[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"School of Health Sciences Geneva\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":141},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,46,80,110],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100627093","post-stroke-fatigue-perception-study-refast-100627093",false,"NCT07444151","Post-Stroke Fatigue Perception Study (ReFast)","Exploration of Subjective Post-Stroke Fatigue: A Mixed-Methods Questionnaire Study (ReFast - Recovery and Fatigue Study)","ReFast","Inclusion Criteria:\n\n* Age 18 years or older\n* Living in French-speaking Switzerland\n* Confirmed history of ischemic or hemorrhagic stroke\n* Self-reported fatigue attributed to stroke\n* Living in the community (not institutionalized)\n* Able to read and understand written French\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Transient ischemic attack (TIA) without confirmed stroke\n* History of two or more strokes\n* Currently institutionalized (e.g., nursing home, long-term hospital care, rehabilitation center)\n* Fatigue primarily caused by another chronic medical condition (e.g., cancer, primary depression, multiple sclerosis)\n* Severe cognitive or communication impairment preventing independent completion of the questionnaire\n* Unable to understand written French","ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","OBSERVATIONAL","The goal of this observational study is to better understand fatigue after stroke. Many people feel ongoing tiredness months or years after a stroke. This fatigue may affect daily activities, work, and social life. It does not always improve with rest.\n\nThis study aims to answer these questions:\n\nHow do participants describe their fatigue?\n\nHow strong and how often does it occur?\n\nHow does it affect daily life and quality of life?\n\nWhat strategies do participants use to manage it?\n\nAbout 20 to 30 adults living in French-speaking Switzerland who have had a stroke will take part.\n\nParticipants will:\n\nComplete one anonymous questionnaire online or on paper.\n\nAnswer questions about their fatigue and daily life.\n\nShare their experience in their own words.\n\nThe questionnaire takes about 15 to 20 minutes. There are no medical tests, treatments, or follow-up visits.\n\nParticipation is voluntary. Participants may stop at any time. No names or identifying information are collected.\n\nThe results may help health professionals better understand post-stroke fatigue and improve rehabilitation care.",[25],"Post-stroke Fatigue",[27,28,29,30,31,32],"Post-Stroke Fatigue","Quality of Life","Coping Strategies","Questionnaire Study","Neurological Rehabilitation","Stroke","RECRUITING","2026-02-27",{"date":36,"type":37},"2026-03-02","ACTUAL",{"date":39,"type":37},"2026-01-27",{"date":41,"type":21},"2026-12-31",{"name":43,"class":44},"School of Health Sciences Geneva","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":45},"100626725","multifocal-theta-burst-stimulation-to-enhance-upper-limb-motor-recovery-after-stroke-inspire-100626725","NCT07439367","Multifocal Theta-Burst Stimulation to Enhance Upper Limb Motor Recovery After Stroke (INSPIRE)","Advancing Stroke Rehabilitation Through Multifocal Network-based Theta-burst Stimulation and Assistive Technology: Enhancing Upper Limb Motor Learning: A Single-center, Randomized, Sham-controlled Study With Parallel Groups.","INSPIRE","Inclusion Criteria:\n\nFor Stroke Participants:\n\n* Age ≥ 18 years\n* First-ever ischemic or hemorrhagic stroke\n* Time since stroke ≥ 6 months\n* Unilateral upper limb hemiparesis\n* Fugl-Meyer Assessment Upper Extremity (FMA-UE) score between 29 and 57\n* Modified Ashworth Scale score \\\u003C 2 at elbow, wrist, or finger flexors\n* Manual muscle testing ≥ 3\u002F5 in proximal upper limb muscles (deltoid, biceps, triceps, wrist pronators\u002Fsupinators)\n* Ability to understand and follow study procedures\n* Provided written informed consent\n\nFor Healthy Participants:\n\n* Age ≥ 18 years\n* No history of neurological disease\n* Ability to understand and follow study procedures\n* Provided written informed consent\n\nExclusion Criteria:\n\nFor Stroke Participants:\n\n* Second stroke occurring during the study period\n* Botulinum toxin injection within 3 months prior to study start\n* History of one or more epileptic seizures\n* Metallic object near the stimulation site\n* Implanted electronic or metallic devices (e.g., pacemaker, neurostimulator) incompatible with TMS\n* Severe comorbid conditions affecting the upper limb (traumatic, rheumatologic, osteoarticular, or neurodegenerative disorders)\n* Pregnancy\n* Delirium or impaired vigilance\n* Inability to participate in one-hour treatment