[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Scuola Superiore di Studi Universitari e di Perfezionamento Sant'Anna\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":104},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,45,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100644492","funcitonality-and-safety-of-a-knee-device-for-gait-rehabilitation-in-neurological-patients-100644492",false,"NCT07670325","Funcitonality and Safety of a Knee Device for Gait Rehabilitation in Neurological Patients","Funzionalità e Sicurezza di un Dispositivo di Ginocchio Per Riabilitazione Della Deambulazione Con Pazienti Neurologici","AKO-R","Inclusion Criteria:\n\n* diagnosed stroke with fMRI\n* within 2 years from stroke event\n* FAC\\>= 3\n* height \\[1.5 - 2\\]m\n* weigth \\\u003C= 100 Kg\n\nExclusion Criteria:\n\n* MoCA\\\u003C18\n* Pregnancy\n* Implanted cardiac devices, such as pacemakers or implantable cardioverter defibrillators (ICDs)\n* Recent or current participation in research studies that, in the opinion of the Principal Investigator, may affect the subject's response to the study intervention\n* Severe aphasia\n* MAS=4","ALL","18 Years",{"count":20,"type":21},20,"ESTIMATED","INTERVENTIONAL",[24],"NA","This clinical investigation aims to evaluate the safety, feasibility, and preliminary performance of the AKO-R wearable robotic device for knee assistance during walking. The study involves participants performing treadmill and overground gait training under supervised conditions, with the device providing assistive torque to support movement. Clinical and functional outcomes are assessed using validated measurement tools, while additional data are collected to characterize user performance and interaction with the device. The study is designed as an exploratory investigation to gather evidence supporting the clinical use and further development of the device. Primary outcomes regards safety of the device and preliminary clinical benefit on gait symmetry.",[27],"Stroke",[29,30,31],"exoskeleton","robotics rehabilitation","stroke","RECRUITING","2026-06-24",{"date":35,"type":36},"2026-06-26","ACTUAL",{"date":38,"type":36},"2026-06-22",{"date":40,"type":21},"2026-11-30",{"name":42,"class":43},"Scuola Superiore di Studi Universitari e di Perfezionamento Sant'Anna","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":44},"100584204","clinical-evaluation-of-intuitive-bidirectional-strategies-for-the-control-of-multi-articulated-prostheses-for-upper-limb-amputation-100584204","NCT06886295","Clinical Evaluation of Intuitive, Bidirectional Strategies for the Control of Multi-articulated Prostheses for Upper Limb Amputation","Inclusion Criteria:\n\n* subjects with transradial amputation, and minimum experience in the use of myoelectric prosthesis;\n* subjects who have expressed informed consent to participate in the study and consent to data processing.\n\nExclusion Criteria:\n\n* subjects with obvious visual and oculomotor defects;\n* concomitant comorbidities\u002Fdisabilities\u002Fchronic conditions, general or localized (Multiple Sclerosis, Parkinson's disease, muscle tone disorders, malignant neoplasms, etc.), which may interfere with the performance of the study;\n* pregnancy or breastfeeding;\n* declared or evident cognitive deficits that compromise the understanding of the required tasks (mini Mental State Examination≤ 24);\n* difficulty in understanding the Italian language.","65 Years",{"count":53,"type":21},14,[24],"The investigators propose to validate a non-invasive upper limb prosthesis capable of combining: 1) intuitive movement control through machine learning applied to myoelectric signals, and 2) vibrotactile sensory feedback in response to touch and object release events. The prosthesis is composed at the minimum of skin-surface electrodes for myoelectric signals, vibrotactile actuators, a multi-articulated and instrumented hand prosthesis and a centralized control system. Such system is validated for several weeks in non-supervised environments.",[57],"Upper Limb Amputation",[59,60,61,62,63,64,65,66],"amputation","prosthesis","pattern recognition","regression","vibrotactile","sensory feedback","myoelectric","EMG","2025-04-02",{"date":69,"type":36},"2025-04-03",{"date":71,"type":21},"2025-04-01",{"date":73,"type":21},"2026-12-31",{"name":42,"class":43},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":82,"sex":17,"minAge":83,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":87,"briefSummary":88,"conditions":89,"keywords":92,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},"100585839","a-novel-accessible-and-widespread-healthcare-service-model-based-on-technology-innovation-for-objective-early-diagnosis-and-therapeutic-monitoring-of-parkinsons-disease-promoting-continuity-of-care-100585839","NCT06907589","A Novel Accessible and Widespread Healthcare Service Model Based on Technology Innovation for Objective (Early) Diagnosis and Therapeutic Monitoring of Parkinson's