[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"San Diego State University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":650},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,39,0,25,[9,62,89,119,147,169,193,224,249,276,307,340,359,389,417,438,460,479,506,528,558,577,597,616,635],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":32,"overallStatus":49,"whyStopped":4,"lastUpdateSubmitDate":50,"lastUpdatePostDateStruct":51,"startDateStruct":54,"completionDateStruct":56,"leadSponsor":58,"locationsCount":61},"100630369","taabo-tutoring-study-100630369",false,"NCT07486778","Taabo Tutoring Study","Tutoring and Targeting to Reduce Secondary School Dropout in Côte d'Ivoire","Inclusion Criteria (Substudy 1)\n\n* Enrolled in Grade 10 (troisième) during the 2025\u002F26 school year in one of the 25 participating lower secondary schools.\n* Identified by school principals as weak performers at high risk of failing the final grade 10 exam (based on exam scores, teacher assessments, or internal academic performance indicators).\n* Males or females, aged 12 years or older at enrollment.\n* Residing in the Taabo HDSS catchment area.\n* Able to participate in small-group tutoring sessions.\n* Parent or guardian provides written informed consent for minors; student provides written assent.\n\nInclusion Criteria (Substudy 2)\n\n* Attended Grades 7-9 (6e, 5e, or 4e) during the 2025\u002F26 academic year.\n* Did not re-enroll in any lower secondary school at the start of the 2026\u002F27 academic year, verified through school records and home visits.\n* Males or females aged 12 years or older at enrollment.\n* Residing in the Taabo HDSS catchment area.\n* Able to participate in tutoring sessions organized after recruitment.\n* Parent or legal guardian provides written informed consent for minors; student provides written assent.\n\nExclusion Criteria (both substudies)\n\n* Individuals with severe cognitive or physical disabilities that would prevent meaningful participation in tutoring, based on information from parents, principals, and teachers.\n* Adolescents or families planning to move out of the study area during the intervention period.\n* For Substudy 2 only: adolescents who have already enrolled in an alternative education or vocational training programme at baseline.","ALL","12 Years",{"count":20,"type":21},1000,"ESTIMATED","INTERVENTIONAL",[24],"NA","Secondary school completion rates remain low in many low- and middle-income countries, including Côte d'Ivoire. Limited progression through lower secondary education may affect future educational and employment opportunities. In rural areas, pass rates on the Grade 10 national examination are modest, and some students leave school before completing lower secondary education. This study will evaluate whether tutoring improves academic outcomes and school continuation in the Taabo region of Côte d'Ivoire.\n\nApproximately 1,000 adolescents will participate in two related substudies. The first substudy will include 500 Grade 10 students identified by schools as being at risk of not passing the national examination. The second substudy will include 500 adolescents who previously attended Grades 7-9 but are not currently enrolled in school. Within each substudy, participants will be randomly assigned to one of three groups: peer tutoring, teacher tutoring, or no additional tutoring (control group).\n\nStudents assigned to tutoring may receive up to 15 sessions over approximately 6 to 8 months. Tutoring sessions will focus on reviewing core curriculum content, preparing for examinations, and strengthening academic skills.\n\nThe primary outcomes are (1) passing the Grade 10 national examination and (2) enrollment in lower secondary school in the following academic year. Secondary outcomes include grade progression, study time, academic confidence, cost-effectiveness of the tutoring models, academic and well-being outcomes among peer tutors, and other longer-term outcomes (educational attainment, early family formation, mental health).",[27,28,29,30,31],"Secondary School Entry and Completion","Education Advancement","School Attendance","Educational Attainment","Academic Performance",[33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48],"Secondary education","School completion","Grade 10 national examination","Tutoring intervention","Peer tutoring","Teacher tutoring","Randomized controlled trial","Education intervention","Academic achievement","School enrollment","School re-enrollment","Lower secondary school","Adolescents","Côte d'Ivoire","Sub-Saharan Africa","Cost-effectiveness","NOT_YET_RECRUITING","2026-06-30",{"date":52,"type":53},"2026-07-02","ACTUAL",{"date":55,"type":21},"2026-09",{"date":57,"type":21},"2041-08",{"name":59,"class":60},"San Diego State University","OTHER",1,{"id":63,"slug":64,"hasResults":12,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":4,"eligibilityCriteria":68,"healthyVolunteers":12,"sex":69,"minAge":4,"maxAge":4,"enrollmentInfo":70,"targetDuration":4,"studyType":22,"phases":72,"briefSummary":73,"conditions":74,"keywords":76,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":61},"100530274","elucidating-the-minimal-effective-dose-of-prunes-for-bone-health-in-postmenopausal-women-100530274","NCT06184646","Elucidating the Minimal Effective Dose of Prunes for Bone Health in Postmenopausal Women","Effect of Calcium and Vitamin D Supplements and\u002For Prunes on Bone Health","Inclusion Criteria:\n\n* Postmenopausal\n* BMD t-score is between 0.5 and 2 SD below the mean\n* Not on hormone replacement therapy (HRT) and\u002For other pharmacological agents known to affect bone for at least three months prior to initiation of the study\n\nExclusion Criteria:\n\n* Women whose BMD t-score at any site falls below 2.5 SD of the mean\n* Subjects receiving endocrine (e.g., prednisone, other glucocorticoids) or neuroactive (e.g., dilantin, phenobarbital) drugs or any drugs known to influence bone and calcium metabolism\n* Subjects who smoke cigarettes or vape\n* Regular consumption of dried plum or prune juice","FEMALE",{"count":71,"type":21},200,[24],"The objective of this study is to examine if calcium and vitamin D supplements and\u002For prune can prevent bone loss in postmenopausal women.",[75],"Bone Disease, Metabolic",[77,78,79],"Osteopenia","Prune","Functional food","RECRUITING","2026-06-29",{"date":83,"type":53},"2026-07-01",{"date":85,"type":53},"2024-03-15",{"date":87,"type":21},"2028-12",{"name":59,"class":60},{"id":90,"slug":91,"hasResults":12,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":97,"sex":17,"minAge":98,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":22,"phases":101,"briefSummary":102,"conditions":103,"keywords":106,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":61},"100642848","teen-helpline-motivational-interviewing-study-100642848","NCT07639736","Teen Helpline Motivational Interviewing Study","Using Performance Feedback and Facilitation to Integrate Motivational Interviewing in Teen Helpline Services","MI","Inclusion Criteria\n\nTeen Helpers\n\n* Current helpline peer helpers\n* Aged 14-19 years.\n* Provides assent and documented parental consent (when applicable).\n* Completes study measures prior to the first Motivational Interviewing (MI) training session.\n* Attends and completes assigned MI training activities.\n* Has access to technology required for online participation (computer, tablet, or smartphone with internet access; videoconferencing capability if needed).\n* Plans to continue helpline activities throughout the study period.\n\nTeen Users\n\n* Aged 13-19 years.\n* Current U.S. resident.\n* Has engaged in at least 20 back-and-forth text exchanges with a helpline volunteer.\n* Demonstrates active communication and engagement on the helpline platform.\n* Has access to technology required to complete online surveys and, if selected, interviews (computer, tablet, or smartphone with internet access).\n\nExclusion Criteria\n\nTeen Helpers\n\n\\- Plans to discontinue helpline activities within the next 8 months.