[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Saint-Joseph University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":308},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,54,86,122,146,178,206,236,265,287],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":36,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100635703","dexmedetomidine-and-propofol-for-sedation-in-cataract-surgery-100635703",false,"NCT07556133","Dexmedetomidine and Propofol for Sedation in Cataract Surgery.","Dexmedetomidine vs Propofol for Sedation in Cataract Surgery : a Prospective Randomized Controlled Trial.","Inclusion Criteria:\n\n* Adults undergoing cataract surgery\n\nExclusion Criteria:\n\n* Severe hepatic insufficiency\n* Third degree AV block\n* Patient refusal","ALL","18 Years",{"count":19,"type":20},1000,"ESTIMATED","INTERVENTIONAL",[23],"NA","The goal of this prospective, randomized, single-blinded is to learn if there is an ideal sedation protocol in cataract surgery in adults.\n\nThe main questions it aims to answer are:\n\n* Does the combination of Dexmedetomidine and Propofol affect significantly Ramsay sedation scale, compared to Dexmedetomidine and compared to Propofol?\n* How does each sedation protocol affect hemodynamics? (Heart rate and blood pressure)\n* Are respiratory events more common in a certain group?\n* Is the surgeon's satisfaction similar among groups?\n* Are adverse effects (bradycardia, hypotension, nausea) more common in a certain group?\n\nResearchers will compare 3 sedation protocols : Dexmedetomidine versus Propofol versus the combination of these 2 drugs and to see if one protocol is overall superior to the others. Fentanyl will also be used in all 3 sedation protocols.\n\nParticipants will :\n\n* Receive one of these three protocols\n* Be operated for one or both eyes\n* Monitored during the whole surgery and in the recovery room\n* Be evaluated by the Ramsay sedation scale by a trained Anesthesiologist or CRNA during surgery and in the recovery room Surgeons will be asked about how much they were satisfied.",[26,27,28,29,30,31,32,33,34,35],"Sedation","Cataract","Hemodynamic","Hemodynamic Changes","Dexmedetomidine","Propofol Dosage","Fentanyl","Bradycardia","Tachycardia","Nausea and Vomiting",[37,27,38,39,40],"Dexmedetomidine and propofol in cataract surgery","sedation","Dexmedetomidine in cataract surgery","Sedation for cataract surgery","RECRUITING","2026-04-21",{"date":44,"type":45},"2026-04-29","ACTUAL",{"date":47,"type":45},"2025-11-09",{"date":49,"type":20},"2026-12-09",{"name":51,"class":52},"Saint-Joseph University","OTHER",1,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":62,"targetDuration":4,"studyType":21,"phases":64,"briefSummary":65,"conditions":66,"keywords":68,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":4},"100634452","orofacial-myofunctional-therapy-and-positive-airway-pressure-cpap-trial-for-mild-to-moderate-obstructive-sleep-apnea-100634452","NCT07539870","Orofacial Myofunctional Therapy and Positive Airway Pressure-CPAP Trial for Mild-to-Moderate Obstructive Sleep Apnea","Isolated and Combined Effects of Orofacial Myofunctional Therapy and Continuous Positive Airway Pressure on the Apnea-Hypopnea Index and Mandibular Excursion in Adults With Mild-to-Moderate Obstructive Sleep Apnea: The OMPACT-OSA Randomized Controlled Trial","OMPACT-OSA","Inclusion Criteria:\n\n* Age 18 years or older.\n* Mild-to-moderate OSA (AHI 5.0-29.9 events\u002Fhour) confirmed by Type I polysomnography.\n* Protrusive excursion of at least 5 mm measured with the George Gauge.\n* No previous treatment with CPAP or OMT.\n* Ability to perform oropharyngeal exercises.\n* Written informed consent.\n\nExclusion Criteria:\n\n* Severe obstructive sleep apnea (AHI 30 events\u002Fhour or higher) or urgent need for CPAP\n* Suspected or confirmed obesity hypoventilation syndrome, chronic ventilatory failure, or severe obesity associated with daytime hypercapnia or hypoxemia\n* Clinically significant insomnia, defined as an Insomnia Severity Index (ISI) score \\> 14 at screening.