[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Shady Grove Fertility Reproductive Science Center\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":141},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,44,68,96],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100610290","hormonal-optimization-late-vs-immediate-start-after-discontinuation-of-oral-contraceptives-in-assisted-reproductive-technology-holiday-100610290",false,"NCT07225660","Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)","A Randomized Blinded Controlled Trial Assessing Hormonal Optimization: Late vs. Immediate Start After Discontinuation of Oral Contraceptives in Assisted Reproductive technologY (HOLIDAY)","HOLIDAY","Inclusion Criteria:\n\n1. Ovary-bearing individuals 18 to 40 years of age.\n2. BMI \\\u003C 40 kg\u002Fm2\n3. Non-smoker for at least 3 months prior to study enrollment.\n\nExclusion Criteria:\n\n1. BMI greater than or equal to 40 kg\u002Fm2\n2. Current Smoker\n3. Any contraindications to ovarian stimulation or outpatient egg retrieval under anesthesia","FEMALE","18 Years","40 Years",{"count":21,"type":22},394,"ESTIMATED","INTERVENTIONAL",[25],"NA","HOLIDAY is a two-arm, parallel-group, multi-center, randomized trial in which subjects undergoing planned oocyte cryopreservation will be randomized to receive either a 2-month pause of Combined Hormonal Contraceptives (CHC) or immediate start (without a pause).",[28],"Fertility Preservation",[30],"planned oocyte cryopreservation","RECRUITING","2026-02-26",{"date":34,"type":35},"2026-03-02","ACTUAL",{"date":37,"type":35},"2026-02-25",{"date":39,"type":22},"2027-07-01",{"name":41,"class":42},"Shady Grove Fertility Reproductive Science Center","OTHER",3,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":51,"enrollmentInfo":52,"targetDuration":54,"studyType":55,"phases":4,"briefSummary":56,"conditions":57,"keywords":4,"overallStatus":59,"whyStopped":4,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":4},"100612364","progesterone-levels-and-frozen-embryo-transfer-outcomes-100612364","NCT07252622","Progesterone Levels and Frozen Embryo Transfer Outcomes","PLATO","Inclusion Criteria:\n\n1. Signed informed consent\n2. Female patient undergoing programmed frozen embryo transfer using exogenous estrogen and progesterone, with exogenous progesterone administered via a combination of vaginal progesterone (Endometrin®) (2-3 times daily) and intermittent progesterone-in-oil (PIO) (every 3rd day) according to standard protocol. Protocols involving other formulations of vaginal progesterone (e.g. Crinone®, Prometrium®, will also be included).\n3. Planned transfer one 1 euploid embryo. Recruited patients will have at least 1 euploid embryo available for transfer.\n4. Standard eligibility criteria to undergo frozen embryo transfer at Shady Grove Fertility.\n5. 18 years and older\n\nExclusion Criteria:\n\n1. Age less than 18 years or greater than 51 years\n2. Planned intervention based on serum progesterone concentration measured any time after initiation of intramuscular or vaginal progesterone.\n3. Uterine cavity abnormality that has not been surgically corrected.\n4. Any medical or surgical contraindication to undergoing programmed frozen embryo transfer or pregnancy.\n5. Planned use of embryos cryopreserved by slow-freeze, prior to blastocyst stage, or other than PGT-A normal.\n6. Currently breast feeding, pregnancy, or having a contraindication to pregnancy.\n7. Participation in any experimental drug study within 60 days prior to screening.","50 Years",{"count":53,"type":22},659,"9 Months","OBSERVATIONAL","Frozen embryo transfers (FET) now represent the majority of all embryo transfer cycles, and upwards of 60% live births in United States are now attributable to frozen embryo transfers (1). Exogenous progesterone for endometrial decidualization and luteal phase support is thought to be critical to both optimizing endometrial receptivity for implantation as well as sustaining early pregnancy prior to reliable secretory activity of the early placenta.\n\nThe purpose of this study is to:\n\n1. Determine the prevalence of low serum progesterone levels (less than 10 ng\u002Fml) among patients undergoing a programmed embryo transfer cycle on the day of frozen embryo transfer.\n2. Determine if serum progesterone \\\u003C 10 ng\u002Fml on the day of frozen embryo transfer is associated with poorer FET outcomes: ongoing pregnancy (primary outcome), live birth, biochemical pregnancy, and clinical pregnancy.",[58],"IVF","NOT_YET_RECRUITING","2025-11-19",{"date":62,"type":35},"2025-11-28",{"date":64,"type":22},"2025-12-01",{"date":66,"type":22},"2028-11-01",{"name":41,"class":42},{"id":69,"slug":70,"hasResults":11,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":74,"eligibilityCriteria":75,"healthyVolunteers":76,"sex":77,"minAge":4,"maxAge":4,"enrollmentInfo":78,"targetDuration":80,"studyType":55,"phases":4,"briefSummary":81,"conditions":82,"keywords":85,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":95},"100610402","evaluating-the-status-of-complex-aneuploidy-to-locate-additional-transferrable-embryos-100610402","NCT07227116","Evaluating the Status of Complex