\n\nTeen Users\n\n* Identified as currently experiencing acute suicide risk (i.e., assigned a \"high-risk\" flag by the helpline algorithm or identified as high risk by helpline staff).\n* Requires immediate crisis intervention or emergency services that could be disrupted by participation in the research study.",true,"13 Years",{"count":100,"type":21},206,[24],"The proposed study will establish a foundation for research within peer-delivered helplines for teens. It aims to evaluate the impact of a Motivational Interviewing training at peer-to-peer helpline. The study will leverage emerging technologies to surmount the challenges of providing tailored training to a large and diverse mental health workforce at scale.\n\nAim 1: Adapt Motivational Interviewing (MI) strategies for use in a teen peer-delivered text-based digital helpline.\n\nAim 2: Co-design performance feedback (PF) and facilitated practice (FP) processes to support MI adherence among peer helpers.\n\nAim 3: Examine feasibility, acceptability, and initial outcomes in a pilot feasibility trial. Peer helpers (N=50) will be randomized to receive MI training or MI training + PF-FP.",[104,105],"Implementation Research","Help Seeking",[107,108,109,110],"Adolescent mental health","Implementation Science","Motivational Interviewing","Mental health helplines","2026-06-22",{"date":113,"type":53},"2026-06-25",{"date":115,"type":53},"2025-08-28",{"date":117,"type":21},"2029-10-31",{"name":59,"class":60},{"id":120,"slug":121,"hasResults":12,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":125,"eligibilityCriteria":126,"healthyVolunteers":12,"sex":17,"minAge":127,"maxAge":4,"enrollmentInfo":128,"targetDuration":4,"studyType":22,"phases":130,"briefSummary":131,"conditions":132,"keywords":135,"overallStatus":49,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":142,"completionDateStruct":144,"leadSponsor":146,"locationsCount":61},"100585305","pilot-of-an-intervention-to-reduce-alcohol-use-and-improve-art-adherence-among-men-living-with-hiv-with-pregnant-partners-in-uganda-100585305","NCT06900634","Pilot of an Intervention to Reduce Alcohol Use and Improve ART Adherence Among Men Living With HIV With Pregnant Partners in Uganda.","Utilizing Implementation Research Methodologies to Adapt an Intervention to Reduce Alcohol Use and Improve HIV Care Outcomes Among Men Living With HIV Who Have Serodiscordant Pregnant Partners","Kisoboka Amaka","Inclusion Criteria:\n\nFOR MEN\n\n1. living with HIV;\n2. AUDIT-C positive (≥4) indicating potential hazardous drinking;\n3. \\>6 months since initial antiretroviral treatment (ART) initiation;\n4. an indicator of potential suboptimal treatment as prevention (TasP) either: (i) last HIV viral load test (within 6 months) was detectable (\\>20) or (ii) last viral load test between 6 and 13 months ago was detectable (\\>20) and reports missing ≥2 ART doses in the past 2 weeks or (iii) a lack of viral load test results for the prior 13 months in clinic records and reports missing ≥2 ART doses in the past 2 weeks\n5. not planning to move from the area within the next 6 months;\n6. have their own mobile phone and can be reached via phone.\n\nFOR WOMEN\n\n1. 18+ years of age (or emancipated minor)\n2. Pregnant\n3. HIV negative\n\nFOR COUPLES (IF INDIVIDUAL ELIGIBILITY CRITERIA ABOVE ARE MET)\n\n1. married\u002Fliving together \\>6 months;\n2. planning to stay together \\>6 months\n3. lived in the area for \\>3 months and\n4. not planning to move within \\\u003C6 months.\n5. similar responses on Couple Verification Screening (CVS) form, an instrument to determine if couples are legitimate (e.g., asking each person what they ate the last time they shared a meal with their partner).\n\nExclusion Criteria:\n\nFOR MEN\n\n1. visibly intoxicated at enrollment (eligible to enroll when not intoxicated);\n2. does not speak Luganda or English;\n3. currently receiving a majority of work payments via mobile money\u002Fdigital payments;\n4. participated in the Kisoboka pilot RCT;\n5. unable to read basic Luganda or English\n\nFOR WOMEN For safety purposes, we will not enroll women who do not feel they can safely participate in the study.","18 Years",{"count":129,"type":21},60,[24],"Hazardous alcohol use, which is common among men in Uganda, is a primary driver of both HIV risk and intimate partner violence (IPV) in this setting. Among men living with HIV, alcohol use is associated with non-adherence to antiretroviral therapy (ART) and a detectable viral load, increasing the risk of onward HIV transmission to partners. This risk is further heightened when the partner is pregnant, due to the potential for vertical transmission. Therefore, addressing factors that interfere with optimal HIV care outcomes among men living with HIV is critical to HIV prevention in pregnant women.\n\nThe goal of this randomized controlled trial (RCT) is to pilot test an intervention that combines alcohol reduction and economic strengthening to improve ART adherence. The study will assess implementation outcomes and preliminary efficacy among men living with HIV who engage in hazardous alcohol use and their pregnant partners (n=30 couples). The main questions it aims to answer are:\n\n1. What are the implementation outcomes (acceptability, appropriateness, feasibility, fidelity, and safety) at the individual, implementer, and organizational levels, and what bridging factors may impede success (e.g., community-academic partnership)?\n2. Does the intervention reduce hazardous alcohol use and improve ART adherence among men living with HIV?\n\nResearchers will compare the intervention group (n=15 couples) to the standard of care group (n=15 couples) to determine if the intervention leads to behavior change in alcohol use and ART adherence among men living with HIV.\n\nParticipants will:\n\n1. Men in the intervention group will receive the Amaka intervention, designed to reduce alcohol use and improve ART adherence.\n2. Complete assessments on hazardous alcohol use, ART adherence, and implementation outcomes at multiple time points (baseline, 3 and 6 months).\n3. Engage with implementers to provide post-implementation feedback on feasibility and acceptability.",[133,134],"HIV Antiretroviral Therapy (ART) Adherence","Alcohol Consumption",[136,137,138,139],"hiv","motivational interviewing","behavioral economics","alcohol use disorder","2026-06-17",{"date":111,"type":53},{"date":143,"type":21},"2027-02-01",{"date":145,"type":21},"2028-02-01",{"name":59,"class":60},{"id":148,"slug":149,"hasResults":12,"nctId":150,"briefTitle":151,"officialTitle":152,"acronym":153,"eligibilityCriteria":154,"healthyVolunteers":12,"sex":17,"minAge":127,"maxAge":155,"enrollmentInfo":156,"targetDuration":4,"studyType":22,"phases":158,"briefSummary":159,"conditions":160,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":61},"100532131","creatine-supplementation-in-concussion-recovery-100532131","NCT06208813","Creatine Supplementation in Concussion Recovery","Assigned Creatine Ingestion With Usual Diet or Usual Diet Alone.","CSCR","Inclusion Criteria:\n\n* 18-35 years old with a diagnosed concussion within 72 hours post-injury\n\nExclusion Criteria:\n\n* Learning disability, renal disease, mental behavior or migraine history, and current creatine use or have not taken creatine in the past 6 weeks","35 Years",{"count":157,"type":21},20,[24],"The proposed study aims to compare concussion recovery in those supplementing creatine and those not supplementing creatine. Specific aim 1: To compare number of days until asymptomatic between those taking creatine vs. those not taking creatine following a concussion. Hypothesis: The investigators hypothesize that individuals taking creatine will become asymptomatic sooner than those not taking creatine.Specific aim 2: To compare typical concussion assessment scores (i.e., symptom score, mental status, neurocognition, balance, motor coordination, and visual performance) between those taking creatine vs those not taking creatine following a concussion once asymptomatic.Hypothesis: The investigators hypothesize that individuals taking creatine will have better symptom scores, balance, mental status, and neurocognition assessment scores than those not taking creatine once asymptomatic.