[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Saint Thomas Hospital, Panama\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":137},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,45,69,95,116],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100613342","excess-base-comparison-between-pregnant-subjects-with-severe-preeclampsia-vs-normotensive-pregnant-women-100613342",false,"NCT07265336","Excess Base Comparison Between Pregnant Subjects With Severe Preeclampsia vs. Normotensive Pregnant Women","Comparison of Base Excess in Arterial Blood Gases Between Patients With Severe Preeclampsia and Normotensive Pregnant Patients","Inclusion Criteria:\n\n* Gestational age: 24-40 weeks\n* Cases: Diagnosis of severe preeclampsia\n* Control: Normal blood pressure\n\nExclusion Criteria:\n\n* Metabolic conditions that could hinder the results (diabetic ketoacidosis, sepsis, renal failure).\n* Clinical conditions that could hinder the results (diarrhea, vomit)\n* Recent use of bicarbonate",true,"FEMALE",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"NA","The study's primary goal is to compare the base excess (BE) values-an indicator of metabolic changes-in two groups of patients at Santo Tomás Hospital: those with severe preeclampsia and healthy, pregnant individuals. Researchers will measure these values using an arterial blood gas test before delivery or surgery.\n\nThis is a prospective cohort study. The researchers will analyze various blood gas parameters, including pH, lactate, and BE, and then correlate the BE values with clinical variables and negative maternal outcomes.\n\nThe expected outcome is that a abnormal BE values will be linked to a greater severity of preeclampsia. If this association is confirmed, BE could serve as an additional marker for predicting the severity of the condition and may lay the groundwork for future research on diagnostic and therapeutic standards based on blood gas analysis.",[26,27],"Preeclampsia","Severe Preeclampsia",[29,30,31],"Excess base","Severe preeclampsia","Arterial blood gases","RECRUITING","2025-12-02",{"date":35,"type":36},"2025-12-04","ACTUAL",{"date":38,"type":36},"2025-08-15",{"date":40,"type":20},"2026-01-31",{"name":42,"class":43},"Saint Thomas Hospital, Panama","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":52,"targetDuration":4,"studyType":21,"phases":54,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":68,"locationsCount":44},"100613082","lung-ultrasound-for-the-detection-of-volume-overload-in-patients-with-severe-preeclampsia-100613082","NCT07261956","Lung Ultrasound for the Detection of Volume Overload in Patients With Severe Preeclampsia","Usefulness of Lung Ultrasound for the Detection of Volume Overload in Patients With Severe Preeclampsia","Inclusion Criteria:\n\n* Preeclampsia with severe features.\n* Gestational age 24 weeks - 41 weeks.\n\nExclusion Criteria:\n\n* Chronic lung disease.\n* Known heart disease.\n* Diagnosis of lung edema at admission\n* Body mass index \\> 40\n* Need for immediate delivery",{"count":53,"type":20},202,[23],"This research aims to evaluate the usefulness of lung ultrasound (LUS) for detecting and monitoring fluid overload in patients with severe preeclampsia. Severe preeclampsia is a leading cause of maternal death and illness worldwide, often causing fluid buildup that can lead to a serious complication called pulmonary edema, especially after delivery.\n\nThe study will be a prospective, longitudinal observational study with a diagnostic validation component. It will involve patients with a diagnosis of severe preeclampsia who meet specific inclusion criteria. Each participant will undergo a clinical exam and a lung ultrasound, which will assess eight zones of the lungs. The total number of B-lines-a sign of interstitial edema-will be documented.\n\nData will be collected at three key times: upon admission, in the immediate postpartum period (within 24 hours of delivery), and 7-10 days postpartum. The results from the LUS will be compared to clinical signs like shortness of breath, rapid breathing, crackling sounds in the lungs, and oxygen saturation levels.\n\nThe expected impact of this research is to provide evidence that LUS is a valuable, non-invasive, and accessible tool for the early detection of pulmonary congestion in patients with severe preeclampsia. This could lead to improved clinical decision-making and a reduction in maternal respiratory complications.",[57,26],"Pulmonary Edema - Acute",[59,30,60,61],"Pulmonary edema","B lines","Lung ultrasound","2025-11-29",{"date":64,"type":36},"2025-12-03",{"date":66,"type":36},"2025-08-25",{"date":40,"type":20},{"name":42,"class":43},{"id":70,"slug":71,"hasResults":11,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":4,"eligibilityCriteria":75,"healthyVolunteers":11,"sex":17,"minAge":76,"maxAge":4,"enrollmentInfo":77,"targetDuration":4,"studyType":79,"phases":4,"briefSummary":80,"conditions":81,"keywords":83,"overallStatus":86,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":44},"100528863","number-of-previous-cesarean-sections-on-the-results-of-angiogenic-factors-100528863","NCT06166303","Number of Previous Cesarean Sections on the Results of Angiogenic Factors.","Effect of Number of Previous Cesarean Sections on the Results of Angiogenic Factors. A Descriptive, Prospective Study.","Inclusion Criteria:\n\n* 36 weeks of gestation or more\n* Singleton pregnancy\n* Previous cesarean section (case)\n\nExclusion Criteria:\n\n* Vasculitis\n* Twin pregnancy\n* Chronic endometritis\n* Smoking\n* Lupus\n* Renal failure\n* Liver disease\n* Thrombocytopenia","18 Years",{"count":78,"type":20},540,"OBSERVATIONAL","Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries. The only cure for THE is termination of pregnancy, which ends up being a decision in which gestational age and maternal risks must be balanced. Angiogenic factors have come to occupy an indispensable place in the arsenal of tools that can be used to separate the patient with a high likelihood of complications from those in whom prolongation of pregnancy could represent an important neonatal benefit.