[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Sakarya University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":691},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,45,0,25,[9,42,70,95,140,168,194,227,251,282,307,336,360,385,406,437,461,492,517,543,572,597,622,643,669],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100645400","impact-of-major-ozone-autohemotherapy-on-sarcopenia-parameters-in-fibromyalgia-100645400",false,"NCT07680621","Impact of Major Ozone Autohemotherapy on Sarcopenia Parameters in Fibromyalgia","Effects of Major Ozone Autohemotherapy on Sarcopenia Parameters and Clinical Features in Fibromyalgia","Inclusion Criteria:\n\n* Female patients aged 18-65 years\n* Diagnosis of fibromyalgia syndrome according to the 2016 ACR criteria:\n* Symptoms present at a similar level for at least 3 months\n* Widespread Pain Index (WPI) ≥ 7 and Symptom Severity Scale (SSS) ≥ 5\n* WPI 4-6 and SSS ≥ 9\n* Not currently receiving medical treatment for fibromyalgia (except NSAIDs)\n\nExclusion Criteria:\n\n* Current or previous pharmacological treatment specifically for fibromyalgia\n* Pregnancy or breastfeeding\n* History of active or previous malignancy\n* History of systemic inflammatory diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, psoriatic arthritis, dermatomyositis, familial Mediterranean fever)\n* Endocrine disorders (e.g., hypothyroidism, Cushing's syndrome, adrenal insufficiency)\n* Anemia\n* Chronic renal failure\n* Chronic liver failure\n* Chronic obstructive pulmonary disease (COPD)\n* Known severe cardiovascular disease\n* Body mass index (BMI) \\> 30 kg\u002Fm²\n* Glucose-6-phosphate dehydrogenase (G6PD) deficiency","ALL","18 Years","65 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","Fibromyalgia syndrome (FMS) is a chronic and heterogeneous disorder characterized primarily by widespread pain, accompanied by sleep disturbances, fatigue, depressive symptoms, and cognitive dysfunction. Although multiple therapeutic options are available, no curative treatment currently exists. Previous studies have demonstrated increased oxidative stress, dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, and a predisposition to sarcopenia in patients with FMS.\n\nOzone therapy has increasingly been used in chronic diseases due to its regulatory effects on oxidative stress. Although ozone is inherently an oxidative molecule, when administered at therapeutic doses it may induce antioxidant responses at the cellular level and exert anti-inflammatory effects by modulating inflammatory mediators. However, limited studies have evaluated the efficacy and underlying mechanisms of major ozone autohemotherapy (MOA) in FMS.\n\nThis controlled, prospective, single-blind study aims to investigate the effects of major ozone autohemotherapy on clinical parameters of FMS, as well as its impact on HPA axis function and sarcopenia-related parameters. A total of 60 patients with FMS will be enrolled and randomized into two groups: (1) exercise therapy alone and (2) exercise therapy plus major ozone autohemotherapy. MOA will be administered twice weekly for a total of 10 sessions at a dose of 20-40 μg\u002FmL.\n\nParticipants will be evaluated at baseline, at week 6, and at 3 months. Outcome measures will include Visual Analog Scale (VAS), Fibromyalgia Impact Questionnaire (FIQ), Fatigue Severity Scale (FSS), Pittsburgh Sleep Quality Index (PSQI), Short Form-12 (SF-12), and Hospital Anxiety and Depression Scale (HADS). Morning fasting serum cortisol levels will be measured to assess HPA axis function. Sarcopenia assessment will include handgrip strength measured by Jamar dynamometer, and ultrasonographic evaluation of muscle mass, muscle thickness, pennation angle, fascicle length, echogenicity, and cross-sectional area. Physical performance will be assessed using the Short Physical Performance Battery (SPPB).\n\nUnlike previous studies, this trial includes a 3-month follow-up evaluation after completion of ozone therapy to assess longer-term effects. By incorporating objective sarcopenia and endocrine assessments alongside validated clinical scales, the study aims to provide comprehensive evidence regarding the role of major ozone autohemotherapy in FMS management. This will be the first study to specifically evaluate the effects of major ozone autohemotherapy on sarcopenia parameters in patients with FMS.",[28],"Fibromyalgia","NOT_YET_RECRUITING","2026-07-01",{"date":32,"type":33},"2026-07-02","ACTUAL",{"date":35,"type":22},"2026-08",{"date":37,"type":22},"2027-03",{"name":39,"class":40},"Sakarya University","OTHER",1,{"id":43,"slug":44,"hasResults":12,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":49,"targetDuration":51,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":57,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":41},"100618118","ultrasound-guided-transversus-abdominis-plane-block-versus-epidural-block-for-umbilical-hernia-analgesia-100618118","NCT07327463","Ultrasound-Guided Transversus Abdominis Plane Block Versus Epidural Block for Umbilical Hernia Analgesia","Comparison of the Analgesic Efficacy of Ultrasound-guided Transversus Abdominis Plane Block and Single-dose Epidural Block in Patients Undergoing Umbilical Hernia Surgery.","Inclusion Criteria:\n\n* Patients aged 18 to 65 years\n* Patients scheduled for elective umbilical hernia surgery\n* ASA physical status I or II\n* Patients who undergo surgery under either: Single-dose epidural anesthesia, or general anesthesia with postoperative ultrasound-guided transversus abdominis plane (TAP) block, as part of routine clinical practice\n* Ability to understand and use the Visual Analog Scale (VAS)\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* ASA physical status III or higher\n* Known allergy or contraindication to local anesthetic agents\n* Coagulopathy or ongoing anticoagulant\u002Fantiplatelet therapy contraindicating regional anesthesia\n* Infection at the site of epidural or TAP block application\n* History of chronic pain, long-term opioid use, or chronic analgesic consumption\n* Neurological disorders affecting pain perception or assessment\n* Severe hepatic or renal disease\n* Pregnancy or lactation\n* Inability to cooperate with postoperative pain assessment or inability to use VAS\n* Emergency surgery",{"count":50,"type":22},30,"1 Day","OBSERVATIONAL","This observational study aims to compare the postoperative analgesic effectiveness of ultrasound-guided transversus abdominis plane (TAP) block and single-dose epidural anesthesia in patients undergoing umbilical hernia surgery. Pain intensity will be assessed using the Visual Analog Scale (VAS) at predefined postoperative time points. The study seeks to determine which analgesic approach provides superior pain control and patient satisfaction in the postoperative period.",[55,56],"Umbilical Hernia","Postoperative Pain Management",[58,59,56,60],"Single-Dose Epidural Analgesia","Transversus Abdominis Plane Block","Umbilical Hernia Surgery","RECRUITING","2026-06-23",{"date":64,"type":33},"2026-06-24",{"date":66,"type":33},"2026-01-15",{"date":68,"type":22},"2026-06-20",{"name":39,"class":40},{"id":71,"slug":72,"hasResults":12,"nctId":73,"briefTitle":74,"officialTitle":75,"acronym":4,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":78,"targetDuration":51,"studyType":52,"phases":4,"briefSummary":79,"conditions":80,"keywords":82,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":41},"100644056","pulse-wave-transit-time-after-infraclavicular-block-100644056","NCT07669688","Pulse Wave Transit Time After Infraclavicular Block","Time-Dependent Changes in Pulse Wave Transit Time Following Infraclavicular Block: A Non-Invasive Assessment of Sympathetic Blockade","Inclusion Criteria:\n\n* Patients undergoing elective upper extremity hand surgery\n* 18 - 65 years\n* ASA I\n* No coagulopathy, thrombocytopenia, coagulation disorders\n* Patients who provide informed consent to participate in the study\n\nExclusion Criteria:\n\n* History of drug allergy relevant to study procedures or local anesthetics\n* Body mass index (BMI) ≥ 30 kg\u002Fm²\n* Body weight \\\u003C 40 kg\n* Age \\\u003C 18 years or \\> 65 years\n* History of significant cardiac disease (e.g., arrhythmia, conduction abnormalities)\n* Coagulopathy (INR \\> 1.5 or platelet count \\\u003C 100,000\u002Fmm³)\n* Pregnancy or lactation\n* Infection at the site of peripheral nerve block\n* ASA II-IV\n* Failed block or motor block duration exceeding 30 minutes\n* Patients reporting pain (NRS ≥ 3), due to potential influence on sympathetic activity\n* Chronic opioid use",true,{"count":7,"type":22},"This prospective observational study aims to evaluate the time-dependent changes in Pulse Wave Transit Time (PWTT) following ultrasound-guided infraclavicular brachial plexus block. PWTT is a non-invasive hemodynamic parameter reflecting vascular tone and sympathetic nervous system activity. Patients undergoing upper extremity surgery under infraclavicular block will be monitored using standard perioperative monitoring devices. PWTT measurements will be obtained before and after block placement at predefined time intervals. Secondary outcomes will include perfusion index, skin temperature, heart rate, blood pressure, respiratory rate, and oxygen saturation. The study seeks to determine whether PWTT can serve as an objective and non-invasive marker of sympathetic blockade following infraclavicular block.",[81],"Infraclavicular Brachial Plexus Block",[83,84,85,86,87],"Infraclavicular Block","Pulse Wave Transit Time","Regional Anesthesia","Brachial Plexus Block","Sympathetic Blockade",{"date":89,"type":33},"2026-06-25",{"date":91,"type":22},"2026-07-20",{"date":93,"type":22},"2026-11-15",{"name":39,"class":40},{"id":96,"slug":97,"hasResults":12,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":77,"sex":102,"minAge":103,"maxAge":104,"enrollmentInfo":105,"targetDuration":4,"studyType":23,"phases":107,"briefSummary":108,"conditions":109,"keywords":119,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":41},"100641975","use-of-perineal-mirror-during-the-second-stage-of-labor-100641975","NCT07659249","USE OF PERINEAL MIRROR DURING THE SECOND STAGE OF LABOR","THE EFFECT OF PERİNEAL MİRROR USE DURİNG THE SECOND STAGE OF LABOR ON THE DURATİON OF THE SECOND STAGE, RECOVERY, AND PERCEİVED PAİN, SUPPORT, AND CONTROL LEVELS DURİNG DELİVERY","Inclusion Criteria:\n\n* Women aged 19 and over\n* Women with term pregnancy (38+0 - 41+6)\n* Women with singleton pregnancy\n* Women who have had spontaneous vaginal delivery\n* Primiparous pregnant women\n* Women who voluntarily agree to participate in the study will be included.