\n\nThe investigators will calculate descriptive statistics for all demographic, days to asymptomatic, and concussion assessments. For specific aim 1, The investigators will calculate a t-test to determine if days to asymptomatic differed in those taking creatine vs. those not taking creatine. For specific aim 2, the investigators will calculate t-tests with Bonferonni corrections to determine if concussion assessment scores (Sport Concussion Office Assessment Tool-6 assessments, CNS Vital Signs, visual assessment) differed in those taking creatine vs. those not taking creatine.",[161],"Concussion, Brain",{"date":163,"type":53},"2026-06-18",{"date":165,"type":53},"2024-02-01",{"date":167,"type":21},"2027-05-31",{"name":59,"class":60},{"id":170,"slug":171,"hasResults":12,"nctId":172,"briefTitle":173,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":97,"sex":17,"minAge":176,"maxAge":177,"enrollmentInfo":178,"targetDuration":4,"studyType":22,"phases":179,"briefSummary":180,"conditions":181,"keywords":183,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":185,"lastUpdatePostDateStruct":186,"startDateStruct":188,"completionDateStruct":190,"leadSponsor":192,"locationsCount":61},"100417190","implementation-supports-to-reduce-burnout-in-therapists-delivering-child-trauma-ebps-100417190","NCT04712461","Implementation Supports to Reduce Burnout in Therapists Delivering Child Trauma EBPs","SUPPORTS","Inclusion Criteria:\n\n* Therapists who have delivered a (or components of a) trauma EBP to a child in the past year.\n\nExclusion Criteria:\n\n* Therapists employed at their current agency for less than 6 months.","3 Years","99 Years",{"count":129,"type":21},[24],"The majority of children exposed to early adversity and trauma do not have access to sustainably delivered evidence-based mental health programs (EBPs), despite the growing prevalence of large-scale multiple-EBP implementation efforts aimed at increasing access to these services. The objective of this proposal is to develop and test a package of implementation strategies designed to promote the sustained delivery of child trauma EBPs by reducing provider turnover through targeting the associated mechanisms of provider burnout and organizational psychological safety climate. Findings will have a significant public health impact by informing efforts to increase the sustained availability of child trauma EBPs, thereby improving outcomes for children exposed to trauma.",[182],"Mental Health Issue",[184],"Mental Health","2026-06-04",{"date":187,"type":53},"2026-06-08",{"date":189,"type":53},"2023-01-01",{"date":191,"type":21},"2027-05-01",{"name":59,"class":60},{"id":194,"slug":195,"hasResults":12,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":4,"eligibilityCriteria":199,"healthyVolunteers":12,"sex":17,"minAge":127,"maxAge":4,"enrollmentInfo":200,"targetDuration":4,"studyType":22,"phases":202,"briefSummary":203,"conditions":204,"keywords":208,"overallStatus":49,"whyStopped":4,"lastUpdateSubmitDate":217,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":221,"leadSponsor":223,"locationsCount":61},"100571800","trans-stair-implementing-an-evidence-based-trauma-treatment-with-community-led-prep-navigation-100571800","NCT06724965","Trans STAIR: Implementing an Evidence Based Trauma Treatment With Community Led PrEP Navigation","Trans STAIR: Implementing an Evidence Based Trauma Treatment With Community Led PrEP Navigation for Transgender and Nonbinary Persons Affected by Violence","Inclusion Criteria:\n\n* identify as transgender or nonbinary (non-cisgender)\n* be age 18 or older\n* confirmed HIV-negative status\n* eligible for PrEP based on CDC guidelines\n* indication of clinically significant PTSD or depressive symptoms\n* ability to speak and read in English and\u002For Spanish\n\nExclusion Criteria:\n\n* under 18 years old\n* cognitively impaired to the extent that it limits ability to consent\n* currently in a relationship or home where violence is occurring",{"count":201,"type":21},90,[24],"This pilot trial will leverage \"PrEP Well,\" an ongoing multi-level implementation strategy for providing PrEP in transgender\u002Fgender diverse (TGD)-serving contexts by integrating peer-led PrEP navigation with programming that addresses other social and structural needs of the TGD community (e.g., housing, legal, employment, gender-affirmation, primary care). PrEP Well has been implemented at the Trans Wellness Center (TWC) in LA since 2021. TWC is a first-of-its-kind community-led, trans-affirming, TGD community center made up of 5 community-based TGD service organizations that serve the local racially and ethnically diverse TGD community. Together with our community and implementation partners this NIMH-funded R34 will adapt evidence-based Skills Training in Affect and Interpersonal Regulation (STAIR) into a trans-affirming, culturally appropriate trauma treatment for TGD persons affected by HIV and violence (Trans STAIR); evaluate the acceptability, appropriateness, and feasibility of the Trans STAIR intervention (Phase 1 beta test; Aim 1); and conduct a Type 1: Hybrid Effectiveness-Implementation pilot randomized controlled trail (Phase 2 pilot RCT; Aims 2 and 3) of PrEP Well + Trans STAIR vs. PrEP Well alone to provide preliminary support for a fully powered larger multisite R01 to test the efficacy of PrEP Well + Trans STAIR.",[205,206,207],"PrEP Uptake Experiences","PrEP Adherence Experiences","Mental Health Symptoms",[209,210,211,184,212,213,214,215,216],"PrEP","HIV prevention","Trauma","PrEP adherence","PrEP uptake","STAIR","Skills Training in Affect and Interpersonal Regulation","Trauma Treatment","2026-05-29",{"date":219,"type":53},"2026-06-01",{"date":55,"type":21},{"date":222,"type":21},"2026-12",{"name":59,"class":60},{"id":225,"slug":226,"hasResults":12,"nctId":227,"briefTitle":228,"officialTitle":229,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":12,"sex":17,"minAge":127,"maxAge":4,"enrollmentInfo":231,"targetDuration":4,"studyType":22,"phases":233,"briefSummary":234,"conditions":235,"keywords":238,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":245,"completionDateStruct":246,"leadSponsor":248,"locationsCount":61},"100573964","be-well-at-work-plus-a-depression-and-physical-activity-intervention-for-hospital-service-workers-aim-2-100573964","NCT06753123","Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 2)","Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers.","Inclusion Criteria:\n\n* part-time or full-time employment (at least 20 hours per week);\n* ≥18 years old;\n* employed in low-wage-earning jobs in the Environmental Services or Food \\& Nutrition Services Departments;\n* presence of depression symptoms as measured by the Patient Health Questionnaire-9 item version; individuals who score ≥5 (indicating mild depression symptoms or higher) will be eligible;\n* presence of impairment in work functioning, as measured by the Work Limitations Questionnaire; individuals who score ≥5% (indicating mild work productivity loss) will be eligible;\n* possession of a cell phone with ability to receive text-messages;\n* Fluent in either English or Spanish.