[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Sascha Battig\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":42},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":4},"100566744","effects-of-beginning-a-glp1-agonist-therapy-on-residual-gastric-content-and-gastric-emptying-100566744",false,"NCT06659159","Effects of Beginning a GLP1-Agonist Therapy on Residual Gastric Content and Gastric Emptying","Effects of Beginning a GLP1-Agonist Therapy on Residual Gastric Content and Gastric Emptying: a Prospective Ultrasound Approach with Focus on Perioperative Aspiration Risk.","GLP-1","Inclusion Criteria:\n\n* Beginning a new treatment with GLP-1 Agonists. Indication and prescription determined by an endocrinologist\u002Fobesity specialist\n* Signed informed consent\n\nExclusion Criteria:\n\n* Known pregnancy, known lactation\n* Underage (\\\u003C 18 years)\n* Absence of informed consent (missing or inability to provide)\n* Anomalies of the gastrointestinal tract\n* Known illnesses of the gastrointestinal tract\n* Previous surgery of the gastrointestinal tract\n* Elevated risk for hypoglycaemia (Sulfonylurea or Insulin)\n* No investigator with completed structural education in gastric sonography is available\n* Lack of intention to respect the fasting intervals and predefined standardised meals for the sonographic examination","ALL","18 Years",{"count":20,"type":21},50,"ESTIMATED","OBSERVATIONAL","This project explores the elevated risk of pulmonary aspiration during anesthesia in patients undergoing GLP-1 agonist therapy, which prolongs gastric emptying. Despite standard fasting guidelines (6 hours for solids, 2 hours for liquids), some patients still experience aspiration, indicating that GLP-1 therapy may heighten risk. The American Society of Anesthesiologists has advised pausing GLP-1 therapy before surgery, but this recommendation has faced criticism for being too broad. More data on this issue is needed, particularly concerning the effect of tachyphylaxis (reduced drug response over time) on gastric emptying.\n\nThe study proposes using gastric ultrasound as a non-invasive tool to evaluate residual gastric content and categorize patients by their aspiration risk. The study will assess the stomach's content and gastric emptying time in patients both before and after starting GLP-1 therapy, comparing results under standard fasting conditions.\n\nThe project is a national, single-center, prospective observational study targeting 50 patients, examining factors like patient demographics, GLP-1 therapy details, and gastrointestinal side effects. Data collection will occur through baseline and follow-up sonographic exams before and after therapy initiation. The study aims to improve perioperative management strategies by clarifying the risks associated with GLP-1 therapy",[25],"Pulmonary Aspiration During Anaesthetic Induction",[27,28,15,29],"Pulmonary aspiration","Gastric ultrasound","Gastroparesis","NOT_YET_RECRUITING","2024-10-23",{"date":33,"type":34},"2024-10-26","ACTUAL",{"date":36,"type":21},"2024-11-01",{"date":38,"type":21},"2026-12-31",{"name":40,"class":41},"Sascha Battig","OTHER",""]