\n* Uncontrolled psychiatric or neurological conditions likely to substantially affect sleep quality or daytime symptoms independently of OSA (e.g., major depressive episode, severe anxiety disorder, chronic disabling migraine)., as judged by the investigator.\n* Current use of medications likely to affect sleep architecture, respiratory drive, or PAP tolerance, including chronic opioid therapy and other sedative medications judged incompatible with study participation.\n* Unstable or severe cardiovascular disease requiring priority standard management, including poorly controlled arrhythmia, nocturnal angina, decompensated heart failure, treatment-resistant hypertension, or recent acute coronary syndrome\n* Uncontrolled diabetes mellitus requiring treatment intensification, for example - HbA1c greater than 10% and\u002For symptomatic hyperglycemia\n* Neurological or ear-nose-throat disease affecting the upper airway\n* Craniofacial abnormalities\n* Maxillofacial surgery within the previous 6 months\n* Temporomandibular pain preventing completion of exercises\n* Active periodontitis\n* Pregnancy\n* Foreseeable non-adherence to the intervention\n* Inability to use CPAP despite standard fitting and troubleshooting, or any contraindication to CPAP treatment.\n* Ongoing CPAP or OMT at inclusion",{"count":63,"type":20},168,[23],"The goal of this clinical trial is to evaluate the isolated and combined effects of orofacial myofunctional therapy (OMT) and continuous positive airway pressure (CPAP) in adults with mild-to-moderate obstructive sleep apnea. The main questions it aims to answer are whether OMT alone, CPAP alone, or combined OMT plus CPAP improves obstructive sleep apnea severity at Week 12, as measured by the apnea-hypopnea index (AHI), and whether these interventions improve mandibular excursion. Researchers will compare 4 groups-sham plus standard of care, OMT plus standard of care, CPAP plus standard of care, and combined OMT plus CPAP plus standard of care-to assess differences in respiratory and anatomical-functional outcomes. Participants will be randomized to 1 of the 4 study arms. During the 12-week supervised intervention phase, participants will receive their assigned intervention together with standardized sleep-hygiene and lifestyle counseling. Assessments include sleep recording, mandibular excursion measurements, questionnaires on sleepiness and sleep quality, dento-occlusal and anthropometric measurements, and treatment adherence monitoring. After Week 12, participants will enter an observational follow-up phase through Week 52 to evaluate durability of treatment effects, treatment persistence, symptom recurrence, and clinically indicated treatment modifications.",[67],"Obstructive Sleep Apnea",[69,70,71,72,73,74,75,76],"Mild-to-Moderate Obstructive Sleep Apnea","Orofacial Myofunctional Therapy","Continuous Positive Airway Pressure","Apnea-Hypopnea Index","Mandibular Excursion","George Gauge","Jaw Motion Analyser","Randomized Controlled Trial","NOT_YET_RECRUITING","2026-04-13",{"date":80,"type":45},"2026-04-20",{"date":82,"type":20},"2026-05",{"date":84,"type":20},"2028-05",{"name":51,"class":52},{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":92,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":96,"conditions":97,"keywords":106,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":53},"100633411","digital-planning-and-clinical-assessment-of-the-treated-atrophic-posterior-maxilla-with-a-sinus-lift-procedure-a-cross-sectional-study-100633411","NCT07526337","Digital Planning and Clinical Assessment of the Treated Atrophic Posterior Maxilla With a Sinus Lift Procedure: a Cross-sectional Study.","Inclusion Criteria:\n\n* \\- Patient aged more than 18 years.\n* Partially edentulous patients having an implant rehabilitation treated with a sinus lift procedure in the atrophic posterior maxilla.\n* Patient with no systemic disease that contraindicate the surgical procedure as uncontrolled diabetes mellitus, bleeding disorders, recent myocardial infarction, head and neck radiation, and mental disorders.