\n\nExclusion Criteria:\n\n* Women with high-risk pregnancies\n* Women with multiple pregnancies","FEMALE","19 Years","49 Years",{"count":106,"type":22},80,[25],"Objective: This study was designed to evaluate the effect of perineal mirror use during the second stage of labor on the duration of the second stage, postpartum recovery, and perceived pain, support, and control levels during delivery.\n\nMethod: The study was designed as a randomized controlled experimental study to examine the effect of perineal mirror use on delivery outcomes in primiparous women. The study population consisted of primiparous pregnant women admitted to the maternity clinic between June 29, 2026, and October 30, 2026. The sample size was calculated using the G\\*Power 3.1.9.2 program with an effect size of 0.50, 5% Type I error, and 95% power level; a total of 72 participants were selected, 36 in the intervention group and 36 in the control group. Considering potential losses, the sample size was increased by 10%, and a total of 80 pregnant women were planned to be included in the study. Participants were randomly assigned to the intervention group using a perineal mirror and the control group receiving routine care. The following instruments will be used as data collection tools: Pregnancy Demographic Information Form, REEDA Scale, Visual Analog Scale (VAS), and Perceived Support and Control in Childbirth Scale.\n\nExpected Outcome: It is predicted that the perineal mirror may increase the woman's active participation, motivation, and perceived control by allowing her to see the fetal descent and the progress of labor; consequently, it may reduce the duration of active pushing and the duration of the second stage. It is also thought that it may have positive effects on the birth experience, postpartum recovery, and perceived level of support and control. The research results are expected to provide evidence for non-invasive and low-cost applications that can be used in childbirth care.",[110,111,112,113,114,115,116,117,118],"Labor, Second Stage","Vaginal Delivery","Primiparity","Perineal Mirror Use","Childbirth Experience","Labor Pain","Perceived Support During Childbirth","Perceived Control During Childbirth","Postpartum Perineal Healing",[120,121,122,123,124,125,126,127,128,129,130,131],"Midwifery","Perineal mirror","Second stage of labor","Vaginal birth","Primiparous women","Labor duration","Childbirth pain","Perceived support","Perceived control","REEDA scale","Maternal outcomes","Non-invasive intervention","2026-06-18",{"date":134,"type":33},"2026-06-22",{"date":136,"type":22},"2026-06-29",{"date":138,"type":22},"2026-10-30",{"name":39,"class":40},{"id":141,"slug":142,"hasResults":12,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":12,"sex":102,"minAge":18,"maxAge":19,"enrollmentInfo":147,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":148,"conditions":149,"keywords":151,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":41},"100628865","effect-of-trendelenburg-position-on-patient-state-index-100628865","NCT07467200","Effect of Trendelenburg Position on Patient State Index","Effect of the Trendelenburg Position on Patient State Index and Frontal Cerebral Oxygenation: A Prospective Observational Study","Inclusion Criteria:\n\n* Female patients aged 18-65 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for elective laparoscopic hysterectomy under general anesthesia\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* History of neurological disease (e.g., stroke, epilepsy)\n* Known cerebrovascular disease, glaucoma, or retinal disease\n* Severe cardiac or pulmonary disease\n* Contraindication to near-infrared spectroscopy sensor placement\n* Obesity (Body Mass Index \\> 35 kg\u002Fm²)",{"count":21,"type":22},"The goal of this observational study is to evaluate whether the Trendelenburg position affects electroencephalography-based depth of anesthesia monitoring and cerebral oxygenation during general anesthesia.\n\nThe main questions it aims to answer are:\n\n* Does the Trendelenburg position cause a change in the Patient State Index (PSI), an Electroensephalography (EEG)-derived indicator of anesthetic depth?\n* Are changes in PSI associated with changes in frontal cerebral oxygen saturation (rSO₂) and hemodynamic parameters?\n\nThe study will include adult female patients undergoing elective laparoscopic gynecologic surgery under general anesthesia.\n\nParticipants will receive standard anesthesia and routine intraoperative monitoring. In addition to standard monitoring, Patient State Index (PSI) and frontal cerebral oxygen saturation (rSO₂) will be recorded using non-invasive sensors. No additional intervention will be performed for research purposes.\n\nPhysiological parameters including PSI, cerebral oxygen saturation, mean arterial pressure, heart rate, oxygen saturation, and end-tidal carbon dioxide will be recorded at predefined intraoperative time points before and after the Trendelenburg position.\n\nThe study aims to determine whether position-related physiological changes influence EEG-based anesthesia depth indices and to improve the interpretation of intraoperative brain monitoring.",[150],"Laparoscopic Hysterectomy",[152,153,154,155,156,157,158,159],"Trendelenburg Position","Patient State Index","Processed EEG","Depth of Anesthesia Monitoring","Cerebral Oxygenation","Near-Infrared Spectroscopy","General Anesthesia","Intraoperative Monitoring","2026-06-02",{"date":162,"type":33},"2026-06-04",{"date":164,"type":33},"2026-05-01",{"date":166,"type":22},"2026-12-01",{"name":39,"class":40},{"id":169,"slug":170,"hasResults":12,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":77,"sex":102,"minAge":18,"maxAge":175,"enrollmentInfo":176,"targetDuration":4,"studyType":23,"phases":178,"briefSummary":179,"conditions":180,"keywords":183,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":188,"lastUpdatePostDateStruct":189,"startDateStruct":190,"completionDateStruct":191,"leadSponsor":193,"locationsCount":4},"100640905","effect-of-web-based-education-on-attitudes-and-beliefs-about-hpv-testing-100640905","NCT07620795","Effect of Web-Based Education on Attitudes and Beliefs About HPV Testing","THE EFFECT OF WEB-BASED EDUCATION GIVEN TO WOMEN ON THEIR ATTITUDES AND BELIEFS ABOUT HPV TESTING","Inclusion Criteria:\n\n* Having no prior clinical diagnosis of cervical cancer\n* Being between 18 and 60 years of age\n* Having active access to the internet\n* Being literate at a level sufficient to read and understand the questionnaire forms\n* Being capable of effectively navigating and using a web browser\n* Being registered as a patient at Sakarya Akyazı No. 3 Family Health Center\n* Volunteering to participate in the study and providing informed consent\n\nExclusion Criteria:\n\n* Withdrawing from the study voluntarily at any stage\n* Failing to watch the mandatory educational videos on the platform\n* Submitting incomplete or incorrect responses to the data collection tools\n* Lacking active internet access or proper web browser usage skills\n\nCriteria for Study Discontinuation \u002F Drop-out:\n\n* Participant's request to withdraw from the study\n* Failure to respond to or complete the data collection tools\n* Not using or logging into the web application for more than 2 consecutive weeks during the study period","60 Years",{"count":177,"type":22},120,[25],"Cervical cancer is a highly preventable public health issue that significantly impacts women's quality of life. Although effective screening programs such as Human Papilloma Virus (HPV) testing and Pap-smears are widely available, women's participation in these early detection services often remains limited. The primary barriers to screening attendance include insufficient education, lack of information, negative beliefs, psychosocial or cultural factors, and misconceptions regarding gynecological examinations. To improve screening uptake, health interventions must focus not only on increasing knowledge but also on promoting correct beliefs and positive attitudes toward testing.\n\nWeb-based health education serves as an effective method to overcome barriers such as cost, transportation difficulties, and geographical limitations, allowing wider access to healthcare guidance. This study aims to evaluate the effects of a specialized web-based educational intervention on women's attitudes and beliefs regarding the HPV test. The research is designed as a randomized controlled trial with a pre-test and post-test design. Participants will be assigned to either an intervention group or a control group. The intervention group will receive structured health education through a dedicated web platform, while the control group will receive routine standard follow-up. Data will be gathered using a specific attitude and belief scale before and after the application to measure the intervention's impact.",[181,182],"Cervical Cancer","HPV",[184,185,186,187],"HPV Testing","Health Education","Web-based learning","Attitudes and Beliefs","2026-05-27",{"date":160,"type":33},{"date":30,"type":22},{"date":192,"type":22},"2026-09-01",{"name":39,"class":40},{"id":195,"slug":196,"hasResults":12,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":4,"eligibilityCriteria":200,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":201,"enrollmentInfo":202,"targetDuration":4,"studyType":23,"phases":204,"briefSummary":205,"conditions":206,"keywords":209,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":41},"100637370","programmed-intermittent-epidural-bolus-versus-continuous-epidural-infusion-for-postoperative-analgesia-after-total-knee-arthroplasty-100637370","NCT07605208","Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Postoperative Analgesia After Total Knee Arthroplasty","Effect of Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion on Postoperative Analgesia and Quality of Recovery After Total Knee Arthroplasty: A Prospective Randomized Double-Blind Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 to 80 years\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Scheduled for elective primary total knee arthroplasty\n* Eligible for combined spinal-epidural anesthesia and postoperative epidural analgesia\n* Able to understand and use patient-controlled epidural analgesia\n* Provided written informed consent\n\nExclusion Criteria:\n\n* Refusal to participate in the study\n* Known allergy or hypersensitivity to study medications\n* Body mass index (BMI) ≥ 40 kg\u002Fm²\n* Body weight \\\u003C 40 kg\n* Severe cardiac disease, including symptomatic arrhythmia or advanced conduction abnormalities\n* Coagulopathy (INR \\> 1.5 or platelet count \\\u003C 100,000\u002Fmm³)\n* Pregnancy or breastfeeding\n* Revision total knee arthroplasty or emergency surgery\n* Active infection at the site of regional anesthesia\n* Chronic opioid use or opioid dependence\n* Neurological disease or preexisting motor\u002Fsensory deficit in the lower extremities\n* ASA physical status IV or V\n* Requirement for intraoperative epidural local anesthetic supplementation due to inadequate spinal anesthesia","80 Years",{"count":203,"type":22},90,[25],"The goal of this clinical trial is to compare two different epidural analgesia delivery methods for pain control after total knee arthroplasty in adults undergoing elective surgery. The study will evaluate whether programmed intermittent epidural bolus (PIEB) provides better postoperative analgesia and recovery outcomes than continuous epidural infusion (CEI).