[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"San Luigi Gonzaga Hospital\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":150},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,71,97,122],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100575963","intracoronary-optical-coherence-tomography-guidance-vs-angiography-only-guidance-for-treatment-of-coronary-in-stent-restenosis-100575963",false,"NCT06779110","Intracoronary Optical Coherence Tomography Guidance Vs. Angiography Only Guidance for Treatment of Coronary In-stent Restenosis","IN-Stent RestenosIs Detection and TrEtment by Optical Coherence Tomography","INSIDE OCT","Inclusion Criteria:\n\n* Informed consent signed\n* Age ≥ 18 years\n* Referred for angiography either in stable or ACS setting suitability for PCI through femoral or radial access\n* A coronary in-stent restenosis between 70% and 99% in at least two projections in a vessel with a lumen diameter ≥ 2.25 - ≤ 5.75 mm (The severity of the stenosis should be based on visual estimation, with current online state-of-the-art angiographic equipment of the participating centres and after a mandatory dose of 50-200 mcg intracoronary of nitroglycerine.\n* Stable hemodynamics\n\nExclusion Criteria:\n\n* Inability to give informed consent\n* Participation in another clinical study with an investigational product\n* OCT pullback not technically feasible in vessel site","ALL","18 Years","99 Years",{"count":21,"type":22},360,"ESTIMATED","INTERVENTIONAL",[25],"NA","Although advances in drug-eluting stents (DES) have substantially reduced the risk of coronary in-stent restenosis (ISR) and the need for target lesion revascularisation (TLR), ISR persists. There are several treatment options for ISR (conventional balloon angioplasty, cutting or scoring balloons, drug-coated balloons, repeat DES implantation or bypass surgery). Coronary imaging is mandatory to perform PCI on ISR. Optimal coherence tomography (OCT) is an excellent option to guide PCI, but its role in ISR-PCI remains unclear. The INSIDE OCT Trial aims to compare the acute performance of PCI for ISR, either guided by OCT and angiography or by angiography alone.",[28,29,30],"Coronary Artery Disease","Stent Restenosis","STENT",[32,33],"Percutaneous Coronary Intervention (PCI)","Optimal Coherence Tomography (OCT)","RECRUITING","2025-01-12",{"date":37,"type":38},"2025-01-16","ACTUAL",{"date":40,"type":38},"2024-09-01",{"date":42,"type":22},"2028-09-01",{"name":44,"class":45},"San Luigi Gonzaga Hospital","OTHER",12,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":58,"conditions":59,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":62,"lastUpdatePostDateStruct":63,"startDateStruct":65,"completionDateStruct":67,"leadSponsor":69,"locationsCount":70},"100568987","anastomotic-leakage-after-right-hemicolectomy-for-cancer-a-prospective-multicenter-study-of-sico-cc-network-100568987","NCT06688383","Anastomotic Leakage After Right Hemicolectomy for Cancer, a Prospective Multicenter Study of SICO-CC Network","\"Anastomotic Leakage After Right Hemicolectomy for Cancer, a Prospective Multicenter Study of SICO-CC Network.\" (AL RIGHT).","ALRIGHT","Inclusion Criteria:\n\n* Patients from all participating centers older than 18 years, males or females, with the diagnosis of primary right colon cancer including the cecum, ascendent, liver flexure, and proximal third of the transverse colon, in both emergency and elective settings, with the indication of RH, referred as to the resection of a portion of the distal ileum, cecum, ascending colon, and proximal to the mid-transverse colon, with intraperitoneal or extraperitoneal primary handsewn or mechanical ileocolic anastomosis by minimally invasive(robotic or laparoscopic) or open approach.\n\nExclusion Criteria:\n\n* -Long steroid treatment for any cause.\n* Right colon resection for benign disease.\n* History of supra-mesocolic space radiotherapy.\n* Inflammatory bowel disease (Crohn's disease and ulcerative colitis). No healthy volunteers are accepted.",{"count":56,"type":22},1839,"OBSERVATIONAL","This is a nationwide prospective observational study to assess the overall clinical anastomotic leakage rate after right hemicolectomy for cancer, to detect the independent risk factors for AL, and to develop a clinical prediction model to estimates of the probability of the occurrence of an AL after surgery. Since this is a multicenter prospective study, the Division of Surgical Oncology and Digestive Surgery from the University of Turin, Department of Oncology, AOU San Luigi Gonzaga di Orbassano will be the Coordinator Center of the study, Ethics committee approves will be requested before the implementation of this study.