[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"San Francisco Veterans Affairs Medical Center\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":80},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,56],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":32,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":45,"startDateStruct":48,"completionDateStruct":50,"leadSponsor":52,"locationsCount":55},"100522286","reward-processing-and-depressive-subtypes-identifying-neural-biotypes-100522286",false,"NCT06080646","Reward Processing and Depressive Subtypes: Identifying Neural Biotypes","Reward Processing and Depressive Subtypes: Identifying Neural Biotypes Related to Suicide Risk, Resilience, and Treatment Response","* Our studies require some in-person visits to our research lab, located at 42nd Ave and Clement St in San Francisco.\n* Because this study includes an MRI, part of the screening process will be to ensure you don't have any metal in your body, you do not have head or neck tattoos, and you are comfortable inside the MRI scanner.\n\nInclusion Criteria:\n\n* 18-70 years with a diagnosis of major depressive disorder (MDD) for MDD group, or without for unaffected comparison (UC) group\n* Negative metal screen for MRI safety\n* Normal (or corrected to normal) vision\n\nExclusion Criteria:\n\n* Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive symptoms)\n* Loss of consciousness (LOC) greater than 30 minutes or any LOC with neurologic symptoms\n* Major medical conditions (e.g., seizure disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology)\n* Substance dependence, within the past year, or failed urine toxicology on the day of neuroimaging sessions\n* Known claustrophobia\n* Current Pregnancy\n* IQ estimate \\\u003C 70",true,"ALL","18 Years","70 Years",{"count":21,"type":22},150,"ESTIMATED","OBSERVATIONAL","Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related information. However, reward processing is a complex, multi-circuit phenomenon, and the precise neural mechanisms that contribute to the absence or reduction of pleasure and motivation are not well understood. Variation in the clinical presentation of depression has long been a rule rather than an exception, including individual variation in symptoms, severity, and treatment response. This heterogeneity complicates understanding of depression and thwarts progress toward disease classification and treatment planning. Discovery of depression-specific biomarkers that account for neurobiological variation that presumably underlies distinct clinical manifestations is critical to this larger effort.",[26,27,28,29,30,31],"Depression","Depressive Disorder","Major Depressive Disorder","Major Depressive Episode","Depressive Symptoms","Anhedonia",[33,34,35,36,37,38,39,40,41,42],"reward","motivation","EEG","fMRI","MRI","functional MRI","amotivation","avolition","suicidality","suicide","RECRUITING","2024-07-31",{"date":46,"type":47},"2024-08-02","ACTUAL",{"date":49,"type":47},"2021-06-01",{"date":51,"type":22},"2025-09-01",{"name":53,"class":54},"San Francisco Veterans Affairs Medical Center","FED",1,{"id":57,"slug":58,"hasResults":11,"nctId":59,"briefTitle":60,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":65,"phases":66,"briefSummary":68,"conditions":69,"keywords":70,"overallStatus":43,"whyStopped":4,"lastUpdateSubmitDate":44,"lastUpdatePostDateStruct":74,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":55},"100454173","using-electrophysiology-to-index-non-invasive-brain-stimulation-effects-on-reward-system-functioning-in-depression-100454173","NCT05194098","Using Electrophysiology to Index Non-invasive Brain Stimulation Effects on Reward System Functioning in Depression","• Our studies require some in-person visits to our research lab, located at 42nd Ave and Clement St in San Francisco.\n\nInclusion Criteria:\n\n* All participants\n\n  * 18-65 years old\n  * Normal (or corrected to normal) vision\n* Participants with MDD\n\n  * Meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for MDD\n  * Screened for TMS and MRI safety\n  * On a stable psychiatric medication regime for \\> 1 month\n\nExclusion Criteria (all participants):\n\n* Premorbid IQ estimate \\\u003C 70\n* Past or present neurological problems (including seizures and head trauma resulting in neurological or cognitive sequelae)\n* Loss of consciousness \\> 30 minutes or any loss of consciousness with neurological sequelae\n* Major medical conditions (e.g., seizure disorders, treatment with anticonvulsant medication, endocrine disorders, significant cardiac pathology), or other physical conditions if they preclude participation in EEG, TMS, or MRI protocols (e.g. peripheral nerve damage, limb paralysis etc.)\n* Substance dependence, within the past year, current (past 3 months) substance misuse, or failed urine toxicology on the day of neuroimaging sessions\n* Known claustrophobia\n* Pregnancy (a pregnancy urine test will be conducted to rule-out pregnancy)\n\nExclusion criteria (Participants with MDD only)\n\n* Past or present DSM-5 (SCID-5) 'Schizophrenia Spectrum or Other Psychotic Disorder' diagnosis\n* Past or present DSM-5 (SCID-5) Bipolar and Related Disorders Diagnosis\n* Past or present DSM-5 (SCID-5) MDD with psychotic features (mood congruent or mood incongruent)\n* Past or present DSM-5 (SCID-5) Gambling Disorder\n\nExclusion Criteria (HCs only)\n\n• DSM-5 (SCID-5) criteria for any psychiatric disorder","65 Years",{"count":64,"type":22},45,"INTERVENTIONAL",[67],"NA","Depression is a leading cause of morbidity and mortality, conferring substantial healthcare and societal costs. By studying methods to non-invasively target neural circuitry involved in reward responsivity, information generated by this project will improve understanding of the circuit alterations that underlie motivation and pleasure deficits in depression, and could also lead to the development of biologically-based markers of neurostimulation-based treatment response.",[28],[28,71,35,72,73],"Reward Processing","rTMS Neurostimulation","dorsal medial prefrontal cortex",{"date":46,"type":47},{"date":76,"type":47},"2021-10-01",{"date":78,"type":22},"2024-09-30",{"name":53,"class":54},""]