\n\nExclusion Criteria:\n\n* plan to leave Scripps employment in \\\u003C6 months;\n* severe mental illness or substance use condition (e.g., bipolar disorder, schizophrenia, active alcohol use disorder)",{"count":232,"type":21},10,[24],"This study develops and tests a dynamic workplace-based depression intervention that is tailored to the specific social and behavioral needs of low-wage hospital service workers. The intervention involves assessment of depression-related work impairment, work-focused cognitive behavioral therapy, work coaching, social needs screening and referral, and text message support for mood and physical activity.",[236,237],"Depression","Physical Inactivity",[236,239,240,241,242],"Physical Activity","Employees","Low-income","Social needs","2026-05-28",{"date":219,"type":53},{"date":243,"type":53},{"date":247,"type":21},"2026-07-31",{"name":59,"class":60},{"id":250,"slug":251,"hasResults":12,"nctId":252,"briefTitle":253,"officialTitle":254,"acronym":255,"eligibilityCriteria":256,"healthyVolunteers":12,"sex":257,"minAge":127,"maxAge":4,"enrollmentInfo":258,"targetDuration":4,"studyType":22,"phases":260,"briefSummary":261,"conditions":262,"keywords":267,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":268,"lastUpdatePostDateStruct":269,"startDateStruct":271,"completionDateStruct":273,"leadSponsor":275,"locationsCount":61},"100575404","reducing-hazardous-alcohol-use-and-optimizing-treatment-as-prevention-among-men-living-with-hiv-in-risk-environments-100575404","NCT06771843","Reducing Hazardous Alcohol Use and Optimizing Treatment as Prevention Among Men Living With HIV in Risk Environments","Kisoboka: Reducing Hazardous Alcohol Use and Optimizing Treatment as Prevention Among Men Living With HIV in Risk Environments","Kisoboka","Inclusion Criteria:\n\n1. living with HIV;\n2. residing in a fishing community (on most days\u002Fnights);\n3. AUDIT-C positive (≥4) indicating potential hazardous drinking;\n4. \\>6 months since initial antiretroviral treatment (ART) initiation;\n5. not planning to move from the area within the next 6 months;\n6. have their own mobile phone and can be reached via phone.\n7. an indicator of potential suboptimal treatment as prevention (TasP) either:\n\n(i) last HIV viral load test (within 6 months) was detectable (\\>20) or (ii) last viral load test between 6 and 13 months ago was detectable (\\>20) and reports missing ≥2 ART doses in the past 2 weeks or (iii) a lack of viral load test results for the prior 13 months in clinic records and reports missing ≥2 ART doses in the past 2 weeks;\n\nExclusion Criteria:\n\n1. visibly intoxicated at enrollment (eligible to enroll when not intoxicated);\n2. does not speak Luganda or English;\n3. currently receiving a majority of work payments via mobile money\u002Fdigital payments;\n4. participated in the Kisoboka pilot RCT;\n5. unable to read basic Luganda or English","MALE",{"count":259,"type":21},716,[24],"The investigators developed the Kisoboka (\"It is possible\") Intervention to address limitations of existing evidence-based interventions to optimize treatment as prevention among men living with HIV who drink alcohol at hazardous levels in \"risk environments\" such as fishing communities through reductions in hazardous alcohol use, improved adherence to HIV medications and achieving undetectable HIV viral loads.\n\nSocial and structural determinants unique to fishing communities interact to create a risk environment where hazardous drinking impedes adherence to HIV medications among men living with HIV, including prevalent social norms of drinking, drinking as a way of experiencing \"reward\" and connecting with others (e.g. in the context of transactional sex), stressful work conditions, a \"live for today\" outlook, and a cash-based economy with no traditional savings infrastructure leading to ease of daily expenditure on drinking and sex work. These social and environmental conditions result in high levels of alcohol misuse and HIV risk, poor HIV outcomes, and exacerbation of HIV-associated wellness comorbidities such as poor mental and subjective physical health and food insecurity.\n\nThe goal of this study is to learn if the intervention called Kisoboka works to help men in fishing communities reduce hazardous alcohol use, be better able to take the participants HIV medication as prescribed, and have undetectable HIV viral loads. The investigators will compare the Kisoboka intervention to a brief alcohol screening, adherence counseling, and referrals, and to components of the Kisoboka intervention.\n\nParticipants will attend intervention counseling sessions according to the study arm to which the participants are randomly assigned. The number of sessions ranges from 1 to 6 over 1 to 16 weeks and are individual only or both individual and group sessions.",[133,263,264,265,266],"Alcohol Abuse","HIV Infection","Alcohol Use Disorder","HIV Infections",[138,137],"2026-05-11",{"date":270,"type":53},"2026-05-12",{"date":272,"type":53},"2025-06-16",{"date":274,"type":21},"2029-02",{"name":59,"class":60},{"id":277,"slug":278,"hasResults":12,"nctId":279,"briefTitle":280,"officialTitle":281,"acronym":4,"eligibilityCriteria":282,"healthyVolunteers":12,"sex":69,"minAge":283,"maxAge":284,"enrollmentInfo":285,"targetDuration":4,"studyType":22,"phases":287,"briefSummary":288,"conditions":289,"keywords":292,"overallStatus":49,"whyStopped":4,"lastUpdateSubmitDate":300,"lastUpdatePostDateStruct":301,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":306,"locationsCount":61},"100582626","collaborative-research-multiscale-modeling-and-intervention-for-improving-long-term-medication-100582626","NCT06865755","Collaborative Research: Multiscale Modeling and Intervention for Improving Long-Term Medication","Deploying and Evaluating a Technology Based System to Help People Adhere to Long Term Medications","Inclusion Criteria:\n\n* are English-speaking and reading;\n* are between ages 21 and 70 years;\n* are diagnosed with stage 0-3 breast cancer in the past 5 years;\n* have completed all surgery, radiation, and chemotherapy, except endocrine therapy;\n* are prescribed endocrine therapy;\n* do not have a physical impairment that would prevent them from using the MM system;\n* are able to provide informed consent;\n* are willing and able to use the MM system for 6 months;\n* have an Iphone or Android phone.","21 Years","70 Years",{"count":286,"type":21},15,[24],"The goal of this study is to learn about the impact of an integrated medication monitoring system in breast cancer survivors aged 21-70 who are prescribed endocrine therapy. The main question it aims to address is: Does the integrated medication monitoring system improve medication adherence among breast cancer survivors when used over a six-month period?\n\nFifteen English-speaking breast cancer survivors who meet the inclusion criteria will use a combination of smartphone-based ecological momentary assessments, a medication event monitoring system (Wisepill), and a wearable sensor (Fitbit). After 2 months, participants will be provided personalized content to facilitate medication adherence through an app (Digital Trails) and through WisePill. Participants will complete online surveys at baseline, 3 months, and 6 months to assess their experiences and adherence.",[290,291],"Breast Cancer Survivor","Breast Cancer Early Stage Breast Cancer (Stage 1-3)",[293,294,295,296,297,298,299],"Single-Arm Study Design","Medication Event Monitoring System (MEMS)","Medication Adherence","Breast Cancer Survivors","Personalized Interventions","endocrine therapy","mobile health","2026-04-22",{"date":302,"type":53},"2026-04-27",{"date":304,"type":21},"2026-07",{"date":222,"type":21},{"name":59,"class":60},{"id":308,"slug":309,"hasResults":12,"nctId":310,"briefTitle":311,"officialTitle":311,"acronym":312,"eligibilityCriteria":313,"healthyVolunteers":97,"sex":17,"minAge":127,"maxAge":4,"enrollmentInfo":314,"targetDuration":4,"studyType":22,"phases":315,"briefSummary":316,"conditions":317,"keywords":321,"overallStatus":49,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":335,"completionDateStruct":337,"leadSponsor":339,"locationsCount":61},"100635568","a-multilevel-intervention-to-prevent-noise-exposure-in-farmworkers-100635568","NCT07554378","A Multilevel Intervention to Prevent Noise Exposure in Farmworkers","POP","Inclusion Criteria:\n\n* Age 18 years or older\n* Currently employed as a farmworker or supervisor at a participating farm\n* Able to provide informed consent\n* Able to understand and communicate in Spanish or English\n\nExclusion Criteria:\n\n* Not currently working at a participating farm at the time of recruitment\n* Unable or unwilling to wear a personal noise dosimeter during a work shift\n* Unable to complete study procedures (e.g., surveys or training)",{"count":71,"type":21},[24],"This study will test a program to reduce noise exposure and prevent hearing loss among farmworkers. Farmworkers are often exposed to high levels of noise from machinery, which can lead to hearing loss over time.