sessions\n* Inability to comply with study procedures (e.g., language barrier, psychological disorder, dementia)\n* Current or past substance abuse, including excessive alcohol consumption\n* Participation in another interventional clinical trial within 30 days prior to enrollment\n\nFor Healthy Participants:\n\n* Severe musculoskeletal or neurological condition affecting the non-dominant upper limb\n* Pregnancy\n* Delirium or impaired vigilance\n* Inability to participate in one-hour treatment sessions\n* Inability to comply with study procedures\n* Current or past substance abuse, including excessive alcohol consumption\n* Participation in another interventional clinical trial within 30 days prior to enrollment",true,{"count":56,"type":21},46,"INTERVENTIONAL",[59],"NA","Stroke is one of the leading causes of long-term disability worldwide. Many individuals who survive a stroke continue to experience weakness and reduced control of one arm, even months or years after the event. These motor impairments significantly affect independence, daily activities, and quality of life. Despite rehabilitation efforts, recovery of upper limb function remains incomplete for many patients.\n\nMotor recovery after stroke depends on the brain's ability to reorganize itself, a process known as neuroplasticity. Recent research suggests that motor learning and brain recovery are influenced not only by activity in the primary motor cortex (M1), but also by its functional connectivity with other brain regions, particularly the parietal cortex (PC). Strengthening communication between these regions may enhance motor recovery.\n\nThis study aims to investigate a novel, non-invasive brain stimulation approach called intermittent theta-burst stimulation (iTBS). Unlike traditional stimulation methods that target a single brain region, this study uses a multifocal stimulation protocol targeting both the primary motor cortex and the parietal cortex. The stimulation is combined with structured motor training using an interactive tablet-based rehabilitation device (REAtouch®Lite 2), designed to improve arm movement through goal-directed reaching tasks.\n\nThe study is a single-center, randomized, sham-controlled, triple-blind clinical trial with parallel groups. Thirty-six individuals with chronic stroke-related upper limb impairment will be randomly assigned to receive either active multifocal iTBS or sham (placebo) stimulation. Both groups will complete identical motor training sessions. In addition, ten healthy participants will complete the same motor training protocol (without brain stimulation) to provide reference data.\n\nParticipants will attend six visits over approximately 10 days. Assessments will include motor performance tests using the interactive tablet, a standardized clinical motor scale (Fugl-Meyer Assessment for Upper Extremity), and resting-state electroencephalography (EEG) to measure brain connectivity changes.\n\nThe primary outcome is improvement in motor performance between baseline and one week after the intervention. Secondary outcomes include short-term motor improvements, retention of learning, changes in movement quality, and changes in brain functional connectivity.\n\nThis study seeks to determine whether combining multifocal brain stimulation with targeted motor training can enhance motor learning and promote better recovery of arm function after stroke. If effective, this approach could contribute to the development of more precise, network-based neurorehabilitation strategies.",[62,63,64,65],"Chronic Stroke Patient","Motor Impairment","Neurorehabilitation","Theta Burst Stimulation",[67,68,69,70,71,72],"Chronic Stroke","Upper Limb Rehabilitation","Intermittent Theta Burst Stimulation","Tablet-Based Rehabilitation","Neuroplasticity","Motor Learning","2026-02-23",{"date":34,"type":37},{"date":76,"type":37},"2025-09-05",{"date":78,"type":21},"2026-08-31",{"name":43,"class":44},{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":54,"sex":17,"minAge":87,"maxAge":88,"enrollmentInfo":89,"targetDuration":4,"studyType":57,"phases":91,"briefSummary":92,"conditions":93,"keywords":96,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":101,"lastUpdatePostDateStruct":102,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},"100510246","video-game-play-to-alleviate-adolescent-anxiety-100510246","NCT05923944","Video Game Play to Alleviate Adolescent Anxiety","Evaluating the Effect of Gamified Cognitive Training and of Casual Videogame Play on Anxiety in Adolescents: Protocol for a Randomized Controlled Trial","Inclusion Criteria:\n\n1. Adolescents aged 11-15 years\n2. High-anxious score from the 41 items SCARED-Parent version (i.e. total score equal or above 17)\n3. Access to a computer (at least Windows 7 or Mac OSX) at home and a reliable internet connection\n\nExclusion Criteria:\n\n1. DSM diagnoses of Bipolar, Psychosis, Autism Spectrum Disorder, present or past.