\n\nThe main questions it aims to answer are:\n\nDoes PIEB reduce total epidural local anesthetic consumption during the first 24 postoperative hours compared with CEI? Does PIEB improve postoperative pain control and quality of recovery? Are there differences between the two methods regarding motor block, rescue analgesic requirement, patient-controlled epidural analgesia use, and adverse effects?\n\nResearchers will compare PIEB plus patient-controlled epidural analgesia (PCEA) with CEI plus PCEA in patients undergoing total knee arthroplasty.\n\nParticipants will:\n\nReceive combined spinal-epidural anesthesia during surgery Receive postoperative epidural analgesia using either PIEB or CEI Be evaluated for pain scores, motor block, recovery quality, epidural local anesthetic consumption, rescue analgesic requirement, and adverse events during the first 24 postoperative hours",[207,208],"Total Knee Anthroplasty","Epidural Analgesia",[210,211,212,213,214,215,216,217,218],"Programmed Intermittent Epidural Bolus","PIEB","Continuous Epidural Infusion","CEI","Patient-Controlled Epidural Analgesia","PCEA","Total Knee Arthroplasty","Postoperative Analgesia","QoR-15","2026-05-24",{"date":221,"type":33},"2026-05-28",{"date":223,"type":22},"2026-06-01",{"date":225,"type":22},"2027-12-01",{"name":39,"class":40},{"id":228,"slug":229,"hasResults":12,"nctId":230,"briefTitle":231,"officialTitle":232,"acronym":4,"eligibilityCriteria":233,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":201,"enrollmentInfo":234,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":235,"conditions":236,"keywords":239,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":244,"lastUpdatePostDateStruct":245,"startDateStruct":247,"completionDateStruct":248,"leadSponsor":250,"locationsCount":41},"100632045","effect-of-hypothermia-on-bis-and-psi-correlation-during-cardiopulmonary-bypass-100632045","NCT07508579","Effect of Hypothermia on BIS and PSI Correlation During Cardiopulmonary Bypass","Effect of Hypothermia on the Correlation Between Bispectral Index (BIS) and Patient State Index (PSI) During Cardiopulmonary Bypass","Inclusion Criteria:\n\n* Age ≥18 years\n* Elective on-pump Coronary Artery Bypass Grafting (CABG) surgery\n* Planned use of general anesthesia\n* Written informed consent\n\nExclusion Criteria:\n\n* Preexisting neurological disease\n* Use of medications affecting Electroencephalography (e.g., antiepileptics)\n* Severe hepatic dysfunction\n* Emergency surgery\n* Inadequate signal quality for anesthesia depth monitoring",{"count":21,"type":22},"The goal of this observational study is to evaluate whether hypothermia affects the relationship between electroencephalography-derived indices during cardiac surgery in adult patients undergoing cardiopulmonary bypass.\n\nThe main questions it aims to answer are:\n\nDoes the correlation between Bispectral Index (BIS) and Patient State Index (PSI) change between normothermic and hypothermic phases during cardiopulmonary bypass? How do BIS and PSI values change in response to decreasing body temperature?\n\nParticipants will:\n\nUndergo standard general anesthesia for elective on-pump coronary artery bypass surgery Be monitored simultaneously with BIS and PSI devices during surgery Have data recorded at predefined temperature-based time points during cardiopulmonary bypass",[237,238,155],"Cardiopulmonary Bypass","Hypothermia; Anesthesia",[240,153,154,241,242,243,159],"Bispectral Index","Cardiac Surgery","Hypothermic CPB","Depth of Anesthesia","2026-05-05",{"date":246,"type":33},"2026-05-11",{"date":164,"type":33},{"date":249,"type":22},"2026-12-31",{"name":39,"class":40},{"id":252,"slug":253,"hasResults":12,"nctId":254,"briefTitle":255,"officialTitle":256,"acronym":257,"eligibilityCriteria":258,"healthyVolunteers":77,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":259,"targetDuration":4,"studyType":23,"phases":261,"briefSummary":262,"conditions":263,"keywords":267,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":277,"completionDateStruct":279,"leadSponsor":281,"locationsCount":41},"100633975","effect-of-a-preoperative-sensory-modulation-room-on-pain-anxiety-and-sleep-in-kidney-transplant-patients-100633975","NCT07533669","Effect of a Preoperative Sensory Modulation Room on Pain, Anxiety, and Sleep in Kidney Transplant Patients","The Effect of a Sensory Modulation Room Applied in the Preoperative Period on Pain, Anxiety, and Sleep in Kidney Transplantation: An Innovative Nursing Intervention","SMRT-KT","Inclusion Criteria:\n\n* Be 18 years of age or older\n* Be involved as a donor or recipient in a living kidney transplant process\n* Be scheduled for elective surgical admission\n* Have adequate cognitive function and mental stability (fully oriented, able to cooperate)\n* Willing to participate in the study and provide written informed consent\n\nExclusion Criteria:\n\n* Undergoing emergency organ transplantation\n* Presence of impaired consciousness, severe cognitive deficits, or a diagnosed psychiatric disorder\n* Severe loss of vision, hearing, or tactile sensation that prevents perception of sensory modulation stimuli\n* Refusal to complete assessment scales or withdrawal from the study during the study process",{"count":260,"type":22},40,[25],"The goal of this prospective study is to evaluate whether preoperative exposure to a sensory modulation room can influence postoperative pain, anxiety, and sleep outcomes in adult living kidney donors and recipients. Organ transplantation involves complex surgical experiences that generate substantial physiological and psychological stress. Increased preoperative anxiety, sleep disturbances, and pain perception can adversely affect surgical outcomes and postoperative recovery. Given the limited availability of non-pharmacological nursing interventions for preoperative stress management, examining the effects of sensory modulation as a non-pharmacological approach is of clinical importance. The main questions this study aims to answer are:\n\n* Does preoperative exposure to a sensory modulation room reduce postoperative pain levels compared to standard care?\n* Does preoperative exposure to a sensory modulation room reduce preoperative and postoperative anxiety compared to standard care?\n* Does preoperative exposure to a sensory modulation room improve postoperative sleep quality compared to standard care?\n* How do individual sensory processing profiles influence the effectiveness of sensory modulation on postoperative pain, anxiety, and sleep? Comparison group: Researchers will compare participants who undergo preoperative sensory modulation (intervention group) to participants receiving standard preoperative care (control group) to determine differences in postoperative pain, anxiety, and sleep quality. Participants will: Be adult living kidney donors and recipients scheduled for elective transplantation at the Sakarya Training and Research Hospital Organ Transplant Unit. Undergo a single 15-20 minute sensory modulation session in a specially designed preoperative room equipped with dim lighting, nature videos, relaxing music, and tactile objects (stress balls, grounding mats).\n\nComplete a structured sequence during the intervention: orientation (0-5 min), visual stimulation with nature video (5-10 min), auditory stimulation with music (10-15 min), free sensory exploration (15-20 min), followed by questionnaires assessing immediate effects (20-25 min).\n\nComplete study instruments including a Demographic Information Form, the Adult Sensory Processing Questionnaire, the Surgical Anxiety Scale, the Athens Insomnia Scale, and a Visual Analogue Scale for pain. Be monitored postoperatively, with primary outcomes (pain, anxiety, and sleep quality) measured on postoperative day 3 to ensure clinical stability and reliable self-reporting. The study sample is planned to include 40 participants (20 donors and 20 recipients) using sequential assignment rather than randomization to minimize cross-group interaction and behavioral contamination. Control group participants will receive routine preoperative care including surgical preparation, laboratory testing, and standard clinical monitoring, without structured relaxation or sensory modulation interventions. All participants will be evaluated at identical time points using the same assessment tools.