\n\nFarms will be randomly assigned to either receive the program or serve as a comparison group. The program includes a short educational video, group discussion, and hands-on training on how to use hearing protection (such as earplugs). Supervisors will also receive brief training on how to support hearing protection use in the workplace.\n\nParticipants will wear a small device (dosimeter) during a work shift to measure noise exposure before the program and again about one month later. Participants will also complete surveys about their knowledge, attitudes, and behaviors related to hearing protection.\n\nA subset of participants will be invited to take part in interviews to understand barriers and facilitators to using hearing protection and implementing the program.\n\nThe results of this study will help inform future efforts to improve hearing health and reduce noise exposure in agricultural settings.",[318,319,320],"Noise Exposure","Hearing Loss, Noise-Induced","Occupational Exposure",[322,323,324,325,326,327,328,329,330,331],"farmworkers","agriculture","hearing protection","earplugs","occupational noise","hearing conservation","implementation science","Community Health Workers","Workplace intervention","Cluster randomized trial","2026-04-21",{"date":334,"type":53},"2026-04-28",{"date":336,"type":21},"2026-10",{"date":338,"type":21},"2032-07",{"name":59,"class":60},{"id":341,"slug":342,"hasResults":12,"nctId":343,"briefTitle":344,"officialTitle":345,"acronym":4,"eligibilityCriteria":230,"healthyVolunteers":12,"sex":17,"minAge":127,"maxAge":4,"enrollmentInfo":346,"targetDuration":4,"studyType":22,"phases":347,"briefSummary":348,"conditions":349,"keywords":350,"overallStatus":49,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":353,"startDateStruct":355,"completionDateStruct":356,"leadSponsor":358,"locationsCount":61},"100593722","be-well-at-work-plus-a-depression-and-physical-activity-intervention-for-hospital-service-workers-aim-3-100593722","NCT07010133","Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 3)","Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 3).",{"count":129,"type":21},[24],"This small randomized controlled trial will evaluate a workplace-based depression intervention that is tailored to the specific social and behavioral needs of low-wage hospital service workers. The intervention involves assessment of depression-related work impairment, work-focused cognitive behavioral therapy, work coaching, social needs screening and referral, and text message support for mood and physical activity.",[236,237],[236,239,240,351,241,242],"Worker Health","2026-04-15",{"date":354,"type":53},"2026-04-16",{"date":219,"type":21},{"date":357,"type":21},"2027-01-31",{"name":59,"class":60},{"id":360,"slug":361,"hasResults":12,"nctId":362,"briefTitle":363,"officialTitle":363,"acronym":4,"eligibilityCriteria":364,"healthyVolunteers":97,"sex":17,"minAge":365,"maxAge":177,"enrollmentInfo":366,"targetDuration":4,"studyType":22,"phases":368,"briefSummary":369,"conditions":370,"keywords":373,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":381,"startDateStruct":383,"completionDateStruct":385,"leadSponsor":387,"locationsCount":388},"100566123","hybrid-effectiveness-implementation-trial-of-an-executive-functioning-intervention-for-childrens-mental-health-services-100566123","NCT06651086","Hybrid Effectiveness-Implementation Trial of an Executive Functioning Intervention for Children's Mental Health Services","Inclusion Criteria:\n\nMental Health Programs:\n\n* Publicly-funded\n* Providing outpatient or school-based psychotherapy services to children\n* Have at least 8 mental health providers on staff\n\nTherapists:\n\n* Employed as staff or trainee at a participating program\n* Employed at the program for at least the next 12 months\n* Providing psychotherapy services to children\n* Has an eligible child on current caseload (see below)\n\nAutistic Child\u002FCaregiver Participants (enrolled in a dyad with a participating therapist):\n\n* Child age 6-12 years\n* Receiving services from an enrolled therapist\n* Documented or suspected\\* autism diagnosis\n\n  * In the event of suspected autism diagnosis, the presence of elevated autism symptoms on the Social Responsiveness Scale-2nd Edition or the Autism Diagnostic Observation Scale-2nd Edition\n\nNon-Autistic Child\u002FCaregiver Participants (enrolled in a dyad with a participating therapist):\n\n* Child age 6-12 years\n* Receiving services from an enrolled provider\n* No history of documented or suspected autism diagnosis","6 Years",{"count":367,"type":21},672,[24],"This project aims to follow up on a prior project examining the impact of training therapists in an executive functioning intervention Unstuck and On Target (UOT) adapted for community mental health settings. Study aims are to test the clinical and implementation effectiveness of training mental health therapists in Unstuck and On Target, an executive functioning intervention, relative to Unified Protocol for Children, a transdiagnostic intervention for emotional disorders. This includes examining the implementation of Unstuck and associated outcomes (e.g., effective delivery, expanded use of Unstuck beyond autism, the feasibility of Unstuck) and impact on changes in child executive functioning and behaviors.",[371,372],"Autism Spectrum Disorder","Executive Functioning",[374,375,376,377,378,379,380],"Autism spectrum disorder","executive functioning","emotion regulation","mental health symptoms","Unified Protcol for Children","Unstuck and On Target","evidence based intervention",{"date":382,"type":53},"2026-04-20",{"date":384,"type":53},"2024-12-15",{"date":386,"type":21},"2029-08-31",{"name":59,"class":60},2,{"id":390,"slug":391,"hasResults":12,"nctId":392,"briefTitle":393,"officialTitle":394,"acronym":4,"eligibilityCriteria":395,"healthyVolunteers":97,"sex":17,"minAge":127,"maxAge":4,"enrollmentInfo":396,"targetDuration":4,"studyType":22,"phases":398,"briefSummary":400,"conditions":401,"keywords":404,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":410,"lastUpdatePostDateStruct":411,"startDateStruct":412,"completionDateStruct":414,"leadSponsor":416,"locationsCount":61},"100625251","phase-2-sleep-health-in-us-marines-100625251","NCT07420205","Sleep Health in U.S. Marines","Reducing Suicidality Through Improved Sleep Health","Inclusion Criteria:\n\n* Age 18+\n* Able to read and write in English\n* Currently serving as an active duty member of the U.S. Marine Corp\n* Currently assigned to duty at the approved study site\n\nExclusion Criteria:\n\n* Planned deployment or training operation lasting 30 days or longer and \u002For planned change of duty station within the study period (i.e., 24 weeks postrecruitment)\n* Under 18 years of age\n* Unable to read and write in English",{"count":397,"type":21},860,[399],"PHASE2","The goal of this study is to test a sleep health program designed specifically for U.S. Marine Corps personnel. Researchers want to determine if this program helps Marines improve the participants sleep quality and overall mental health. The study will evaluate whether the program improves sleep quality and duration and reduces symptoms of depression, anxiety, PTSD, and suicide ideation. There are three distinct sleep health programs that will be evaluated; participants will be randomly assigned to one of five groups to receive different combinations of the sleep health programs. To measure results, researchers will use participant surveys for all enrolled participants and wearable sleep-tracking devices for a sub-set of participants. The study team expects that Marines who receive the most comprehensive