\n\nExclusion Criteria:\n\n* \\- Fully Edentulous patients.\n* Patients presenting sinus pathologies (sinusitis, thickening of the membrane).\n* Patient smoking more than 20 cigarettes.\n* Patient taking systemic drugs that could affect bone healing as immune suppressive drugs and bisphosphonates.\n* Patient with systemic disease that contraindicate the surgical procedure as uncontrolled diabetes mellitus, bleeding disorders, recent myocardial infarction, head and neck radiation, and mental disorders.",true,{"count":94,"type":20},100,"OBSERVATIONAL","Maxillary posterior area is the most challenging site for dental implant placement. Indeed, complex remodeling processes, resulting in changes of the maxillary sinus and shape of the alveolar ridge will cause difficulties in rehabilitating the posterior maxillae sites. Various techniques have been proposed in order to achieve the necessary bone volume for the placement of long term successful implants. However, unbalanced crown to implant ratio remains a risk factor after successful dental implants installation following sinus graft. No study on humans assessed the effect of apical positioning of the implants in posterior grafted sites (sinus graft or sinus graft + vertical GBR) on the following clinical parameters: The peri-implant bone remodeling (vertical bone loss (mm) and probing depth (mm) around the implants, crown bulkiness, emergence profile and crown height, and Patients satisfaction, food impaction (PROM)).\n\nThis study will elucidate these points and based on the parameter's results, suggest a treatment based classification facilitating the treatment decision-making of the clinicians in case of an atrophic posterior maxilla; aiming to ensure a long-term successful supra-implant rehabilitation which will maintain its bio-mechanically and biological success.",[98,99,100,101,102,103,104,105],"Alveolar Bone Atrophy","Alveolar Bone Grafting","Peri-Implant Health","Sinus Floor Augmentation","Vertical Ridge Deficiency","Guided Bone Regeneration","Digital Guided Bone Regeneration","Prosthetic Complication",[107,108,109,110,111,112,113,114],"alveolar bone atrophy","digital planning","guided bone regeneration","maxillary sinus","peri-implant disease","peri-implantits","sinus floor augmentation","vertical ridge deficiency","2026-04-06",{"date":78,"type":45},{"date":118,"type":45},"2025-01-01",{"date":120,"type":20},"2026-05-30",{"name":51,"class":52},{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":4,"eligibilityCriteria":128,"healthyVolunteers":92,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":129,"targetDuration":131,"studyType":95,"phases":4,"briefSummary":132,"conditions":133,"keywords":137,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":142,"startDateStruct":143,"completionDateStruct":144,"leadSponsor":145,"locationsCount":53},"100633395","impact-of-alveolar-ridge-preservation-on-the-potential-need-for-sinus-floor-elevation-a-10-year-retrospective-radiographical-study-100633395","NCT07526129","Impact of Alveolar Ridge Preservation on the Potential Need for Sinus Floor Elevation: A 10-year Retrospective Radiographical Study","Impact of Alveolar Ridge Preservation on the Potential Need for Sinus Floor Elevation in Posterior Maxillary Implant Sites: A 10-year Retrospective Radiographical Study","Inclusion Criteria:\n\n* • Patients aged ≥18 years.\n\n  * Patients who underwent alveolar ridge preservation after extraction of maxillary posterior teeth, as a test group.\n  * Patients who underwent extraction of maxillary posterior teeth with unassisted socket healing without alveolar ridge preservation as a control group.