[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"Shaheed Mohtarma Benazir Bhutto Institue of Trauma\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":165},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,43,67,91,116,141],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":39,"locationsCount":42},"100642985","comparison-of-different-epidural-lidocaine-bupivacaine-mixtures-for-lower-limb-surgeries-100642985",false,"NCT07648784","Comparison of Different Epidural Lidocaine-Bupivacaine Mixtures for Lower Limb Surgeries","Comparison of the Outcomes of Epidural Injection of Different Lidocaine-Bupivacaine Mixtures for Lower Limb Surgeries at a Tertiary Care Hospital, Karachi","LBM-LLS","Inclusion Criteria:\n\nPatients undergoing lower limb surgeries under epidural block Age between 20-60 years Either gender American Society of Anesthesiologists (ASA) physical status I and II Patients willing to provide informed consent\n\nExclusion Criteria:\n\nContraindications to regional anesthesia including patient refusal and bleeding diathesis History of allergy to local anesthetics Patients undergoing emergency surgeries Deformities of the spine History of hypothyroidism or hyperthyroidism Pregnant patients","ALL","20 Years","60 Years",{"count":21,"type":22},96,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized controlled trial will evaluate different epidural lidocaine-bupivacaine mixtures in patients undergoing lower limb surgery at a tertiary care hospital in Karachi, Pakistan. Ninety-six participants will be randomly assigned to one of three study groups receiving different combinations of lidocaine and bupivacaine for epidural anesthesia.\n\nThe purpose of this study is to determine which anesthetic mixture provides the most effective anesthesia for lower limb surgery. The study will compare the speed of onset and duration of anesthesia, as well as the effects of the anesthetic mixtures on cardiovascular stability during surgery.\n\nThe results of this study may help identify an epidural anesthetic regimen that provides optimal surgical conditions, effective pain control, and stable hemodynamic parameters for patients undergoing lower limb procedures.",[28],"Epidural Dosage of Lidocaine Bupivacaine in Lower Limb Surgeries",[30],"Epidural, Lidocaine, Bupivacaine, lower limb surgeries","RECRUITING","2026-06-12",{"date":34,"type":35},"2026-06-15","ACTUAL",{"date":37,"type":35},"2025-12-18",{"date":34,"type":22},{"name":40,"class":41},"Shaheed Mohtarma Benazir Bhutto Institue of Trauma","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":42},"100620924","height-based-and-conventional-spinal-anaesthetic-dosing-in-geriatric-patients-100620924","NCT07363941","HEIGHT-BASED AND CONVENTIONAL SPINAL ANAESTHETIC DOSING IN GERIATRIC PATIENTS","COMPARISON OF HEMODYNAMIC AND ANAESTHETIC OUTCOMES BETWEEN HEIGHT-BASED AND CONVENTIONAL SPINAL ANAESTHETIC DOSING IN GERIATRIC PATIENTS UNDERGOING LOWER LIMB ORTHOPAEDIC SURGERIES","Inclusion Criteria:\n\nIndividuals aged 60 to 80 years. Either gender (male or female). Patients who are ASA physical status I-III. Individuals scheduled to undergo elective lower limb orthopaedic surgeries (e.g., fracture fixation, total knee replacement, open reduction and internal fixation).\n\nPatients planned to receive spinal anaesthesia as the primary anaesthetic technique.\n\nThose who provide informed written consent for participation in the study.\n\nExclusion Criteria:\n\nIndividuals exhibiting a stature inferior to 150 cm. Patients receiving anti-hypertensive drugs or those on beta blockers or beta-agonists.\n\nPatients with a history of neurological disease like CVA or Parkinsonism. Patients presenting with sepsis (≥ 2 positive SIRS criteria with positive aseptically obtained blood or wound culture).\n\nPatients with a history of coagulation disorders like haemophilia or vWD or those with a history of anti-platelet drug intake in the last 2 weeks.\n\nIndividuals possessing a documented history of hypersensitivity reactions to pharmacological agents utilized in the research.\n\nPatients who will be diagnosed with a skin infection at the spinal needle puncture site.