emergency or salvage surgery.\n* Off-pump coronary artery bypass grafting.\n* Preoperative mechanical circulatory support (IABP, ECMO) requirement.\n* Pre-existing chronic renal failure requiring dialysis (HD\u002FPD).\n* Pre-existing cognitive impairment, dementia, or history of psychiatric disorders affecting cooperation.\n* Pregnancy.",{"count":268,"type":21},230,"Intraoperative hemodynamic instability (IOHI) is a common occurrence during cardiac surgery and is associated with organ hypoperfusion. However, the specific impact of IOHI on composite adverse outcomes remains unclear. This prospective cohort study aims to evaluate the association between intraoperative hemodynamic instability (defined as MAP \\\u003C 65 mmHg or vasopressor requirement) and major postoperative complications (Delirium, Acute Kidney Injury, Stroke, or Mortality) in adult patients undergoing elective cardiac surgery with cardiopulmonary bypass.",[135,271,272,202,273],"Intraoperative Hemodynamic Instability","Postoperative Complication","Postoperative Delirium (POD)",[275,276,277,278],"Intraoperative Hypotension","Cardiopulmonary Bypass","Mean Arterial Pressure","Cohort Study","2026-01-09",{"date":281,"type":34},"2026-01-12",{"date":283,"type":34},"2025-04-26",{"date":285,"type":21},"2026-02-05",{"name":40,"class":41},{"id":288,"slug":289,"hasResults":11,"nctId":290,"briefTitle":291,"officialTitle":292,"acronym":293,"eligibilityCriteria":294,"healthyVolunteers":245,"sex":50,"minAge":78,"maxAge":104,"enrollmentInfo":295,"targetDuration":4,"studyType":22,"phases":297,"briefSummary":298,"conditions":299,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":304,"completionDateStruct":306,"leadSponsor":308,"locationsCount":70},"100594607","comparison-of-erector-spina-plan-block-and-thoracic-paravertebral-block-for-perioperative-analgesia-100594607","NCT07021651","COMPARISON OF ERECTOR SPINA PLAN BLOCK AND THORACIC PARAVERTEBRAL BLOCK FOR PERIOPERATIVE ANALGESIA","A Two-Center Randomized Controlled Trial","A Two-Center","Inclusion Criteria:\n\n* Patients who will undergo thoracotomy and are between the ages of 18-65\n* have American Society of Anesthesiologists (ASA) risk classification I-II will be included in the study.\n\nExclusion Criteria:\n\n* Patients who did not agree to participate in the study,\n* had an infection in the application area,\n* had coagulopathy,\n* were morbidly obese (Body mass index (BMI)\\>35),\n* had drug allergy,\n* had chronic pain, long-term opioid use, psychiatric illness history, and required emergency surgery were excluded from the study.",{"count":296,"type":21},60,[24],"The primary aim of this study was to compare the postoperative analgesic efficacy of thoracic paravertebral block with erector spinae plane block, which we use in thoracotomy surgeries. Secondary aims were to compare these groups in terms of Riker Agitation-Sedation Scale (RASS) scores, postoperative complications, postoperative opioid consumption, and patient satisfaction.",[300],"Paravertebral Block","2025-06-13",{"date":303,"type":34},"2025-06-15",{"date":305,"type":21},"2025-07-10",{"date":307,"type":21},"2025-08-01",{"name":40,"class":41},{"id":310,"slug":311,"hasResults":11,"nctId":312,"briefTitle":313,"officialTitle":314,"acronym":315,"eligibilityCriteria":316,"healthyVolunteers":11,"sex":50,"minAge":317,"maxAge":318,"enrollmentInfo":319,"targetDuration":4,"studyType":22,"phases":321,"briefSummary":322,"conditions":323,"keywords":326,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":337,"locationsCount":4},"100589727","the-effects-of-core-stabilization-on-desk-workers-with-postural-disorders-100589727","NCT06958172","The Effects of Core Stabilization on Desk Workers With Postural Disorders","Investigation of The Effects of Core Stabilization, Hip and Thoracic Mobility Exercises on Desk Workers With Postural Disorders","CORE","Inclusion Criteria:\n\n* Having a desk job\n* Being between the ages of 25-45,\n* Written approval of