\n\nExclusion Criteria:\n\n* • The presence of a clinically symptomatic periapical radiolucency, acute abscesses, or chronic sinus tract, that may falsify the classification of posterior maxillary teeth on 2D radiographs.",{"count":130,"type":20},130,"12 Months","This research aims to investigate the influence of alveolar ridge preservation, after extraction of maxillary posterior teeth, on the potential need of sinus floor augmentation procedures (that include lateral or crestal sinus augmentations). From peri-apical radiographs, maxillary posterior teeth will be divided into 4 groups according to the relationship of their apexes with the sinus. Then, the patients will be divided into 2 sub-groups: unassisted socket healing (only extraction) and ARP group (extraction + ARP) and their CBCT scans before implant placement will be collected. The CBCT scans should be at least 4 months post-extraction and ARP. Depending on the residual bone height, patients will be divided into 3 categories, according to the ABC classification:\n\n1. In need of lateral sinus floor augmentation\n2. In need of crestal sinus floor augmentation\n3. No need for sinus floor augmentation, therefore, implant placement.\n\nThese divisions will be conducted, according to:\n\n\\- The residual bone height (RBH) which is the height in mm from the alveolar ridge crest to the lowest point of the maxillary sinus floor.\n\nThe results of the proposed hypothesis are verified and interpreted after statistical analysis.",[134,101,135,98,136],"Alveolar Bone Loss","Sinus Pneumatization","Alveolar Ridge Preservation",[138,139,140,141,113],"alveolar bone loss","alveolar process atrophy","extraction","tooth socket",{"date":78,"type":45},{"date":118,"type":45},{"date":120,"type":20},{"name":51,"class":52},{"id":147,"slug":148,"hasResults":11,"nctId":149,"briefTitle":150,"officialTitle":151,"acronym":4,"eligibilityCriteria":152,"healthyVolunteers":92,"sex":16,"minAge":153,"maxAge":154,"enrollmentInfo":155,"targetDuration":4,"studyType":21,"phases":157,"briefSummary":158,"conditions":159,"keywords":164,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":177,"locationsCount":53},"100627534","ai-avatar-video-vs-tell-show-do-for-reducing-anxiety-and-improving-cooperation-in-children-during-local-anesthesia-100627534","NCT07449884","AI Avatar Video vs. Tell-Show-Do for Reducing Anxiety and Improving Cooperation in Children During Local Anesthesia","Artificial Intelligence-driven Avatar-based Video vs. Tell-show-do for Reducing Anxiety and Improving Cooperation in Children During Local Anesthesia: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Inclusion Criteria:\n\n  * Children aged 5 to 7 years\n  * Medically healthy (ASA I)\n  * Cooperative behavior during dental examination\n  * No known allergy to local anesthetics\n  * Require non-urgent dental treatment under local anesthesia\n  * First-time experience receiving local anesthesia\n  * Able to understand and communicate\n\nExclusion Criteria:\n\n* History of epilepsy\n* Diagnosed anxiety or behavioral disorders\n* Cognitive or developmental delay\n* Hearing or visual impairment\n* Previous experience with dental anesthesia\n* Require inferior alveolar nerve block anesthesia\n\nExclusion Criteria:\n\n\\-","5 Years","7 Years",{"count":156,"type":20},70,[23],"This randomized clinical trial aims to compare two behavior guidance techniques used to reduce anxiety in children during local anesthesia injections in dental treatment. The study evaluates the traditional Tell-Show-Do (TSD) technique versus an artificial intelligence (AI)-driven, avatar-based video method called the \"Mini Dentist.\"\n\nChildren aged 5 to 7 years who require local anesthesia for routine dental treatment will be randomly assigned to one of two groups. The control group will receive the conventional Tell-Show-Do explanation from the pediatric dentist. The experimental group will watch a short animated video featuring an AI-generated avatar that explains and demonstrates the procedure in a child-friendly manner before the injection.\n\nAnxiety and behavior will be assessed using heart rate monitoring, behavioral observation (FLACC scale), and a self-reported pain scale (Wong-Baker FACES). The goal is to determine whether the AI-based method improves cooperation and reduces anxiety compared to the traditional approach.