[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Sana'a University\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":297},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,10,0,[8,59,82,107,136,169,190,215,242,274],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":32,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":47,"lastUpdatePostDateStruct":48,"startDateStruct":51,"completionDateStruct":53,"leadSponsor":55,"locationsCount":58},"100642443","phase-4-oral-nifedipine-versus-placebo-for-pain-and-healing-after-hemorrhoidectomy-100642443",false,"NCT07659665","Oral Nifedipine Versus Placebo for Pain and Healing After Hemorrhoidectomy","The Effect of Oral Nifedipine Versus Placebo on Postoperative Pain and Healing Following Hemorrhoidectomy in Adult Patients: A Randomized Controlled Trial in Sana'a, Yemen","NIFEDIPINE-HD","Inclusion Criteria:\n\n* Adult patients aged 18-65 years\n* Scheduled for elective hemorrhoidectomy for grade III or IV hemorrhoids\n* Ability to provide written informed consent\n* Ability to understand and complete study questionnaires\n* Willingness to comply with the study protocol and follow-up visits\n\nExclusion Criteria:\n\n* Known hypersensitivity to nifedipine\n* Severe cardiovascular disease (unstable angina, recent myocardial infarction, severe heart failure)\n* Hypotension (systolic blood pressure \\\u003C 90 mmHg)\n* Severe hepatic or renal impairment\n* Pregnancy or breastfeeding\n* Current use of calcium channel blockers or nitrates\n* Emergency hemorrhoidectomy\n* Concurrent inflammatory bowel disease\n* History of anorectal surgery within the past 6 months","ALL","18 Years","65 Years",{"count":21,"type":22},100,"ESTIMATED","INTERVENTIONAL",[25],"PHASE4","The goal of this clinical trial is to evaluate whether oral nifedipine reduces postoperative pain and improves wound healing after hemorrhoidectomy in adult patients aged 18-65 years undergoing elective surgery for grade III or IV hemorrhoids in Sana'a, Yemen.\n\nThe main questions it aims to answer are:\n\n* Does oral nifedipine 20 mg twice daily for 14 days reduce postoperative pain compared with placebo?\n* Does oral nifedipine improve wound healing progression and shorten time to complete healing compared with placebo?\n\nResearchers will compare the nifedipine group to the placebo group to see if there is a significant reduction in pain scores, faster wound healing, lower analgesic consumption, and fewer complications.\n\nParticipants will:\n\n* Take either oral nifedipine 20 mg or an identical-looking placebo capsule twice daily for 14 consecutive days, starting 6 hours after surgery.\n* Report pain intensity using a standard 0-10 Visual Analogue Scale at multiple time points during the first 28 days.\n* Attend follow-up visits on postoperative days 7, 14, and 28 for wound healing assessment and safety monitoring.\n* Use rescue analgesia (paracetamol and\u002For diclofenac) as needed for breakthrough pain.",[28,29,30,31],"Hemorrhoids","Postoperative Pain","Wound Healing","Analgesia",[33,34,35,36,37,38,39,40,41,42,43,44,45],"Hemorrhoidectomy","Post-hemorrhoidectomy pain","Internal anal sphincter","Anal sphincter spasm","Nifedipine","Calcium channel blocker","Randomized controlled trial","Yemen","Placebo","Visual Analogue Scale","Pain management","Wound healing","Ecchymosis Discharge Approximation score","NOT_YET_RECRUITING","2026-06-27",{"date":49,"type":50},"2026-07-01","ACTUAL",{"date":52,"type":22},"2026-08-01",{"date":54,"type":22},"2026-12-30",{"name":56,"class":57},"Sana'a University","OTHER",1,{"id":60,"slug":61,"hasResults":11,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":4,"eligibilityCriteria":65,"healthyVolunteers":66,"sex":17,"minAge":18,"maxAge":67,"enrollmentInfo":68,"targetDuration":4,"studyType":23,"phases":70,"briefSummary":72,"conditions":73,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":79,"leadSponsor":81,"locationsCount":4},"100645022","delayed-short-dental-implants-with-immediate-loading-100645022","NCT07675772","Delayed Short Dental Implants With Immediate Loading","Clinical and Radiographic Evaluation of the Role of Concentrated Growth Factor (CGF) and Advanced Platelet-Rich Fibrin (A-PRF) in Enhancing the Wound Healing and Stability of Delayed Short Dental Implants With Immediate Loading: Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n\\-\n\n• Patient aged 18 - 45 years old.