\n\nIt has received ethical approval from the Sakarya University Health Sciences Scientific Research Ethics Committee (Date: 18.11.2025, Approval No: E-43012747-050.04-533621-570), and informed consent will be obtained from all participants in accordance with the Declaration of Helsinki. Data analysis will be conducted using SPSS 25.0.",[264,265,266],"Renal Transplantation","Transplant Donation","Donor Nephrectomy",[264,268,269,270,271,272,273,274],"Sleep","pain","postoperative period","Nursing Care","Anxiety","preoperative period","sensory modulation room","2026-04-27",{"date":164,"type":33},{"date":278,"type":33},"2025-12-01",{"date":280,"type":22},"2027-05-31",{"name":39,"class":40},{"id":283,"slug":284,"hasResults":12,"nctId":285,"briefTitle":286,"officialTitle":287,"acronym":4,"eligibilityCriteria":288,"healthyVolunteers":12,"sex":17,"minAge":289,"maxAge":19,"enrollmentInfo":290,"targetDuration":4,"studyType":23,"phases":292,"briefSummary":293,"conditions":294,"keywords":296,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":301,"lastUpdatePostDateStruct":302,"startDateStruct":303,"completionDateStruct":304,"leadSponsor":306,"locationsCount":4},"100636143","serratus-posterior-superior-vs-erector-spinae-plane-block-for-breast-surgery-100636143","NCT07561853","Serratus Posterior Superior vs Erector Spinae Plane Block for Breast Surgery","Comparison of Serratus Posterior Superior Intercostal Plane Block and Erector Spinae Plane Block in Breast Surgery in Terms of Ease of Application and Patient Comfort","Inclusion Criteria:\n\n* Patients aged 25-65 years American Society of Anesthesiologists (ASA) physical status I-III Patients scheduled for mastectomy under general anesthesia Patients with no history of previous breast surgery Patients who provide written informed consent to participate in the study\n\nExclusion Criteria:\n\n* ASA physical status IV and above History of alcohol or substance abuse Known allergy to local anesthetics or opioids Patients with severe psychiatric disorders Patients who refuse to participate or do not provide informed consent","25 Years",{"count":291,"type":22},64,[25],"Postoperative pain after mastectomy remains a significant clinical problem that may impair patient comfort and delay early rehabilitation, potentially affecting functional recovery. Various analgesic techniques are used to manage postoperative pain. This study aims to compare serratus posterior superior intercostal plane block and erector spinae plane block, which are routinely used in our clinic for postoperative analgesia in patients undergoing mastectomy, in terms of ease of application and patient comfort.",[295],"Postoperative Pain",[297,298,299,295,300],"Serratus Posterior Superior Intercostal Plane Block","Erector Spinae Plane Block","Mastectomy","Fascial Plane Block","2026-04-24",{"date":164,"type":33},{"date":223,"type":22},{"date":305,"type":22},"2026-12-15",{"name":39,"class":40},{"id":308,"slug":309,"hasResults":12,"nctId":310,"briefTitle":311,"officialTitle":312,"acronym":313,"eligibilityCriteria":314,"healthyVolunteers":77,"sex":102,"minAge":103,"maxAge":4,"enrollmentInfo":315,"targetDuration":4,"studyType":23,"phases":316,"briefSummary":317,"conditions":318,"keywords":321,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":332,"completionDateStruct":333,"leadSponsor":335,"locationsCount":4},"100626417","breath-based-yoga-supported-breastfeeding-education-in-primiparous-mothers-100626417","NCT07435363","Breath-Based Yoga-Supported Breastfeeding Education in Primiparous Mothers","Effects of Breath-Based Yoga Supported Breastfeeding Education on Anxiety, Breastfeeding Self-Efficacy, and Perceived Insufficient Milk Supply in Primiparous Mothers: A Randomized Controlled Trial","BYBSE","Inclusion Criteria:\n\nInclusion Criteria for Intervention and Control Groups\n\n* Primiparous mothers aged 19 years or older who delivered at term (37-42 weeks),\n* Mothers who gave birth in a Baby-Friendly Hospital in Sakarya,\n* Mothers who are open to communication and cooperation, voluntarily agree to participate in the study, and had a normal vaginal delivery,\n* Mothers who agree to participate in the study during postpartum weeks 0-2 and who will be in postpartum weeks 2-10 during the intervention period,\n* Mothers who breastfeed or practice mixed feeding,\n* Mothers and infants who are in good health,\n* Mothers with a Body Mass Index within the normal range,\n* Mothers without sensory impairments such as hearing or vision problems,\n* Mothers without a diagnosed psychiatric history,\n* Mothers who can read and write in Turkish,\n* Mothers who score below 13 on the Edinburgh Postpartum Depression Scale (EPDS) at the first assessment.\n\nExclusion Criteria for Intervention and Control Groups\n\n* Infant loss,\n* Mothers with visual, auditory, or cognitive impairments,\n* Infants with physical disabilities or congenital anomalies,\n* Mothers with any neurological, orthopedic, or chronic condition that may prevent participation in exercise,\n* Mothers scoring 13 or above on the Edinburgh Postnatal Depression Scale (EPDS) at the first assessment,\n* Mothers who practiced yoga or breathing exercises during pregnancy or postpartum will be excluded,\n* Since brief educational sessions provided before discharge in Baby-Friendly Hospitals are routine in Turkey, they will not be considered exclusion criteria.\n* However, mothers who received a structured breastfeeding education program during pregnancy or postpartum will be excluded from the study.\n\nWithdrawal Criteria for Intervention and Control Groups\n\n* Participants who request to withdraw from the study at any time,\n* Participants who miss more than two yoga-breathing sessions, more than two breastfeeding education sessions, or who cannot be reached will be removed from the study.",{"count":203,"type":22},[25],"This study is designed as a randomized controlled trial (RCT) focused on improving breastfeeding outcomes among primiparous mothers in the postpartum period. Although the World Health Organization (WHO) recommends exclusive breastfeeding for the first six months as the ideal nutritional source for newborns, the rate in Turkey (41% according to TDHS 2018) lags behind global targets (50-70%). Early cessation of breastfeeding is generally associated with mothers' inability to adapt to physical and psychological challenges. In particular, anxiety and stress experienced during the postpartum period lead to the development of a perceived insufficient milk supply, which negatively affects the acquisition of breastfeeding self-efficacy. In this context, this study investigates the potential of a supportive intervention facilitating stress management and relaxation on breastfeeding sustainability. Participants will be randomized into three groups: Intervention Group I (Online Breastfeeding Education + Breath-Based Yoga), Intervention Group II (Online Breastfeeding Education Only), and the Control Group (Routine Care). The interventions will be delivered remotely via Google Meet over a maximum period of seven weeks (3 weeks of breastfeeding education + 4 weeks of yoga practice). The primary objective of the study is to evaluate whether these structured interventions significantly improve maternal breastfeeding self-efficacy and reduce the perception of insufficient milk. Additionally, secondary outcomes will assess the impact on maternal anxiety levels. To ensure internal validity and isolate the intervention effect, mothers at high risk of postpartum depression (EPDS score \\> 13) are excluded from the study.\n\nThe Hypotheses of the Study\n\nEach hypothesis will be tested independently:\n\nH₀: The pre- and post-intervention measurement differences do not significantly differ between groups.\n\nH₁: The pre- and post-intervention measurement differences significantly differ between groups (p \\\u003C 0.05).\n\nIf a significant difference is detected, H₀ will be rejected and H₁ will be accepted. Multiple comparisons will be evaluated using the Holm-Bonferroni correction to control the Type I error rate.\n\n* H1a: Online breastfeeding education provided to primiparous mothers positively affects their anxiety levels.\n* H1b: Online breastfeeding education provided to primiparous mothers positively affects their breastfeeding self-efficacy.\n* H1c: Online breastfeeding education provided to primiparous mothers positively affects their perceived insufficient milk supply.\n* H2a: Breath-based yoga-supported online breastfeeding education provided to primiparous mothers positively affects their anxiety levels.\n* H2b: Breath-based yoga-supported online breastfeeding education provided to primiparous mothers positively affects their breastfeeding self-efficacy.\n* H2c: Breath-based yoga-supported online breastfeeding education provided to primiparous mothers positively affects their perceived insufficient milk supply.",[319,320],"Breastfeeding","Perceived Insufficient Milk Supply",[322,323,324,325,326,327,328],"breastfeeding","breastfeeding education","breastfeeding self-efficacy","perceived insufficient milk supply","yoga","breath-based yoga","primiparous mothers","2026-04-22",{"date":331,"type":33},"2026-04-28",{"date":223,"type":22},{"date":334,"type":22},"2027-06-01",{"name":39,"class":40},{"id":337,"slug":338,"hasResults":12,"nctId":339,"briefTitle":340,"officialTitle":341,"acronym":342,"eligibilityCriteria":343,"healthyVolunteers":12,"sex":17,"minAge":344,"maxAge":201,"enrollmentInfo":345,"targetDuration":4,"studyType":23,"phases":347,"briefSummary":348,"conditions":349,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":353,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":357,"leadSponsor":359,"locationsCount":4},"100634257","knee-osteoartritis-genicular-nerve-rf-ablation-vs-alcohol-neurolysis-100634257","NCT07537335","Knee Osteoartritis Genicular Nerve RF Ablation vs Alcohol Neurolysis","Comparison of Genicular Nerve Radiofrequency Ablation and Neurolytic Alcohol Injection for Chronic Knee Osteoarthritis Pain: A Randomized Controlled Trial","GEN-AL-RF","Inclusion Criteria:\n\n* Age: Patients aged 45 to 85 years.\n* Diagnosis: Chronic knee pain for at least 6 months diagnosed with knee osteoarthritis according to American College of Rheumatology (ACR) criteria.\n* Radiological Grade: Grade 3 or 4 according to the Kellgren-Lawrence (K-L) classification.\n* Pain Severity: Baseline Numerical Rating Scale (NRS) score of 5 or higher.\n* Failure of Conservative Treatment: Inadequate response to conservative treatments (e.g., physical therapy, NSAIDs, or intra-articular injections) for at least 3 months.\n* Positive Diagnostic Block: At least 50% reduction in pain for minimum 24 hours following a prognostic genicular nerve block with local anesthetic.\n\nExclusion Criteria:\n\n* Previous Surgery: History of knee arthroplasty or major knee surgery on the affected side.\n* Specific Conditions: Presence of inflammatory arthritis (e.g., rheumatoid arthritis), gouty arthritis, or active infection at the injection site.