\n\nParticipation is voluntary, and all procedures follow ethical research standards.",[160,161,162,163],"Anxiety","Fear","Local Anesthesia","Pediatric Dentistry",[165,166,167,168,169],"Artificial intelligence","Child behavior","Dental anxiety","Local anesthesia.","Randomized Controlled trial","2026-03-24",{"date":172,"type":45},"2026-03-30",{"date":174,"type":45},"2026-02-16",{"date":176,"type":20},"2027-05-30",{"name":51,"class":52},{"id":179,"slug":180,"hasResults":11,"nctId":181,"briefTitle":182,"officialTitle":183,"acronym":184,"eligibilityCriteria":185,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":186,"targetDuration":4,"studyType":21,"phases":188,"briefSummary":189,"conditions":190,"keywords":192,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":198,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":53},"100599268","short-term-atrial-pacing-and-hemodynamics-after-cardiac-surgery-100599268","NCT07082283","Short-Term Atrial Pacing and Hemodynamics After Cardiac Surgery","STAPH-CS Study: Short-Term Atrial Pacing and Hemodynamics After Cardiac Surgery - A Prospective Randomized Evaluation of Variable-Rate Atrial Stimulation After Cardiac Surgery With Cardiopulmonary Bypass","STAPH-CS","Inclusion Criteria:\n\n* Patients aged 18 years or older\n* Cardiac surgery under CPB (coronary artery bypass grafting, valve replacement or repair, or combined procedures)\n* Placement of epicardial atrioventricular pacing wires during surgery\n* Placement of a Swan-Ganz catheter intraoperatively\n* Signed informed consent\n\nExclusion Criteria:\n\n* Emergency surgery\n* Patients with an internal pacemaker\n* History of permanent atrial fibrillation\n* Complete atrioventricular block upon weaning from CPB\n* Junctional rhythm upon weaning from CPB\n* Sinus rhythm \\\u003C 50 bpm upon weaning from CPB\n* Failure of atrial or dual-chamber pacing (patients paced in ventricular mode VVI)\n* Contraindication to Swan-Ganz catheter placement\n* Hemodynamic instability defined by significant bleeding or tamponade requiring surgical re-intervention, or the need for escalating doses of vasopressors (Norepinephrine \\> 1 μg\u002Fkg\u002Fmin, Dobutamine \\> 10 μg\u002Fkg\u002Fmin)",{"count":187,"type":20},200,[23],"The goal of this clinical trial is to learn whether temporary atrial pacing improves heart function after cardiac surgery under cardiopulmonary bypass (CPB). It will also help determine the best pacing rate during the first 24 hours after surgery. The main questions it aims to answer are:\n\n* Does atrial pacing improve cardiac output after surgery?\n* Is 70, 80, or 90 bpm the most effective pacing rate?\n* Does pacing reduce the risk of atrial fibrillation after surgery?",[191],"Cardiac Output",[193,194,195,196,197],"Cardiopulmonary bypass","Temporary atrial pacing","Pacing frequency","Hemodynamic profile","Cardiac output","2025-08-15",{"date":200,"type":45},"2025-08-17",{"date":202,"type":45},"2025-08-04",{"date":204,"type":20},"2026-09-30",{"name":51,"class":52},{"id":207,"slug":208,"hasResults":11,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":212,"eligibilityCriteria":213,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":214,"targetDuration":4,"studyType":21,"phases":216,"briefSummary":217,"conditions":218,"keywords":225,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":229,"lastUpdatePostDateStruct":230,"startDateStruct":232,"completionDateStruct":233,"leadSponsor":235,"locationsCount":53},"100574543","fluorescein-angiography-in-patients-with-diabetes-and-chronic-kidney-disease-100574543","NCT06760650","Fluorescein Angiography in Patients With Diabetes and Chronic Kidney Disease","Fluorescein-Induced Acute Kidney Injury in Patients With Diabetes and Chronic Kidney Disease","Fluo-AKI","Inclusion Criteria:\n\n* \\>18 years old with type 2 or type 1 diabetes and chronic kidney disease stage 3b to 5 (eGFR\\\u003C45 mL\u002Fmin\u002F1.73 m2)\n\nExclusion Criteria:\n\n* Patients who do not give their consent\n* Patients who are