\n\n• Patients maintaining excellent oral hygiene standards.\n\n• Systemically healthy patient.\n\n• Single or multiple missing teeth in premolar and molar region.\n\n• Patients should have adequate bone width volume (\\>4 mm) and bone density with sufficient mesiodistal and interocclusal space. Bone height (≤10mm).\n\n• The patient should physically and psychologically be able to tolerate short implant surgical procedure.\n\n• Patient with a sufficient platelet count (\\>200,000\u002Fmm3) for CGF and A-PRF preparation.\n\n• Patients who provided informed consent.\n\nExclusion Criteria:\n\n* \\> Presence of active periodontal disease.\n\nPatients with a significant medical history which contradicts placement of dental implants such as:\n\n• Diabetes.\n\n• Diseases affecting bone metabolism.\n\n• Patients currently on antibiotics, steroids, hormonal therapy, or medications known to affect bone metabolism.\n\n• Patients with a history of radiotherapy or chemotherapy, coagulation defects, or currently on anticoagulant treatment.\n\n• Pregnant or lactating women.\n\n• Patients with poor oral hygiene.\n\n• Habits such as khat chewing, smoking and alcohol intake.\n\n• Insufficient vertical interarch space.\n\n• Temporomandibular joint disorder.\n\n• Parafunctional habits.",true,"55 Years",{"count":69,"type":22},72,[71],"NA","\\> Evaluation of the wound healing in immediate occlusal loading of endosseous delayed short dental implant with or without CGF or A-PRF.\n\n\\> Detection of the primary and secondary implant stability of immediate occlusal loading of endosseous delayed short dental implant with or without CGF or A-PRF.\n\n\\> Evaluation of the hard and soft tissue thickness after immediate occlusal loading of endosseous delayed short dental implant with or without CGF or A-PRF.",[74],"DENT IMPLANTS","2026-06-23",{"date":77,"type":50},"2026-06-30",{"date":49,"type":22},{"date":80,"type":22},"2030-07-01",{"name":56,"class":57},{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":88,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":90,"minAge":18,"maxAge":91,"enrollmentInfo":92,"targetDuration":4,"studyType":23,"phases":94,"briefSummary":95,"conditions":96,"keywords":4,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":58},"100642709","vitamin-d3-supplementation-regimens-and-preeclampsia-risk-100642709","NCT07648706","Vitamin D3 Supplementation Regimens and Preeclampsia Risk","Effect of Different Dosages of Vitamin D3 Supplementation on the Risk of Preeclampsia in Pregnant Women With Vitamin D Deficiency","VitD-PE-RCT","Inclusion Criteria:\n\n* Singleton pregnancy\n* Pregnant women between 8 and 18 weeks of gestation\n* Serum 25-hydroxyvitamin D \\[25(OH)D\\] level \\\u003C 25 ng\u002FmL\n* Willing and able to provide written informed consent\n* Planning to receive ongoing antenatal care and deliver at Al-Thawra Modern General Hospital.\n\nExclusion Criteria:\n\n* Uncontrolled chronic hypertension\n* Current use of vitamin D supplementation before enrollment\n* Severe chronic kidney disease\n* Pre-existing diabetes mellitus\n* Autoimmune or immunological disorders\n* Known fetal congenital anomalies\n* Primary hyperparathyroidism\n* Thyroid disease\n* Use of medications that affect vitamin D or calcium metabolism\n* Inability or unwillingness to comply with the study protocol or follow-up schedule","FEMALE","40 Years",{"count":93,"type":22},268,[71],"This study is a randomized controlled trial with two parallel groups connected at Al-Thawra Modern General Hospital in Sana'a, Yemen.\n\nIt aims to compara the effect of two different vitamin D3 supplementation regimens during pregnancy on the risk of pre-eclampsia among women with confirmed vitamin D deficiency.\n\nPregnant women attending antenatal care and diagnosed with vitamin D deficiency will be screened for eligibility. Eligible participants will be randomly assigned to one of two intervention groups:one group receiving vitamin D3 50,000 IU every two weeks and the other group receiving vitamin D3 5,000 IU weekly,in addition to standard antenatal care.