\n* Neurological Deficit: Severe neurological or psychiatric disorders that may interfere with pain assessment.\n* Coagulopathy: Uncontrolled bleeding disorders or use of anticoagulant therapy that cannot be temporarily discontinued.\n* Recent Injections: Intra-articular steroid or hyaluronic acid injection within the last 3 months.\n* Allergy: Known allergy to local anesthetics, contrast agents, or ethyl alcohol.\n* Pacemaker: Presence of a cardiac pacemaker or implanted electronic device (specifically for the RFA group).","45 Years",{"count":346,"type":22},50,[25],"The GEN-AL-RF study is a randomized controlled trial designed to compare the clinical efficacy of two interventional techniques for managing chronic knee pain due to osteoarthritis. The study focuses on genicular nerve radiofrequency (RF) ablation versus neurolytic alcohol injection for pain blockade.\n\nPatients diagnosed with knee osteoarthritis are randomly assigned to either the RF ablation group or the neurolytic alcohol group. The primary objective is to evaluate the superiority and duration of analgesic effects between these two methods. Clinical outcomes are assessed at baseline and at 1, 3, and 6 months post-procedure using the Numeric Rating Scale (NRS) for pain intensity, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for physical function, and the Short Form-12 (SF-12) for health-related quality of life.\n\nThe results of this study aim to provide high-quality evidence regarding the comparative effectiveness and long-term outcomes of genicular nerve RF and alcohol neurolysis in the clinical management of chronic knee osteoarthritis pain.",[350,351,352],"Knee Osteoarthristis","Radiofrequency Ablation","NEUROLYSIS","2026-04-10",{"date":355,"type":33},"2026-04-17",{"date":164,"type":22},{"date":358,"type":22},"2026-12-30",{"name":39,"class":40},{"id":361,"slug":362,"hasResults":12,"nctId":363,"briefTitle":364,"officialTitle":365,"acronym":4,"eligibilityCriteria":366,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":367,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":369,"conditions":370,"keywords":373,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":378,"lastUpdatePostDateStruct":379,"startDateStruct":381,"completionDateStruct":383,"leadSponsor":384,"locationsCount":41},"100627899","bis-variability-and-change-in-quality-of-recovery-after-surgery-100627899","NCT07454629","BIS Variability and Change in Quality of Recovery After Surgery","Association Between Intraoperative Bispectral Index Variability and Change in Quality of Recovery-15 Score: A Prospective Observational Study","Inclusion Criteria:\n\n* Adults aged 18 to 65 years\n* Scheduled for elective laparoscopic cholecystectomy\n* American Society of Anesthesiologists (ASA) physical status I-III\n* Planned general anesthesia with routine bispectral index (BIS) monitoring\n* Ability to provide written informed consent\n\nExclusion Criteria:\n\n* History of neurological disease\n* Use of neuropsychiatric medications\n* Cognitive impairment or mental retardation\n* Inability to complete the Quality of Recovery-15 (QoR-15) questionnaire",{"count":368,"type":22},126,"This prospective observational study aims to examine the relationship between fluctuations in anesthesia depth, measured by bispectral index (BIS) monitoring during surgery, and changes in patients' postoperative recovery quality.\n\nBIS monitoring is routinely used during general anesthesia to assess the depth of anesthesia, but BIS values often fluctuate over time rather than remaining stable. The clinical significance of this variability is not well understood. In this study, BIS variability during anesthesia induction and maintenance will be evaluated and compared with changes in postoperative recovery quality.\n\nRecovery quality will be assessed using the Quality of Recovery-15 (QoR-15) questionnaire, which will be administered before surgery and again on the first postoperative day. The primary outcome of the study will be the change in QoR-15 score from the preoperative baseline to postoperative day one (ΔQoR-15). Delirium screening and routine perioperative clinical data will also be collected.\n\nNo additional interventions beyond standard anesthesia care will be performed. The results of this study may help improve understanding of how intraoperative anesthesia stability relates to patient recovery after surgery.",[371,372],"Bispectral Index Variability During General Anesthesia and Postoperative Recovery","Cholecystectomy, Laparoscopic",[240,374,375,158,376,377],"Anesthesia Depth","Quality of Recovery","Postoperative Recovery","Bispectral Index Variability","2026-04-02",{"date":380,"type":33},"2026-04-08",{"date":382,"type":33},"2026-01-01",{"date":358,"type":22},{"name":39,"class":40},{"id":386,"slug":387,"hasResults":12,"nctId":388,"briefTitle":389,"officialTitle":390,"acronym":4,"eligibilityCriteria":391,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":392,"targetDuration":4,"studyType":23,"phases":394,"briefSummary":395,"conditions":396,"keywords":4,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":399,"lastUpdatePostDateStruct":400,"startDateStruct":401,"completionDateStruct":403,"leadSponsor":405,"locationsCount":41},"100631908","impact-of-combined-intravenous-inhalational-vs-inhalational-anesthesia-on-qor-15-recovery-scores-in-gynecologic-surgery-100631908","NCT07506798","Impact of Combined Intravenous-Inhalational vs Inhalational Anesthesia on QoR-15 Recovery Scores in Gynecologic Surgery","Effects of Combined Intravenous-Inhalational Anesthesia Versus Inhalational Anesthesia on Postoperative Recovery in Gynecological Operations: A Comparison Based on QoR-15 Scores","Inclusion Criteria:\n\n1. Patients aged 18-65 years\n2. Scheduled for elective gynecologic surgery at Sakarya University Faculty of Medicine Training and Research Hospital\n3. Classified as ASA I-III\n4. Able to understand and complete the QoR-15 questionnaire\n5. Provided written informed consent\n\nExclusion Criteria:\n\n1. Severe comorbidities (beyond ASA III)\n2. Patients with advanced neurological disease or cognitive impairment\n3. Known allergy to anesthetic drugs used in the study\n4. Classified as ASA IV-V\n5. Refusal to participate in the study\n6. Emergency or urgent surgery",{"count":393,"type":22},100,[25],"This study aims to compare the effects of combined intravenous-inhalational anesthesia versus inhalational anesthesia alone on postoperative recovery in patients undergoing elective gynecologic surgery.\n\nA total of 100 patients, aged 18-65 years and classified as ASA I-III, scheduled for elective gynecologic procedures at Sakarya University Faculty of Medicine Training and Research Hospital, will be included. The sample size was calculated based on the primary outcome, the Quality of Recovery-15 (QoR-15) score.\n\nPatients will complete the QoR-15 questionnaire preoperatively, before knowing which anesthesia method will be applied. Postoperative QoR-15 scores will be collected on postoperative days 1 and 2, and intraoperative data will be obtained from anesthesia records.\n\nThe study evaluates postoperative recovery using QoR-15 scores, covering physical comfort, emotional state, psychological support, pain, and ability to perform daily activities. Higher scores indicate better recovery, whereas lower scores indicate impaired postoperative recovery.",[397,376,398],"Gynecologic Surgery","Anesthesia","2026-03-28",{"date":378,"type":33},{"date":402,"type":33},"2025-10-01",{"date":404,"type":22},"2027-04",{"name":39,"class":40},{"id":407,"slug":408,"hasResults":12,"nctId":409,"briefTitle":410,"officialTitle":411,"acronym":4,"eligibilityCriteria":412,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":344,"enrollmentInfo":413,"targetDuration":4,"studyType":23,"phases":415,"briefSummary":416,"conditions":417,"keywords":423,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":430,"lastUpdatePostDateStruct":431,"startDateStruct":433,"completionDateStruct":434,"leadSponsor":436,"locationsCount":41},"100628900","the-effect-of-digital-storytelling-on-nursing-students-nursing-process-education-100628900","NCT07467655","THE EFFECT OF DIGITAL STORYTELLING ON NURSING STUDENTS' NURSING PROCESS EDUCATION","THE EFFECT OF DIGITAL STORYTELLING ON NURSING STUDENTS' NURSING PROCESS EDUCATION: AN EXPERIMENTAL STUDY","Inclusion Criteria:\n\n* Undergraduate nursing students enrolled in the Nursing Fundamentals I course for the first time\n* Students who attend and complete all educational activities related to the course\n* Students who voluntarily agree to participate in the study\n\nExclusion Criteria:\n\n* Graduates of a health vocational high school\n* Students who report prior knowledge or formal education related to the nursing process\n* Students who are currently employed in any healthcare institution",{"count":414,"type":22},104,[25],"Study Type: Randomized Controlled Experimental Study\n\nPurpose:\n\nThis study aims to evaluate the effects of digital storytelling-enhanced nursing process education on nursing students' knowledge, nursing process competency, and clinical reasoning skills. The nursing process, which includes assessment, diagnosis, planning, implementation, and evaluation, forms the foundation of evidence-based and holistic care. However, the literature indicates that nursing students often face difficulties in assessment, prioritization, and individualization of care interventions and frequently apply the process mechanically.\n\nThe study addresses the following primary questions:\n\nDoes digital storytelling improve nursing students' knowledge of the nursing process?\n\nDoes digital storytelling enhance students' nursing process competency and clinical reasoning skills?\n\nStudy Design and Comparison:\n\nParticipants will be assigned to either the intervention or control group based on their Nursing Process knowledge scores. Groups will be stratified by gender and knowledge test scores using a stratified randomization method to ensure balanced distribution and group homogeneity. Researchers will compare outcomes between groups to evaluate the effectiveness of the educational approach.\n\nParticipants' Key Activities:\n\nParticipants must be first-time enrollees in the Fundamentals of Nursing I course, have completed all course content, and have voluntarily agreed to attend.