\n\nAlthough the usefulness of angiogenic factors in these scenarios is known, little is known about the effects that other conditions might have on their serum levels, mainly those that have an effect on trophoblastic invasion, the process that initiates implantation of the pregnancy in the endometrium. The purpose of the present study is to assess the effect that a history of uterine surgery, such as caesarean section, might have on angiogenic factor scores in subjects with no history of a hypertensive disorder of pregnancy.",[82],"Cesarean Section",[84,85,26],"Cesarean section","Angiogenic factors","NOT_YET_RECRUITING","2025-08-23",{"date":89,"type":36},"2025-08-26",{"date":91,"type":20},"2025-10-01",{"date":93,"type":20},"2026-03-30",{"name":42,"class":43},{"id":96,"slug":97,"hasResults":11,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":11,"sex":17,"minAge":76,"maxAge":4,"enrollmentInfo":102,"targetDuration":4,"studyType":21,"phases":104,"briefSummary":105,"conditions":106,"keywords":108,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":110,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":44},"100525564","angiogenic-factors-in-the-conservative-management-of-gestational-hypertension-100525564","NCT06123377","Angiogenic Factors in the Conservative Management of Gestational Hypertension","Use of Angiogenic Factors in the Conservative Management of Gestational Hypertension. Prospective, Randomised, Controlled Study.","Inclusion Criteria:\n\n* Pregnant women between 24 and 40 weeks of gestation.\n* Diagnosis of Gestational Hypertension based on ACOG criteria\n* index sFlt-1\u002FPIGF equal or below 33\n\nExclusion Criteria:\n\n* Multiple gestation\n* Maternal vasculitis\n* Previous cesarean section (3 or more)\n* Neurological conditions\n* Chronic renal disease\n* Purpura\n* Heart disease\n* Index sFlt-1\u002FPIGF of 34 or more",{"count":103,"type":20},150,[23],"Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries. The only cure for THE is termination of pregnancy, which ends up being a decision in which gestational age and maternal risks must be balanced. Angiogenic factors have come to occupy an indispensable place in the arsenal of tools that can be used to separate the patient with a high likelihood of complications from those in whom prolongation of pregnancy could represent an important neonatal benefit. One of the most controversial scenarios is gestational hypertension, a group of hypertensive disorders considered the mildest form of the pre-eclamptic spectrum, where current recommendations indicate termination of pregnancy at 37 weeks. However, the decision is based on outdated guidelines developed at a time when angiogenic factors were just beginning to be known. The purpose of the study is to use angiogenic factors as a guide to decide the most appropriate gestational age for termination of pregnancy in patients diagnosed with gestational hypertension.",[107],"Gestational Hypertension",[109,85],"Gestational hypertension",{"date":89,"type":36},{"date":112,"type":36},"2024-06-01",{"date":114,"type":20},"2026-09-30",{"name":42,"class":43},{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":16,"sex":17,"minAge":76,"maxAge":4,"enrollmentInfo":123,"targetDuration":4,"studyType":21,"phases":125,"briefSummary":126,"conditions":127,"keywords":129,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":132,"startDateStruct":133,"completionDateStruct":134,"leadSponsor":136,"locationsCount":44},"100525475","optic-nerve-sheath-measurement-and-angiogenic-factors-in-patients-with-pre-eclampsia-100525475","NCT06122220","Optic Nerve Sheath Measurement and Angiogenic Factors in Patients With Pre-eclampsia.","Optic Nerve Sheath Measurement and Angiogenic Factors for the Diagnosis of Pre-eclampsia","Inclusion Criteria:\n\n* Pregnant women between 24 and 40 weeks of gestation.\n\nExclusion Criteria:\n\n* Multiple gestation\n* Maternal vasculitis\n* Previous cesarean section (3 or more)\n* Brain or eye tumors\n* Neurological conditions\n* Chronic renal disease\n* Purpura\n* Heart disease",{"count":124,"type":20},200,[23],"Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries. The only cure for THE is termination of pregnancy, which ends up being a decision in which gestational age and maternal risks must be balanced. Angiogenic factors have come to occupy an indispensable place in the arsenal of tools that can be used to separate the patient with a high likelihood of complications from those in whom prolongation of pregnancy could represent an important neonatal benefit. Refining the diagnostic capability of this test would further improve maternal-fetal outcomes and the use of optic nerve sheath diameter (ONSD) measurement could make the difference.\n\nThe purpose of the present study is to correlate the measurement of ONSD with serum angiogenic factor (AF) values in patients with pre-eclampsia and to determine its predictive ability for adverse perinatal outcomes.",[128],"Pre-Eclampsia",[85,130,131],"Optic nerve sheath diameter","Pre-eclampsia",{"date":89,"type":36},{"date":38,"type":36},{"date":135,"type":20},"2026-01-30",{"name":42,"class":43},""]