\n\nThe study will include singleton pregnancies between 8\\_18 weeks of gestation with serum 25-hydroxyvitamin D level below 25 ng \u002FmL . Women with chronic conditions that may affect pregnancy outcomes or vitamin D metabolism will be excluded. Participants will be followed throughout pregnancy to assess the development of pre-eclampsia and other maternal and fetal outcomes.",[97],"Preeclampsia","RECRUITING","2026-06-12",{"date":101,"type":50},"2026-06-15",{"date":103,"type":50},"2024-08-04",{"date":105,"type":22},"2026-09",{"name":56,"class":57},{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":117,"briefSummary":118,"conditions":119,"keywords":122,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":58},"100637205","supine-vs-prone-pcnl-for-large-renal-stones-a-randomized-trial-in-yemen-100637205","NCT07627503","Supine vs. Prone PCNL for Large Renal Stones: A Randomized Trial in Yemen.","Comparative Evaluation of Early Postoperative Complications, Cost-Effectiveness, and Patient-Centered Outcomes Following Supine and Prone Standard Percutaneous Nephrolithotomy (PCNL): A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 18-70 years.\n* Diagnosis of solitary or multiple renal stones with a cumulative diameter greater than 2 cm, confirmed by imaging (CT KUB).\n* Patients eligible for standard PCNL (24-30 Fr).\n* American Society of Anesthesiologists (ASA) physical status I-III.\n* Willingness and ability to provide informed consent.\n\nExclusion Criteria:\n\n* Patients with active urinary tract infection (UTI) not responding to antibiotics.\n* Patients with bleeding diathesis or on anticoagulant therapy that cannot be safely discontinued.\n* Patients with anatomical abnormalities of the kidney or urinary tract that preclude standard PCNL.\n* Pregnant women.\n* Patients with severe cardiopulmonary disease where general anesthesia or prolonged surgical positioning is contraindicated.\n* Patients with a history of previous ipsilateral renal surgery.\n* Patients unwilling or unable to comply with follow-up protocols.","70 Years",{"count":116,"type":22},140,[71],"The goal of this clinical trial is to compare the safety, cost-effectiveness, and patient recovery of two different surgical positions for percutaneous nephrolithotomy (PCNL) in adults aged 18 to 70 years who have kidney stones larger than 2 cm. The main questions it aims to answer are:\n\n* Does the supine (lying on the back) surgical position result in fewer early postoperative complications than the traditional prone (lying on the stomach) position?\n* Does the supine position reduce the total surgery time, direct hospital costs, and postoperative pain?\n\nResearchers will compare patients assigned to undergo PCNL in the supine position to those assigned to the prone position to see if the supine approach offers a safer, more cost-effective, and more comfortable recovery.\n\nParticipants will:\n\n* Undergo standard PCNL surgery to remove their kidney stones in either the supine or prone position.\n* Have their pain levels, surgery time, and any early surgical complications monitored during their hospital stay.\n* Complete brief questionnaires regarding their overall surgical satisfaction and quality of life at 1 month and 3 months after the procedure.",[120,121],"Kidney Calculi","Nephrolithiasis",[123,124,125,126,127],"PCNL","Percutaneous Nephrolithotomy","Kidney Stones","Supine PCNL","Prone PCNL","2026-06-03",{"date":130,"type":50},"2026-06-05",{"date":132,"type":22},"2026-06-01",{"date":134,"type":22},"2027-06-30",{"name":56,"class":57},{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":144,"enrollmentInfo":145,"targetDuration":4,"studyType":23,"phases":147,"briefSummary":148,"conditions":149,"keywords":153,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":58},"100625600","graftless-tsfe-via-self-tapping-implants-100625600","NCT07424742","Graftless TSFE Via Self-tapping Implants","Transcrestal Graftless Schneiderian Membrane Elevation by Self-tapping Dental Implant","G-TSFE","Inclusion Criteria:\n\n1. Adults aged 18-80 years.\n2. Patients with edentulous posterior maxilla.\n3. Residual bone height approximately 4-6 mm.