[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Sahiwal medical college sahiwal\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":173},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,41,72,103,125,150],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":4},"100643895","comparison-between-excision-and-primary-anastomosis-urethroplasty-and-tunica-vaginalis-graft-urethroplasty-100643895",false,"NCT07668973","Comparison Between Excision And Primary Anastomosis Urethroplasty And Tunica Vaginalis Graft Urethroplasty.","Comparison of Outcome Between Excision and Primary Anastomosis Urethroplasty and Tunica Vaginalis Graft Urethroplasty in Patients With Bulbar Urethral Stricture Upto 2cm in Length : A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients with diagnosis of bulbar urethral stricture upto 2cm in length.\n* Patients aged between 18-50 years.\n* Patients with non-traumatic bulbar urethral stricture.\n* Isolated short (≤ 2 cm) bulbar urethral stricture\n* Patient is able and willing to comply with the postoperative protocol.\n\nExclusion Criteria:\n\n* Urethral stricture which is completely obliterated stricture.\n* Patients with history of hypospadias or previous open urethral surgery.\n* Patients with uncontrolled diabetes or Immunocompromised patients.\n* Patients unwilling for the follow-up.\n* History of pelvic radiation therapy\n* Patient with history of urethral instrumentation in last 3 months.\n* Lichen sclerosus related strictures.\n* Patients with history of erectile dysfunction, priapism or treatment to enhance erectile function.","MALE","18 Years","50 Years",{"count":20,"type":21},94,"ESTIMATED","INTERVENTIONAL",[24],"NA","Urethroplasty is considered as a gold standard in treatment of urethral stricture disease having success rate of more than 93% in terms of recurrence of stricture. The objective of the study is to compare the outcome between excision and primary anastomosis (EPA) urethroplasty, a transecting urethroplasty technique and Tunica Vaginalis Graft (TVG) Urethroplasty, a non-transecting urethroplasty technique, in patients with bulbar urethral stricture upto 2cm in length. It will be a Randomized Controlled Trial (RCT) in which 94 patients admitted in Sahiwal Teaching Hospital, Sahiwal will be included. The patients will be divided into two equal groups. Randomization will be performed using a computer-generated random sequence. The Group-A patients will undergo excision and primary anastomosis (EPA) urethroplasty while Group-B patients will undergo Tunica Vaginalis Graft (TVG) Urethroplasty. Non-probability convenience sampling will be carried out. Detailed history of urinary symptoms, Sexual function, catheterization, instrumentation, urinary tract infection and trauma will be taken to obtain the cause of stricture. Demographic information like name, age, and contact number will be recorded. Investigations will include preoperative complete blood count, renal function test, liver function test, urine complete examination, ultrasonogram kidney, ureter and bladder with post void residual volume (PVR) uroflowmetry and retrograde urethrogram for diagnosis and length of stricture. Other parameters of study will be length of hospital stay, postoperative complication such as graft failure, wound infection, urinary tract infection and fistula formation. Data will be collected through proforma, which will be entered and analyzed using statistical package for social sciences version 26.0. For quantitative variables mean and standard deviation will be calculated and for qualitative variables frequency and percentages will be calculated. Data will be presented in tables and graphs for both quantitative and qualitative variables. Chi-square test will be used to estimate the association between qualitative variables. An Independent sample t-test will be applied for quantitative variables. P-value \\\u003C0.05 will be considered significant. It is anticipated that the Tunica Vaginalis Graft (TVG) Urethroplasty provides better outcome as compared to excision and primary anastomosis (EPA) urethroplasty.",[27,28],"Urethral Stricture","Erectile Dysfunction","NOT_YET_RECRUITING","2026-06-21",{"date":32,"type":33},"2026-06-25","ACTUAL",{"date":35,"type":21},"2026-07",{"date":37,"type":21},"2027-07",{"name":39,"class":40},"Sahiwal medical college sahiwal","OTHER_GOV",{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":4,"eligibilityCriteria":47,"healthyVolunteers":48,"sex":49,"minAge":50,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":57,"conditions":58,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},"100639167","phase-2-dexa-vs-dexmedetomidine-with-bupivacaine-in-tap-block-for-laparotomy-analgesia-100639167","NCT07590752","\"Dexa vs Dexmedetomidine With Bupivacaine in TAP Block for Laparotomy Analgesia","Comparison Of Dexamethasone Versus Dexmedetomidine As An Adjuvant To 0.25% Bupivacaine In Ultrasound Guided Tap Block On Post-Op Analgesia Duration In Patients Undergoing Laparotomy","Inclusion Criteria:\n\n* Patients undergoing laparotomy.