allergic to fluorescein\n* Patients who are on dialysis\n* Patients who had fever, vomiting, diarrhea or any dehydration 48 hours before the intervention\n* Patients who had a treatment modification one week before the intervention",{"count":215,"type":20},35,[23],"Our study hypothesizes that fluorescein exposure in diabetic patients with advanced chronic kidney disease results in deterioration of kidney function. It will therefore aim to evaluate the incidence of acute kidney injury induced by fluorescein in diabetic patients with CKD. The objective is to determine the incidence, severity and risk factors associated with this deterioration to improve the care of this specific population.",[219,220,221,222,223,224],"Chronic Kidney Disease Stage 4","Chronic Kidney Disease Stage 3B","Chronic Kidney Disease Stage 5","Diabetes Mellitus","Fluorescein Angiography","Acute Kidney Injury",[223,226,227,228],"Acute kidney injury","Chronic kidney disease","Diabetes","2025-01-03",{"date":231,"type":45},"2025-01-07",{"date":231,"type":20},{"date":234,"type":20},"2025-10-10",{"name":51,"class":52},{"id":237,"slug":238,"hasResults":11,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":4,"eligibilityCriteria":242,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":243,"targetDuration":4,"studyType":21,"phases":244,"briefSummary":245,"conditions":246,"keywords":251,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":4},"100572116","propofol-vs-sevoflurane-in-cardiac-surgery-100572116","NCT06729086","Propofol vs Sevoflurane in Cardiac Surgery","Propofol vs Sevoflurane in Cardiac Surgery: a Randomized Clinical Trial During the Peroperative and Postoperative Phase","Inclusion Criteria:\n\n* all patients above 18 yeras old that will undergo a cardiac surgery\n\nExclusion Criteria:\n\n* below 18 yeras old",{"count":94,"type":20},[23],"The hypothesis of our study: presence of a relationship between the type of anesthesia and complications after cardiac surgery. The aim is to assess the benefit of using intravenous or inhaled anesthesia on the patients\\' stay and its complications.",[247,248,249,250],"Cardiac Complications","Cardiac Surgery","Neurologic Complications","Respiratory Complications",[252,253,254,255,256],"propofol vs sevoflurane in cardiac surgery","peroperative","postoperative","randomized clinical trial","complications","2024-12-09",{"date":259,"type":45},"2024-12-11",{"date":261,"type":20},"2025-01-04",{"date":263,"type":20},"2025-05-31",{"name":51,"class":52},{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":272,"targetDuration":4,"studyType":21,"phases":274,"briefSummary":275,"conditions":276,"keywords":4,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":279,"lastUpdatePostDateStruct":280,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":286,"locationsCount":53},"100558100","transversus-thoracic-plane-block-for-perioperative-analgesia-in-cardiac-surgery-100558100","NCT06546722","Transversus Thoracic Plane Block for Perioperative Analgesia in Cardiac Surgery","Transversus Thoracic Plane Block for Perioperative Analgesia in Cardiac Surgery: a Randomized Controlled Prospective Study","Inclusion Criteria:\n\n\\- All patients scheduled for cardiac surgery via sternotomy under cardiopulmonary bypass\n\nExclusion Criteria:\n\n* Previous cardiac surgery\n* Urgent surgery\n* Pregnant women\n* Allergy to local anesthetics\n* Opioid dependence\n* Low ejection fraction \\\u003C 30%\n* Presence or onset of cognitive or neurological disorders preventing pain assessment\n* Infection at injection sites\n* Coagulopathy\n* Patients on dual antiplatelet therapy\n* Renal insufficiency with Glomerular filtration rate (GFR) \\\u003C 30 mL\u002Fmin\n* History of thoracic radiotherapy\n* History of mastectomy",{"count":273,"type":20},150,[23],"The goal of this clinical trial is to learn if perioperative Transversus Thoracic Plane Block (TTPB) decrease perioperative pain after cardiac surgery. The main questions it aims to answer are:\n\n1. does Transversus Thoracic Plane Block decrease perioperative pain after cardiac surgery more than the standard analgesic treatment?