participation in the study by himself\u002Fherself or his\u002Fher legal representative\n\nExclusion Criteria:\n\n* Having had surgery within the last six months,\n* Having a previously identified and diagnosed cardiovascular or pulmonary disease","25 Years","45 Years",{"count":320,"type":21},40,[24],"This study aimed to investigate the effects of core, thoracic and hip mobility exercises on trunk stabilization and postural improvement in desk workers with postural disorders.",[324,325],"Postural Imbalance","Worker Health",[327,328,329],"Balance","Core Stabilization","Mobility Exercise","2025-05-02",{"date":332,"type":34},"2025-05-06",{"date":334,"type":21},"2025-05-25",{"date":336,"type":21},"2025-06-25",{"name":40,"class":41},{"id":339,"slug":340,"hasResults":11,"nctId":341,"briefTitle":342,"officialTitle":342,"acronym":343,"eligibilityCriteria":344,"healthyVolunteers":11,"sex":103,"minAge":78,"maxAge":345,"enrollmentInfo":346,"targetDuration":4,"studyType":22,"phases":348,"briefSummary":349,"conditions":350,"keywords":356,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":370,"locationsCount":70},"100583021","comparison-of-transvaginal-paracervical-and-transperitoneal-approaches-in-lymphadenectomy-during-v-notes-surgery-for-patients-diagnosed-with-endometrial-cancer-100583021","NCT06870903","Comparison of Transvaginal Paracervical and Transperitoneal Approaches in Lymphadenectomy During v-NOTES Surgery for Patients Diagnosed With Endometrial Cancer","ENDONOTE","Patient Selection and Data Collection This study will be implemented in a single institution, Diyarbakır Gazi Yaşargil Training and Research Hospital, which functions as a tertiary cancer treatment facility.\n\nBetween March 2025 and December 2025, patients with newly diagnosed clinical early stage (FIGO 2023 stages 1 and 2) endometrial cancer who will be treated with laparoscopic surgical staging with SLN mapping at our institution will be randomized into groups. The research procedure has been approved by the ethics committee\u002Finstitutional review board of Diyarbakır Gazi Yaşargil Training and Research Hospital and informed consent signed by the patient will be included in each table reviewed.\n\nEligible participants will be required to give informed consent to participate in the study.\n\nInclusion criteria will include\n\n* Participants whose endometrial biopsy resulted in endometrial cancer and whose disease will be detected limited to the uterus using imaging modalities (computed tomography \\[CT\\], magnetic resonance imaging or Fluorine-18 fluorodeoxyglucose positron emission tomography\u002FCT)\n* Absence of synchronous malignancies.\n* No neoadjuvant treatment before surgical intervention.\n\nExclusion criteria will include:\n\n* Contraindications to using methylene blue dye or contraindications to the vNOTES procedure.\n* Patients who have had previous malignancy surgery.\n* Severe, deeply penetrating endometriosis or enlarged uterus that may require forced vaginal extraction\n* Receiving neodajuvant therapy","85 Years",{"count":347,"type":21},52,[24],"The aim of this study is to compare two types of lymphadenectomy (transperitoneal vs. paracervical) during the lymphadenectomy phase of endometrial cancer staging surgery performed using V-NOTES, a new and advanced technique. This study seeks to optimize the V-NOTES technique for endometrial cancer staging. This randomized, prospective, controlled study will include patients diagnosed with endometrial cancer via histology, following physical examination and imaging, and who are electively scheduled for the V-NOTES endometrial cancer staging procedure. Patients will be randomized into two groups: the transvaginal paracervical lymphadenectomy group and the transperitoneal lymphadenectomy group. The parameters related with surgical and functional outcomes will be compared in both groups.",[351,352,353,354,355],"Endometrial Cancer","Lymphadenectomy","Sentinel Lymph Node Biopsy","Minimally