\n4. Indicated for transcrestal sinus membrane elevation.\n5. Good general health (ASA I or II).\n6. Ability to provide written informed consent.\n7. Willingness to attend follow-up visits.\n\nExclusion Criteria:\n\n1. Severe systemic diseases (ASA III or above).\n2. Uncontrolled diabetes mellitus.\n3. Active sinus pathology.\n4. History of radiotherapy in the head and neck region.\n5. Heavy smokers (\\>10 cigarettes\u002Fday).\n6. Pregnancy or lactation.\n7. Untreated periodontal disease.\n\n7\\. Poor oral hygiene.","80 Years",{"count":146,"type":22},20,[71],"This prospective clinical trial aims to evaluate the efficiency, safety, and reliability of a minimally invasive graftless transcrestal sinus lifting approach with simultaneous dental implant placement in patients with edentulous posterior maxilla and limited residual bone height.\n\nThe study investigates bone formation beneath the Schneiderian membrane, implant stability, osseointegration, and long-term implant survival.",[150,151,152],"Edentulous Posterior Maxilla","Maxillary Sinus Pneumatization","Alveolar Bone Atrophy",[154,155,156,157,158,159,160],"Transcrestal Sinus Lift","Graftless Sinus Elevation","Schneiderian Membrane","Dental Implant","Posterior Maxilla","Osseointegration","CBCT","2026-05-30",{"date":163,"type":50},"2026-06-02",{"date":165,"type":50},"2024-09-09",{"date":167,"type":22},"2026-09-09",{"name":56,"class":57},{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":173,"acronym":174,"eligibilityCriteria":175,"healthyVolunteers":66,"sex":17,"minAge":18,"maxAge":176,"enrollmentInfo":177,"targetDuration":4,"studyType":23,"phases":179,"briefSummary":180,"conditions":181,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":187,"leadSponsor":189,"locationsCount":4},"100638986","the-effect-of-low-level-laser-therapy-on-accelerating-tooth-movement-and-reducing-pain-during-orthodontic-treatment-100638986","NCT07591948","The Effect of Low-Level Laser Therapy on Accelerating Tooth Movement and Reducing Pain During Orthodontic Treatment","LLLT","Inclusion Criteria:\n\n* Patients aged 15-30 years requiring fixed orthodontic treatment.\n\n  * Extraction treatment plan with bilateral canine retraction.\n  * Good oral hygiene and periodontal health.\n  * No systemic diseases or medications affecting bone metabolism.\n\nExclusion Criteria:\n\n* Previous orthodontic treatment.\n\n  * Smoking or alcohol consumption.\n  * Pregnancy or lactation.\n  * Use of analgesics or anti-inflammatory drugs during the study period.","30 Years",{"count":178,"type":22},30,[71],"Orthodontic treatment is a common and effective approach to correcting dental malocclusions and improving oral function and aesthetics. The process involves applying mechanical forces to move teeth into their desired positions, which can lead to discomfort and pain for patients, especially during the initial stages of treatment. While the ultimate goal of orthodontic therapy is to achieve proper alignment, the associated pain and the time required to complete the treatment often become significant concerns for patients. (Jheon et al., 2017). The duration of treatment, which typically spans several months or even years, is influenced by various factors including the type of malocclusion, the force applied, and the biological response of the periodontal tissues to the applied forces. (Sangle et al., 2023). Recent advancements in orthodontic care have focused on finding ways to accelerate tooth movement while minimizing the discomfort experienced by patients. Low-level laser therapy (LLLT), also known as photobiomodulation (PBM), has garnered significant attention as a non-invasive method to enhance biological healing processes. LLLT has been shown to stimulate cellular activity, increase collagen production, and improve blood circulation, potentially influencing the rate of tooth movement (Fini et al., 2020). Several studies suggest that LLLT may enhance the osteoclast and osteoblast activity in the periodontal tissues, leading to more rapid bone resorption and apposition, which could expedite the tooth movement process (Suzuki et al., 2016). Additionally, LLLT has been shown to reduce pain perception, possibly by modulating nerve activity and