\n\nComplete pre- and post-intervention assessments, including the Nursing Process Knowledge Test, Nursing Process Competency Scale, Clinical Reasoning Assessment Rubric, and Instructional Material Motivation Scales.\n\nEngage in follow-up evaluations immediately after the intervention and three months later to assess the retention and sustainability of learning outcomes.\n\nAdditional Notes:\n\nDigital storytelling materials will be validated through expert review and pilot testing. The Clinical Reasoning Assessment Rubric will undergo Turkish-language validity and reliability evaluation. Findings are expected to provide evidence on the effectiveness of digital storytelling in nursing process education, support curriculum development at the undergraduate level, and guide the broader implementation of technology-enhanced, reflective learning approaches in nursing education.",[418,419,420,421,422],"Education, Nursing","Students, Nursing","Clinical Competence","Clinical Decision-Making in Nursing","Evidence-Based Practice",[424,425,426,427,428,429],"Nursing Education","Digital Storytelling","Nursing Process","Clinical Reasoning","Educational Intervention","Undergraduate Nursing Students","2026-03-22",{"date":432,"type":33},"2026-03-25",{"date":138,"type":22},{"date":435,"type":22},"2027-01-30",{"name":39,"class":40},{"id":438,"slug":439,"hasResults":12,"nctId":440,"briefTitle":441,"officialTitle":442,"acronym":4,"eligibilityCriteria":443,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":201,"enrollmentInfo":444,"targetDuration":51,"studyType":52,"phases":4,"briefSummary":445,"conditions":446,"keywords":449,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":457,"completionDateStruct":459,"leadSponsor":460,"locationsCount":41},"100630411","oxygenation-in-posterior-stabilization-surgery-100630411","NCT07487324","Oxygenation in Posterior Stabilization Surgery","Factors Determining Oxygenation in Posterior Stabilization Surgery: The Role of Positioning and Mechanical Ventilation Parameters","Inclusion Criteria:\n\nPatients aged 18 to 75 years Patients classified as ASA physical status I, II, or III according to the American Society of Anesthesiologists Patients undergoing posterior stabilization surgery Patients who voluntarily agreed to participate in the study Patients with a body mass index (BMI) \\\u003C35 kg\u002Fm² Patients followed with a standard mechanical ventilation procedure\n\nExclusion Criteria:\n\n* \\- ASA 4 olarak değerlendirilenler\n* Anestezik ajan alerjisi olanlar\n* Kanama diatezi bozukluğu olanlar\n* Cerrahi süresi 3 saatin üstünde olanlar\n* Bilinen ileri akciğer hastalığı olanlar (intertisyel akciğer hastalığı, ileri düzey KOAH, ileri düzey astım vb)\n* VKI≥35 olanlar\n* Obstrüktif uyku apne sendromu tanısı olanlar\n* Toraks deformitesi olanlar\n* Ciddi kalp yetmezliği öyküsü olanlar (EF\\\u003C30)\n* Şiddetli anemi öyküsü olanlar (Hg\\\u003C8 mg\u002Fdl)\n* Cerrahi operasyon sırasında kan transfüzyonu ihtiyacı olan hastalar",{"count":346,"type":22},"This study aims to evaluate the effects of prone positioning on oxygenation, ventilation, and hemodynamic parameters in patients undergoing posterior stabilization surgery under general anesthesia. By comparing routine anesthesia and monitoring data obtained in the supine and prone positions, the study seeks to determine how positional changes influence respiratory mechanics and perioperative physiological stability.",[447,448],"Oxygen","Oxygen Saturation",[450,451,452,453],"oxygenation","Posterior Stabilization Surgery","Mechanical Ventilation Parameters","optic nerve sheath diamater","2026-03-17",{"date":456,"type":33},"2026-03-23",{"date":458,"type":22},"2026-04-01",{"date":93,"type":22},{"name":39,"class":40},{"id":462,"slug":463,"hasResults":12,"nctId":464,"briefTitle":465,"officialTitle":466,"acronym":4,"eligibilityCriteria":467,"healthyVolunteers":77,"sex":17,"minAge":468,"maxAge":469,"enrollmentInfo":470,"targetDuration":51,"studyType":52,"phases":4,"briefSummary":472,"conditions":473,"keywords":478,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":484,"lastUpdatePostDateStruct":485,"startDateStruct":487,"completionDateStruct":489,"leadSponsor":491,"locationsCount":41},"100611562","transversalis-fascia-plane-versus-transversus-abdominis-plane-block-for-postoperative-analgesia-in-children-100611562","NCT07242196","Transversalis Fascia Plane Versus Transversus Abdominis Plane Block for Postoperative Analgesia in Children","Comparison of the Analgesic Effects of Ultrasound-Guided Transversalis Fascia Plane Block and Transversus Abdominis Plane Block in Pediatric Laparoscopic Surgery","Inclusion Criteria:\n\n* Pediatric patients aged 6 months to 16 years\n* Classified as ASA physical status I or II\n* Scheduled to undergo laparoscopic surgery under general anesthesia\n\nExclusion Criteria:\n\n* Patients classified as ASA physical status III or IV\n* Known allergy or hypersensitivity to local anesthetic agents\n* Presence of bleeding diathesis or coagulation disorders\n* Infection at the injection site or local skin lesions preventing block application","6 Months","16 Years",{"count":471,"type":22},36,"This prospective clinical study aims to compare the postoperative analgesic efficacy of the ultrasound-guided transversalis fascia plane block (TFPB) and the transversus abdominis plane (TAP) block in pediatric patients undergoing laparoscopic surgery. Effective and long-lasting postoperative analgesia is essential for patient and parental satisfaction in pediatric anesthesia. With recent advances in ultrasound technology, regional anesthesia techniques have become increasingly utilized in pediatric practice.\n\nIn the TAP block, local anesthetic is injected between the internal oblique and transversus abdominis muscles, providing analgesia typically between Torachal vertebra 10 (T10) and Lumbar vertebra (L1) dermatomes. The transversalis fascia plane block, developed as a modification of this approach, targets the proximal portions of the T12 and L1 nerves by depositing local anesthetic between the transversus abdominis muscle and the transversalis fascia, potentially offering wider sensory coverage.\n\nThis study compares both blocks in terms of postoperative pain scores, duration of analgesia, and requirement for rescue analgesics in children undergoing laparoscopic surgery. The results are expected to contribute to the optimization of regional anesthesia techniques and improve pain management strategies in pediatric surgical patients.",[217,474,475,476,477],"Transversus Abdominis Plane (TAP) Block","Transversalis Fascia Plane Block","Pediatric Surgical Procedures","Laparoscopic Abdominal Surgeries",[479,480,481,482,483],"transversus abdominis plane block","transversalis fascia plane block","pediatrics","laparoscopic abdominal surgery","postoperative analgesia","2026-03-09",{"date":486,"type":33},"2026-03-10",{"date":488,"type":33},"2025-12-18",{"date":490,"type":22},"2026-06-15",{"name":39,"class":40},{"id":493,"slug":494,"hasResults":12,"nctId":495,"briefTitle":496,"officialTitle":497,"acronym":4,"eligibilityCriteria":498,"healthyVolunteers":12,"sex":102,"minAge":18,"maxAge":499,"enrollmentInfo":500,"targetDuration":501,"studyType":52,"phases":4,"briefSummary":502,"conditions":503,"keywords":506,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":484,"lastUpdatePostDateStruct":512,"startDateStruct":513,"completionDateStruct":514,"leadSponsor":516,"locationsCount":41},"100611563","sugammadex-and-menstrual-cycle-in-postoperative-nausea-and-vomiting-100611563","NCT07242209","Sugammadex and Menstrual Cycle in Postoperative Nausea and Vomiting","The Relationship Between Menstrual Cycle Phases and Postoperative Nausea and Vomiting: The Role of Sugammadex","Inclusion Criteria:\n\n* Female sex\n* Age between 18 and 40 years\n* Regular menstrual cycle\n* Scheduled for ENT (ear, nose, and throat) surgery\n* Classified as ASA physical status I or II\n\nExclusion Criteria:\n\n* Irregular menstrual cycle\n* Unknown date of last menstrual period\n* Receiving estrogen and\u002For progesterone supplementation\n* Pre-menopausal or menopausal status\n* Pregnant\n* Breastfeeding\n* Classified as ASA physical status III or IV\n* Apfel score ≥ 3\n* History of drug allergy\n* Surgery duration exceeding 3 hours\n* Age \\\u003C18 or \\>40 years","40 Years",{"count":21,"type":22},"3 Days","This observational study aims to evaluate the relationship between menstrual cycle phases and the incidence of postoperative nausea and vomiting (PONV) in women of reproductive age undergoing septorhinoplasty surgery. The study's primary objective is to determine whether different phases of the menstrual cycle are associated with variations in PONV frequency. As a secondary objective, the relationship between menstrual phases, PONV incidence, and the use of sugammadex during anesthesia will be analyzed. No additional intervention will be applied beyond routine clinical practice; all data will be collected prospectively from anesthesia records and postoperative evaluations.",[504,505],"Postoperative Nausea and Vomiting","Menstrual Cycle",[507,508,509,510,511],"postoperative nausea and vomiting","menstruel cycle","septorhinoplasty","sugammadex","female reproductive age",{"date":486,"type":33},{"date":488,"type":33},{"date":515,"type":22},"2026-05-15",{"name":39,"class":40},{"id":518,"slug":519,"hasResults":12,"nctId":520,"briefTitle":521,"officialTitle":522,"acronym":523,"eligibilityCriteria":524,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":525,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":526,"conditions":527,"keywords":529,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":535,"lastUpdatePostDateStruct":536,"startDateStruct":538,"completionDateStruct":540,"leadSponsor":542,"locationsCount":41},"100626885","evaluation-of-muscle-strength-and-muscle-mass-in-patients-with-inflammatory-bowel-disease-100626885","NCT07441447","Evaluation of Muscle Strength and Muscle Mass in Patients With Inflammatory Bowel Disease","Evaluation of Sarcopenia in Patients With Inflammatory Bowel Disease","IBDSARC","Inclusion Criteria:\n\n* Age ≥18 years\n* Established diagnosis of inflammatory bowel disease (ICD-10: K50.\\* Crohn's disease, K51.