\n* Patients aged 25 to 65 years.\n* Both genders.\n* Patients with ASA Class I, II.\n\nExclusion Criteria:\n\n* Patients who do not give consent.\n* Patients with Comorbidities like DM, HTN, CKD, CLD.\n* Patients with bleeding disorders.\n* Infection at site of injection.\n* Allergy to any drug, local anaesthetic, or other drugs used.\n* Patients with polytrauma.",true,"ALL","25 Years","65 Years",{"count":53,"type":21},96,[55,56],"PHASE2","PHASE3","Transversus abdominis plane block is a regional anesthetic technique which blocks the abdominal neural afferents by introducing local anesthetic into the neuro-fascial plane between the internal oblique and the transversus abdominis muscle and gives analgesia from the skin to parietal peritoneum. There are studies showing evidence of improved post operative analgesia with addition of adjuvants such as dexmedetomidine or dexamethasone in comparison with plane local anesthesia in terms of time to rescue analgesia and the overall quantity of analgesic used post operatively.",[59,60,61],"Pain, Postoperative","Opioid Use","Laparotomy","RECRUITING","2026-05-08",{"date":65,"type":33},"2026-05-15",{"date":67,"type":33},"2024-03-03",{"date":69,"type":21},"2026-07-04",{"name":39,"class":40},1,{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":78,"eligibilityCriteria":79,"healthyVolunteers":11,"sex":49,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":90,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":71},"100609984","phase-2-comparison-of-supra-vs-infra-inguinal-fascia-iliaca-blocks-for-spinal-positioning-and-analgesia-in-lower-limb-surgery-100609984","NCT07221682","Comparison of Supra vs Infra Inguinal Fascia Iliaca Blocks for Spinal Positioning and Analgesia in Lower Limb Surgery","Comparison For Ease Of Spinal Positioning & Duration Of Post-Op Analgesia Between Ultrasound Guided Supra-Inguinal Fascia Iliaca Block Vs Ultrasound Guided Infra-Inguinal Fascia Iliaca Block In Patients Undergoing Thigh & Knee Surgeries","27G","Inclusion Criteria:\n\n1. Both Genders (Male \u002FFemale).\n2. Age between 30 years to 60 years.\n3. ASA Class I, II, III.\n\nExclusion Criteria:\n\n1. Patient refusal\n2. Other distracting painful pathology\n3. Any contraindication to Spinal Anesthesia or peripheral nerve blocks\n4. Coagulopathic disorders\n5. Patients with significant cognitive impairment\n6. Patients with no pain while sitting by themselves without any support\n7. H\u002FO polytrauma involving other limbs\n8. H\u002FO allergy to the drugs used in study","30 Years","60 Years",{"count":83,"type":21},60,[55,56],"Severe pain associated with thigh and knee fractures makes the positioning for regional anesthesia a challenge. Different modalities to make patient pain free for spinal positioning, post op analgesia and patient satisfaction including supra-inguinal fascia iliaca block (S-FIB) and infra-inguinal fascia iliaca blocks (I-FIB) have been studies. The aim of this study is to compare two blocks in patients undergoing thigh and knee surgeries.\n\nA randomized controlled trial study design will be used and 60 patients fulfilling the inclusion criteria will be included. The patients will be divided into 2 groups by simple random sampling. Group A (S-FIB) (n = 30, those who will receive 30 ml of 0.125% bupivacaine) and Group B (I-FIB) (n = 30, those who will receive 30 ml of 0.125% bupivacaine). Depending on the allotted group, patients will be given the block under the guidance of ultrasound in the preoperative area. After block patients will be assessed for ease of spinal positioning using EOSP Scale, postoperative duration of analgesia and patient satisfaction using Likert Scale and data will be recorded on prescribed proforma.