version of the program will show the greatest improvements in sleep and psychological well-being.",[236,402,403],"Suicidality","Sleep",[403,405,406,407,402,408,409],"Psychological Health","U.S. Military","United States Marine Corps","Sleep Health","Health Promotion","2026-04-14",{"date":354,"type":53},{"date":413,"type":53},"2026-03-31",{"date":415,"type":21},"2027-06",{"name":59,"class":60},{"id":418,"slug":419,"hasResults":12,"nctId":420,"briefTitle":421,"officialTitle":422,"acronym":4,"eligibilityCriteria":423,"healthyVolunteers":97,"sex":17,"minAge":127,"maxAge":424,"enrollmentInfo":425,"targetDuration":4,"studyType":22,"phases":426,"briefSummary":427,"conditions":428,"keywords":4,"overallStatus":49,"whyStopped":4,"lastUpdateSubmitDate":432,"lastUpdatePostDateStruct":433,"startDateStruct":434,"completionDateStruct":436,"leadSponsor":437,"locationsCount":4},"100487140","pilot-study-of-capacity-oriented-intervention-to-promote-food-security-and-diet-quality-among-hispanicslatinos-100487140","NCT05623202","Pilot Study of Capacity-oriented Intervention to Promote Food Security and Diet Quality Among Hispanics\u002FLatinos","Pilot Intervention Study for Capacity-oriented Approaches to Food Security, Diet Quality, and Cardiovascular Disease Risk Among Hispanics\u002FLatinos","Inclusion Criteria:\n\n* Self-identified Hispanic\u002FLatino\n* Living full-time in San Diego County with no plan to move in next 3 months\n* At or below 200% of Federal Poverty Line\n\nExclusion Criteria:\n\n* Not Hispanic\u002FLatino\n* Living outside San Diego County\n* Living only part-time in San Diego County\n* Planning to move out of San Diego County in next 3 months\n* \\>200% of Federal Poverty Line","74 Years",{"count":129,"type":21},[24],"Despite a large proportion exhibiting cardiovascular disease risk factors and experiencing food insecurity, U.S. Hispanics\u002FLatinos demonstrate low cardiovascular mortality, which may indicate existing capital (e.g., assets) protecting health and diet. The goal of this study is to evaluate the feasibility and short-term efficacy of a pilot intervention aimed at improving diet quality through strengthening food- and diet-related capital and food security among low-income, Hispanic\u002FLatino adults in San Diego, California. The pilot intervention will be integrated into an existing local health or nutrition program serving low-income Hispanic\u002FLatino adults. Participants will be asked to:\n\n* Complete questionnaires before and after the intervention\n* Engage in nutrition education activities\n* Engage in food access-related activities",[429,430,431],"Nutrition, Healthy","Knowledge, Attitudes, Practice","Self Efficacy","2026-04-13",{"date":354,"type":53},{"date":435,"type":21},"2026-08",{"date":222,"type":21},{"name":59,"class":60},{"id":439,"slug":440,"hasResults":12,"nctId":441,"briefTitle":442,"officialTitle":442,"acronym":4,"eligibilityCriteria":443,"healthyVolunteers":97,"sex":17,"minAge":127,"maxAge":444,"enrollmentInfo":445,"targetDuration":4,"studyType":22,"phases":447,"briefSummary":449,"conditions":450,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":453,"lastUpdatePostDateStruct":454,"startDateStruct":455,"completionDateStruct":457,"leadSponsor":459,"locationsCount":61},"100439843","early-phase-1-understanding-how-opioids-affect-the-experiential-and-neural-signatures-of-social-experiences-100439843","NCT05007561","Understanding How Opioids Affect the Experiential and Neural Signatures of Social Experiences","Inclusion Criteria:\n\n* good health\n* English fluency\n* willing to provide contact information for 4-6 close others\n* willing to provide digital photographs of 2 close others\n* own a smartphone\n\nExclusion Criteria:\n\n* presence of medical devices, implants, or other metal objects in or on the body that cannot be removed\n* tattooed eyeliner\n* a body habitus prohibiting MRI scanning\n* claustrophobia\n* self-reported chronic mental or physical illness\n* current and regular use of prescription medication\n* previous history of having difficulty taking pills\n* current use of opioid analgesics\n* depressive symptoms above a 9 on Patient Health Questionnaire\n* excessive alcohol use\n* positive urine drug test\n* body mass index (BMI) greater than 35\n* pregnancy or plans to become pregnant in next 6 months\n* positive urine pregnancy test","25 Years",{"count":446,"type":21},210,[448],"EARLY_PHASE1","The study is a randomized, placebo-controlled design with the opioid antagonist, oral naltrexone. Following random assignment, participants will take 50mg of naltrexone or placebo once a day for 7 days. On days 1 - 7, participants complete reports of their feelings of social connection and mood in order to assess more naturalistic feelings in response to opportunities for social connection outside of the laboratory setting. Additionally, at the end of each day, they complete a physical symptoms questionnaire. On the 7th day, participants will come to the SDSU MRI scanning facility to complete tasks designed to elicit feelings of social connection in the fMRI scanner. After the scan, feelings in response to the scanner tasks will be collected.",[451,452],"Naltrexone","Placebo","2026-04-08",{"date":432,"type":53},{"date":456,"type":53},"2021-11-16",{"date":458,"type":21},"2027-07",{"name":59,"class":60},{"id":461,"slug":462,"hasResults":12,"nctId":463,"briefTitle":464,"officialTitle":464,"acronym":4,"eligibilityCriteria":465,"healthyVolunteers":97,"sex":17,"minAge":127,"maxAge":466,"enrollmentInfo":467,"targetDuration":4,"studyType":22,"phases":469,"briefSummary":470,"conditions":471,"keywords":4,"overallStatus":49,"whyStopped":4,"lastUpdateSubmitDate":473,"lastUpdatePostDateStruct":474,"startDateStruct":476,"completionDateStruct":477,"leadSponsor":478,"locationsCount":4},"100559522","microvascular-blood-flow-during-passive-heating-100559522","NCT06565221","Microvascular Blood Flow During Passive Heating","Inclusion Criteria:\n\n* between 18 and 50 years\n\nExclusion Criteria:\n\n* Diagnosis of peripheral neuropathy\n* open wounds on feet","50 Years",{"count":468,"type":21},50,[24],"Determine whether passive heating intervention effects microvascular blood flow as measured with near-infrared spectroscopy",[472],"Blood Flow","2026-03-11",{"date":475,"type":53},"2026-03-13",{"date":435,"type":21},{"date":222,"type":21},{"name":59,"class":60},{"id":480,"slug":481,"hasResults":12,"nctId":482,"briefTitle":483,"officialTitle":484,"acronym":4,"eligibilityCriteria":485,"healthyVolunteers":97,"sex":69,"minAge":127,"maxAge":486,"enrollmentInfo":487,"targetDuration":4,"studyType":22,"phases":489,"briefSummary":490,"conditions":491,"keywords":493,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":498,"lastUpdatePostDateStruct":499,"startDateStruct":501,"completionDateStruct":503,"leadSponsor":505,"locationsCount":61},"100475664","enhancing-capacity-in-churches-to-implement-pa-programs-100475664","NCT05473871","Enhancing Capacity in Churches to Implement PA Programs","Enhancing Capacity in Faith-based Organizations to Implement and Sustain Multilevel Innovations to Improve Physical Activity","Inclusion Criteria:\n\n* Self-identifying as Latina\n* Aged 18-65 years\n* Planning on attending the FBO for the next 18 months\n* Low self-reported leisure-time MVPA (\\\u003C50 min of weekly leisure MVPA)\n* No health factors interfering with PA\n\nExclusion Criteria:\n\n* Anyone with a health condition precluding them from engaging in PA\n* Cognitive impairment preventing participation\n* Inability to complete the informed consent in English or Spanish\n* Attending other churches besides the church of recruitment","65 Years",{"count":488,"type":21},560,[24],"Despite the benefits of physical activity (PA) to prevent cardiovascular disease and other chronic diseases, few adult Latinas meet PA guidelines. Given the central role of churches within the Latino community and their commitment to the well-being of their members, they are ideal settings for health promotion. Evidence-based interventions (EBIs) for increasing PA and reducing obesity exist, but few PA interventions go to scale. Investigators propose to enhance Faith in Action with three organization-level strategies designed to increase program fit and effectiveness: 1) training church leaders in health promotion; 2) tailoring messaging to enhance fit between Faith in Action and each unique church environment; and 3) empowering community health workers (promotoras) to advocate for organizational change. Given the need to improve strategies to sustain health programs in community settings, investigators will test the influence of two additional sustainment strategies: 1) strengthening community collaborations and 2) providing technical support. Twenty-eight churches will be randomly assigned to a Standard EBI group (Faith in Action as originally implemented), an Enhanced group (Standard intervention + organizational-level implementation strategies), or an Enhanced + Sustainment group (Enhanced implementation group + sustainment strategies). Investigators will test the proposed implementation strategies on organization-level change and individual behavior in diverse churches for a 12-month intervention and 6-month follow-up period. The proposed study aims to: 1) Test the short and long-term impacts of organization-level implementation strategies in 2 Enhanced conditions on organizational outcomes compared to the Standard EBI condition and 2) Examine individual behavior change among Latinas (N=560) in churches in the 2 Enhanced conditions compared to the Standard EBI condition. The study's primary hypothesis is that Latina's receiving the Enhanced interventions will increase their PA levels significantly more than those receiving the Standard Faith in Action intervention, and the improvements in PA will be sustained. If successful, findings from the current study will provide evidence of organizational-level strategies for uptake, sustainment, and implementation strategies for scale-up of PA interventions to increase PA and reduce chronic disease in churches across the US.",[492],"Cardiovascular Diseases",[239,494,495,496,497],"Faith in Action","Hispanic Women","Latinas","Exercise","2026-03-03",{"date":500,"type":53},"2026-03-05",{"date":502,"type":53},"2022-11-15",{"date":504,"type":21},"2027-02-28",{"name":59,"class":60},{"id":507,"slug":508,"hasResults":12,"nctId":509,"briefTitle":510,"officialTitle":510,"acronym":312,"eligibilityCriteria":511,"healthyVolunteers":97,"sex":17,"minAge":127,"maxAge":4,"enrollmentInfo":512,"targetDuration":4,"studyType":22,"phases":513,"briefSummary":514,"conditions":515,"keywords":516,"overallStatus":49,"whyStopped":4,"lastUpdateSubmitDate":520,"lastUpdatePostDateStruct":521,"startDateStruct":523,"completionDateStruct":525,"leadSponsor":527,"locationsCount":4},"100613799","preventing-noise-exposure-in-farmworkers-100613799","NCT07271290","Preventing Noise Exposure in Farmworkers","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Currently employed as a farmworker in agricultural settings with routine exposure to occupational noise\n* Able to understand and provide informed consent in Spanish or English\n\nExclusion Criteria:\n\n* Not currently employed as a farmworker\n* Medical or ear conditions that preclude safe use of foam earplugs (e.g., acute ear infection, recent ear surgery)\n* Inability to complete study procedures as determined by study staff",{"count":286,"type":21},[24],"This study will evaluate a farmworker-level hearing loss prevention training designed to improve hearing protection use among farmworkers exposed to hazardous occupational noise. The intervention consists of a culturally and linguistically adapted, Spanish-language digital training module paired with hands-on earplug fitting and coaching.\n\nThe primary goals of the study are to (1) assess the feasibility and acceptability of delivering the adapted training in community-based settings, and (2) estimate preliminary effectiveness using an objective measure of hearing protection fit. The study uses a single-arm, pre-post pilot design.\n\nA small group of farmworkers will complete pre- and post-training assessments of earplug fit, as well as brief surveys assessing hearing protection knowledge, attitudes, and perceptions. Qualitative feedback will be collected to inform refinement of the training and guide future scale-up.\n\nResults will inform the development of a subsequent multilevel intervention that integrates supervisor and organizational components.",[318],[517,518,519],"noise exposure","hearing loss","farmworker","2026-02-11",{"date":522,"type":53},"2026-02-17",{"date":524,"type":21},"2026-10-01",{"date":526,"type":21},"2031-01-01",{"name":59,"class":60},{"id":529,"slug":530,"hasResults":12,"nctId":531,"briefTitle":532,"officialTitle":533,"acronym":534,"eligibilityCriteria":535,"healthyVolunteers":12,"sex":17,"minAge":127,"maxAge":4,"enrollmentInfo":536,"targetDuration":4,"studyType":22,"phases":538,"briefSummary":539,"conditions":540,"keywords":543,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":550,"lastUpdatePostDateStruct":551,"startDateStruct":553,"completionDateStruct":555,"leadSponsor":557,"locationsCount":61},"100615265","stratified-targeted-engagement-from-primary-care-to-physical-therapy-steppt-100615265","NCT07290361","Stratified Targeted Engagement From Primary Care to Physical Therapy (STEPPT)","Stratified Targeted Engagement From Primary Care to Physical Therapy (STEPPT): A Pragmatic Stepped Wedge Cluster Randomized Trial","STEPPT","Inclusion Criteria\n\n* 18 years or older.\n* Identify as either Hispanic or Non-Hispanic ethnicity, inclusive of all races.\n* Seeking care for spine pain at an Adult or Adult Walk-in primary care clinic within the participating Federally Qualified Health Center (FQHC).\n* New or existing spine pain problem: A new spine pain problem is defined by a new ICD code for neck or back pain added to the problem list during a visit with a primary care physician. An existing spine pain problem is defined by an existing ICD code for neck or back pain on the problem list that is associated with a physician referral for any service during the visit related to the neck or back pain problem.\n* Signed a broad consent for the use of de-identified health information for research at the participating FQHC.\n\nExclusion Criteria:\n\n* Spine pain associated with a non-musculoskeletal etiology (e.g., infection, cancer, urological disorders, pregnancy, etc.)\n* Patients requiring urgent medical intervention (e.g., fracture, cauda equina syndrome, etc)\n* Active physical therapy referral for spine pain at the time of the index encounter.\n* Previously referred to physical therapy through the STEPPT Care Pathway.\n* Physical therapy referrals external to the FQHC will be excluded from the analysis of physical therapy adherence",{"count":537,"type":21},17587,[24],"The goal of this clinical trial is to learn if a health system intervention called \"Stratified Targeted Engagement from Primary Care to Physical Therapy (STEPPT)\" can improve how often doctors refer Hispanic patients with spine pain to physical therapy (referral rate) and how often patients attend physical therapy after being referred (adherence rate). The main questions this study aims to answer are 1) does STEPPT improve physical therapy referral and adherence rates compared to usual care for Hispanic patients with spine pain who seek care in a Federally Qualified Health Center (FQHC) serving low income communities, and 2) how consistently do FQHC providers and staff deliver STEPPT to patients who may benefit? STEPPT will train doctors and other health care providers to educate participants on the benefits of physical therapy for spine pain and participants will receive culturally tailored handouts and videos to teach them about their spine pain and what to expect in physical therapy. Patients will also receive personalized assistance to schedule their physical therapy appointment and address potential barriers for attending the appointment.",[541,542],"Low