\\* ulcerative colitis)\n* Ability to provide written informed consent\n* Ability to undergo ultrasonographic muscle assessment and handgrip strength testing\n* Availability of an abdominal computed tomography (CT) scan performed within the previous 6 months\n\nExclusion Criteria:\n\n* Known neuromuscular disorders or primary muscle diseases\n* Major orthopedic conditions affecting muscle strength assessment\n* Pregnancy\n* Abdominal wall defects or conditions interfering with ultrasound assessment\n* Incomplete clinical or imaging data\n* Any condition preventing reliable ultrasound or handgrip measurement",{"count":393,"type":22},"This prospective observational study aims to evaluate the validity of ultrasonographic muscle measurements in patients with inflammatory bowel disease (IBD). Sarcopenia is commonly assessed using computed tomography (CT)-based skeletal muscle area measurements at the L3 vertebral level, which are considered a gold standard method. However, CT is not always feasible due to radiation exposure and accessibility limitations.\n\nIn this study, muscle strength will be assessed using handgrip dynamometry, and muscle mass will be evaluated using ultrasonography of selected skeletal muscles. In patients with available recent abdominal CT imaging, L3 skeletal muscle area will be recorded. The primary objective is to compare ultrasonographic muscle measurements with CT-based assessments and to evaluate the agreement between these methods.\n\nThis study aims to determine whether ultrasonography can serve as a practical and reliable alternative tool for muscle mass evaluation in patients with IBD.",[528],"Crohn Disease (CD)",[530,531,532,533,534],"Sarcopenia","Muscle Ultrasound","Computed Tomography","Handgrip Strength","L3 Skeletal Muscle","2026-02-23",{"date":537,"type":33},"2026-03-02",{"date":539,"type":33},"2025-11-10",{"date":541,"type":22},"2026-12",{"name":39,"class":40},{"id":544,"slug":545,"hasResults":12,"nctId":546,"briefTitle":547,"officialTitle":548,"acronym":549,"eligibilityCriteria":550,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":551,"targetDuration":4,"studyType":23,"phases":553,"briefSummary":554,"conditions":555,"keywords":558,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":564,"lastUpdatePostDateStruct":565,"startDateStruct":567,"completionDateStruct":569,"leadSponsor":571,"locationsCount":41},"100624006","ai-powered-osce-coaching-in-improving-infertility-counseling-skills-in-nursing-students-100624006","NCT07404020","AI-Powered OSCE Coaching in Improving Infertility Counseling Skills in Nursing Students","AI-Powered OSCE Coaching in Improving Infertility Counseling Skills: A Randomized Controlled Study in Nursing Students","AI-OSCE-Infert","Inclusion Criteria:\n\n* Undergraduate nursing students enrolled at Bartın University Faculty of Health Sciences\n* Successfully completed the Women's Health and Diseases Nursing course (minimum passing grade)\n* Currently enrolled in the infertility nursing course\n* Able to read and understand Turkish\n* Willing to participate and provide written informed consent\n\nExclusion Criteria:\n\n* Students who do not complete the educational intervention\n* Students who do not complete pretest or posttest assessments\n* Students with prior formal training in AI-supported OSCE or similar simulation-based coaching programs",{"count":552,"type":22},96,[25],"This randomized controlled experimental study aims to evaluate the effectiveness of a generative artificial intelligence-based \"OSCE Coach\" in improving infertility counseling communication and empathy skills among nursing students. The study will be conducted with undergraduate nursing students at Bartın University Faculty of Health Sciences and follows a two-group pretest-posttest design.\n\nA total of 96 students will be randomly assigned to either the intervention group or the control group using computer-generated randomization. The intervention group will participate in an AI-powered OSCE coaching simulation consisting of 6-8 infertility counseling micro-scenarios, incorporating structured feedback and deliberate practice cycles. The control group will receive conventional infertility counseling education using standard teaching methods.\n\nOutcomes will be assessed using the Therapeutic Communication Skills Scale for Nursing Students, the Jefferson Scale of Empathy for Nursing Students, and a rubric-based infertility counseling communication performance assessment based on the Kalamazoo Consensus Statement. Performance evaluations will be conducted via standardized virtual patient interviews and scored by two blinded independent raters.\n\nData will be analyzed using ANCOVA to assess intervention effects while controlling for baseline scores. This study aims to contribute evidence on the effectiveness of AI-supported OSCE coaching in enhancing communication and empathy skills in nursing education.",[556,557],"Infertility Counseling","Communication Skills",[559,560,561,562,563],"Infertility counseling","nursing education","artificial intelligence","OSCE","therapeutic communication","2026-02-07",{"date":566,"type":33},"2026-02-11",{"date":568,"type":22},"2026-03-01",{"date":570,"type":22},"2026-07-30",{"name":39,"class":40},{"id":573,"slug":574,"hasResults":12,"nctId":575,"briefTitle":576,"officialTitle":577,"acronym":4,"eligibilityCriteria":578,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":579,"targetDuration":4,"studyType":23,"phases":581,"briefSummary":582,"conditions":583,"keywords":585,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":590,"lastUpdatePostDateStruct":591,"startDateStruct":593,"completionDateStruct":595,"leadSponsor":596,"locationsCount":41},"100601261","the-effect-of-hand-holding-and-stress-ball-intervention-on-pain-and-anxiety-100601261","NCT07108192","The Effect of Hand Holding and Stress Ball Intervention on Pain and Anxiety","The Effect of Hand Holding and Stress Ball Intervention on Pain and Anxiety During Cataract Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* 18 years and over\n* Can understand and speak Turkish\n* Clear consciousness, person, place and time oriented\n* No hearing and perception problems\n* Does not have any mental or neurological disorders that may affect communication (Alzheimer's, dementia, etc.)\n* First time cataract surgery\n* Those without any psychiatric diagnosis\u002F treatment (antidepressants, anxiolytics, sedatives, etc.)\n* No physical problems in squeezing the stress ball (muscle, joint problems, etc.)\n* No analgesic or anesthetic medication 24 hours before the procedure\n* Individuals who agree to participate in the study will be included in the study\n\nExclusion Criteria:\n\n* Conversion of topical anesthesia to general anesthesia during surgery\n* A different story of eye surgery\n* Hearing, speech, physical or mental disability\n* Pregnancy or possible pregnancy\n* Those with malignancy\n* Taking an analgesic medication at least 24 hours before the procedure\n* People with chronic pain\n* History of incomplete or canceled cataract procedures\n* Hypertension in the patient (\\>160\u002F100 mmHg)\n* Suppurative\u002Finfective\u002Finflammatory skin condition of the hands\n* Hypersensitivity to touch\n* Patients with contact-transmitted diseases\n* Being uncomfortable with hand-holding,\n* In case of need for emergency intervention by a physician during or immediately after the procedure\n* Failure to perform the stress ball application in accordance with the instruction\n* Pre-existing neuropathy (muscle joint problem, stroke, etc.)\n* Complications during cataract surgery\n* Those who want to leave the study voluntarily\n* Termination of the procedure due to deterioration of the patient's general condition during the procedure\n* Failure to carry out intervention practices in accordance with the determined protocol (Dropping the stress ball during the procedure, etc.)",{"count":580,"type":22},108,[25],"Cataract surgery is currently primarily performed with topical anesthesia. Although topical anesthesia provides many benefits for patients, they may experience pain, anxiety and discomfort during surgery. It has been reported that increased pain and anxiety during surgery may decrease patient cooperation and satisfaction, making surgery more difficult. In this context, in addition to medical interventions, non-pharmacologic methods are recommended to manage pain and anxiety during surgery. Non-pharmacological methods are reported to be simple, effective and cost-effective. In this context, studies have shown that stress ball application and hand holding are effective strategies for the control of pain and anxiety in patients.\n\nAccording to this information, the aim of this study was to evaluate the effect of stress ball application and hand holding method used during cataract surgery on patients' pain and anxiety.\n\nAnother aim of the study was to determine the effects of stress ball application and hand holding method on patients' satisfaction levels and vital signs.",[584],"Cataract Surgery",[586,587,269,588,589],"hand holding","stress ball","anxiety","cataract surgery","2026-02-04",{"date":592,"type":33},"2026-02-06",{"date":594,"type":33},"2025-10-08",{"date":30,"type":22},{"name":39,"class":40},{"id":598,"slug":599,"hasResults":12,"nctId":600,"briefTitle":601,"officialTitle":602,"acronym":4,"eligibilityCriteria":603,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":604,"enrollmentInfo":605,"targetDuration":4,"studyType":23,"phases":606,"briefSummary":607,"conditions":608,"keywords":610,"overallStatus":61,"whyStopped":4,"lastUpdateSubmitDate":616,"lastUpdatePostDateStruct":617,"startDateStruct":618,"completionDateStruct":620,"leadSponsor":621,"locationsCount":41},"100593141","evaluation-of-the-effectiveness-of-ipack-and-adductor-canal-blocks-on-patients-undergoing-arthroscopic-knee-surgery-100593141","NCT07002580","Evaluation of the Effectiveness of iPACK and Adductor Canal Blocks on Patients Undergoing Arthroscopic Knee Surgery","Evaluation of the Effectiveness of iPACK (Local Anesthetic Infiltration of the Interspace Between the Popliteal Artery and the Posterior Knee Capsule) and Adductor Canal Blocks on Quality of Recovery in Patients Undergoing Arthroscopic Knee Surgery","Inclusion Criteria:\n\n* Patients aged between 18 and 50 years,\n* Scheduled for arthroscopic knee surgery under spinal anesthesia due to knee pathology\n* Patients classified as ASA physical status I-II-III according to the American Society of Anesthesiologists risk classification\n\nExclusion Criteria:\n\n* Coagulopathy\n* ASA IV-V patients\n* Uncooperable patients\n* Patients who refuses to participate in study\n* Patients who takes chronic pain treatments","50 Years",{"count":291,"type":22},[25],"Arthroscopic knee surgery is one of the most commonly performed procedures in orthopedic surgery. More than 50% of patients experience moderate to severe pain after the operation. Inadequate postoperative pain control and poor recovery quality can negatively impact physiotherapy protocols, prolong hospital stays, and consequently lead to cognitive dysfunction, systemic infections, and increased healthcare costs.