\n\nAll the findings will be noted in a specially designed proforma by the researcher. All the data collected will be entered and analyzed. Quantitative variables will be presented with mean ± SD. Independent sample t-test for duration of postoperative analgesia. Qualitative variables such as ease of spinal positioning and gender will be presented with Chi-Square. A p-value equal to or less than 0.05 will be considered significant.",[87,88,89],"Post Operative Analgesia","Bradycardia","Hypotension Drug-Induced",[91,92,93,94],"S-FICB","I-FICB","ASA","EOSP","2026-01-28",{"date":97,"type":33},"2026-01-29",{"date":99,"type":33},"2024-05-06",{"date":101,"type":21},"2027-01-01",{"name":39,"class":40},{"id":104,"slug":105,"hasResults":11,"nctId":106,"briefTitle":107,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":48,"sex":49,"minAge":17,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":22,"phases":112,"briefSummary":113,"conditions":114,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":117,"lastUpdatePostDateStruct":118,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":71},"100615283","phase-2-comparative-analysis-of-dexmedetomidine-and-dexamethasone-as-an-adjuvant-to-05ropivacaine-on-onset-of-ultrasound-guided-supraclavicular-brachial-plexus-block-in-patients-undergoing-upper-limb-surgeries-100615283","NCT07290595","Comparative Analysis Of Dexmedetomidine And Dexamethasone As An Adjuvant To 0.5%Ropivacaine On Onset Of Ultrasound Guided Supraclavicular Brachial Plexus Block In Patients Undergoing Upper Limb Surgeries","Inclusion Criteria\n\n* Patients scheduled for upper limb surgery below mid-humerus level\n* Patients aged 18 to 70 years\n* Patients with ASA class I, II and III\n* Male and non-pregnant females Exclusion Criteria\n* Patients refusal\n* Patients with pre-existing peripheral neuropathy of the upper limb\n* Patients with the Infection at block site\n* Patients with history of ischemic heart disease\n* Patients with bleeding disorder or deranged coagulation profile\n* Patients with known history of allergy to local anaesthetic or any other drugs used","70 Years",{"count":111,"type":21},66,[55,56],"To compare the efficacy of dexmedetomidine and dexamethasone as an adjuvant to 0.5%ropivacaine on onset of ultrasound guided supraclavicular brachial plexus block in patients undergoing upper limb surgeries.\n\nRopivacaine hydrochloride, a long acting local anesthetic, is commonly used for supraclavicular block owing to its favorable safety profile especially in terms of minimal cardiotoxicity and less motor block. Dexmedetomidine, a highly selective alpha-2 adrenergic agonist, enhances the quality of supraclavicular block by providing sedation and analgesia while potentially prolonging the duration of block through hyperpolarization of nerve fibers. While, Dexamethasone, a synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties, prolongs duration of analgesia by reducing perineural inflammation and inhibiting nociceptive signal transmission. Supraclavicular brachial plexus block offers dense anesthesia for surgical procedures at or distal to the elbow with relatively high success rate, once described as \"spinal of the arm\". Moreover, supraclavicular brachial plexus block is an excellent alternative to general anesthesia in upper limb surgeries.",[87,88,115,116],"Hypotension","Upper Limb Surgeries","2025-12-20",{"date":119,"type":33},"2025-12-23",{"date":121,"type":33},"2025-01-13",{"date":123,"type":21},"2026-03-12",{"name":39,"class":40},{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":11,"sex":49,"minAge":132,"maxAge":109,"enrollmentInfo":133,"targetDuration":4,"studyType":22,"phases":135,"briefSummary":136,"conditions":137,"keywords":140,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":71},"100559794","phase-2-comparison-of-eosp-between-usg-guided-s-ficb-vs-usg-guided-peng-block-in-pts-undergoing-femur-fracture-surgery-100559794","NCT06568770","Comparison of EOSP Between Usg Guided S-FICB vs USG Guided PENG Block in Pts Undergoing Femur Fracture Surgery","Comparison of Ease of SPINAL Positioning Between USG Guided Supra-inguinal Fascia Iliaca Block vs USG Guided Pericapsular Nerve Group Block in Patients Undergoing Femur Fracture Surgery","Inclusion Criteria:\n\n* 1\\. Both Genders (Male \u002FFemale). 2. Age between 20 years to 70 years. 3. Radiologically confirmed femur fracture. 4. ASA Class I, II, III.\n\nExclusion Criteria:\n\n1. Patient refusal\n2. Other distracting painful pathology\n3. Any contraindication to Spinal Anesthesia or peripheral nerve blocks\n4. Coagulopathic disorders\n5. H\u002FO ischemic heart disease\n6. Patients on opioids for chronic pain\n7. Patients with significant cognitive impairment\n8. Patients with no pain while sitting by themselves without any support.","20 Years",{"count":134,"type":21},70,[55,56],"To compare the immediate and postoperative analgesic efficacy of S-FICB and PENG block will be the objective. The use of ultrasonography in anesthesia has helped the anesthetist to see the nerve, needle and the distribution of the drug, thereby enhancing the chances of a favorable outcome of the nerve block. Grade A recommendation for an ultrasound guided approach to the peripheral nerve blocks is supported by level Ib evidence for a shortened time for the onset of sensory block, decreased performance time and lower drug doses10.