[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Sean Fain\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":71},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,46],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100587200","phase-2-using-xe-mri-to-guide-radiation-therapy-for-lung-cancer-100587200",false,"NCT06925295","Using Xe MRI to Guide Radiation Therapy for Lung Cancer","Image-Based Functionally Adapted Radiation Therapy for Lung Cancer","(XeRTLC)","Inclusion Criteria:\n\nSubjects must meet all of the following inclusion criteria to be eligible for enrollment into the trial\n\n1. Aged 18-80 years\n2. Willing and able to provide informed consent and adhere to visit\u002Fprotocol schedules (Consent must be given before any study procedures are performed.)\n3. Clinical diagnosis of lung cancer made by a board-certified oncologist with intent to treat with stereotactic body radiation therapy. We will not exclude individuals based on cancer type or severity of disease with the exception of the below criteria\n\nExclusion Criteria:\n\nSubjects presenting with any of the following will not be included in the trial:\n\n1. Subject is less than 18 years old or incarcerated\n2. MRI is contraindicated based on responses to MRI screening questionnaire\n3. Subject is pregnant or lactating\n4. Resting oxygen saturation \\\u003C90% on supplemental oxygen\n5. Respiratory illness of bacterial or viral etiology within 30 days of planned treatment\n6. Subject has history of any known ventricular cardiac arrhythmia\n7. Subject has history of cardiac arrest within the last year\n8. Subject has prior history of cancer treatment with radiation therapy to the lung\n9. Subject has concurrent cancer treatment with agents associated with increased risk of radiation pneumonitis (e.g. immunotherapy, chemotherapy)\n10. Subject does not fit into 129Xe vest coil used for MRI\n11. Subject cannot hold his\u002Fher breath for 15 seconds\n12. Subject deemed unlikely to be able to comply with instructions during imaging\n13. Medical or psychological conditions which, in the opinion of the investigator, might create undue risk to the subject or interfere with the subject's ability to comply with the protocol requirements","ALL","18 Years","80 Years",{"count":21,"type":22},15,"ESTIMATED","INTERVENTIONAL",[25],"PHASE2","The purpose of this research study is to explore using MRI scans with xenon to better image lung function, how lung function changes after radiation therapy, and to guide radiation therapy away from parts of the lung that have good function. This project is foundational to performing additional studies to establish if novel MRI imaging can serve as a guidance tool for lung cancer radiation treatment.",[28],"Imaging Techniques",[30,31,32],"Lung cancer","Xenon","Imaging","RECRUITING","2025-12-30",{"date":36,"type":37},"2026-01-02","ACTUAL",{"date":39,"type":37},"2025-08-30",{"date":41,"type":22},"2027-01",{"name":43,"class":44},"Sean Fain","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":53,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":45},"100547346","phase-1-chronic-lung-allograft-dysfunction-mri-study-100547346","NCT06406777","Chronic Lung Allograft Dysfunction MRI Study","Validation of MRI, CT and Pulmonary Function Tests for Early Detection of Chronic Lung Allograft Dysfunction","All subjects-Inclusion Criteria:\n\n* Ages 18-80\n* English Speaking Subjects\n* Willingness and ability to provide informed consent\n* Non-smoker\n\nLung transplant patients-inclusion criteria:\n\n* \\>\u002F= 6 months from lung transplant\n* History of bilateral lung transplant\n\nCLAD-free patients-inclusion criteria:\n\n* Stable spirometry with FEV1 \\> 90% of baseline value (average of 2 best values) and forced mid-expiratory flow (FEF) (25-75) \\> 75% of baseline\n* Total Lung Capacity (TLC) \\> 90 % of baseline\n* Post-transplant chest radiograph without significant abnormality\n* No evidence of on-going lung infection or allograft rejection\n\nEarly CLAD patients-inclusion criteria:\n\n* FEV1 \\\u003C 80% of baseline value (average of 2 best values)\n* Follow up 6-months or decline in lung function (20% decrease in FEV1 without evidence of infection or acute rejection)\n\nExclusion Criteria:\n\n* SAO2 drops below 90% (in absence of mechanical failure) during normal tidal breathing\n* Unilateral diaphragm paralysis\n* Evidence of acute illness on day of study\n* Evidence of restrictive lung disease\n* Dependence on supplemental oxygen\n* History of cardiac disease\n* Pregnancy (self-declared)\n* Lactating women\n* Participants with metal objects in their body\n* Known contraindication to MRI examination\n* Systolic blood pressure reading of \\\u003C 100 mmHg or \\> 200 mmHg\n* Diastolic blood pressure reading of \\\u003C60 mmHg or \\> 100 mmHg",true,{"count":55,"type":22},100,[57,25],"PHASE1","This studies purpose is to confirm the efficacy and efficiency of using OE-MRI and MRI with hyperpolarized gas techniques and Iodinated contrast CT scan, this will enhance understanding of CLAD pathophysiology. Moreover, this project is foundational to performing additional studies to establish if novel MRI imaging can serve as an objective confirmatory diagnostic tool for CLAD in post-transplant patients.",[60],"Chronic Lung Allograft Dysfunction Lung MRI (CLAD)",[62],"Lung Transplant","2025-03-24",{"date":65,"type":37},"2025-03-27",{"date":67,"type":37},"2025-03-20",{"date":69,"type":22},"2028-09",{"name":43,"class":44},""]