\n2. Are the results different if the investigators perform Transversus Thoracic Plane Block before surgery or at the end of surgery?",[277,248,278],"Transversus Thoracic Plane Block","Post Operative Pain","2024-08-07",{"date":281,"type":45},"2024-08-09",{"date":283,"type":20},"2024-09-01",{"date":285,"type":20},"2025-12-30",{"name":51,"class":52},{"id":288,"slug":289,"hasResults":11,"nctId":290,"briefTitle":291,"officialTitle":292,"acronym":4,"eligibilityCriteria":293,"healthyVolunteers":92,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":294,"targetDuration":4,"studyType":21,"phases":296,"briefSummary":297,"conditions":298,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":300,"lastUpdatePostDateStruct":301,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":53},"100551564","minimal-instrumentation-with-intracanal-heating-and-activation-of-sodium-hypochlorite-for-the-management-of-teeth-with-periapical-lesions-100551564","NCT06461728","Minimal Instrumentation With Intracanal Heating and Activation of Sodium Hypochlorite for the Management of Teeth With Periapical Lesions","Minimal Instrumentation With Intracanal Heating ad Activation of Sodium Hypochlorite for","Inclusion Criteria:\n\n* Healthy patients without any known allergic reactions or systemic diseases.\n* Single rooted teeth.\n* Fully formed roots.\n* The ability to place #15 hand file to working length (WL).\n* Absence of canal calcifications.\n* Absence of root fracture.\n* Absence of resorption.\n* Teeth with pre-operative periapical radiolucency and PAI score ≥ 3 according to the classification of Ørstavik et al. 1986(20).\n* Estimated WL 20-23mm.\n\nExclusion Criteria:\n\n* Roots with broken or immature open apices.\n* Roots presenting resorption.\n* Patients younger than 18 years old.\n* Pregnant patients.\n* Teeth with previous root canal treatment.\n* Teeth with calcified canals.\n* Teeth with two canals or any other anatomic variations.\n* Root length less than 16 mm.\n* Patients with chronic generalized periodontitis.\n* Teeth with caries affecting the roots.\n* Abnormal mobility of the tooth.\n* Extensively restored and prepared teeth.\n* Open apices.\n* Previously root canal therapy.\n* Root cracks.",{"count":295,"type":20},32,[23],"this study is the first to demonstrate the efficacy of minimally invasive root canal treatment combined with intracanal heating and activation of NaOCl using a prototype needle on the healing of asymptomatic apical periodontitis of necrotic single rooted teeth. 32 teeth will be randomaly assigned into 2 groups :conventional and conservative technique .In the conventional group : each canal will be prepared using Reciproc Blue 25\u002F08, approximetly 27 ml of NaOCl will be used , the canal will be activated using 20.02 taper tip of a sonic decive . This cyclel will be repeated 3 times and the obturation will be done using a single cone technique with AH plus resin-based sealer . In the second group a size 10 k file will be introduced to confirm patency and to record working length after filling the canal with NaOCl. A glide path will be established using the size 10 FlexoFile to the WL, than Proglider 16.02 to the foramen. After the glide path, the canal will be irrigated with 3 ml of 5, 25 % of NaOCL .The prototype needle tip will be placed in the canal to the length that is a little shorter than the length at binding point , in order to heat and activate the irrigant solution for 30 seconds.Step one is repeated 4 more times and a fresh solution of NaOCl is replaced every time. Canals will be dried using sterile paper points size 15 and the obturation will be performed for all teeth using the same technique as group 1 but with a standardized gutta percha point 2% tapered",[299],"Heating and Activation of Sodium Hypochlorite","2024-06-23",{"date":302,"type":45},"2024-06-25",{"date":304,"type":45},"2023-11-07",{"date":306,"type":20},"2025-06-07",{"name":51,"class":52},""]