\n\nItalian high-volume colorectal surgery centers members of SICO (The Italian Society of Oncological Surgery) have agreed to participate as collaborators of this study, notification and revision from their local ethics committee will be requested as well. A certified general surgeon with a large experience in the preoperative, operative, and postoperative management of patients with colorectal cancer has been identified to coordinate the study in each center. Id information of the potential collaborators is specified in the section \"Trial Setting\". Once the study is activated, eligible patients (or a representative) must provide written, informed consent before any study procedures occur. No intervention or modification of the habitual clinical practice is planned All data will enter into a database provided by the promoting center. There are three main sections of data collection for each patient:\n\n* Preoperative: baseline, disease and demographics.\n* Operative: details about the surgery, anastomosis construction and enterotomy closure.\n* Follow-up: outcomes data about the early (within 30 postoperative day) and late postoperative course (31 th - 60th postoperative day) and pathology report. The definition of AL is based on the presence of clinical signs (pain, fever, tachycardia, peritonitis, feculent or enteric drainage, purulent drainage, postoperative ileus, abscess, septicemia, and\u002For organ failure) with radiographic signs (fluid collections, gas containing collections at CT scan) suggestive of AL and-or intraoperative or autopsy findings (gross enteric spillage, anastomotic disruption). The absence of AL will be assumed by a normal postoperative course and the absence of symptoms suggestive of AL with or without radiologic confirmation.",[60,61],"Anastomotic Leak Large Intestine","Right Colon Tumors","2024-11-12",{"date":64,"type":38},"2024-11-14",{"date":66,"type":38},"2021-01-01",{"date":68,"type":22},"2026-06",{"name":44,"class":45},1,{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":78,"targetDuration":80,"studyType":57,"phases":4,"briefSummary":81,"conditions":82,"keywords":86,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":92,"completionDateStruct":94,"leadSponsor":96,"locationsCount":70},"100553327","comparing-t-stenting-and-minimal-protrusion-with-external-minicrush-for-treatment-of-complex-coronary-bifurcation-100553327","NCT06484647","Comparing T-stenting And Minimal Protrusion With External Minicrush for Treatment of Complex Coronary Bifurcation","Comparing T-stenting And Minimal Protrusion With External Minicrush for Treatment of Complex Coronary Bifurcation: Insights From TREX Registry","Inclusion Criteria:\n\n* Patients \\>18 years of age\n* Patients with an indication for PCI, including chronic coronary syndrome and acute coronary syndromes (STEMI, NSTEMI, unstable angina)\n* Patients with at least one true coronary bifurcation according to the Medina classification 1.1.1, 0.1.1, 1.0.1, 0.0.1\n\nExclusion Criteria:\n\n* Patients who do not want or cannot sign the informed consent for the procedure.\n* Patients with severe peripheral vascular disease that limits vascular access to the point of making the procedure unsafe.\n* Patients with a life expectancy of \\\u003C1 year.\n* Patients with planned major surgery require prolonged discontinuation of antiplatelet therapy.\n* Pregnant women.\n* Patients who cannot take antiplatelet therapy for any reason.",{"count":79,"type":22},382,"5 Years","Nowadays, no studies compare the T-stenting And Minimal Protrusion (TAP) and External Minicrush techniques in treating complex coronary bifurcation, so eventually, procedural, clinical and safety differences remain unknown.",[28,83,84,85],"Ischemic Heart Disease","Chronic Coronary Syndrome","Acute Coronary Syndrome",[32,87,88],"Coronary Artery Disease (CAD)","Coronary Bifurcation Lesion (CBL)","2024-07-04",{"date":91,"type":38},"2024-07-08",{"date":93,"type":38},"2024-06-01",{"date":95,"type":22},"2024-10-01",{"name":44,"class":45},{"id":98,"slug":99,"hasResults":11,"nctId":100,"briefTitle":101,"officialTitle":102,"acronym":103,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":57,"phases":4,"briefSummary":107,"conditions":108,"keywords":110,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":114,"lastUpdatePostDateStruct":115,"startDateStruct":117,"completionDateStruct":119,"leadSponsor":121,"locationsCount":70},"100552359","upfront-surgery-versus-neoadjuvant-chemotherapy-followed-by-surgery-for-resectable-advanced-gastric-cancer-snac-study-100552359","NCT06472063","Upfront Surgery Versus NeoAdjuvant Chemotherapy Followed by Surgery for Resectable Advanced Gastric Cancer: SNAC Study","Upfront Surgery Versus NeoAdjuvant Chemotherapy Followed by Surgery for Resectable Advanced Gastric Cancer (SNAC Study): An Observational Retrospective Multicenter Study With Matched Treatment Comparison","SNAC","Inclusion Criteria:\n\n* 3.1.1. Locally advanced (T\\>2 any N or N+ any T) histologically proven adenocarcinoma of the stomach without distant metastases (M0) and without infiltration of adjacent structures and organs.