\n2. Neurological injury (i.e. head injury)\n3. Currently enrolled in another cognitive training intervention","11 Years","15 Years",{"count":90,"type":21},150,[59],"Adolescence is a critical period for the onset and maintenance of anxiety disorders, which raises the importance of intervening early; one possibility of doing so is via digital interventions. At least two lines of research have been explored in the past years in this area. First, studies have tested the anxiolytic effects of casual video games, hypothesizing that, through the induction of flow, these games can effectively distract individuals from anxiety-related thoughts and feelings. Second, the bidirectional link between poor attentional control and higher anxiety has led to the design of novel interventions aiming to improve attentional control such as working memory training studies. Importantly, action video games, classified as a distinct gaming genre, have been shown to enhance attentional control. In this study, we aim to compare the effects of action video game play and casual game play to a no-training group, assessing their potential to alleviate anxiety when delivered entirely online. The goal of this three- arms randomized controlled trial is to evaluate the feasibility of a 6-week video game training intervention to reduce adolescent anxiety-related symptoms. We will also examine the efficacy of the proposed treatment when entirely deployed at adolescents' home.",[94,95],"Anxiety","Anxiety Disorders and Symptoms",[97,98,99,100],"Digital mental health","Video Games","Cognitive Training","Emotion Regulation","2025-05-20",{"date":103,"type":37},"2025-05-23",{"date":105,"type":37},"2024-06-01",{"date":107,"type":21},"2026-06",{"name":43,"class":44},2,{"id":111,"slug":112,"hasResults":11,"nctId":113,"briefTitle":114,"officialTitle":114,"acronym":115,"eligibilityCriteria":116,"healthyVolunteers":54,"sex":17,"minAge":117,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":57,"phases":120,"briefSummary":121,"conditions":122,"keywords":4,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":138,"leadSponsor":140,"locationsCount":45},"100509349","orchestra-in-class-a-novel-booster-for-executive-functions-and-brain-development-in-young-primary-school-children-100509349","NCT05912270","Orchestra in Class, a Novel Booster for Executive Functions and Brain Development in Young Primary School Children","ORBIT","Inclusion Criteria:\n\n* School grade 3P\u002F4P (3rd and 4th year of elementary school (6-8-year-old children)\n* Right-handedness\n* Sufficient Mastery of the French Language\n* Able to give oral informed consent (child)\n* Able to give written informed consent (parent)\n\nExclusion Criteria:\n\n* Non-consent (children and or parents)\n* Repeated or skipped a class with respect to standard curriculum\n* Not corrected\u002Fsevere hearing deficits\n* Not corrected\u002Fsevere vision deficits\n* Severe neurodevelopmental disorders (eg. severe dyslexia, severe ADHD)\n* Older than 7 at the beginning of the school year if 3P\n* Older than 8 at the beginning of the school year if 4P\n* Protocolled music instrumental practice in the preceding year\n* Protocolled visual arts courses in the preceding year\n* MRI incompatibility (physical or psychological)\n* Psychometric battery incompatibility (psychological)","6 Years","8 Years",{"count":90,"type":21},[59],"How to optimally stimulate the developing brain is still unclear. Executive functions (EF) exhibited substantially stronger far transfer effects in children who learned to play a musical instrument than in children who acquired other arts.\n\nWhat is crucially lacking is a large-scale, long-term genuine randomized controlled trial (RCT) in cognitive neuroscience, comparing musical instrumental training (MIP) to another art form and a control group. Collected data of this proposal will allow, using machine learning, to build a data-driven multivariate model of children's interconnected brain and EF development over the first 2 years of their academic curriculum (6-8 years), with or without music or other art training.",[123,124,125,126,127,128,129,130,131,132,133],"Development, Child","Executive Functions","Interventions","Music","Arts","Brain Plasticity","Behavior","Brain Imaging","Magnetic Resonance Imaging","Functional Magnetic Resonance Imaging","Structural Brain Connectivity","2023-12-12",{"date":136,"type":37},"2023-12-18",{"date":136,"type":21},{"date":139,"type":21},"2027-04-30",{"name":43,"class":44},""]