\n\nPatients undergoing emergency orthopaedic procedures requiring immediate intervention","80 Years",{"count":52,"type":22},104,[25],"The goal of this clinical trial is to find out whether height-based dosing of spinal anaesthesia provides better hemodynamic stability and anesthetic outcome than conventional fixed dosing in elderly patients undergoing lower limb orthopaedic surgery.The main questions this study aims to answer are:\n\n1. Does height-based spinal anaesthetic dosing reduce the risk of hypotension and bradycardia during surgery as compared to conventional fixed dosing?\n2. Does it improve anaesthetic outcomes, such as the onset and duration of sensory and motor block?",[56,57,58],"Geriatric Population","Spinal Anesthesia Induced Hypotension","Spinal Anesthesia in Elderly Patients","2026-01-15",{"date":61,"type":35},"2026-01-23",{"date":63,"type":35},"2026-01-03",{"date":65,"type":22},"2026-05-04",{"name":40,"class":41},{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":4,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":17,"minAge":74,"maxAge":75,"enrollmentInfo":76,"targetDuration":4,"studyType":23,"phases":78,"briefSummary":79,"conditions":80,"keywords":4,"overallStatus":82,"whyStopped":4,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":4},"100612777","comparison-of-dressing-materials-of-donor-site-of-split-thickness-skin-graft-paraffin-mesh-gauze-vs-povidone-iodine-foam-at-smbb-institute-of-trauma-karachi-100612777","NCT07257991","Comparison of Dressing Materials of Donor Site of Split-thickness Skin Graft; Paraffin Mesh Gauze vs Povidone-Iodine Foam at SMBB Institute of Trauma Karachi","Inclusion Criteria:\n\n* Undergoing skin graft with donor site size between 25 to 200 cm2\n\nExclusion Criteria:'\n\n* Patients wit history of disease impairing wound healing (Diabetes, Malignancy, Cancer, taking immunosuppressants)\n* Pregnant or lactating females",true,"18 Years","75 Years",{"count":77,"type":22},82,[25],"The goal of this clinical trial is to learn if povidone-iodine foam dressing is better in achieving complete reepithelialization of donor site wounds after harvest of split-thickness skin graft as paraffin mesh gauze.\n\nThe main questions it aims to answer are:\n\nDoes povidone-iodine foam dressing promotes complete reepithelialization earlier in comparison? Which type of dressing will require fewer replacements? Which type of dressing material is associated with less pain?\n\nNon-probability consecutive sampling method will be used and participants divided in two groups. Donor site wounds after split-thickness skin graft harvest will be dressed using two different dressing materials. Participants will be followed until complete epithelialization with change of dressing on follow-ups if required. Complete epithelialization is usually achieved within two weeks.",[81],"Skin Graft Wounds","NOT_YET_RECRUITING","2025-12-05",{"date":85,"type":35},"2025-12-15",{"date":87,"type":22},"2026-01-01",{"date":89,"type":22},"2026-05-01",{"name":40,"class":41},{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":96,"acronym":4,"eligibilityCriteria":97,"healthyVolunteers":73,"sex":17,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":4,"studyType":23,"phases":102,"briefSummary":104,"conditions":105,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":42},"100579064","phase-4-effect-of-dexamethasone-on-post-spinal-hypotension-100579064","NCT06819436","Effect of Dexamethasone on Post-spinal Hypotension","Effect of Dexamethasone on Post-spinal Hypotension in Geriatric Patients Undergoing Orthopaedic Surgery at Tertiary Care Hospital Karachi.","Inclusion Criteria:\n\nPatient undergoing orthopedic surgery in spinal anesthesia. ASA ≤ 2.\n\nExclusion Criteria:\n\nPatients with history of cardiac arrhythmias. Patients with history of acute coronary syndrome. Patient with history of polytrauma. Patients with contraindication to SA (e.g., coagulopathy, thrombocytopenia, allergy to local anesthetic agent) and those on steroids or serotonin related medications (e.g., selective serotonin reuptake inhibitor) will be excluded.","65 Years","85 Years",{"count":101,"type":22},170,[103],"PHASE4","The goal of this clinical trial is to learn if intravenous dexamethasone is effective for prevention of post spinal hypotension in geriatric population undergoing orthopedic surgeries. The main question aim to answer is:\n\nDoes intravenous dexamethasone in participants undergoing orthopedic procedures of lower limb under spinal anesthesia prevents post spinal hypotension? Researchers are comparing two groups of participants\n\n* Participants in (Dexamethasone Group) Group D are receiving intravenous dexamethasone 8mg preoperatively\n* Participants