Back Pain","Neck Pain",[544,545,546,547,548,549],"Physical therapy","Rehabilitation","Hispanic","Heatlh Services","Healthcare utilization","Federally Qualified Health Center","2026-02-03",{"date":552,"type":53},"2026-02-06",{"date":554,"type":53},"2025-12-01",{"date":556,"type":21},"2029-02-28",{"name":59,"class":60},{"id":559,"slug":560,"hasResults":12,"nctId":561,"briefTitle":562,"officialTitle":562,"acronym":4,"eligibilityCriteria":563,"healthyVolunteers":97,"sex":17,"minAge":127,"maxAge":466,"enrollmentInfo":564,"targetDuration":4,"studyType":22,"phases":565,"briefSummary":566,"conditions":567,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":569,"lastUpdatePostDateStruct":570,"startDateStruct":572,"completionDateStruct":574,"leadSponsor":576,"locationsCount":61},"100577633","effects-of-mango-or-low-fat-cookie-consumption-on-gut-health-and-its-relationship-with-mental-sexual-and-skin-health-100577633","NCT06800833","Effects of Mango or Low-Fat Cookie Consumption on Gut Health, and Its Relationship With Mental, Sexual and Skin Health","Inclusion Criteria:\n\n* Generally healthy subjects\n* BMI 20-40 kg\u002Fm2\n\nExclusion Criteria:\n\n* Smoker\n* Pregnant woman\n* Required antibiotics use\n* Required dietary supplement use\n* Required medication of metabolic disorders, mental health and sexual health\n* Allergy to mango or wheat",{"count":129,"type":21},[24],"The objective of the proposed research is to determine the effects of fresh mango consumption on gut microbiome, and its relationship with skin health, sexual and mental health in relatively healthy adults.",[568],"Gut Microbiome","2026-01-28",{"date":571,"type":53},"2026-01-30",{"date":573,"type":53},"2025-01-23",{"date":575,"type":21},"2027-12-31",{"name":59,"class":60},{"id":578,"slug":579,"hasResults":12,"nctId":580,"briefTitle":581,"officialTitle":582,"acronym":4,"eligibilityCriteria":583,"healthyVolunteers":97,"sex":17,"minAge":127,"maxAge":4,"enrollmentInfo":584,"targetDuration":4,"studyType":22,"phases":585,"briefSummary":586,"conditions":587,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":589,"lastUpdatePostDateStruct":590,"startDateStruct":592,"completionDateStruct":594,"leadSponsor":596,"locationsCount":61},"100581313","prevention-ambassadors-intervention-to-promote-hiv-service-engagement-in-the-networks-of-ssp-clients-100581313","NCT06848686","Prevention Ambassadors: Intervention to Promote HIV Service Engagement in the Networks of SSP Clients","Prevention Ambassadors: an HIV Self-testing Intervention to Promote HIV Service Engagement in the Networks of SSP Clients","Index Participant Inclusion Criteria:\n\n* Being greater than or equal to 18 years old\n* Reporting drug use (past month)\n* Having other people who use drugs (PWUD) in one's social network\n* Being willing to talk about HIV testing and services with at least 2 PWUD in their networks and attempt to refer them to the study\n* Speaking English fluently\n\nPeer-Recruit Participant Inclusion Criteria:\n\n* Being greater than or equal to 18 years old\n* Reporting drug use (past 3 months)\n* Being recruited by an index participant (evidenced by presenting the coupon used to recruit them)\n* Speaking English fluently\n\nExclusion Criteria:\n\n\\- Persons who participated in formative study activities related to the development of the PA intervention will not be eligible to participate.",{"count":446,"type":21},[24],"HIV testing and service uptake are infrequent among people who use drugs (PWUD) in the United States. In partnership with a community-based syringe service program (SSP), this project will develop the SSP-based \"Prevention Ambassadors\" (PA) intervention to promote HIV testing and service uptake among PWUD via the secondary distribution (i.e., peer delivery) of HIV self-testing (HIVST) kits with local HIV service information and referrals to HIV service navigation in the social networks of SSP clients (i.e., PWUD). The PA intervention will then be piloted to assess its preliminary effects, acceptability, and feasibility among PWUD in the Ending the HIV Epidemic priority jurisdiction of Riverside County, California.",[588],"HIV","2026-01-27",{"date":591,"type":53},"2026-01-29",{"date":593,"type":53},"2025-02-03",{"date":595,"type":21},"2027-02",{"name":59,"class":60},{"id":598,"slug":599,"hasResults":12,"nctId":600,"briefTitle":601,"officialTitle":601,"acronym":4,"eligibilityCriteria":602,"healthyVolunteers":97,"sex":17,"minAge":127,"maxAge":466,"enrollmentInfo":603,"targetDuration":4,"studyType":22,"phases":605,"briefSummary":606,"conditions":607,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":609,"lastUpdatePostDateStruct":610,"startDateStruct":612,"completionDateStruct":614,"leadSponsor":615,"locationsCount":61},"100540916","effects-of-watermelon-or-low-fat-cookie-consumption-on-wellness-100540916","NCT06323070","Effects of Watermelon or Low-fat Cookie Consumption on Wellness","Inclusion Criteria:\n\n* Generally healthy subjects\n* BMI 20-40 kg\u002Fm2\n\nExclusion Criteria:\n\n* Smoker\n* Pregnant woman\n* Required antibiotics use\n* Required dietary supplement use\n* Required medication of metabolic disorders, mental health and sexual health\n* Allergy to watermelon or wheat",{"count":604,"type":21},80,[24],"The objective of the proposed research is to determine the effects of fresh watermelon consumption on physiological indicators of wellness regarding sexual, skin and gut health in adults.",[608],"Overweight and Obesity","2026-01-16",{"date":611,"type":53},"2026-01-21",{"date":613,"type":53},"2024-03-01",{"date":87,"type":21},{"name":59,"class":60},{"id":617,"slug":618,"hasResults":12,"nctId":619,"briefTitle":620,"officialTitle":620,"acronym":4,"eligibilityCriteria":621,"healthyVolunteers":97,"sex":17,"minAge":622,"maxAge":623,"enrollmentInfo":624,"targetDuration":4,"studyType":22,"phases":625,"briefSummary":626,"conditions":627,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":609,"lastUpdatePostDateStruct":629,"startDateStruct":630,"completionDateStruct":632,"leadSponsor":634,"locationsCount":61},"100369918","effects-of-watermelon-consumption-on-satiety-and-digestive-health-100369918","NCT04096586","Effects of Watermelon Consumption on Satiety and Digestive Health","Inclusion Criteria:\n\n* Generally healthy subjects\n\nExclusion Criteria:\n\n* Smoker\n* Pregnant woman\n* Required dietary supplement use\n* Required medication of metabolic disorders\n* Allergy to watermelon","10 Years","55 Years",{"count":604,"type":21},[24],"The objective of the proposed research is to determine the effects of watermelon (fruit and rind blenderized) on satiety, metabolic markers, bowel habits, microbiome and weight management in children and adults",[628],"Satiety",{"date":611,"type":53},{"date":631,"type":53},"2019-08-01",{"date":633,"type":21},"2028-12-31",{"name":59,"class":60},{"id":636,"slug":637,"hasResults":12,"nctId":638,"briefTitle":639,"officialTitle":639,"acronym":4,"eligibilityCriteria":640,"healthyVolunteers":97,"sex":17,"minAge":127,"maxAge":623,"enrollmentInfo":641,"targetDuration":4,"studyType":22,"phases":642,"briefSummary":643,"conditions":644,"keywords":4,"overallStatus":80,"whyStopped":4,"lastUpdateSubmitDate":609,"lastUpdatePostDateStruct":645,"startDateStruct":646,"completionDateStruct":648,"leadSponsor":649,"locationsCount":61},"100359273","effects-of-fresh-mango-pulp-consumption-on-satiety-and-cardiometabolic-health-100359273","NCT03957928","Effects of Fresh Mango Pulp Consumption on Satiety and Cardiometabolic Health","Inclusion Criteria:\n\n* 18-55 years old\n* BMI 27-40\n\nExclusion Criteria:\n\n* Smoker\n* Pregnant woman\n* Required dietary supplement use\n* Required medication of metabolic disorders\n* Allergy to mango or gluten",{"count":468,"type":21},[24],"The objective of the study is to determine the effects of fresh mango pulp consumption on satiety and metabolic parameters in overweight\u002Fobese adults.",[628],{"date":611,"type":53},{"date":647,"type":53},"2019-03-01",{"date":87,"type":21},{"name":59,"class":60},""]