\n\nTherefore, reducing postoperative pain and improving recovery quality are of great importance. In our clinic, a variety of analgesic techniques are routinely employed as part of a multimodal analgesia approach for patients undergoing arthroscopic knee surgery. One of these techniques is the simultaneous application of the IPACK block and the adductor canal block.\n\nIn this study, we aim to evaluate the effectiveness of these blocks on postoperative recovery quality in patients undergoing arthroscopic knee surgery.",[609],"Patients Undergoing Arthroscopic Knee Surgery",[611,612,613,614,615,218],"Arthroscopic Knee Surgery","Perifheric Nerve Block","Analgesia","iPACK","Adductor Canal Block","2026-02-03",{"date":592,"type":33},{"date":619,"type":33},"2025-07-01",{"date":458,"type":22},{"name":39,"class":40},{"id":623,"slug":624,"hasResults":12,"nctId":625,"briefTitle":626,"officialTitle":626,"acronym":4,"eligibilityCriteria":627,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":175,"enrollmentInfo":628,"targetDuration":4,"studyType":23,"phases":629,"briefSummary":630,"conditions":631,"keywords":633,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":637,"lastUpdatePostDateStruct":638,"startDateStruct":640,"completionDateStruct":641,"leadSponsor":642,"locationsCount":4},"100613637","impact-of-ultrasound-guidance-on-central-neuraxial-block-success-in-patients-with-non-palpable-vertebral-anatomy-100613637","NCT07269184","Impact of Ultrasound Guidance on Central Neuraxial Block Success in Patients With Non-Palpable Vertebral Anatomy","Inclusion Criteria:\n\n* Scheduled for elective general surgery\n* Planned epidural catheterization\n* Aged 18-60 years\n* ASA physical status I-III\n* Spinous processes not palpable (class3)\n\nExclusion Criteria:\n\n* Contraindication to epidural catheterization\n* ASA physical status IV-V\n* Diagnosed with scoliosis\n* Presence of anatomical deformities\n* Declining to participate in the study\n* Patients for whom follow-up conditions cannot be ensured",{"count":21,"type":22},[25],"Patients scheduled to undergo general surgery with planned epidural catheter placement will be evaluated by comparing two different techniques routinely used in anesthesia practice for catheter insertion.\n\nA total of 60 patients aged 18-60 years, classified as ASA I-III, and scheduled to undergo general surgical procedures with epidural catheter placement at Sakarya University Faculty of Medicine Training and Research Hospital will be included in the study. All patients will be classified according to the following palpation scoring system to assess the difficulty of vertebral palpation:\n\nPalpation Score: All patients will be evaluated in the sitting position, and the difficulty of palpating vertebral landmarks will be scored between 0 and 3:\n\n0: Spinous processes and interspinous spaces are clearly identifiable\n\n1. Spinous processes are palpable, but interspinous spaces are not clearly identifiable\n2. Spinous processes are not palpable, interspinous spaces are not identifiable, but the vertebral column can be palpated either on or off the midline\n3. Spinous processes and interspinous spaces are not palpable, and vertebral structures are not clearly distinguishable Patients with a palpation score of 3 will be included in the study group. Patients with a score of 0 will be included as the control group.\n\nPatients will be divided into two groups: Anatomical Landmark Group and Ultrasound Group.\n\nIn the Ultrasound Group, surface marking will be performed in the operating room using ultrasonography.\n\nIn the Anatomical Landmark Group, after the patient is positioned sitting in the operating room, the insertion site will be estimated by palpation of anatomical landmarks.\n\nAfter determining the needle entry point in both groups, epidural catheterization will be performed under sterile conditions according to our routine practice. The two groups will be compared in terms of first-attempt success rate, total procedure time, number of needle redirections, and complications occurring during the procedure.",[208,632],"Ultrasound Assistance",[634,635,636],"epidural","ultrasound","non-palpable spinous processes","2025-12-05",{"date":639,"type":33},"2025-12-08",{"date":278,"type":22},{"date":164,"type":22},{"name":39,"class":40},{"id":644,"slug":645,"hasResults":12,"nctId":646,"briefTitle":647,"officialTitle":648,"acronym":4,"eligibilityCriteria":649,"healthyVolunteers":12,"sex":17,"minAge":650,"maxAge":469,"enrollmentInfo":651,"targetDuration":4,"studyType":23,"phases":652,"briefSummary":653,"conditions":654,"keywords":656,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":662,"lastUpdatePostDateStruct":663,"startDateStruct":664,"completionDateStruct":666,"leadSponsor":668,"locationsCount":4},"100613538","nebulized-lidocaine-vs-3-sodium-chloride-in-pediatric-adenoidtonsil-surgery-100613538","NCT07267897","Nebulized Lidocaine vs 3% Sodium Chloride in Pediatric Adenoid\u002FTonsil Surgery","The Effect of Preoperative Nebulized Lidocaine and Nebulized 3% NaCl Premedication on Postoperative Respiratory Complications in Pediatric Patients Undergoing Adenoidectomy and\u002For Adenotonsillectomy Surgery","Inclusion Criteria:\n\n* Patients who agree to participate in the study\n* Patients undergoing adenoidectomy or adenotonsillectomy\n* Patients with ASA physical status 1-2\n* Children aged 18 months to 16 years\n\nExclusion Criteria:\n\n* Patients who do not agree to participate in the study\n* Patients with allergy to lidocaine or 3% NaCl\n* Patients with ASA physical status 3-4\n* Patients whose surgery duration exceeds 1 hour","18 Months",{"count":203,"type":22},[25],"This prospective, randomized clinical trial aims to evaluate the effect of preoperative nebulized lidocaine and nebulized 3% hypertonic sodium chloride (NaCl) on the incidence of postoperative respiratory complications in pediatric patients undergoing adenoidectomy and\u002For adenotonsillectomy. Lidocaine, a versatile sodium channel blocker, has shown antitussive, bronchodilatory, and anti-inflammatory benefits when nebulized, and has been safely used in children for respiratory procedures. Hypertonic 3% NaCl is known to improve mucociliary clearance, reduce airway edema, and enhance secretion mobilization, particularly in pediatric respiratory conditions. Both agents have demonstrated individual safety and efficacy in respiratory management, yet their preoperative nebulized use for preventing postoperative respiratory adverse events (PRAEs) in pediatric airway surgery has not been previously studied. This trial seeks to determine whether preoperative nebulization with these agents can reduce postoperative respiratory complications, improve recovery, and enhance perioperative safety in this high-risk population.",[655],"Postoperative Respiratory Complication",[655,657,658,659,660,661],"Lidocaine","%3 Sodium Chloride","Pediatric","Adenoidectomy","Adenotonsillectomy","2025-11-25",{"date":637,"type":33},{"date":665,"type":22},"2026-03-15",{"date":667,"type":22},"2026-10-15",{"name":39,"class":40},{"id":670,"slug":671,"hasResults":12,"nctId":672,"briefTitle":673,"officialTitle":674,"acronym":4,"eligibilityCriteria":675,"healthyVolunteers":12,"sex":17,"minAge":676,"maxAge":677,"enrollmentInfo":678,"targetDuration":4,"studyType":23,"phases":679,"briefSummary":680,"conditions":681,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":684,"lastUpdatePostDateStruct":685,"startDateStruct":687,"completionDateStruct":689,"leadSponsor":690,"locationsCount":4},"100611700","impact-of-neuromonitoring-on-postoperative-agitation-in-pediatric-general-anesthesia-100611700","NCT07243990","Impact of Neuromonitoring on Postoperative Agitation in Pediatric General Anesthesia","The Effect of Neuromonitoring on the Incidence of Postoperative Agitation in Pediatric Patients Undergoing General Anesthesia","Inclusion Criteria:\n\nPatients aged 6-12 years\n\nWithout chronic comorbid conditions\n\nNo history of epilepsy\n\nPresenting for surgery with preserved consciousness, oriented and cooperative\n\nExclusion Criteria:\n\nIntracranial surgeries\n\nIntellectual disability\n\nEmergency trauma cases\n\nForehead area unsuitable for electrode placement","6 Years","12 Years",{"count":106,"type":22},[25],"Postoperative agitation is frequently observed in the pediatric patient group following general anesthesia. The exact cause of this agitation has not been clearly determined; however, it may be associated with various factors such as anesthesia depth, family approach, postoperative pain, or unpleasant odors perceived by the child. The depth of anesthesia is indirectly monitored by observing the patient's blood pressure, heart rate, and oxygen saturation, as well as by assessing the alveolar concentration of the inhalation agent. Patients under anesthesia are in a state of deep sleep. In recent years, this sleep state has begun to be monitored more closely with the development of new devices.\n\nElectroencephalography (EEG) is a test that records and measures the brain's electrical activity, providing information about the depth of sleep according to the patient's brain activity. The Density Spectral Array (DSA) device, developed for use in operating rooms, facilitates the interpretation of EEG data and guides the anesthesiologist. In our operating room, patients under anesthesia are also monitored using this device.\n\nOur aim is to evaluate emergence agitation in patients monitored with this device compared to those who are not monitored.",[682,683],"Postoperative Agitation","Emergence Delirium, Anesthesia","2025-11-21",{"date":686,"type":33},"2025-11-24",{"date":688,"type":22},"2025-12-30",{"date":223,"type":22},{"name":39,"class":40},""]