in (Placebo Group) Group P are receiving placebo preoperatively.",[106,56,107],"Post Spinal Anaesthesia Hypotension","Orthopedic Surgeries","2025-02-05",{"date":110,"type":35},"2025-02-11",{"date":112,"type":22},"2025-02",{"date":114,"type":22},"2025-05",{"name":40,"class":41},{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":17,"minAge":74,"maxAge":19,"enrollmentInfo":123,"targetDuration":4,"studyType":23,"phases":125,"briefSummary":128,"conditions":129,"keywords":132,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":139,"leadSponsor":140,"locationsCount":42},"100577686","phase-2-adrenaline-nasal-pack-vs-xylometazoline-nasal-drops-during-nasotracheal-intubation-100577686","NCT06801522","Adrenaline Nasal Pack vs Xylometazoline Nasal Drops During Nasotracheal Intubation","Comparison of the Efficacy of Adrenaline Nasal Pack and Xylometazoline Nasal Drops in Decreasing Nasal Bleeding During Nasotracheal Intubation","Inclusion Criteria:\n\n* ASA 1 and 2\n* Age group between 18-60 years\n* Mallampati score 1 and 2\n* Either gender\n* Participants who undergo elective oromaxillofacial surgery\n\nExclusion Criteria:\n\n* Lack of consent\n* Participants with anticipated difficult airway\n* Participants receiving anticoagulant therapy\n* History of nasal abnormality (nasal surgery, trauma, polyp, obstruction)\n* History of repeated epistaxis\n* History of uncontrolled hypertension, diabetes, pregnancy, and any other cardiac or cerebral events.",{"count":124,"type":22},70,[126,127],"PHASE2","PHASE3","The goal of this trial is to compare efficacy of xylometazoline nasal drops and adrenaline nasal pack in participants undergoing elective oromaxillofacial surgeries.\n\nThe main question aim to answer is xylometazoline nasal drops better than adrenaline nasal packing in terms of nasal bleeding during nasotracheal intubation. Researchers are comparing 2 groups of participants.\n\nParticipants in group Xylometazoline are receiving 0.1% xylometaxoline nasal drops.\n\nParticipants in group Adrenaline are receiving adrenaline nasal packing.",[130,131],"Nasal Bleeding","Nasotracheal Intubation",[133],"Nasal bleeding, Nasotracheal intubation, adrenaline pack, xylometazoline nasal drops","2025-01-24",{"date":136,"type":35},"2025-01-30",{"date":138,"type":35},"2024-12-01",{"date":114,"type":22},{"name":40,"class":41},{"id":142,"slug":143,"hasResults":11,"nctId":144,"briefTitle":145,"officialTitle":146,"acronym":147,"eligibilityCriteria":148,"healthyVolunteers":73,"sex":17,"minAge":74,"maxAge":19,"enrollmentInfo":149,"targetDuration":4,"studyType":23,"phases":151,"briefSummary":152,"conditions":153,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":42},"100574419","c-mac-blade-d-video-vs-macintosh-laryngoscope-for-double-lumen-tube-insertion-100574419","NCT06759038","C-MAC Blade D Video Vs Macintosh Laryngoscope for Double Lumen Tube Insertion","Comparison Between C-MAC Blade D Video Laryngoscope and Macintosh Laryngoscope for Double Lumen Tube Insertion in Patients Undergoing Elective Thoracic Surgeries","DLT","Inclusion Criteria:\n\n* Mallampati 1 and 2.\n* ASA 1 and 2.\n* Patients who will be prepared for elective thoracic surgeries under general anesthesia.\n\nExclusion Criteria:\n\n* Pregnant Patients.\n* Patients with anticipated difficult airway.\n* Patients with limited neck extension.\n* Thyromental distance less than 6.5cm.\n* BMI greater than 35. (Weight in kilogram (kg) divided by height in meters squared)\n* Patients at a risk of aspiration.\n* Failure to intubate the patient after 3 attempts.",{"count":150,"type":22},60,[25],"The goal of this clinical trial is to know which type of laryngoscope is better for Double Lumen Tube (DLT) insertion, in participants undergoing elective thoracic surgeries.\n\nThe main question aim to answer is Is C-MAC blade D video laryngoscope better than Macintosh laryngoscope for DLT insertion in term of time taking for intubation and hemodynamic changes to laryngoscopy? Researchers are comparing two groups of participants\n\n* Participants in Group A are receiving intubation from C-MAC blade D video laryngoscope.\n* Participants in Group B are receiving intubations from Macintosh laryngoscope.",[154,155,156],"Video Laryngoscope","Double Lumen Tube Intubation","Elective Thoracic Surgery","2024-12-27",{"date":159,"type":35},"2025-01-06",{"date":161,"type":35},"2024-12-03",{"date":163,"type":22},"2025-03",{"name":40,"class":41},""]