inflammation (Guo et al., 2021).",[182],"Acceleration of Tooth Movement","2026-05-14",{"date":185,"type":50},"2026-05-18",{"date":163,"type":22},{"date":188,"type":22},"2028-02-02",{"name":56,"class":57},{"id":191,"slug":192,"hasResults":11,"nctId":193,"briefTitle":194,"officialTitle":195,"acronym":196,"eligibilityCriteria":197,"healthyVolunteers":11,"sex":17,"minAge":198,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":23,"phases":201,"briefSummary":202,"conditions":203,"keywords":205,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":58},"100616561","sliding-jigs-vs-retraction-hooks-for-maxillary-dentition-distalization-using-izc-miniscrews-100616561","NCT07307209","\"Sliding Jigs vs Retraction Hooks for Maxillary Dentition Distalization Using IZC Miniscrews\"","A Comparative Evaluation of Whole Maxillary Dentition Distalization Using Sliding Jig vs. Retraction Hooks Anchored by IZC Miniscrews: A Randomized Clinical Trial","SJRH-IZC","Inclusion Criteria:\n\n* The inclusion criteria will be the following: Adult patients with class II malocclusion (\\>14 years), present of all permanent teeth fully erupted, Bilateral Class II molar relationship skeletal malocclusion, moderate maxillary arch crowding (less than 5 mm) with maxillary protrusion, absence of craniofacial syndrome. and, except third molars\n\nExclusion Criteria:\n\n* The subjects having the following conditions will be excluded from the study (1) Patients with transverse dental or skeletal discrepancies. (2) Patients indicated for extraction treatment (except for third molars) or unilateral distalisation treatment (3) Patients with Vertical growth pattern, (4) Patients having periodontal disease, (5) Patients with previous orthodontic treatment.","14 Years",{"count":200,"type":22},40,[71],"This randomized controlled clinical trial aims to compare the clinical efficacy, efficiency, and biomechanical differences between two methods for total maxillary dentition distalization: (1) the use of a Sliding Jig and (2) the use of Retraction Hooks, both anchored by Infrazygomatic Crest (IZC) miniscrews. The study will assess rates of distalization, anchorage loss, dentoalveolar tipping, patient comfort, and treatment-associated side effects.",[204],"Skeletal Class II Malocclusion",[206],"Maxillary Distalization; IZC Miniscrew; Sliding Jig","2026-05-10",{"date":209,"type":50},"2026-05-13",{"date":211,"type":50},"2026-02-11",{"date":213,"type":22},"2026-12",{"name":56,"class":57},{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":221,"eligibilityCriteria":222,"healthyVolunteers":66,"sex":17,"minAge":223,"maxAge":4,"enrollmentInfo":224,"targetDuration":4,"studyType":23,"phases":225,"briefSummary":226,"conditions":227,"keywords":229,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":58},"100623635","3-d-evaluation-of-alveolar-bone-changes-and-root-resorption-after-traction-of-buccally-displaced-maxillary-canines-100623635","NCT07399197","3-D Evaluation of Alveolar Bone Changes and Root Resorption After Traction of Buccally Displaced Maxillary Canines","Three-Dimensional Evaluation of Alveolar Bone Changes and Root Resorption After Orthodontic Traction of Unilateral Buccally Displaced Maxillary Canines Using Two Different Techniques: A Randomized Clinical Trial","BDMC","Inclusion Criteria:\n\n* Yemeni ethnic patients.\n* Presence of unilateral BDMC.\n* The presence of a properly positioned and normally erupted contralateral canine.\n* Mild to moderate crowding.\n* The need for fixed orthodontic treatment.\n* No sagittal discrepancy\n\nExclusion Criteria:\n\n* History of severe facial trauma.\n* Previous orthodontic treatment.\n* Presence of bilateral BDMC.\n* Presence of developmental dental anomalies.\n* Presence of facial syndromes and bone metabolism disease.","12 Years",{"count":200,"type":22},[71],"This clinical study used CBCT images to investigate the alveolar bone changes and root resorption in unilateral buccally displaced maxillary canines and adjacent teeth before and after orthodontic traction of unilateral BDMCs.