Aneuploidy to Locate Additional Transferrable Embryos","ESCALATE: Evaluating the Status of Complex Aneuploidy to Locate Additional Transferrable Embryos","ESCALATE","Inclusion Criteria:\n\n* Having ≥ 1 embryo classified as whole chromosome chaotic or complex aneuploid of 3 or more chromosomes following preimplantation genetic testing for aneuploidy using an NGS based platform Signed informed consent\n\nExclusion Criteria:\n\n* Embryos not meeting complex\u002Fchaotic criteria Patients declining consent",true,"ALL",{"count":79,"type":22},280,"12 Months","This study aims to evaluate the reproductive potential of embryos classified as \"complex aneuploid\" (involving three or more abnormal chromosomes) or \"chaotic\" (six or more abnormal chromosomes) through preimplantation genetic testing for aneuploidy (PGT-A). Specifically, we seek to determine whether embryos initially reported as having multiple chromosomal abnormalities might still have the potential for normal chromosomal composition, the opportunity for transfer, and ultimately, the potential to achieve a live birth through re-biopsy and reanalysis.\n\nKey Information:\n\nThis portion of the study seeks your consent for the re-biopsy and genetic reanalysis of the embryos only. It does not yet include consent for potential future transfer.\n\nParticipation remains completely voluntary, and your decision will not affect your current or future care.\n\nWe deeply appreciate your support and commitment to advancing fertility research.",[83,84],"Complex Aneuploidy","Chaotic Aneuploidy",[86],"Chaotic, Complex, Aneuploidies, Embryos","2025-11-07",{"date":89,"type":35},"2025-11-12",{"date":91,"type":22},"2025-11-01",{"date":93,"type":22},"2026-06",{"name":41,"class":42},12,{"id":97,"slug":98,"hasResults":11,"nctId":99,"briefTitle":100,"officialTitle":101,"acronym":102,"eligibilityCriteria":103,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":104,"targetDuration":4,"studyType":23,"phases":106,"briefSummary":107,"conditions":108,"keywords":112,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":140},"100606439","sister-sibling-oocyte-insemination-with-frozen-sperm-from-third-party-donors-evaluation-of-reproductive-techniques-100606439","NCT07175571","SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques","Prospective Randomized Sibling-Oocyte Trial Comparing Fertilization and Embryo Development Outcomes Between Intracytoplasmic Sperm Injection (ICSI) and Conventional IVF Using Frozen Donor Sperm","SISTER","Inclusion Criteria:\n\n* Female patients undergoing IVF with frozen donor sperm at Shady Grove Fertility Center\n* Normal ovarian reserve (AMH \\> 1 ng\u002FmL, AFC \\> 10)\n* Absence of male factor infertility\n* Post-wash parameters: \\>50% motility, \\>5mil concentration\n* \\> 4 oocytes retrieved at time of transvaginal oocyte retrieval\n\nExclusion Criteria:\n\n* Donor Sperm with significant male factor infertility (e.g., abnormal sperm concentration, motility, or morphology)\n* Any medical condition contraindicating ART",{"count":105,"type":22},95,[25],"The goal of this clinical trial is to learn whether two different methods of helping eggs and sperm join-intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)-lead to better embryo development when using frozen donor sperm in people who do not have male fertility problems. The main questions it aims to answer are:\n\nDoes one method create more usable embryos (blastocysts) than the other?\n\nIs there a difference in how often fertilization does not happen at all?\n\nDo either of the methods lead to better embryo quality or early pregnancy?\n\nParticipants will:\n\nHave their eggs divided into two groups. One group will be fertilized using ICSI (where a sperm is injected directly into an egg), and the other using conventional IVF (where eggs are mixed with sperm in a dish).\n\nThe fertilization method for each egg will be randomly assigned, with a random process also used to determine the assignment of any extra egg when an odd number is collected.\n\nContinue regular fertility treatment while the study team compares the results of each fertilization method.\n\nThis study includes people with non-male factor infertility and uses frozen donor sperm. It hopes to learn whether ICSI, which is often used even when it may not be needed, truly helps improve outcomes compared to conventional IVF in these cases.",[109,110,111],"Infertility, Female","Reproductive Techniques, Assisted","Fertilization in Vitro",[113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131],"Intracytoplasmic Sperm Injection (ICSI)","Conventional IVF","Frozen Donor Sperm","Sibling-Oocyte Design","Non-Male Factor Infertility","Blastulation Rate","Total Fertilization Failure (TFF)","Fertilization Outcomes","Embryo Quality","Clinical Pregnancy Rate","Assisted Reproductive Technology (ART)","Embryo Development","In Vitro Fertilization","Oocyte Randomization","Female Infertility","Cryopreserved Sperm","Randomized Controlled Trial (RCT)","Reproductive Medicine","Fertility Treatment","2025-09-09",{"date":134,"type":35},"2025-09-16",{"date":136,"type":22},"2025-09-15",{"date":138,"type":22},"2026-05-01",{"name":41,"class":42},1,""]