Invasive Surgical Procedures","Natural Orifice Transluminal Endoscopic Surgery",[357,358,359,360,361,362],"endometrial cancer","V-NOTES","lymphadenectomy","sentinel lymph node","transperitoneal","extraperitoneal","2025-03-17",{"date":365,"type":34},"2025-03-20",{"date":367,"type":34},"2025-03-15",{"date":369,"type":21},"2026-03-01",{"name":40,"class":41},{"id":372,"slug":373,"hasResults":11,"nctId":374,"briefTitle":375,"officialTitle":375,"acronym":4,"eligibilityCriteria":376,"healthyVolunteers":245,"sex":50,"minAge":78,"maxAge":377,"enrollmentInfo":378,"targetDuration":4,"studyType":197,"phases":4,"briefSummary":380,"conditions":381,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":383,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":389,"locationsCount":70},"100572869","monitoring-changes-in-endotracheal-tube-cuff-pressure-during-laparoscopic-bariatric-surgery-100572869","NCT06738875","Monitoring Changes in Endotracheal Tube Cuff Pressure During Laparoscopic Bariatric Surgery","Inclusion Criteria:\n\n* American Society of Anesthesiologists (ASA) risk indicators I-III manage to undergo Laparoscopic bariatric surgery between the ages of 18-70\n\nExclusion Criteria:\n\n* Patients with drug allergies, chronic pain, long-term opioid use, history of psychiatric illness, and need for emergency surgery were excluded from the study.","70 Years",{"count":379,"type":21},28,"This prospective observational cohort study was designed to assess the relationship between ETT cuff pressures and airway pressures in obese patients undergoing laparoscopic bariatric surgery. We hypothesized that the ETT cuff pressures will rise in direct relationship to increases in the peak and mean airway pressures.",[251],"2024-12-13",{"date":384,"type":34},"2024-12-18",{"date":386,"type":34},"2024-12-10",{"date":388,"type":21},"2025-01-15",{"name":40,"class":41},{"id":391,"slug":392,"hasResults":11,"nctId":393,"briefTitle":394,"officialTitle":395,"acronym":396,"eligibilityCriteria":397,"healthyVolunteers":245,"sex":50,"minAge":78,"maxAge":377,"enrollmentInfo":398,"targetDuration":4,"studyType":22,"phases":400,"briefSummary":401,"conditions":402,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":403,"lastUpdatePostDateStruct":404,"startDateStruct":406,"completionDateStruct":407,"leadSponsor":409,"locationsCount":70},"100557507","efficacy-of-remifentanil-in-preventing-emergence-agitation-100557507","NCT06539013","Efficacy of Remifentanil in Preventing Emergence Agitation","Efficacy of Remifentanil in Preventing Emergence Agitation in Patients Undergoing Nasal Surgery Under Desflurane Anesthesia: A Prospective Double-blind Randomized Controlled Trial.","agitation","Inclusion Criteria:\n\nThe study included patients over the age of 18, planned to undergo rhinoplasty by the plastic and reconstructive surgery department, and American Society of Anesthesiologist (ASA) I-II.\n\n\\-\n\nExclusion Criteria:\n\n* Patients with a known history of allergy to the drugs to be administered in the study, ASA III and above, body mass index (BMI) 35\\>kg\u002Fm2, younger than 18 years of age, any problems that would prevent general anesthesia in the preoperative evaluation (upper respiratory tract infection, etc.), and those who did not agree to participate in the study were excluded from the study.",{"count":399,"type":21},99,[24],"The primary aim of the study was to test the hypothesis that remifentanil administered for analgesia prevents emergence agitation more effectively than fentanyl and N2O in patients undergoing rhinoplasty who received desflurane as an inhaled anesthetic agent. The secondary aim of the study was to compare the demographic data, intraoperative and postoperative hemodynamic data, surgical time and modified Aldrete score of patients who received different intraoperative analgesia methods.",[155],"2024-08-01",{"date":405,"type":34},"2024-08-06",{"date":403,"type":34},{"date":408,"type":21},"2024-10-01",{"name":40,"class":41},""]