\n\nAlthough individually both the blocks have been studied, there are only a handful of studies comparing both techniques under ultrasound guidance for making patient positioning for spinal anesthesia easy. And no local data is available comparing these blocks. So, we want to compare the analgesic efficacy of USG PENG block with USG S-FICB block in patients with fracture femur in reducing pain associated with positioning (sitting) for subarachnoid block, duration of analgesia, opioid sparing effect and complications. So that procedure with better analgesic efficacy and less complications will be included in our local guidelines as a part of multimodal analgesia.",[138,88,115,139],"Post Operative Pain","Femur Fracture",[141],"PENG,S-FICB,ASA,EOSP","2025-10-21",{"date":144,"type":33},"2025-10-23",{"date":146,"type":33},"2024-07-10",{"date":148,"type":21},"2026-01-10",{"name":39,"class":40},{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":155,"acronym":4,"eligibilityCriteria":156,"healthyVolunteers":48,"sex":49,"minAge":132,"maxAge":109,"enrollmentInfo":157,"targetDuration":4,"studyType":22,"phases":159,"briefSummary":160,"conditions":161,"keywords":4,"overallStatus":62,"whyStopped":4,"lastUpdateSubmitDate":165,"lastUpdatePostDateStruct":166,"startDateStruct":168,"completionDateStruct":170,"leadSponsor":172,"locationsCount":71},"100573025","phase-2-evaluating-perioperative-outcomes-dexmedetomidine-vs-lignocaine-in-laparoscopic-chlolecystectomy-100573025","NCT06740903","Evaluating Perioperative Outcomes: Dexmedetomidine vs Lignocaine in Laparoscopic Chlolecystectomy","Comparison of Dexmedetomidine & Lignocaine Infusion on Perioperative Hemodynamics, Postoperative Analgesia & Recovery of Postoperative Gastrointestinal Function in Patients for Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n1. Patients of age 20-70 years\n2. Both gender\n3. Laparoscopic cholecystectomy under general Anaesthesia\n4. ASA I-II.\n\nExclusion Criteria:\n\n* Emergency surgery\n* Patients with history of allergic reaction to trial drugs\n* Patients with cardiovascular disease, sickle cell disease, psychiatric disorder, peripheral vascular disease, and neurological diseases (on medical record)\n* Anemia\n* Patient on TCA or Beta blocker drugs.\n* Uncontrolled hypertension (P≥160\u002F100 mmHg)\n* Uncontrolled diabetes mellitus\n* Obesity BMI \\> 35",{"count":158,"type":21},140,[55,56],"Nowadays laparoscopic surgery is the first choice for many surgeries. Such surgeries have revolutionized the surgical practice and has markedly reduced the incidence of intraoperative and postoperative complications. To minimize these side effects associated with the use of opioids, various methods have been adopted. Recently, different trials have highlighted the possible role of dexmedetomidine and lignocaine in providing postoperative analgesia and attenuating hemodynamic response. Literature showed conflicting results regarding both these drugs. So, we want to find the evidence for local setting. This Randomized Controlled Trial will be done at Department of Anesthesia, Sahiwal teaching hospital, Sahiwal for 12 months. Sample size of 140 cases; 70 cases in each group will be included through non-probability consecutive sampling. Then patients will be divided in two groups by using computer generated random number table. In group A, patients will be given dexmedetomidine infusion. In group B, patients will be given lignocaine infusion. All anesthesia procedures will be done by researcher. Heart rate and mean arterial pressure will be assessed before induction of anesthesia, after every 10 mins every 30 mins till completion of surgery. Total operative time will be noted. After procedure, patients will be assessed for postoperative pain score. when pain will be ≥4 on visual analogue scale rescue analgesia will be given and time will be noted. Total duration from time of surgery till need for rescue analgesia will be noted. Duration of postoperative analgesia opioid consumption \u002F24 hrs.) will be presented by using mean± SD.",[162,138,163,164],"Hemodynamics Instability","Gastrointestinal Dysfunction","Cholecystitis","2024-12-14",{"date":167,"type":33},"2024-12-18",{"date":169,"type":33},"2024-08-06",{"date":171,"type":21},"2025-09-06",{"name":39,"class":40},""]