\n\n3.1.2. D2 lymphadenectomy (based on Japanese gastric cancer guideline) 3.1.3. Age \\> 18 years 3.1.4. surgical resectability 3.1.5. follow-up time of at least 36 months.\n\nExclusion Criteria:\n\n3.2.1. distant metastases (cM+) or infiltration of adjacent structures or organs (cT4b) and all primarily not resectable stages 3.2.2. Other types of lymphadenectomy lower than D2 3.2.3. Siewert type I and II Cardia cancers 3.2.2. Relapsed gastric cancers 3.2.3. malignant secondary disease, dated back \\\u003C 5 years (exception: In-situ-carcinoma of the cervix uteri, adequately treated skin basal cell carcinoma)\n\n\\-",{"count":106,"type":22},684,"Based on the concerns about the actual low strength of evidence of the efficacy of NAC on survival of proper gastric cancer treated with adequate D2 gastrectomy as compared to the results of optimal upfront surgery (S), and considering the actual difficulties of additional RCTs, the aim of this study is to assess the non-inferiority of upfront surgery alone with optimal D2 dissection compared to NAC regimens followed by surgery. Methods: This is a nationwide Multicenter observational retrospective study with matched comparison of two therapeutic strategies (NAC vs S). We will include patients with cT\\>2, every cN M0, or with every T and N+ M0, histologically proven adenocarcinoma of the stomach, submitted either to pre- or peri-operative treatment and D2 gastrectomy or to upfront D2 gastrectomy, between January 2012 and December 2019, followed by adjuvant treatment when recommended.\n\nAll patients matching the inclusion\u002Fexclusion criteria will be registered into the study and classified into one of the two arms: a, patients who underwent pre- or perioperative treatment and D2 gastrectomy (NAC) or b, patients submitted to upfront D2 gastrectomy (S). Given the results reported in the \"FLOT\" trial, a 3-years OS of 55% in the control arm (NAC) was assumed. Three-year OS in the experimental arm (S) was assumed to be 47.4% under the null hypothesis of inferiority and 55% under the alternative hypothesis of non-inferiority. A sample size of 684 patients (342 in each arm) achieves 80% power to detect a non-inferiority margin Hazard Ratio of 1.25",[109],"Gastric Cancer",[111,112,113],"upfront surgery","perioperative treatment","D2 lymphadenectomy","2024-06-23",{"date":116,"type":38},"2024-06-24",{"date":118,"type":38},"2022-09-22",{"date":120,"type":22},"2024-09-30",{"name":44,"class":45},{"id":123,"slug":124,"hasResults":11,"nctId":125,"briefTitle":126,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":23,"phases":132,"briefSummary":133,"conditions":134,"keywords":137,"overallStatus":141,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":5},"100499398","reverse-t-stenting-and-minimal-protrusion-with-external-minicrush-for-treatment-of-complex-coronary-bifurcation-100499398","NCT05782738","Reverse T-stenting and Minimal Protrusion With External Minicrush for Treatment of Complex Coronary Bifurcation","A Randomized Clinical Study Comparing Reverse T-stenting and Minimal Protrusion With External Minicrush for Treatment of Complex Coronary Bifurcation (T-REX Trial)","T-REX","Inclusion Criteria:\n\n* Patients \\>18 years old;\n* Patients with an indication of PCI, including Chronic Coronary syndrome (CCS) and Acute Coronary Syndrome (ACS), according to current guidelines recommendations; According to Medina and Definition criteria, patients with at least true and complex coronary lesions involved in coronary bifurcation.\n\nExclusion Criteria:\n\n* Patients that refused informed consent;\n* Patients without valid vascular access that could make unsafe PCI;\n* Patients with an expected life of less than one year;\n* Patients with scheduled major surgery that required prolonged DAPT interruption;\n* Pregnant patients;\n* Patients with DAPT contraindications.",{"count":131,"type":22},361,[25],"The Reverse T-stenting And Minimal Protrusion (Reverse TAP) is an up-front 2-stent technique that treats complex coronary bifurcation. Compared to crush techniques, it does not require crushing of the side branch stent but only minimal protrusion of the side branch stent before main vessel stenting. Nowadays, no studies compare the Reverse-TAP and the External Minicrush in treating complex coronary bifurcation, so eventually, procedural, clinical and safety differences remain unknown.",[28,135,136],"Coronary Stenosis","Coronary Disease",[138,139,140],"Reverse TAP","External Minicrush","Coronary bifurcation lesion","NOT_YET_RECRUITING","2023-04-14",{"date":144,"type":38},"2023-04-19",{"date":146,"type":22},"2023-06-01",{"date":148,"type":22},"2029-06-01",{"name":44,"class":45},""]