\n\nThe CBCT images will also be used to compare these changes to the normal contralateral side. The study outcome is to compare the 3-D changes in the alveolar bone and dental roots between the 2 interventional techniques (segmentalT-loop and piggyback NiTi traction) methods.",[228],"Malocclusion; Displaced Teeth",[230,231,232,233],"Buccally Displaced Maxillary Canines","Alveolar Bone Changes","Root Resorption","Orthodontic Treatment","2026-04-30",{"date":236,"type":50},"2026-05-07",{"date":238,"type":50},"2026-03-02",{"date":240,"type":22},"2027-09-30",{"name":56,"class":57},{"id":243,"slug":244,"hasResults":11,"nctId":245,"briefTitle":246,"officialTitle":247,"acronym":248,"eligibilityCriteria":249,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":144,"enrollmentInfo":250,"targetDuration":4,"studyType":23,"phases":251,"briefSummary":252,"conditions":253,"keywords":257,"overallStatus":98,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":271,"leadSponsor":273,"locationsCount":58},"100625598","bone-regeneration-using-prf-after-cyst-enucleation-100625598","NCT07424716","Bone Regeneration Using PRF After Cyst Enucleation","Clinical Efficacy of Platelet-Rich Fibrin in Osseous Regeneration After Cystic Enucleation","PRF-Bone","Inclusion Criteria:\n\n* Patients diagnosed with odontogenic cysts requiring surgical enucleation.\n* Presence of a postoperative osseous defect in the jaws after cyst enucleation.\n* Age ≥ 18 years.\n* Systemically healthy patients (ASA I or II).\n* Patients willing to participate and sign informed consent.\n\nExclusion Criteria:\n\n* Patients with systemic diseases affecting bone healing (e.g., uncontrolled diabetes, osteoporosis).\n* Patients receiving bisphosphonates or long-term corticosteroid therapy.\n* Smokers (\\>10 cigarettes\u002Fday).\n* Pregnant or lactating women.\n* Patients with acute infection at the surgical site.\n* Patients unwilling to participate or unable to attend follow-up visits.",{"count":146,"type":22},[71],"This randomized controlled clinical trial aims to evaluate the clinical efficacy of autologous platelet-rich fibrin (PRF) in promoting osseous regeneration following cystic enucleation in the jaws. The study will assess bone healing outcomes and compare PRF application with conventional management methods.",[254,255,256],"Odontogenic Cyst","Jaw Cysts","Osseous Defect After Cyst Enucleation",[258,259,260,261,262,263,264,265],"Platelet-Rich Fibrin","PRF","Cyst Enucleation","Bone Regeneration","Randomized Controlled Trial","Oral Surgery","Osseous Healing","Jaw Bone Defect","2026-02-14",{"date":268,"type":50},"2026-02-20",{"date":270,"type":50},"2025-05-19",{"date":272,"type":22},"2026-10-19",{"name":56,"class":57},{"id":275,"slug":276,"hasResults":11,"nctId":277,"briefTitle":278,"officialTitle":279,"acronym":4,"eligibilityCriteria":280,"healthyVolunteers":66,"sex":17,"minAge":281,"maxAge":282,"enrollmentInfo":283,"targetDuration":4,"studyType":23,"phases":285,"briefSummary":286,"conditions":287,"keywords":4,"overallStatus":46,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":296,"locationsCount":58},"100541024","clinical-and-immunological-evaluation-of-ha-in-treatment-of-periodontitis-100541024","NCT06324474","Clinical and Immunological Evaluation of HA in Treatment of Periodontitis","Clinical and Immunological Evaluation of Hyaluronic Acid Topical Application in Non-surgical Treatment of Periodontitis","Inclusion Criteria:\n\n* systemically healthy.\n* at least 20 teeth and suffers from moderate \\\u003C7mm to severe. \\>8mm.periodontitis with probing depth \\>5m and in the contralateral side.\n* ability to attend to the clinic in a regular manner.\n\nExclusion Criteria:\n\n* allergy to HA.\n* Chronic disease.\n* orthodontic treatment.\n* Qat chewer and smokers.\n* antibiotic in previous 3 months.\n* supplements and mouthwash.","20 Years","60 Years",{"count":284,"type":22},24,[71],"To evaluate the immunological effectiveness of Hyaluronic acid as adjunction treatment to scaling and root planning and scaling and root planning alone.\n\nComparison between clinical measurement before and after treatment. Evaluate the level of IGF-1 in treated site as immunological marker if periodontal regeneration.",[288],"Periodontitis","2024-12-03",{"date":291,"type":50},"2024-12-05",{"date":293,"type":22},"2025-04",{"date":295,"type":22},"2025-12-12",{"name":56,"class":57},""]