Disease Promoting Continuity of Care","OLIMPIA","Inclusion Criteria:\n\n1. Healthy subjects - Inclusion Criteria:\n\n   * Adult subjects, both sexes, aged 50-80 years old\n   * MMSE score \\>= 24 absence of olfactory deficit detected on IOIT olfactory test (22). Age class 50-59 years: normal with score \\\u003C=5; age class 60-69 years: normal with score \\\u003C=6; age class \\> 70 years: normal with score \\\u003C=7\n   * absence of neurological diseases\n   * absence of functional deficit in the sphere of locomotion as a result of traumatic injury or from other cause to the upper and\u002For lower limbs and\u002For pelvis and\u002For spine\n   * expression of informed consent to participate in the study\n2. Subjects with Parkinson's disease -- Inclusion criteria:\n\n   * adult subjects, both sexes, 50-80 years of age\n   * MMSE score \\>= 24\n   * subjects with Parkinson's disease in the absence of motor fluctuations and dyskinesias, or subjects with Parkinson's disease with mild motor fluctuations throughout the day, but to be examined in the ON phase and in the absence of dyskinesias\n   * Hoehn and Yahr stage 1, 2, 3\n   * absence of functional deficit in the sphere of locomotion as a result of traumatic injury or from other cause to the upper and\u002For lower limbs and\u002For pelvis and\u002For spine\n   * expression of informed consent to participate in the study\n\nExclusion Criteria:\n\n1. Healthy subjects - Exclusion criteria:\n\n   * denial of informed consent to participate in the study\n   * Presence of olfactory deficit detected on IOIT olfactory test. Age class 50-59 years: hyposmia with score \\>=6; age class 60-69 years: hyposmia with score \\>=7; age class \\> 70 years: hyposmia with score \\>=8\n   * body weight greater than 120 kg\n   * insufficient degree of cooperation\n   * malignant neoplasm in progress or with negative follow-up of less than 6 years\n   * structured joint stiffness in the upper and\u002For lower extremities preventing proper execution of movements\n   * paresis and\u002For plegia of upper and\u002For lower limb muscle groups from both peripheral and central nerve injury\n   * mono\u002Fmulti\u002Fpoly sensory and\u002For motor neuropathy\n   * chronic inflammatory diseases with joint involvement of the upper and\u002For lower limbs\n   * vertiginous syndromes in the acute phase\n   * neurodegenerative diseases\n   * fever\n   * venous thrombosis\n   * cardiovascular disorders or other acute or chronic conditions capable of affecting the proper performance of motor exercises\n   * spinal or joint pain of various etiologies that may affect the performance of motor exercises\n   * positive history of recurrent acute cervico-brachialgia and\u002For lumbosciatica\n2. Subjects with Parkinson's disease - Exclusion criteria:\n\n   * Denial of informed consent to participate in the study\n   * Hoenn and Yahr stage 4, 5\n   * Patient who needs to use an aid (cane or walker) while walking or cannot walk unless aided by a person\n   * body weight greater than 120 kg\n   * insufficient degree of cooperation\n   * malignant neoplasm in place or with negative follow-up of less than 6 years\n   * structured joint stiffness in the upper and\u002For lower extremities that prevents proper execution of movements\n   * paresis and\u002For plegia of upper and\u002For lower limb muscle groups from both peripheral and central nerve injury mono\u002Fmulti\u002Fpoly sensory and\u002For motor neuropathy\n   * chronic inflammatory diseases with joint involvement of the upper and\u002For lower limbs\n   * vertiginous syndromes in the acute phase\n   * neurodegenerative diseases, excluding Parkinson's disease\n   * fever\n   * venous thrombosis\n   * cardiovascular disorders or other acute or chronic conditions capable of affecting the proper performance of motor exercises\n   * spinal or joint pain of various etiologies that may affect the performance of motor exercises\n   * positive history of recurrent acute cervico-brachialgia and\u002For low back pain",true,"50 Years","80 Years",{"count":86,"type":21},250,[24],"The present study aims to use the SensMode System - a system composed of wearable devices for upper and lower limb movement analysis and electronic device for data acquisition and processing - on healthy subjects, subjects with idiopathic hyposmia, patients with Parkinson's disease, and subjects with de-novo drug-naïve extrapyramidal syndrome. The purpose is to identify normative data of objective motor measures obtained with such a system, as well as to increase knowledge about the potential contribution such a solution can make to the preclinical diagnosis of Parkinson's disease and the management of patients with this disease.",[90,91],"Parkinson Disease","Healthy Adult",[93,94,95],"parkinson's disease","wearable sensors","motor data","2025-03-26",{"date":67,"type":36},{"date":99,"type":36},"2024-05-13",{"date":101,"type":21},"2026-01-08",{"name":42,"class":43},5,""]